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P081

Matrix Metalloproteinase Degraded Biglycan (BGM) and Citrullinated and MMP-degraded Vimentin (VICM) differentiates Crohn's disease from ulcerative colitis.

Authors:

J.H. Mortensen*1, L. Godskesen2, M.D. Jensen2, L. Klinge2, J. Kjeldsen2, M. Karsdal1, A.-C. Bay-Jensen1, A. Krag2

1Nordic Bioscience, Rheumatology, Herlev, Denmark, 2Odense University Hospital, Gastroenterology , Odense, Denmark

P082.

Divergent effects of gut bacteria altered in dysbiosis of inflammatory bowel disease on monocytes and macrophage polarisation

Authors:

T. Kruis1, A. Batra1, G. Loh2, M. Blaut2, B. Siegmund1, 1Charité Universitätsmedizin Berlin, Abteilung für Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany, 2Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke, Abteilung für Gastrointestinale Mikrobiologie, Potsdam, Germany

P082. Altered oligosaccharide structures reduce colitis induction in mice defective in glycosyltransferases
Authors:

S. Shinzaki1, H. Iijima1, T. Inoue1, M. Tsujii1, E. Miyoshi2, T. Takehara1, 1Osaka University, Gastroenterology and Hepatology, Suita, Japan, 2Osaka University, Molecular Biochemistry and Clinical Investigation, Suita, Japan

P082. Diagnostic accuracy of confocal fluorescence microscopy in diagnosing dysplasia in patients affected by long-standing ulcerative colitis
P082. Survival over >20 years in a large Australian metropolitan cohort of inflammatory bowel disease patients: No excess overall mortality
P082

The relationship between onset days and clinical characteristics of pouchitis after ileal pouch-anal anastomosis in Ulcerative Colitis

Authors:

Y. Okita*, T. Araki, M. Kawamura, Y. Nagano, S. Kondo, M. Inoue, Y. Toiyama, K. Tanaka, Y. Inoue, K. Uchida, Y. Mohri, M. Kusunoki

Mie University Graduate School of Medicine, Gastrointestinal and Pediatric Surgery, Tsu, Japan

P083.

Divalent metal-ion transporter 1 deficiency contributes to the anemia in inflammatory bowel disease

Authors:

C. Liu, W. Wu, T. Chen, L. Fang, M. Sun, R. Wu, Z. Liu, Shanghai Tenth People's Hospital, Tongji University, Department of Gastroenterology, Shanghai, China

P083. ADAMDEC1: a novel molecule linked to Crohn's disease, is associated with an increased susceptibility to Citrobacter rodentium colitis in the knock out mouse
Authors:

N. O'Shea1, A. Smith1, J. Dunne1, T. Chew1, A. Segal1, 1University College London, Centre of Molecular Medicine, Division of Medicine, London, United Kingdom

P083. Atypical disease phenotypes in paediatric ulcerative colitis: 5‑year analyses of the EUROKIDS registry [EUROKIDS Porto IBD Working Group of ESPGHAN]
P083. Risk factors and impact of Clostridium difficile infection in acute severe colitis needing hospitalization
P083

Low-grade Dysplasia in Ulcerative Colitis: Risk Factors associated with Progression to High-grade Dysplasia or Colorectal Cancer

Authors:

C.H.R. Choi*1, A. Ignjatovic Wilson1, M. Rutter2, M. Moorghen1, S. Thomas-Gibson1, J. Warusavitarne1, B. Saunders1, T. Graham3, A. Hart1

1St Mark's Hospital, Department of IBD, Colorectal Surgery and Wolfson Unit of Endoscopy, London, United Kingdom, 2University Hospital of North Tees, Department of Gastroenterology, Stockton-on-Tees, Teesside, United Kingdom, 3Queen Mary University of London, Centre for Tumour Biology, Barts Cancer Institute, London, United Kingdom

P084.

Dissecting the role of PPARgamma in intestinal fibrosis: EMT-activator ZEB1 as new molecular target

Authors:

S. Speca1, V. Flati2, C. Rousseaux3, C. Dubuquoy3, A. Langlois4, L. Dubuquoy1, B. Bertin4, S. Bellinvia5, P. Desreumaux1,6, G. Latella7, 1INSERM, U995, Lille, France, 2University of L'Aquila, Scienze cliniche applicate e biotecnologiche, L'Aquila, Italy, 3Intestinal Biotech Development, Intestinal Biotech Development, Lille, France, 4Université Lille-Nord de France, U995, Lille, France, 5Giuliani Spa, Milan, Italy, 6CHRU Lille, Gastroenterology, Lille, France, 7University of L'Aquila, Medicina clinica, sanità pubblica, scienze della vita e dell'ambiente, L'Aquila, Italy

P084. Effect of infliximab on monocyte subtypes in blood of patients with chronic inflammatory bowel disease
Authors:

S. Slevin1, C. Dennedy1, M. Griffin1, L. Egan2, 1National University of Ireland, Galway, REMEDI, Galway, Ireland, 2National University of Ireland, Galway, Department of Pharmacology and Therapeutics, Galway, Ireland

P084. Influence of personality on health-related quality of life in inflammatory bowel disease
P084. The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection: A prospective multicenter study
P084

Attributes of anti-TNF treatment that impact on preferences of patients with Crohn's disease candidates for biological treatment (IMPLICA Study)

Authors:

N. Borruel*1, S. Riestra2, J. Castro3, M. Costi4, L. Rodriguez-San Pedro5, C. Taxonera6, F. Casellas7

1Hospital Vall d´Hebrón, , Digestive, Barcelona. , Spain, 2Hospital Central de Asturias,, Digestive, Oviedo, Spain, 3Hospital Arquitecto Marcide, , Digestive, Ferrol, Spain, 4Abbvie, Health Economics and Market Access, Madrid, Spain, 5Abbvie, Medical and Quality Assurance, Madrid, Spain, 6Hospital Clínico San Carlos, ., Digestive, Madrid. , Spain, 7Hospital Vall d´Hebrón, , Digestive , Barcelona, Spain

P085.

Direct smooth muscle stimulatory effect of nitrergic inhibition by L-NMMA on the migrating motor complex modulated by muscarinic and 5-HT3 receptor blockade

Authors:

M.A. Halim1, S. Boghos1, L. Gillberg1, U. Karlbom2, M. Sundbom2, D.-L. Webb1, P.M. Hellström1, 1Uppsala University, Medical sciences, gastroenterology & hepatology, Uppsala, Sweden, 2Uppsala University, Surgical sciences, surgery, Uppsala, Sweden

P085. Effect of phytoestrogenic dietary supplementation on the progression of chronic intestinal inflammation to cancer in an animal model
Authors:

M. Principi1, N. De Tullio1, K. Lofano1, M. Pricci1, M.P. Scavo1, G. Piacentino1, A. Contaldo1, V. Neve1, E. Ierardi2, M.C. Comelli3, A. Di Leo1, 1University of Bari, Bari, Italy, 2University of Foggia, Italy, 3CM&D Pharma srl, Padova, Italy

P085. Primary sclerosing cholangitis in the course of inflammatory bowel disease in children
P085. Serum hepcidin and prohepcidin concentrations in inflammatory bowel disease