J. Panés*¹, D. García-Olmo², G. Van Assche³, J. F. Colombel⁴, W. Reinisch⁵, D. C. Baumgart⁶, M. Nachury⁷, M. Ferrante³, L. Kazemi-Shirazi⁵, J. C. Grimaud⁸, F. de la Portilla⁹, E. Goldin¹⁰, A. Leselbaum¹¹, M. C. Diez¹¹, S. Danese¹²

¹Hospital Clinic Barcelona, Barcelona, Spain, ²Hospital U. Fundación Jiménez-Díaz, Madrid, Spain, ³University Hospitals Leuven, KU Leuven, Leuven, Belgium, ⁴Icahn School of Medicine at Mount Sinai, New York, New York, United States, ⁵Medical University of Vienna, Vienna, Austria, ⁶Charité Medical School - Humboldt-University of Berlin, Berlin, Germany, ⁷CHU Lille, Lille, France, ⁸Hôpital Nord, Marseille, France, ⁹Hospital Virgen del Rocío, Sevilla, Spain, ¹⁰Sharee Zedek MC, Jerusalem, Israel, ¹¹TiGenix, Madrid, Spain, ¹²Istituto Clinico Humanitas, Milano, Italy

R. Atreya*¹, A. Öst², C. Admyre³, A. Karlsson³, T. Knittel³, J. Kowalski³, F. Scaldaferi⁴, M. Neurath¹, C. Hawkey⁵

¹University of Erlangen-Nuernberg, Department of Medicine 1, Erlangen, Germany, ²Aleris Medilab, Department of Pathology and Cytology, Täby, Sweden, ³Index Pharmaceuticals, Stockholm, Sweden, ⁴Catholic University of Rome, Internal Medicine Department / Gastroenterology Division, Rome, Italy, ⁵Nottingham University Hospitals, Department of Gastroenterology, Nottingham, United Kingdom

P. A. Golovics*¹, Z. Vegh¹, M. Rutka², K. Gecse¹, A. Balint², K. Farkas², J. Banai³, L. Bene⁴, B. Gasztonyi⁵, T. Kristof⁶, L. Lakatos⁷, P. Miheller⁸, K. Palatka⁹, A. Patai¹⁰, A. Salamon¹¹, T. Szamosi³, Z. Szepes¹², G.T. Toth¹³, A. Vincze¹⁴, E. Biro¹⁵, B. Lovasz¹, Z. Kurti¹, F. Nagy¹², T. Molnar², P. Lakatos¹

¹Semmelweis University, First Department of Medicine, Budapest, Hungary, ²University of Szeged, First Department of Medicine, Szeged, Hungary, ³Military Hospital, State Health Centre, Department of Gastroenterology, Budapest, Hungary, ⁴Peterfy Hospital, First Department of Medicine, Budapest, Hungary, ⁵Zala County Hospital, Second Department of Medicine, Zalaegerszeg, Hungary, ⁶B-A-Z County and University Teaching Hospital, Second Department of Medicine, Miskolc, Hungary, ⁷Csolnoky F. Province Hospital, Department of Medicine, Veszprem, Hungary, ⁸Semmelweis University, Second Department of Medicine, Budapest, Hungary, ⁹University of Debrecen, Institute of Medicine, Department of Gastroenterology, Debrecen, Hungary, ¹⁰Markusovszky Hospital, First Department of Medicine and Gastroenterology, Szombathely, Iceland, ¹¹Tolna County Teaching Hospital, First Department of Gastroenterology, Szekszard, Hungary, ¹²University of Szeged, First Department of Internal Medicine, Szeged, Hungary, ¹³Janos Hospital, Department of Gastroenterology, Budapest, Hungary, ¹⁴University of Pécs, First Department of Medicine, Pécs, Hungary, ¹⁵Semmelweis University, Department of Laboratory Medicine, Budapest, Hungary

A. Stojmirovic*, R. Dobrin, R. Strauss, D. Chan, K. Li, J. Friedman

Janssen R & D, LLC, Spring House, Pennsylvania, United States

T. Billiet*¹, I. Cleynen¹, M. Ferrante², G. Van Assche², A. Gils³, S. Vermeire²

¹Department of Clinical and Experimental Medicine, KU Leuven, Translational Research in Gastrointestinal Disorders (TARGID), Leuven, Belgium, ²University Hospitals Leuven, Gastroenterology - 
Translational Research Centre for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ³KU Leuven, Laboratory for Therapeutic and Diagnostic Antibodies, Leuven, Belgium

M. Wildenberg*¹, P. Koelink², K. Diederen², A. te Velde², V. Nuij³, M. Peppelenbosch³, M. Nobis⁴, O. Sansom⁴, C.J. van der Woude³, G. D’Haens¹, G. van den Brink¹

¹Academic Medical Centre, Gastroenterology and Hepatology, Amsterdam, Netherlands, ²Academic Medical Centre, Tytgat Institute, Amsterdam, Netherlands, ³Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, Netherlands, ⁴Beatson Institute for Cancer Research, Glasgow, United Kingdom

N. Ventham*¹, N. Kennedy¹, A. Adams¹, R. Kalla¹, S. Heath², K. O’Leary¹, H. Drummond¹, D. Wilson³, T. IBD-BIOM Consortium¹, T. IBD-CHARACTER Consortium¹, I. Gut², E. R. Nimmo¹, J. Satsangi¹

¹University of Edinburgh, CGEM, Edinburgh, United Kingdom, ²Centro Nacional de Análisis Genómico, Barcelona, Spain, ³University Of Edinburgh, Department of Child Life and Health, Edinburgh, United Kingdom

R. Alberts*¹, E. M. de Vries², G. Alexander³, D. Alvaro⁴, A. Bergquist⁵, U. Beuers², E. Björnsson⁶, K. M. Boberg⁷, C. L. Bowlus⁸, R. W. Chapman⁹, O. Chazouillères¹⁰, A. Cheung¹¹, G. Dalekos¹², B. Eksteen¹³, D. Ellinghaus¹⁴, M. Färkkilä¹⁵, E. A. Festen¹, A. Floreani¹⁶, T. Folseraas⁷, E. Goode¹⁷, D. N. Gotthardt¹⁸, G. M. Hirschfield¹⁹, B. van Hoek²⁰, K. Holm⁷, S. Hohenester²¹, J. R. Hov⁷, F. Imhann¹, P. Invernizzi²², X. Jiang⁷, J. Eaton²³, B. D. Juran²⁴, K. N. Lazaridis²⁴, V. Leppa²⁵, J. Z. Liu²⁶, J. Löfberg²⁷, M. P. Manns²⁸, H.-U. Marschall²⁹, M. Marzioni³⁰, A. L. Mason³¹, E. Melum⁷, P. Milkiewicz³², T. Müller³³, A. Pares³⁴, C. Rupp³⁵, S. M. Rushbrook³⁶, C. Rust³⁷, F. Sampaziotis³⁸, R. N. Sandford³⁹, C. Schramm⁴⁰, S. Schreiber¹⁴, E. Schrumpf⁷, M. Silverberg⁴¹, B. Srivastava³⁹, M. Sterneck⁴², A. Teufel⁴³, L. Tittmann⁴⁴, L. Vallier³⁸, A. V. Vila¹, B. de Vries¹, T. J. Weismüller²⁸, C. Wijmenga⁴⁵, K. Zachou⁴⁶, A. Franke¹⁴, C. A. Anderson⁴⁷, T. H. Karlsen⁷, C. Y. Ponsioen², R. K. Weersma¹

¹University of Groningen and University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, ²Academic Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, Netherlands, ³University of Cambridge, Department of Medicine, Division of Hepatology, Cambridge, United Kingdom, ⁴Sapienza University of Rome, Department of Clinical Medicine, Division of Gastroenterology, Rome, Italy, ⁵Karolinska University Hospital Huddinge, Karolinska Institutet, Department of Gastroenterology and Hepatology, Stockholm, Sweden, ⁶Landspitali University Hospital, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Reykjavik, Iceland, ⁷Oslo University Hospital, Rikshospitalet, Norwegian PSC Research Centre, Division of Cancer Medicine, Surgery and Transplantation, Oslo, Norway, ⁸University of California Davis, Division of Gastroenterology and Hepatology, Davis, California, United States, ⁹John Radcliffe University Hospitals NHS Trust, Department of Hepatology, Oxford, United Kingdom, ¹⁰Hôpital Saint Antoine and U.P.M.C. Univ Paris 06, AP-HP and Department of Hepatology, Paris, France, ¹¹University Health Network - Toronto General Hospital, Gen. Internal Medicine, Toronto, Canada, ¹²Medical School, University of Thessaly, Department of Medicine and Research Laboratory of Internal Medicine, Larissa, Greece, ¹³University of Calgary, Snyder Institute of Chronic Diseases, Department of Medicine, Calgary, Canada, ¹⁴Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany, ¹⁵Helsinki University Hospital, Division of Gastroenterology, Department of Medicine, Helsinki, Finland, ¹⁶University of Padova, Dept. of Surgical, Oncological and Gastroenterological Sciences, Padova, Italy, ¹⁷Norfolk and Norwich University Hospital, Department of Gastroenterology, Norwich, United Kingdom, ¹⁸University Hospital of Heidelberg, Department of Medicine, Heidelberg, Germany, ¹⁹University of Toronto, Division of Gastroenterology, Department of Medicine, Toronto, Canada, ²⁰Leiden University Medical Centre, Department of Gastroenterology and Hepatology, Leiden, Netherlands, ²¹University of Munich, Department of Medicine II, Munich, Germany, ²²Humanitas Clinical and Research Centre, Centre for Autoimmune Liver Diseases, Rozzano, Italy, ²³Mayo Clinic, Division of Gastroenterology and Hepatology, Rochester, Minnesota, United States, ²⁴Mayo Clinic, College of Medicine, Centre for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Rochester, Minnesota, United States, ²⁵Institute for Molecular Medicine Finland F.I.M.M., University of Helsinki and National Institute for Health and Welfare, Public Health Genomics Unit, Helsinki, Finland, ²⁶Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom, ²⁷Karolinska Institute, Department of, Stockholm, Sweden, ²⁸Hannover Medical School, Department of Gastroenterology, Hepatology and Endocrinology, Hannover, Germany, ²⁹Institute of Medicine, Sahlgrenska Academy and University Hospital, Department of Internal Medicine, Gothenburg, Sweden, ³⁰Università Politecnica delle Marche, Ospedali Riuniti University Hospital, Department of Gastroenterology, Ancona, Italy, ³¹University of Alberta, Division of Gastroenterology and Hepatology, Edmonton, Alberta, Canada, ³²Medical University of Warsaw, Liver and Internal Medicine Unit, Warsaw, Poland, ³³Charité Universitätsmedizin Berlin, Department of Internal Medicine, Hepatology and Gastroenterology, Berlin, Germany, ³⁴University of Barcelona, Liver Unit, Hospital Clinic, I.D.I.B.A.P.S., C.I.B.E.R.ehd, Barcelona, Spain, ³⁵University Hospital of Heidelberg, Department of Internal Medicine IV, Heidelberg, Germany, ³⁶University Hospitals NHS Trust, Department of Gastroenterology and Hepatology, Norfolk and Norwich, Norwich, United Kingdom, ³⁷University of Munich, Department of Medicine 2, Grosshadern, Munich, Germany, ³⁸Wellcome Trust-Medical Research Council Stem Cell Institute, Anne McLaren Laboratory, Cambridge, United Kingdom, ³⁹University of Cambridge, Academic Department of Medical Genetics, Cambridge, United Kingdom, ⁴⁰University Medical Centre Hamburg-Eppendorf, 1st Department of Medicine, Hamburg, Germany, ⁴¹Mount Sinai Hospital Toronto, Inflammatory Bowel Disease Group, Zane Cohen Centre for Digestive Diseases, Toronto, Ontario, Canada, ⁴²University Medical Centre Hamburg-Eppendorf, Department of Hepatobiliary Surgery and Transplantation, Hamburg, Germany, ⁴³University of Mainz, First Department of Medicine, Mainz, Germany, ⁴⁴Christian-Albrechts-University of Kiel, Institute for Epidemiology, Kiel, Germany, ⁴⁵University of Groningen and University Medical Centre Groningen, Department of Genetics, Groningen, Netherlands, ⁴⁶University of Thessaly, Department of Internal Medicine, Larissa, Greece, ⁴⁷Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, Massachusetts, United States

F. Imhann*¹, A. Vich Vila¹, M. J. Bonder², D. Gevers³, J. Fu², M. C. Visschedijk¹, L.M. Spekhorst¹, L. Franke², H. van Dullemen¹, R. W. F. Ter Steege¹, C. Huttenhower⁴, G. Dijkstra¹, R. J. Xavier³, C. Wijmenga², E. A. M. Festen¹, A. Zhernakova², R. K. Weersma¹

¹University of Groningen and University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, ²University of Groningen and University Medical Centre Groningen, Department of Genetics, Groningen, Netherlands, ³The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States, ⁴Harvard School of Public Health, Biostatistics Department, Boston, Massachusetts, United States

E. Del Tedesco¹, S. Paul², H. Marotte³, C. Jarlot¹, N. Williet⁴, J. M. Phelip⁴, L. Peyrin Biroulet⁵, J. F. Colombel⁶, X. Roblin*⁴

¹University Hospital, Gastroenterology, Saint-Etienne, France, ²University of Saint-Etienne, Immunology, Saint-Etienne, France, ³University Hospital, Rheumatology, Saint-Etienne, France, ⁴CHU Saint-Etienne, Saint-Etienne, France, ⁵CHU de Nancy, Department of Gastroenterology, Vandoeuvre-lès-nancy, France, ⁶Mount Sinai Hospital, New York, New York, United States

T. Matsumoto*¹, S. Motoya², K. Watanabe³, T. Hisamatsu⁴, H. Nakase⁵, N. Yoshimura⁶, T. Ishida⁷, S. Kato⁸, T. Nakagawa⁹, M. Esaki¹⁰, M. Nagahori¹¹, T. Matsui¹², Y. Naito¹³, T. Kanai¹⁴, Y. Suzuki¹⁵, M. Nojima¹⁶, M. Watanabe¹¹, T. Hibi¹⁷

¹Iwate Medical University, Division of Gastroenterology, Department of Medicine, Morioka, Japan, ²Sapporo Kosei General Hospital, Inflammatory Bowel Disease Centre, Sapporo, Japan, ³Osaka City General Hospital, Division of Gastroenterology, Osaka, Japan, ⁴Kyorin University School of Medicine, The Third Department of Internal Medicine, Tokyo, Japan, ⁵Kyoto University, Department of Gastroenterology and Hepatology, Endoscopic Medicine, Kyoto, Japan, ⁶Tokyo Yamate Medical Centre, Department of Medicine, Division of Gastroenterology, Tokyo, Japan, ⁷Oita Red Cross Hospital, Department of Gastroenterology, Oita, Japan, ⁸Saitama Medical Centre, Saitama Medical University, Department of Gastroenterology and Hepatology, Kawagoe, Japan, ⁹Chiba University, Department of Gastroenterology and Nephrology (K1), Graduate School of Medicine, Chiba, Japan, ¹⁰Kyushu University, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Fukuoka, Japan, ¹¹Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Tokyo, Japan, ¹²Fukuoka University Chikushi Hospital, Department of Gastroenterology, Chikushino, Japan, ¹³Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Department of Molecular Gastroenterology and Hepatology, Kyoto, Japan, ¹⁴Keio University, Department of Internal Medicine, School of Medicine, Tokyo, Japan, ¹⁵Toho University Sakura Medical Centre, Department of Internal Medicine, Sakura, Japan, ¹⁶The Institute of Medical Science Hospital, The University of Tokyo, Centre for Translational Research, Tokyo, Japan, ¹⁷Kitasato University Kitasato Institute Hospital, Centre for Advanced IBD Research and Treatment, Tokyo, Japan

C. H. R. Choi*^{1, 2}, I. Al Bakir^{1, 2}, N. S. J. Ding¹, M. Moorghen¹, S. Thomas-Gibson¹, J. Warusavitarne¹, B. Saunders¹, M. Rutter³, T. Graham², A. Hart¹

¹St. Mark’s Hospital, London, United Kingdom, ²Barts Cancer Institute, Tumour Biology, London, United Kingdom, ³University Hospital of North Tees, Department of Gastroenterology, Stockton-on-Tees, Teesside, United Kingdom

S. Jeuring*^{1, 2}, V. Biemans¹, L. Liu¹, T. Van den Heuvel^{1, 2}, M. Zeegers^{3, 4}, 
W. Hameeteman¹, M. Romberg-Camps⁵, L. Oostenbrug⁶, A. Masclee^{1, 2}, D. Jonkers^{1, 2}, M. Pierik^{1, 2}

¹Maastricht University Medical Centre, Internal Medicine - Division of Gastroenterology and Hepatology, Maastricht, Netherlands, ²Maastricht University Medical Centre, NUTRIM - School for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands, ³Maastricht University Medical Centre, Complex Genetics - School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, Netherlands, ⁴Maastricht University Medical Centre, CAPHRI - School for Public Health and Primary Care, Maastricht, Netherlands, ⁵Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Sittard-Geleen, Netherlands, ⁶Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Heerlen, Netherlands

P. Rutgeerts*¹, C. Gasink², M. Blank³, Y. Lang², J. Johanns², L.-L. Gao², B. Sands⁴, S. Hanauer⁵, B. Feagan⁶, S. Targan⁷, S. Ghosh⁸, W. de Villiers⁹, J.-F. Colombel¹⁰, S. Lee¹¹, P. Desreumaux¹², E. V. Loftus, Jr¹³, S. Vermeire¹⁴, W. J. Sandborn¹⁵

¹University Hospital Gasthuisberg, Department of Haematology, Leuven, Netherlands, ²Janssen R & D, LLC, Spring House, United States, ³Janssen Scientific Affairs, LLC., Horsham, United States, ⁴Mount Sinai Medical Centre, New York, New York, United States, ⁵Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States, ⁶Robarts Clinical Trials, Robarts Research Institute, Western University, London, Ontario, Canada, ⁷Cedars-Sinai Medical Centre, Division of Gastroenterology, Los Angeles, California, United States, ⁸University of Calgary, Department of Gastroenterology, Calgary, Canada, ⁹Universiteit Stellenbosch University, Stellenbosch, South Africa, ¹⁰Mount Sinai, Icahn School of 
Medicine, New York, New York, United States, ¹¹University of Washington, Seattle, Washington, United States, ¹²University of Lille, Lille, France, ¹³Mayo Clinic Rochester, Department of Gastoenterology, Rochester, Minnesota, United States, ¹⁴University Hospitals Leuven, Department of Gastroenterology, Leuven, Belgium, ¹⁵University of California San Diego, Division of Gastroenterology, La Jolla, California, United States

S. Danese*¹, S. Vermeire², P. Hellstern³, R. Panaccione⁴, G. Rogler⁵, G. Fraser⁶, A. Kohn⁷, P. Desreumaux⁸, R.W. Leong⁹, G.M. Comer¹⁰, F. Cataldi¹⁰, A. Banerjee¹⁰, M.K. Maguire¹¹, C. Li¹⁰, N. Rath¹¹, J. Beebe¹⁰, S. Schreiber¹²

¹Humanitas University Clinical and Research Hospital, Rozzano, Milan, Italy, ²University Hospitals Leuven, Leuven, Belgium, ³Nature Coast Clinical Research, Inverness, Florida, United States, ⁴University of Calgary, Calgary, Canada, ⁵University of Zürich, Zürich, Switzerland, ⁶Rabin Medical Centre and University of Tel-Aviv, Petah Tikva, Israel, ⁷AO San Camillo Forlanini, Rome, Italy, ⁸University of Lille, Inserm U995, Lille, France, ⁹Concord Hospital, Sydney, New South Wales, Australia, ¹⁰Pfizer Inc, Cambridge, Massachusetts, United States, ¹¹Pfizer Inc, Collegeville, Pennsylvania, United States, ¹²Christian-Albrechts University, Kiel, Germany

L. Birimberg Schwartz¹, D. Zucker², A. Akriv², C. Salvatore³, F. Cameron⁴, I. Lazowska⁵, L. Yianni⁶, P. Siba⁷, S. Kolacek⁸, C. Romano⁹, S. Buderus¹⁰, A. Pærregaard¹¹, J. C. Escher¹², D. Turner*¹³

¹Shaare Zedek Medical Centre, Paediatrics, Jerusalem, Israel, ²The Hebrew University, Jerusalem, Israel, ³Sapienza University of Rome, Rome, Italy, ⁴Yorkhill Children’s Hospital, Glasgow, United Kingdom, ⁵Medical University of Warsaw, Warsaw, Poland, ⁶University Hospital Southampton, Hampshire, United Kingdom, ⁷University of Dundee, Scotland, United Kingdom, ⁸Zagreb University Medical School, Zagreb, Croatia, ⁹University of Messina, Messina, Italy, ¹⁰St Marien Hospital, Bonn, Germany, ¹¹Hvidovre University Hospital, Copenhagen, Denmark, ¹²Erasmus Medical Centre, Holland, Netherlands, ¹³Shaare Zedek Medical Centre, Jerusalem, Israel

S. Paramsothy*¹, M. Kamm^{2, 3}, A. Walsh⁴, J. van den Bogaerde⁵, D. Samuel⁶, R. Leong⁶, S. Connor⁷, W. Ng⁷, R. Paramsothy⁷, N. Kaakoush⁸, H. Mitchell⁸, W. Xuan⁹, E. Lin¹⁰, T. Borody¹⁰

¹University of New South Wales, St Vincent’s Clinical School, Sydney, Australia, ²St Vincent’s Hospital, Melbourne, Australia, ³Imperial College London, London, United Kingdom, ⁴St Vincent’s Hospital, Sydney, Australia, ⁵Nambour General Hospital, Nambour, Australia, ⁶Bankstown-Lidcombe Hospital, Sydney, Australia, ⁷Liverpool Hopsital, Sydney, Australia, ⁸University of New South Wales, School of Biotechnology & Biomolecular Sciences, Sydney, Australia, ⁹Ingham Institute, Sydney, Australia, ¹⁰Centre for Digestive Diseases, Sydney, Australia

V. Svolos*¹, R. Hansen², K. Hughes¹, U. Z. Ijaz³, C. Quince⁴, D. Gaya⁵, R. Russell², K. Gerasimidis¹

¹Human Nutrition, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow, United Kingdom, ²Department of Paediatric Gastroenterology, Hepatology and Nutrition, Royal Hospital for Children, Glasgow, United Kingdom, ³School of Engineering, University of Glasgow, Glasgow, United Kingdom, ⁴Warwick Medical School, University of Warwick, Warwick, United Kingdom, ⁵Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, United Kingdom

W. J. Sandborn¹, B. E. Sands², G. D’Haens*³, S. Vermeire⁴, S. Schreiber⁵, S. Danese⁶, J. Panés⁷, B. G. Feagan⁸, W. Reinisch⁹, W. Niezychowski¹⁰, G. Friedman¹⁰, N. Lawendy¹⁰, D. Yu¹⁰, D. Woodworth¹⁰, A. Mukherjee¹¹, P. Healey¹¹, H. Zhang¹⁰, C. Su¹⁰

¹Division of Gastroenterology, University of California, San Diego, California, United States, ²Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York, United States, ³Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands, ⁴Dept of Gastroenterology, University Hospitals Leuven, Leuven, Belgium, ⁵Klinik für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany, ⁶IBD Centre, Department of Gastroenterology, Humanitas Research Hospital, Milan, Italy, ⁷Hospital Clinicas de Barcelona, IDIBAPS, CIBERehd, Barcelona, Spain, ⁸Robarts Research Institute, London, Ontario, Canada, ⁹McMaster University, Hamilton, Canada, ¹⁰Pfizer Inc, Collegeville, Pennsylvania, United States, ¹¹Pfizer Inc, Groton, Connecticut, United States

S. Vermeire*¹, S. Schreiber², R. Petryka³, T. Kuehbacher⁴, X. Hebuterne⁵, X. Roblin⁶, M. Klopocka⁷, E. Goldis⁸, M. Wisniewska-Jarosinska⁹, A. Baranovsky¹⁰, R. Sike¹¹, C. Tasset¹², A. Van der Aa¹², P. Harrison¹²

¹UZ Leuven, Campus Gasthuisberg, Leuven, Belgium, ²University Medical Centre Schleswig-Holstein Kiel, Department of Internal Medicine I, Kiel, Germany, ³Vivamed, Warsaw, Poland, ⁴Asklepios Hospital West Hamburg, Department of Internal Medicine, Gastroenterology, Hamburg, Germany, ⁵Archet 2 Hospital, Department of Gastroenterology, Nice, France, ⁶Saint Etienne Hospital, Department of Gastroenterology, Saint Priest en Jarez, France, ⁷University Hospital Nr. 2 im. Biziela, Department of Gastroenterology, Bydgoszcz, Poland, ⁸Policlinica Algomed, Department of Gastroenterology, Timisoara, Romania, ⁹Saint Family Hospital Medical Centre, Department of Gastroenterology and Endoscopy, Lodz, Poland, ¹⁰City Clinical Hospital #31, St Petersburg, Russian Federation, ¹¹Szent Margit Hospital, Department of Internal Medicine and Gastroenterology III, Budapest, Hungary, ¹²Galapagos NV, Department of Development, Mechelen, Belgium

Filgotinib is an oral, selective Janus kinase 1 (JAK1) inhibitor, which has demonstrated high efficacy in patients with rheumatoid arthritis. This 20-week Phase 2 study was designed to evaluate the efficacy and safety of filgotinib in patients with active Crohn’s disease.