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P049. Longitudinal assessment of epithelial and immune cell changes following ileostomy closure in patients with ulcerative colitis
Authors:

J. Landy1, H. Omar Al-Hassi2, E. Mann2, S. Peake1, P.J. Ciclitira3, R.J. Nicholls4, S.K. Clark5, S. Knight2, A.L. Hart1, 1St Mark's Hospital, IBD Unit, London, United Kingdom, 2Antigen Presentation Research Group, Imperial College, London, United Kingdom, 3St Thomas' Hospital, Gastroenterology, London, United Kingdom, 4Imperial College, Department of Biosurgery and Surgical Technology, London, United Kingdom, 5St Mark's Hospital, Colorectal Surgery, London, United Kingdom

P049. Mesalazine and prednisolone can ameliorate the harmful effects of per os administration of iron in experimental colitis in rats, while the biologic agents infliximab and adalimumab can not
P049

H2S confers colonoprotection against TNBS-induced colitis by HO-1 upregulation in rats

Authors:

K. Kupai*, M. Veszelka, S. Török, Z. Szalai, A. Pósa, C. Varga

University of Szeged, Faculty of Science and Informatics, Department of Physiology, Anatomy and Neuroscience, Szeged, Hungary

P050.

Intraperitoneally injected mesenchymal stromal cells home significantly more often to the intestines in colitis mice compared to healthy controls

Authors:

I. Molendijk1, J.M. Perez Galarza2, E.S. de Jonge-Muller1, A.E. van der Meulen-de Jong1, W.E. Fibbe2, D.W. Hommes3, M. van Pel2, H.W. Verspaget1, 1Leiden University Medical Center, Gastroenterology and Hepatology, Leiden, Netherlands, 2Leiden University Medical Center, Immunohematology and Blood Transfusion, Leiden, Netherlands, 3University of California Los Angeles, Digestive Diseases, Los Angeles, United States

P050. Relationship between levels of angiogenic and lymphangiogenic factors (ALF) and the extension, endoscopic activity, and acute phase reactants (APR) in patients with ulcerative colitis (UC)
P050. Unravelling the immunomodulatory functions of glucagon like peptide-2 on dendritic cells
P050

The influence of anti-TNF therapy on chosen angiogenesis-related processes in patients with Crohn's disease

Authors:

P. Eder*1, L. Lykowska-Szuber1, K. Korybalska2, A. Wozniak3, I. Krela-Kazmierczak1, K. Stawczyk-Eder1, K. Klimczak1, A. Szymczak1, K. Linke1, J. Witowski2

1Poznan University of Medical Sciences, Department of Gastroenterology, Human Nutrition and Internal Diseases, Poznan, Poland, 2Poznan University of Medical Sciences, Department of Pathophysiology, Poznan, Poland, 3Poznan University of Medical Sciences, Department of Clinical Pathomorphology , Poznan, Poland

P051.

Interleukin 22 and interleukin 23R gene expression in Crohn's disease: preliminary results

Authors:

N. Ben Mustapha, A. Labidi, Y. Kardous, M. Serghini, M. Fekih, J. Boubaker, A. Filali, La Rabta Hospital, Gastroenterology A, Tunis, Tunisia

P051. Angiogenic and lymphangiogenic protein level alterations in colonic mucosa culture supernatant and peripheral blood in patients with inflammatory bowel disease (IBD)
P051. Inhibition of lymphangiogenesis via VEGFR-3 as a novel therapy for IBD-related colorectal cancer
Authors:

S. D'Alessio1, C. Tacconi1, C. Correale1, A. Gandelli1, S. Danese1, 1Istituto Clinico Humanitas, Rozzano, Italy

P051. Relationship between histological activity of inflammatory bowel disease (IBD) and angiogenic and lymphangiogenic factors (ALF)
P051

The N- acyl-homoserine lactone 3-oxo-C12, an inter-bacterial signaling molecule (involved in quorum sensing), exerts effects on the host: thus implicating quorum sensing in inflammatory bowel disease.

Authors:

C. Landman*1, M. Clément1, H. Nsiri1, E. Quévrain1, T. Bazin1, L. Brot1, J.-P. Grill1, M.-A. Maubert1, L. Humbert1, H. Sokol1, 2, G. Trugnan1, D. Rainteau1, P. Seksik1, 2

1UPMC, ERL INSERM 1157 / UMR7203, PARIS, France, 2APHP Saint-Antoine, Service de Gastroentérologie et nutrition, Paris, France

P052.

Interleukin 10 (IL10) expression and distribution pattern in healthy and inflamed bowel. Relationship with steroid response in Crohn's disease (CD)

Authors:

A. Carrasco, F. Fernández-Bañares, C. Loras, E. Pedrosa, M. Aceituno, M. Rosinach, R. Temiño, M. Forné, E. Sainz, X. Andújar, M. Esteve, Hospital Universitari Mútua Terrassa. UB, Gastroenterology, Terrassa, Spain

P052. Fecal calprotectin is reliable surrogate marker of endoscopic and histologic mucosal healing in Crohn's disease and ulcerative colitis
P052. Inflammation, Toll-like receptors and tumorigenic processes in the colon: Studies in murine models
P052. Inhibition of Th17 cells but not of Tregs affects extracellular matrix protein deposition in chronic DSS colitis
Authors:

C. Breynaert1, C. Perrier1, J. Cremer1, L. Coorevits2, M. Ferrante1, S. Vermeire1, P. Rutgeerts1, C. Uyttenhove3, J. Van Snick3, J. Ceuppens2, G. Van Assche1, 1KU Leuven, TARGID, Leuven, Belgium, 2KU Leuven, Clinical immunology, Leuven, Belgium, 3Brussels Branch, Ludwig Institute for Cancer Research, Brussels, Belgium

P052

Allograft inflammatory factor-1 (AIF-1) stimulates Th1 differentiation of human T-cells and protects them from apoptosis

Authors:

D. Cano-Martínez*1, J. Monserrat2, B. Hernández-Breijo1, P. Sanmartín-Salinas1, I.D. Román1, M.D. Fernández-Moreno1, S. Marsal3, J.P. Gisbert4, L. Guijarro1

1Universidad de Alcalá and CIBERehd, Systems Biology, Alcalá de Henares, Spain, 2Universidad de Alcalá, Medicine and Medical Specialties, Alcalá de Henares, Spain, 3Hospital Universitari Vall d'Hebron, Gastroenterology Unit, Barcelona, Spain, 4Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain

P053.

Interleukin-17A homodimer reduces pro-inflammatory cytokine production by inflammatory bowel disease mucosa cultured ex vivo

Authors:

P. Biancheri1,2, A. Di Sabatino2, R. Curciarello1, P. Giuffrida2, F. Ammoscato1, G.R. Corazza2, J.O. Lindsay3, T.T. MacDonald1, 1Barts and The London School of Medicine and Dentistry, Centre for Immunology and Infectious Disease, London, United Kingdom, 2Fondazione IRCCS Policlinico S. Matteo, University of Pavia, First Department of Medicine, Pavia, Italy, 3Barts and The London School of Medicine and Dentistry, Centre for Digestive Diseases, London, United Kingdom

P053. Influence of NADPH oxidase on inflammatory response in the primary intestinal epithelial cells from patients with ulcerative colitis
Authors:

R. Ramonaite1, L. Jonaitis1, G. Kiudelis1, A. Tamelis2, J. Skieceviciene1, V. Borutaite3, L. Kupcinskas1, 1Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania, 2Lithuanian University of Health Sciences, Department of Surgery, Kaunas, Lithuania, 3Lithuanian University of Health Sciences, Institute of Neurosciences, Kaunas, Lithuania

P053. Is there a change in the natural history of Crohn's disease; Surgical rates and medical management in a population-based inception cohort from Western Hungary between 1977–2008