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P057. Micro-RNA expression profiling identifies miR-29b as a relevant pro-fibrogenic factor in Crohn's disease intestinal strictures
Authors:

P. Biancheri1, A. Nijhuis2, A. Di Sabatino3, C. Lai2, A. Ghosh2, T.T. MacDonald1, G.R. Corazza3, J. Lindsay2, A. Silver2, 1Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Immunology and Infectious Disease, London, United Kingdom, 2Blizard Institute, Barts and The London School of Medicine and Dentistry, Centre for Digestive Diseases, London, United Kingdom, 3Fondazione IRCCS Policlinico S. Matteo, University of Pavia, First Department of Medicine, Pavia, Italy

P057

The T-cell compartment of the adipose tissue-differences of Crohn's disease and obesity

Authors:

L.I. Kredel*1, A.A. Kuehl1, C. Romagnani2, I. Freise1, J. Gröne3, J. Ordemann4, B. Siegmund1

1Charité, Campus Benjamin Franklin, Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Deutsches Rheuma-Forschungszentrum, Angeborene Immunität, Berlin, Germany, 3Charité Universitätsmedizin Berlin, CBF, General, Vascular and Thoracic Surgery, Berlin, Germany, 4Charité, Campus Mitte, Center for Obesity and Metabolic Surgery, Berlin, Germany

P058.

Increased expression of microRNA-122, microRNA-146a and microRNA-155 in intestinal mucosa of pediatric patients with Crohn's disease

Authors:

N.J. Béres1, D. Szabó1, A. Arató1, A. Kiss2, G. Lendvai2, G. Veres1, 1Semmelweis University, 1st. Department of Pediatrics, Budapest, Hungary, 2Semmelweis University, 2nd. Department of Pathology, Budapest, Hungary

P058. Beyond the ordinary diagnostic study: The “real life” accuracy of faecal calprotectin for screening children with suspected inflammatory bowel disease
P058. Early Crohn's disease associates with a mixed Th cell response predominant accumulation not related with endoscopic recurrence
P058. In vivo formation of 8-iso-prostaglandin F2 α and platelet activation in inflammatory bowel disease
Authors:

A. Di Sabatino1, P. Biancheri1, P. Giuffrida1, M. Guerci1, C. Salvatore1, A. Massari1, N. Vazzana2, S. Sestili2, S. Lattanzio2, R. Liani2, G. Davì2, G.R. Corazza1, 1IRCCS Policlinico San Matteo, Pavia, Italy, 2Internal Medicine and Center of Excellence on Aging, Chieti-Pescara, Italy

P058

Inhibition of microRNA-29a in human bone marrow mesenchymal stem cells augments their immunosuppressive properties

Authors:

A. Oikonomopoulos*1, C. Polytarchou2, M. Hatziapostolou2, G. Koukos2, D.W. Hommes1

1UCLA, Medicine, Division of Digestive Diseases, Center for Inflammatory Bowel Diseases, Los Angeles, United States, 2UCLA, Medicine, Division of Digestive Diseases, Center for Systems Biomedicine, Los Angelos, United States

P059.

Importance of NOD2 on mRNA and miRNA signatures in monocytes from Crohn's disease

Authors:

M. Salem1, Y. Chen2, J.B. Seidelin1, A. Sandelin2, O.H. Nielsen1, 1Herlev University Hospital, Department of Gastroenterology, Herlev, Denmark, 2The Bioinformatics Centre, Department of Biology and Biotech Research and Innovation Centre, Copenhagen, Denmark

P059. Cigarette smoke improves colonic inflammation through NKT cells activation in mice
P059. Development of patient reported outcome (PRO) instruments in ulcerative colitis and Crohn's disease
P059. Immunohistochemical expression of angiopoietin 1 (Ang1), CD34 and D2.40 in colon of patients with inflammatory bowel disease (IBD) and its association with endoscopic activity
Authors:

P.M. Linares1, M.E. Fernández-Contreras1, A. Algaba2, M. Guijarro Rojas3, F. Bermejo2, M. Chaparro1, J.P. Gisbert1, 1Hospital Universitario de la Princesa-IP, Gastroenterology and CIBEREHD, Madrid, Spain, 2Hospital Universitario de Fuenlabrada, Gastroenterology, Fuenlabrada, Spain, 3Hospital Universitario de la Princesa-IP, Pathology, Madrid, Spain

P059

Human alpha-Defensin 6 regulated by both Atoh1 and beta-catenin might be the pathogenesis of Japanese Crohn's Disease

Authors:

R. Hayashi*1, K. Tsuchiya2, S. Hibiya3, K. Fukushima3, N. Horita3, E. Okada3, A. Araki3, K. Ohtsuka3, M. Watanabe3

1Hiroshima University Hospital, Gastroenterology and Metabolism, Hiroshima, Japan, 2Tokyo Medical and Dental University, Advanced Therapeutics for Gastrointestinal Diseases, Tokyo, Japan, 3Tokyo Medical and Dental University, Gastroenterology and Hepatology, Tokyo, Japan

P060.

Impact of intestinal inflammation on Foxp3+ regulatory T cells

Authors:

G. Boschetti1,2, R. Duclaux-Loras2, R. Kanjarawi2, B. Flourié1,2, D. Kaiserlian2, S. Nancey1,2, 1Lyon-Sud Hospital, Gastroenterology, Pierre-Bénite, France, 2INSERM, U1111, Lyon, France

P060. CARD-024, a vitamin D analog, attenuates the pro-fibrotic response to TGFβ or substrate stiffness in colonic myofibroblasts
P060. Does the development of primary sclerosing cholangitis in IBD require the presence of colonic inflammation?
P060. Immune unresponsiveness of human intestinal dendritic cells in ulcerative colitis is reversed by a novel bacterial peptide STp
Authors:

H. Al-Hassi1, E. Mann1, D. Bernardo1, N. English1, S. Peake2, J. Landy2, R. Man2, A. Hart2, A. Stagg3, S. Knight1, 1Imperial College London, Immunology, London, United Kingdom, 2St Mark's Hospital, London, United Kingdom, 3Queen Mary University of London, London, United Kingdom

P060

Inflammatory bowel disease associates with pro-inflammatory potential of the IgG glycome

Authors:

I.T. Akmacic1, N. Ventham*2, E. Theodoratou3, F. Vuckovic1, N. Kennedy2, J. Kristic1, E.R. Nimmo4, R. Kalla4, H. Drummond4, J. Stambuk1, M.G. Dunlop5, M. Novokmet1, Y. Aulchenko6, O. Gornik7, I. BIOM consortium4, H. Campbell3, M. Pucic-Bakovic1, J. Satsangi4, G. Lauc1

1Genos Glycoscience Research Laboratory, Genos Glycoscience Research Laboratory, Zagreb, Croatia, 2NHS Lothian, Gastroenterology, Edinburgh, United Kingdom, 3University of Edinburgh, Centre for Population Health Sciences, Edinburgh, United Kingdom, 4University of Edinburgh, CGEM, Edinburgh, United Kingdom, 5University of Edinburgh, Colon Cancer Genetics Research Group, Edinburgh, United Kingdom, 6Novosibirsk State University, Institute of Cytology and Genetics , Novosibirsk, Russian Federation, 7University of Zagreb , Department of Biochemistry and Molecular Biology, Zagreb, Croatia

P061.

Identification of the mesocolic mesothelium as a novel source of fibroblasts – implications for Crohn's disease

Authors:

S. Sahebally1, M. Kiernan1, C. Dunne1, P. Kiely2, C. Coffey1, 1University of Limerick, Graduate Entry Medical School, 4i Centre for Interventions in Infection, Inflammation and Immunity, Limerick, Ireland, 2University of Limerick, Life Sciences, Materials and Surface Science and Stoke's Institute, Limerick, Ireland

P061. Anti-TNF-induced regulatory macrophages – mechanisms of immunosuppression
P061. IFN-γ release assay in screening for latent tuberculosis in inflammatory bowel diseases