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P073. Ex vivo activation of triggering receptor expressed on myeloid cells 1 enhances the production of pro-inflammatory cytokines by inflammatory bowel disease mucosa
Authors:

F. Ammoscato1, P. Biancheri1, A. Di Sabatino2, R. Curciarello1, L. Kruidenier3, G.R. Corazza2, T.T. MacDonald1, 1Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Immunology and Infectious Disease, London, United Kingdom, 2Fondazione IRCCS Policlinico S. Matteo, University of Pavia, First Department of Medicine, Pavia, Italy, 3GlaxoSmithKline, Immuno-Inflammation CEDD, Stevenage, United Kingdom

P073

The role of eicosanoids in Inflammatory Bowel Disease

Authors:

U. Pisano1, D. Hildebrand1, B. Maskrey2, P. Whitfield2, A. Watson*1

1NHS Highlands, General Surgery, Raigmore Hospital, Inverness, United Kingdom, 2University of the Highlands and Islands, Lipidomics Research Facility, Inverness, United Kingdom

P074.

Expression of CCL20 and its corresponding receptor CCR6 is located to epithelium and infiltrating cells in the mucosa of IBD patients

Authors:

H.K. Skovdahl1, A.v. Granlund2, A.E. Østvik2, J.K. Damås2, A.K. Sandvik2, 1Norwegian University of Science and Technology, Institute for cancer research and molecular medicine, Trondheim, Norway, 2Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Trondheim, Norway

P074. Extracellular matrix protein expression in chronic repeated DSS colitis reflects transmural remodeling in human Crohn's disease
Authors:

C. Breynaert1, J. Cremer1, C. Perrier1, M. Ferrante1, S. Vermeire1, P. Rutgeerts1, J. Ceuppens2, K. Geboes3, G. Van Assche1, 1KU Leuven, TARGID, Leuven, Belgium, 2KU Leuven, Clinical immunology, Leuven, Belgium, 3KU Leuven, Translational Cell and Tissue Research, Leuven, Belgium

P074. Impact of smoking on Crohn's disease clinical course: Data from the multicenter Spanish study “TABACROHN”
P074. Mucosal mRNA expression profiling from the terminal ileum and colon reveals under‑expression of claudin 8, a tight junction molecule, as potentially causal in ulcerative colitis
P074

Circulating adipokynes and Paraoxonase-1 activity in overweight Crohn's disease patients

Authors:

K. Palatka*1, Z. Veréb2, L. Dávida1, P. Koncsos3, I. Seres3, G. Paragh3

1University Of Debrecen, Institute Of Internal Medicine, Department Of Gastroenterology, Debrecen, Hungary, 2University Of Szeged, Faculty Of Medicine, Department Of Ophthalmology, Stem Cells And Eye Research Laboratory, Szeged, Hungary, 3University Of Debrecen, Institute Of Internal Medicine, First Department Of Internal Medicine, Debrecen, Hungary

P075.

Epithelial Toll-like receptor 3-dependent synthesis of complement factor B and local complement activation in inflammatory bowel disease

Authors:

A.E. Østvik1,2,3, A.v.B. Granlund1,3, B.I. Gustafsson1,2, S.H. Torp4,5, T. Espevik1,3, J.K. Damås1,3,6, T.E. Mollnes3,7,8, A.K. Sandvik1,2,3, 1Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Trondheim, Norway, 2St. Olav's University Hospital, Department of Gastroenterology and Hepatology, Trondheim, Norway, 3Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, Trondheim, Norway, 4Norwegian University of Science and Technology, Department of Laboratory Medicine, Children and Women's Health, Trondheim, Norway, 5St. Olav's University Hospital, Department of Pathology and Medical Genetics, Trondheim, Norway, 6St. Olav's University Hospital, Department of Infectious Diseases, Trondheim, Norway, 7University of Oslo, 8Department of Immunology, Oslo University Hospital Rikshospitalet, and K.G. Jebsen IRC, Oslo, Norway, 8University of Tromsø, Research Laboratory, Nordland Hospital, Bodø, Tromsø, Norway

P075. Can clinical parameters of disease severity help to predict risk for osteoporosis in inflammatory bowel disease?
P075. Evolutive profile of biomarkers in postoperative Crohn's disease patients: identification of recurrence risk predictors
Authors:

E. Cerrillo1, I. Moret2, M. Iborra3, F. Rausell2, L. Tortosa2, G. Bastida3, M. Aguas3, G. Sánchez4, P. Nos3, B. Beltrán3, 1IIS La Fe University Hospital, Valencia, Spain, 2IIS La Fe University Hospital/CIBEREHD, Valencia, Spain, 3Gastroenterology Unit, La Fe University Hospital/CIBEREHD, Valencia, Spain, 4Radiology Unit, La Fe University Hospital, Valencia, Spain

P075. Oncostatin M promotes STAT3-dependent intestinal epithelial cell proliferation and MEK-1-dependent intestinal wound healing
P075

OCT4B1, a spliced variant of OCT4, is expressed in Inflammatory Bowel Disease

Authors:

G. Karamanolis*1, M. Maragkoudaki2, A. Vaiopoulou3, G. Theodoropoulos4, M. Gazouli3

1Athens Medical School, Gastroenterology Unit, 2nd Surgical Department, Athens, Greece, 2"Aghia Sofia" Children's Hospital, University of Athens, Paediatric , Athens, Greece, 3Athens Medical School, 3Department of Basic Medical Sciences, Laboratory of Biology, Athens, Greece, 4Athens Medical School, First Propaedeutic Surgical Department, Athens, Greece

P076.

Enhanced host adaptive response prerequisite to prevent relapse during maintenance therapy of IBD

Authors:

K.B. Hahm, E.H. Kim, P.W. Park, CHA University, Gastroenterology, Seongnam, South Korea

P076. A gene expression outlier strategy towards identifying molecular causes of Crohn's disease
P076. Epithelial apoptotic loss is enhanced even in tissue from uninflamed mucosa in patients with Crohn's disease
Authors:

P. Eder1, L. Lykowska-Szuber1, I. Krela-Kazmierczak1, K. Stawczyk-Eder1, K. Iwanik2, M. Zabel3, K. Linke1, 1Poznan University of Medical Sciences, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan, Poland, 2Poznan University of Medical Sciences, Department of Clinical Pathomorphology, Poznan, Poland, 3Poznan University of Medical Sciences, Department of Histology and Embryology, Poznan, Poland

P076. Magnetic resonance enterography in adolescents and young adults with Crohn's disease
P076

Specific mRNA Expression Profile in Inflamed Colonic Mucosa Derived from Patients with Inflammatory Bowel Disease

Authors:

T. Velikova*1, Z. Spassova2, D. Kyurkchiev1, I. Altankova3, S. Stanilova4

1University Hospital St. Ivan Rilski, Department of Clinical laboratory and clinical immunology, Sofia, Bulgaria, 2University Hospital St. Ivan Rilski, Clinic of gastroenterology, Sofia, Bulgaria, 3University Hospital Lozenets, Clinical Immunology, Sofia, Bulgaria, 4Medical Faculty -Trakia University , Department of Molecular Biology, Immunology and Medical genetics , Stara Zagora, Bulgaria

P077.

Effects of IFN-γ priming on the functional characteristics of human bone marrow and adipose derived mesenchymal stem cells expanded in alternative xeno-free conditions

Authors:

A. Oikonomopoulos, W.K. van Deen, D.W. Hommes, UCLA Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, Los Angeles, United States

P077. Diagnostic utility of anti-Saccharomyces cerevisiae antibody (ASCA) and interferon-gamma assay in the differential diagnosis of Crohn's disease and intestinal tuberculosis
P077. Emerging role of the interleukin (IL)-33/ST2 axis in gut mucosal wound healing and epithelial repair
Authors:

L.R. Lopetuso1,2, H.N. Senkfor1, C. De Salvo1, X.M. Wang1, A. Gasbarrini2, F. Scaldaferri2, T.T. Pizarro1, 1Case Western Reserve University – School of Medicine, Pathology, Cleveland, United States, 2Catholic University of Rome, Internal Medicine/Gastroenterology Division, Rome, Italy