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P065. Mucosal immune environment in colonic carcinogenesis: CD80 over‑expression in ulcerative colitis and dysplasia is associated to oxidative DNA damage and TLR4 expression
P065

Identification of DSG3, MAGI1 and TFF1 as functionally important genes in inflammatory bowel disease pathogenesis

Authors:

M. Vancamelbeke*, T. Vanuytsel, R. Farré, M. Ferrante, K. Verbeke, P. Rutgeerts, S. Vermeire, I. Arijs, I. Cleynen

KU Leuven, Clinical and Experimental Medicine, Leuven, Belgium

P066.

IL-17A has dual actions in the induction of colitis

Authors:

C.S. Eun, D.S. Han, A.R. Lee, H.-J. Park, Hanyang University Guri Hospital, Gastroenterology, Guri, Korea, Republic of

P066. Diagnostic tests for CMV colitis in inflammatory bowel diseases
P066. Human intestinal Vδ2+ T-cells promote mucosal inflammation in Crohn's disease and are selectively ablated by azathioprine therapy
Authors:

N. McCarthy1, C. Hedin1, Z. Bashir1, A. Vossenkämper1, E. Giles1, T. Sanders1, K. Whelan2, T. MacDonald1, J. Lindsay3, A. Stagg1, 1Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Centre for Immunology and Infectious Disease, The Blizard Institute, London, United Kingdom, 2King's College London, School of Medicine, Diabetes and Nutritional Sciences Division, London, United Kingdom, 3Digestive Diseases Clinical Academic Unit, Barts and The London School of Medicine, The Royal London Hospital, London, United Kingdom

P066. Tauroursodeoxycholic acid forces epithelial IRE1 activation and alleviates DSS-induced colitis
P066

Crohn's disease-associated adherent-invasive Escherichia coli induce secretion of exosomes with pro-inflammatory activity by intestinal epithelial cells

Authors:

J. Carrière*, A. Bretin, N. Barnich, H.T.T. Nguyen

UMR 1071 Inserm/University of Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France

P067.

IBD98E promotes mucosal wound healing through epithelial cell proliferation in DSS-induced colitis

Authors:

S. Vetrano1, M. Genua1,2, L. Petti1, P. Naccarato1, A. Gandelli1, C. Tacconi1, V. Arena3, S. D'Alessio1, S. Danese1, 1Humanitas Research Hospital, IBD Center, Rozzano, Milan, Italy, 2Humanitas Research Hospital, Medical Biotechnologies and Translational Medicine, Milano, Italy, 3Catholic University of Sacred Heart, Internal Medicine and Gastroenterology, Rome, Italy

P067. Comparison of wireless capsule endoscopy and enteroclysis in the work-out of patients with established and suspected small bowel Crohn's disease
P067. Dysregulation of human dendritic cell function in ulcerative colitis
P067. Human and rodent ex vivo model for intestinal fibrosis in inflammatory bowel disease (IBD)
Authors:

B.T. Pham1, T. van Haaften1, D. Oosterhuis1, I.A.M. de Graaf2, P. Olinga1, 1University of Groningen, Pharmaceutical Technology and Biopharmacy, Groningen, Netherlands, 2University of Groningen, Pharmacokinetics, Toxicology and Targeting, Groningen, Netherlands

P067

Binding of infliximab (IFX) to human serum exosomes.

Authors:

B. Hernández-Breijo1, M. Chaparro*2, A. Paradela3, I.D. Román1, D. Cano-Martínez1, P. Sanmartín-Salinas1, J.P. Gisbert2, L. Guijarro1

1Universidad de Alcalá and CIBERehd, Systems Biology, Alcalá de Henares, Spain, 2Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, 3Centro Nacional de Biotecnología, Proteomic service, Madrid, Spain

P068.

Hyperbaric oxygen reduces hypoxia-inducible factor-1 alpha expression in experimental acute distal colitis

Authors:

R.S. Parra1, E. Uchoa Carreira2, A.H.P. Lopes2, T.M. Cunha2, S.B. Garcia3, F. Queiroz Cunha2, J. Joaquim Ribeiro da Rocha1, O. Féres1, 1University of São Paulo, Surgery and Anatomy, Ribeirao Preto SP, Brazil, 2University of São Paulo, Pharmacology, Ribeirao Preto SP, Brazil, 3University of São Paulo, Pathology, Ribeirao Preto SP, Brazil

P068. Factors associated with the development of rheumatologic manifestations in patients with ulcerative colitis
P068. High expression level of the T cell potassium channel, KV1.3, is a novel diagnostic marker of inflammatory activity in patients with ulcerative colitis
Authors:

L.K. Hansen1, T. Knudsen2, J. Kjeldsen3, D. Larsen1, R. Köhler1, 1University of Southern Denmark, Institute of Molecular Medicine, Odense, Denmark, 2Hospital of South Denmark, Esbjerg, Department of Gastroenterology and Hepatology, Esbjerg, Denmark, 3Odense University Hospital, Department of Gastroenterology and Hepatology, Odense, Denmark

P068. Prolonged survival of neutrophils in Crohn's disease
P068

PSC - IBD is associated with different microbiota composition as compared to UC

Authors:

L. Bajer1, J. Mrazek2, M. Kverka3, J. Dvorak3, M. Kostovcik3, H. Tlaskalova - Hogenova3, J. Brezina1, J. Spicak1, P. Drastich*1

1Instutute of clinical and experimental medicine, Hepatogastroenterology, Prague, Czech Republic, 2The Academy of Sciences of the Czech Republic, Institute of Animal Physiology and Genetics, Prague, Czech Republic, 3The Academy of Sciences of the Czech Republic, Institute of Microbiology, Prague, Czech Republic

P069.

High autofluorescence of the colon tissues in children with ulcerative colitis

Authors:

E. Jarocka-Cyrta1, J. Branska-Januszewska2, M. Kaczmarski3, H. Ostrowska2, 1University of Warmia and Masuria, Department of Pediatrics, Olsztyn, Poland, 2Medical University of Bialystok, Department of Biology, Bialystok, Poland, 3Medical University of Bialystok, Department of Pediatrics, Gastroenterology and Allergology, Bialystok, Poland

P069. Anti-TNF induced regulatory macrophages display high levels of autophagy
P069. Glycine and glutamine down-regulate IL-6-induced claudin-2 expression in human colonic epithelial cell monolayer
Authors:

T. Nakagawa1, Y. Takahashi1, K. Saito1, S. Sazuka1, T. Katsuno1, O. Yokosuka1, 1Chiba University Hospital, Chiba, Japan