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P061. Ileum versus colon: separate roles for gut dendritic cells in mucosal immune homeostasis and implications for ulcerative colitis
Authors:

E. Mann1, D. Bernardo1, H. Omar Al-Hassi1, N. English1, J. Landy2, S. Peake2, R. Man2, G. Han Lee2, N. Yassin2, S. Knight1, A. Hart2, 1Imperial College London, United Kingdom, 2St. Mark's Hospital, United Kingdom

P061

The efficacy of tonsil-derived mesenchymal stem cell in chronic murine colitis model

Authors:

E.M. Song*1, S.-A. Jung1, S.-E. Kim1, Y.H. Joo1, Y.S. Yu2, C.H. Tae1, C.M. Moon1, H.-K. Jung1, K.-N. Shim1, I.H. Jo2, M.S. Ryu1, J.-M. Lee1

1Ewha Womans University School of Medicine, Department of Internal Medicine, Ewha Medical Research Institute, Seoul , Korea, Republic of, 2Ewha Womans University School of Medicine, Department of Molecular Medicine, Ewha Medical Research Institute, Seoul, Korea, Republic of

P062.

Identification of the XAF1 tumor suppressor as a transcription target of tumor necrosis factor-α – NF-κB signaling in human colon cancer cells

Authors:

J.-W. Kim, C.-K. Lee, H.J. Kim, Kyung Hee University Hospital, Internal Medicine, Seoul, Korea, Republic of

P062. Ileal gene expression profiling of Crohn's disease underlines the importance of the inflammatory load during the disease course
Authors:

J. Van der Goten1, I. Arijs1, L. Van Lommel2, K. Machiels1, G. De Hertogh1, M. Ferrante1, F. Schuit2, S. Vermeire1, P. Rutgeerts1, 1KU Leuven, Translational Research in GastroIntestinal Disorders (TARGID), Leuven, Belgium, 2KU Leuven, Gene Expression Unit, Department of Molecular Cell Biology, Leuven, Belgium

P062. Serum cytokine profile is related with disease activity in ulcerative colitis patients
P062. The effect of steroids on expression of Wnt pathway inhibitors in patients with longstanding ulcerative colitis
P062

Metabolic phenotyping of healthy and IBD children: Perspectives for individual metabolic monitoring

Authors:

F.-P. Martin*1, O. Cominetti1, L. Da Silva1, J. Ezri2, S. Collino1, I. Montoliu1, J.-P. Godin3, A. Nydegger2

1Nestle Institute of Health Sciences, Molecular Biomarkers, Lausanne, Switzerland, 2University of Lausanne, Pediatric Gastroenterology, Lausanne, Switzerland, 3Nestle Research Center, Analytical Sciences, Lausanne, Switzerland

P063.

Identification of novel non-transcriptionally acting glucocorticoid receptor ligands that suppress T cell activation but lack adipogenic activity

Authors:

A. Verhaar1, R. Dvorsky2, M. Wildenberg3, M. Löwenberg1, M. Peppelenbosch4, D.W. Hommes5, G. van den Brink1, 1Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Max Planck Institute of Molecular Physiology, Structural Biology, Dortmund, Germany, 3Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 4Erasmus MC, Gastroenterology and Hepatology, Rotterdam, Netherlands, 5University of California Los Angeles, Center for Inflammatory Bowel Diseases, Los Angeles, United States

P063. Disease extension is the major factor affecting the disease course of ulcerative colitis (UC)
P063. IL-21 and IL-21 receptor expression in the intestine from patients with Crohn's disease
Authors:

D. Tornehave1, S. Zahn2, F. Matthiesen3, B. Olsen Krogh4, D. Lundsgaard5, 1Histology, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Maaloev, Denmark, 2Antibody Technology, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Maaloev, Denmark, 3Protein Purification, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Maaloev, Denmark, 4Mammalian Cell Technology, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Maaloev, Denmark, 5Inflammation Sciences, Biopharmaceuticals Research Unit, Novo Nordisk A/S, Maaloev, Denmark

P063. Investigation of the function of NOD2 in Crohn's disease using phosphoproteomics
P063

Mesalazine and cigarette smoke inhibit neutrophil extracellular trap formation in vitro

Authors:

M. Buis, N. Sinnema, T. Blokzijl, K.-N. Faber, J. Westra, G. Dijkstra*

University of Groningen, University Medical Center, Gastroenterology and Hepatology, Groningen, Netherlands

P064.

Identification of inflammatory mediators in Crohn's disease patients who are unresponsive to anti-TNF therapy – A transcriptional analysis of intestinal mucosa

Authors:

R.F. Leal1, N. Planell2, R. Kajekar3, J.J. Lozano2, I. Ordás4, I. Dotti1, M. Esteller1, M.C. Masamunt1, H. Parmar3, E. Ricart4, J. Panés1, A. Salas1, 1IDIBAPS, Hospital Clínic, CIBERehd, Department of Gastroenterology, Barcelona, Spain, 2IDIBAPS, CIBERehd, Bioinformatics Platform, Barcelona, Spain, 3Hoffmann-La Roche, Nutley, New Jersey, United States, 4Hospital Clínic Barcelona, Department of Gastroenterology, Barcelona, Spain

P064. IL-21 neutralization in experimental colitis: regulation of cytokines, chemokines and colonic transcripts
Authors:

T. Lindebo Holm1, K. Serikawa2, B. Fox2, S. Biswas2, H. Søndergaard1, D. Lundsgaard3, 1Novo Nordisk A/S, Immunopharmacology, Maaloev, Denmark, 2Novo Nordisk A/S, Molecular Immunology, Seattle, United States, 3Novo Nordisk A/S, Inflammation Science, Maaloev, Denmark

P064. Magnetic resonance enterography for Crohn's disease: Surgical aspects
P064. Mucosal immune environment in colonic carcinogenesis: CD80 expression on epithelial cell peaked in dysplasia and its inhibition decreased inflammation but did not stop carcinogenesis progression
P064

The role of fecal calprotectin in the prediction of ankylosing spondylitis associated with early IBD

Authors:

L. Dávida*1, S. Szántó2, S. Kacska1, B. Haraszti1, B. Brúgós3, I. Altorjay1, Z. Szekanecz2, K. Palatka1

1University Of Debrecen, Institute Of Internal Medicine, Department Of Gastroenterology, Debrecen, Hungary, 2University Of Debrecen, Institute Of Internal Medicine, Department Of Rheumatology, Debrecen, Hungary, 3University Of Debrecen, Institute Of Internal Medicine, Department Of Rare Diseases, Debrecen, Hungary

P065.

IL-33/ST2 axis modulates epithelial repair and gut mucosal wound healing in DSS-colitic mice

Authors:

L.R. Lopetuso1,2, C. De Salvo2, H. Senkfor2, X.-M. Wang2, D.W. Abbott2, F. Scaldaferri1, A. Gasbarrini1, T.T. Pizarro2, 1Catholic University of Sacred Heart, Internal Medicine and Gastroenterology, Rome, Italy, 2Case Western Reserve University, Pathology, Cleveland, OH, United States

P065. A tertiary centre experience of vulval Crohn's disease
P065. Humoral immune response to intestinal microbiota in inflammatory bowel diseases
Authors:

D. Abdulganieva1, O. Zinkevich2, N. Saphina2, D. Mukhametova1, A. Odintsova3, 1Kazan State Medical University, Kazan, Russian Federation, 2Kazan State Medical Academy, Kazan, Russian Federation, 3Republican Clinical Hospital, Kazan, Russian Federation