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P053. Regulatory CD25+FoxP3+ T cells in the intestinal mucosa of patients with inflammatory bowel disease. Corticoids treatment effect
P053

Mitochondrial dysfunction impairs epithelial proliferative control and stemness in the intestinal crypts

Authors:

E. Berger*1, D. Yuan2, N. Waldschmitt1, E. Rath1, M. Allgäuer3, O. Staszewski4, O. Kober1, E. Lobner1, T. Schöttl5, M. Prinz4, A. Weber6, M. Gerhard3, M. Klingenspor5, K.-P. Janssen7, M. Heikenwälder2, D. Haller1

1Technische Universität München, ZIEL - Research Center for Nutrition and Food Sciences, Chair of Nutrition and Immunology, Freising-Weihenstephan, Germany, 2Helmholtz-Zentrum München, Institute of Virology, Munich, Germany, 3Technische Universität München, Institute of Medical Microbiology, Immunology and Hygiene, Munich, Germany, 4University of Freiburg, Institute of Neuropathology, Fribourg, Germany, 5Technische Universität München, Chair of Molecular Nutritional Medicine, Else Kröner-Fresenius Center & Research Center for Nutrition and Food Sciences, Freising-Weihenstephan, Germany, 6University Hospital Zurich, Institute of Surgical Pathology, Zurich, Switzerland, 7Technische Universität München, Department of Surgery, Munich, Germany

P054.

Interactions between neutrophil elastase and biologics in IBD

Authors:

K. Kok1, R. Curciarello1, P. Giuffrida1, N. Joshi2, P. Biancheri1, T. MacDonald1, 1Barts and The London School of Medicine and Dentistry, Centre for Immunology and Infectious Disease, London, United Kingdom, 2Barts Health NHS Trust, Gastroenterology, London, United Kingdom

P054. In experimental model of colitis the therapeutic efficacy of mesenchymal stem cells is not gut-homing dependent but is mediated at distance by secretion of TNF-alfa stimulated gene/protein 6
Authors:

S. Emanuela1, A. Anselmo1, V. Arena2, A. Gandelli1, J. Cibella1, A. Malesci1, M. Locati1, S. Danese1, S. Vetrano1, 1Istituto Clinico Humanitas, Italy, 2Catholic University of Rome, Italy

P054. Pregnane X Receptor as a therapeutic target for inflammatory bowel disease
P054. Serial tuberculin skin tests to detect latent tuberculosis in inflammatory bowel disease patients receiving infliximab therapy
P054

A simple biomarker for IBD associated dysbiosis : the ratio of iso-LCA/LCA indicates alteration of isomeration of bile acids in the intestinal lumen.

Authors:

T. Bazin1, C. Landman1, M. Charrier1, C. Hanotte1, L. Humbert1, L. Brot1, V. Leducq1, E. Quévrain1, J. Cosnes1, 2, L. Beaugerie1, 2, H. Sokol1, 2, P. Seksik*1, 2, D. Rainteau1, M.-A. Maubert1

1UPMC, ERL INSERM 1157 / UMR7203, PARIS, France, 2APHP, Service gastroentérologie et nutrition, PARIS, France

P055.

Integrated miRNA and gene expression profiling in patients with ulcerative colitis before and after infliximab treatment

Authors:

J. Van der Goten1, I. Arijs1, L. Van Lommel2, W. Vanhove1, M. Ferrante1, G. Van Assche1, P. Rutgeerts1, F. Schuit2, S. Vermeire1, 1KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Center for GastroIntestinal Disorders (TARGID), Leuven, Belgium, 2KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium

P055. A population-based study: do women with Crohn's disease breastfeed?
P055. HDAC dependent regulation of the IL-6/STAT3 pathway during T helper cell activation
Authors:

E. Sonnenberg1, R. Glauben1, P. Mascagni2, B. Siegmund1, 1Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Gastroenterologie, Berlin, Germany, 2Italfarmaco, Cinisello, Italy

P055. Relationship of impaired macrophage cytokine release to genetic susceptibility polymorphisms in Crohn's disease
P055

Increased Matrix stiffness Modulates MicroRNA expression and fibrogenesis in an in vitro model of intestinal fibrosis

Authors:

L.A. Johnson1, E. Rodansky1, 2, P.D. Higgins*1

1University of Michigan, Internal Medicine - Gastroenterology, Ann Arbor, MI, United States, 2University of Michigan, Internal Medicine - Gastroenterology, Ann Arbor, United States

P056.

Inhibition of matrix metalloproteinase-9 in intestinal inflammation by barbiturate–nitrate hybrids

Authors:

S. O'Sullivan, J. Wang, J. Gilmer, C. Medina, Trinity College Dublin, School of Pharmacy and Pharmaceutical Sciences, Dublin, Ireland

P056. GED-0507–34 Levo, a novel modulator of PPARgamma as new therapeutic strategy in the treatment of intestinal fibrosis
Authors:

S. Speca1, C. Rousseaux1, C. Dubuquoy1, A. Vetuschi2, R. Sferra3, B. Bertin4, L. Dubuquoy1, E. Gaudio5, S. Bellinvia6, P. Desreumaux1, G. Latella3, 1INSERM U995, Lille, France, 2University of L'Aquila, L'aquila, Italy, 3University of L'Aquila, L'Aquila, Italy, 4University Lille 2, Lille, France, 5University “Tor Vergata” of Roma, Roma, Italy, 6Giuliani Pharma, Milano, Italy

P056. Pulmonary function tests in patients with ulcerative colitis
P056. Similar phenotype and functional capacities of T lymphocytes in different anatomic locations of human intestine
P056

Soluble factors from the inflamed mucosa of patients with Crohn's disease (CD) or from cytokine-stimulated epithelial cells induce the expression of TL1A/TNFSF15 in human intestinal subepithelial myofibroblasts (ISMFs)

Authors:

E. Filidou*1, G. Bamias2, D. Goukos3, V. Valatas4, K. Arvanitidis1, M. Panagopoulou1, G. Kouklakis5, G.L. Daikos3, S. Ladas2, G. Kolios1

1Democritus University of Thrace, Laboratory of Pharmacology, Faculty of Medicine, Alexandroupolis, Greece, 2Laikon Hospital, Ethnikon & Kapodistriakon University of Athens, Academic Dpt. of Gastroenterology, Athens, Greece, 3Laikon Hospital, Ethnikon & Kapodistriakon University of Athens, 1st. Dpt of Propaedeutic and Internal Medicine, Laboratory of Infectious Diseases, Athens, Greece, 4University of Crete, Laboratory of Gastroenterology, Faculty of Medicine, Heraklion, Greece, 5Democritus University of Thrace, Endoscopy Unit, Faculty of Medicine, University Hospital of Alexandroupolis, Alexandroupolis, Greece

P057.

Influence of colitis on ileal epithelial barrier and its environment in a new mouse model of ulcerative colitis

Authors:

S. Sedghi1, X. Tréton2, Z. Alnabhani3, F. Barreau4, D. Cazals-Hatem5, E. Pédruzzi1, P. Lepage3, E. Ogier-Denis1, F. Daniel1, 1INSERM, U773, Paris, France, 2Beaujon Hospital, Department of Gastroenterology, Clichy la Garenne, France, 3INRA, UMR 1319 Micalis, Jouy-en-Josas, France, 4INSERM, UMR 843, Paris, France, 5Beaujon Hospital, Anatomo-pathologic Department, Clichy la Garenne, France

P057. Clinical course of concurrence of inflammatory bowel disease and multiple sclerosis: Results of a national multicentre study [GETAID Group]
P057. Enhanced expression of CXCL10 in inflammatory bowel disease – potential role of mucosal Toll-like receptor 3 stimulation