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P021. Glucagon-like peptide‑2 modulates the production of proinflammatory cytokine interferon-γ in human blood and intestinal dendritic cells – a potential new therapy for Crohn's disease
P021. Subepithelial eosinophils expressing muscarinic receptors and corticotropin-releasing factor disrupt mucosal barrier in inactive ulcerative colitis
P021. The urokinase plasminogen activator receptor (uPAR) regulates intestinal macrophage phagocytosis and polarization in experimental colitis
Authors:

M. Genua1, S. D'Alessio1, J. Cibella1, A. Gandelli1, E. Sala1, C. Correale1, V. Arena2, A. Malesci1, S. Vetrano1, S. Danese1, 1Istituto Clinico Humanitas, Rozzano, Italy, 2Catholic University of Rome, Internal Medicine, Rome, Italy

P021

Differential plasma microRNA expression profile in ulcerative colitis patients according to their response to corticosteroids

Authors:

J.E. Naves*1, J. Manye1, 2, V. Loren1, M. Mañosa2, 3, A. García-Jaraquemada1, I. Moret2, 4, G. Bastida2, 4, B. Beltrán2, 4, E. Cabré2, 3, E. Domènech2, 3

1Germans Trias i Pujol Health Sciences Research Institute, Gastroenterology Department, Badalona, Spain, 2Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, CIBERehd, , Spain, 3Hospital Universitari Germans Trias i Pujol, Gastroenterology Department, Badalona, Spain, 4Hospital La Fe, Gastroenterology Unit, Valencia, Spain

P022.

Role of P2X7 purinergic receptor in the control of enteric neuromuscular functions in normal rat distal colon and experimental bowel inflammation

Authors:

L. Antonioli1, M. Fornai1, R. Colucci1, C. Pellegrini1, D. Sacco1, V. Caputi2, G. Orso3, M.C. Giron2, C. Scarpignato4, C. Blandizzi1, 1University of Pisa, Department of Clinical and Experimental Medicine, Pisa, Italy, 2University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Padova, Italy, 3Scientific Institute “E. Medea”, Scientific Institute “E. Medea”, Padova, Italy, 4University of Parma, Laboratory of Clinical Pharmacology, Parma, Italy

P022. IL-23 responsive innate lymphoid cells are increased in inflammatory bowel disease
P022. Therapeutic effect of adipose tissue-derived stem cell in Interleukin-10 knockout mice
Authors:

B.I. Jang1, I.H. Song2, K.O. Kim1, S.H. Lee1, T.N. Kim1, 1Yeungnam University College of Medicine, Division of Gastroenterogy, Department of Internal Medicine, Daegu, South Korea, 2Yeungnam University College of Medicine, Department of Anatomy, Daegu, South Korea

P022. Treatment with CSF and GSF growth factors improves experimental colitis in rats
P022

Histone deacetylases in inflammatory mucosa distinguish Crohn's disease from ulcerative colitis

Authors:

J. de Bruyn*1, C. Wichers2, T. Radstake2, J. Broen2, G. D'Haens1

1Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Wilhelmina Children's Hospital-Utrecht Medical Center, Translational Immunology, Utrecht, Netherlands

P023.

Regulation of colonic inflammation by commensal flora in SAMP1/YitFc mice

Authors:

D. Ishikawa1, T. Osada1, S. Watanabe1, F. Cominelli2, 1Juntendo University, Gastroenterology, Tokyo, Japan, 2Case Western Reserve University, Gastroenterolgy, Cleveland OH, United States

P023. Expression of GH/IGF-1 axis compounds in moderate-severe Crohn's disease: Role of mucosal inflammation and anti TNF-α treatment
P023. Targeting metallothionein in Dextran Sulfate Sodium-induced colitis points to new therapeutic strategies for patients suffering from inflammatory bowel diseases
P023. Therapy with FREMS (Frequency Rhythmic Electrical Modulation System)
Authors:

R. Pola1, M. Massari2, I. Gatto1, I. Giarretta1, G. Costamagna3, 1Catholic University School of Medicine, Medicine, Rome, Italy, 2Catholic University School of Medicine, Surgery, Rome, Italy, 3Catholic University School of Medicine, Endoscopic Surgery, Rome, Italy

P023

Dipotassium glycyrrhizate normalises the mucosal healing gene expression altered by inflammation in a murine model of colitis

Authors:

R. Vitali1, F. Palone1, S. Cucchiara*2, L. Stronati1

1ENEA, Department of Radiobiology and Humal Health, Rome, Italy, 2Sapienza, Rome, Pediatric Gastroenterology and Liver Unit, Rome, Italy

P024.

Regional differences in effect of TGF-beta1 and PDGF on the early onset of intestinal fibrosis

Authors:

B.T. Pham, W.T. van Haaften, R. Iswandana, D. Oosterhuis, P. Olinga, University of Groningen, Pharmaceutical Technology and Biopharmacy, Groningen, Netherlands

P024. Jejunal glucose absorption is decreased in rat models of colitis through extrinsic neuronal mechanisms
P024. Repeated cycles of DSS inducing a chronically relapsing inflammation: A novel model to study fibrosis using in vivo MRI T2 relaxometry
P024. Ulcerative colitis versus Crohn's disease: differences observed in the IMPACT survey
Authors:

S. Lönnfors1, J.O. Lindsay2, S. Vermeire3, M. Greco1, D. Hommes3, C. Bell1, L. Avedano1, B. Wilson1, 1European Federation of Crohn's and Ulcerative Colitis Associations, Brussels, Belgium, 2Barts Health NHS Trust, The Royal London Hospital, London, United Kingdom, 3European Crohn's and Colitis Organization, Vienna, Austria

P024

Role of Interleukin 27 (IL-27) in the Colonic Mucosa of Patients with Inflammatory Bowel Disease.

Authors:

G. Fonseca Camarillo*1, F.-C. Janette2, Y.F. Jesús Kazuo3

1Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán. México D.F, México., Inflammatory Bowel Disease Clinic. Department of Gastroenterology. , Distrito Federal, Mexico, 2Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán. México D.F, México., Department of Gastroenterology, Mexico City, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán. México D.F, México., Inflammatory Bowel Disease Clinic. Department of Gastroenterology., Mexico City, Mexico

P025.

Reduced Butyricicoccus pulli­caecorum levels in mucosa of UC patients correlate with aberrant CLDN1 expression

Authors:

S. Devriese1, V. Eeckhaut2, F. Van Immerseel2, R. Ducatelle2, M. De Vos1, D. Laukens1, 1Ghent University, Department of Gastroenterology, Gent, Belgium, 2Ghent University, Department of Pathology, Bacteriology and Avian Diseases, Merelbeke, Belgium