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P037. Is ulcerative colitis an atypical Th2-mediated disease characterised by excess production of interleukin‑13?
P037. Role of ghrelin and melatonin in pathogenesis of clinical and experimental inflammatory bowel disease
Authors:

P. Konturek1, P. Celinski2, A. Madro2, T. Brzozowski3, S. Konturek3, 1Thuringia Clinic, Department of Internal Medicine, Saalfeld, Germany, 2Medical Academy Lublin, Department of Gastroenterology, Lublin, Poland, 3University Cracow, Institute of Physiology, Cracow, Poland

P037

Patient-derived colonic epithelial cultures as a valuable tool for personalized medicine

Authors:

W. Vanhove*, S. De Schepper, D. Staelens, I. Arijs, G. Van Assche, M. Ferrante, S. Vermeire, K. Nys

KU Leuven, Translational Research Center for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, Leuven, Belgium

P038.

Neuropeptide S: effects on motility, contractility and inflammation in the rat and human gastrointestinal tract

Authors:

M.A. Halim1, L. Gillberg1, U. Karlbom2, M. Sundbom2, E. Rosenqvist3, S. Saudi3, M. Sjöblom3, A. Sommansson3, E. Näslund4, T. Feldreich1, D.-L. Webb1, P.M. Hellström1, 1Uppsala University, Medical sciences, gastroenterology & hepatology, Uppsala, Sweden, 2Uppsala University, Surgical sciences, surgery, Uppsala, Sweden, 3Uppsala University, Neuroscience, Physiology, Uppsala, Sweden, 4Karolinska Institutet, Clinical sciences, Danderyd hospital, Stockholm, Sweden

P038. Enhancement of cytoprotective mechanisms in case of blockage of COX‑2 and introduction of L‑arginine in experimental colitis
P038. Role of 5-HT3 receptors in the anti-inflammatory effects of alosetron in a rat model of colitis
Authors:

A. Motavallian1, M. Minaiyan2, M. Rabbani2, P. Mahzouni2, 1Guilan University of Medical Sciences, Pharmacology, Guilan, Iran, Islamic Republic of, 2Isfahan university of medical sciences, pharmacology, Isfahan, Iran, Islamic Republic of

P038. SOCS3 promoter hypermethylation status in ulcerative colitis related colorectal cancer
P038

Retinoic acid primed dendritic cells induce Interferon gamma (IFN γ ) and reduce FOXP3 expression on human Th9 cells

Authors:

R. Rampal*1, A. Awasthi2, V. Ahuja1

1All India Institute of Medical Sciences, Gastroenterology and Human Nutrition, New Delhi, India, 2Translational Health Science and Technology Institute , CHME, Gurgaon, India

P039.

Mucosal interleukin-33 levels in patients with moderate to severe ulcerative colitis before and after induction of endoscopic remission by infliximab

Authors:

M.D. Gundersen1, R. Goll1,2, G. Haraldsen3, J.R. Florholmen1,2, 1University of Tromsø, The Arctic University of Norway, Research group of Gastroenterology and Nutrition, Institute of Clinical Medicine, Tromsø, Norway, 2University Hospital of North Norway, Department of Medical Gastroenterology, Tromsø, Norway, 3Oslo University Hospital, Department of Pathology, Rikshospitalet, Oslo, Norway

P039. Adipokines of the mesenteric fat tissue modulate subtype and function of resident macrophages
P039. Reprogramming of intestinal epithelial cells by interleukin-22
Authors:

L. Lebenheim1, B. Siegmund1, J.-D. Schulzke1, M. Schumann1, 1Charité – University Medicine Berlin, Germany, Gastroenterology, Infectiology and Rheumatology, Berlin, Germany

P039. Serum MMPs 7–9 and their inhibitors during glucocorticoid and anti-TNF-alpha therapy in IBD
P039

Role of the CARD family (CARD10, CARD11 and CARD14) in the colonic mucosa of patients with Ulcerative Colitis

Authors:

J. Yamamoto-Furusho*, A. Sarmiento, G. Fonseca-Camarillo

IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico

P040.

Mucosal T cell profiles in newly diagnosed, untreated inflammatory bowel disease patients

Authors:

C. Horjus1, M.J. Groenen2, P.J. Wahab3, E. van Lochem4, 1Radboud University, Gastroenterology and hepatology, Nijmegen, Netherlands, 2Rijnstate Hospital, Gastroenterology and hepatology, Arnhem, Netherlands, 3Rijnstate Hospital, Gastroenterology and hepatology, Nijmegen, Netherlands, 4Rijnstate Hospital, Medical Microbiology and Immunology, Arnhem, Netherlands

P040. Protein tyrosine phosphate non receptor type 22 regulates muramyl-dipeptide induced effects in human monocytes
Authors:

M. Scharl1, M. Spalinger1, S. Lang1, A. Weber2, S. Vavricka1, P. Frei1, M. Fried1, G. Rogler1, 1University Hospital Zürich, Division of Gastroenterology and Hepatology, Zürich, Switzerland, 2University Hospital Zürich, Institute for Surgical Pathology, Zürich, Switzerland

P040. Relationship between levels of angiogenic and lymphangiogenic factors (ALF) and the extension, endoscopic activity, and acute phase reactants (APR) in patients with Crohn's disease (CD)
P040. Serum proteome profile of Crohn's disease patients treated with infliximab: A pilot study
P040

The biosimilars of infliximab are equally well quantified in a clinically validated infliximab assay

Authors:

A. Gils, R. Storme, E. Dreesen*, T. Van Stappen, P.J. Declerck

KU Leuven, Department of Pharmaceutical and Pharmacological Sciences, Therapeutic and Diagnostic Antibodies, Leuven, Belgium

P041.

Modulation of inflammatory processes in mouse colitis models and gastrointestinal acute radiation syndrome with AVX-470m, an oral polyclonal anti-TNF antibody

Authors:

D. Hartman, K. Bhol, B. Lemos, E. Erlich, D. Keane, D. Tracey, B. Fox, Avaxia Biologics, Inc, Research, Lexington, United States

P041. Methyl donor deficiency affects small intestinal differentiation and barrier function in rats