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P013.

The effects of Schistosoma japonicum eggs antigen on SAMP1/Yit mice, a spontaneous ileitis model

Authors:

T. Arai, T. Seki, T. Kumagai, R. Shimogawara, N. Ohta, Graduate School of Tokyo Medical and Dental University, Department of Environmental Parasitology, Bunkyo-ku, Japan

P013. Mesenchymal stem cells injection reduces colitis severity and does not increase colitis-associated colon cancer risk in mice
P013. The fall of estrogen receptors expression in long-lasting ulcerative-associated carcinoma
Authors:

M. Principi1, M.P. Scavo1, D. Piscitelli1, V. Villanacci2, A. Contaldo1, V. Neve1, K. Lofano1, G. Piacentino1, N. De Tullio1, E. Ierardi3, A. Di Leo1, 2University of Bari, Bari, 2Spedali Civili, Brescia, 3University of Foggia, Italy

P013. Vidofludimus induces p53-mediated apoptosis in activated T cells and inhibits IL‑17A and IL‑17F expression decoupled from lymphocyte proliferation
P013

Characterization of enterochromaffin cells in pouchitis after proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis

Authors:

P. Giuffrida1, A. Vanoli2, E. Biletta2, G. Sampietro3, O. Luinetti2, R. Manca2, G. Bergamaschi1, D. Bagordo1, C. Salvatore1, C. Alvisi1, P. Fociani4, E. Solcia1, G.R. Corazza1, A. Di Sabatino*1

1Fondazione IRCCS Policlinico San Matteo, University of Pavia, First Department of Medicine, Pavia, Italy, 2Fondazione IRCCS Policlinico San Matteo, University of Pavia, Department of Molecular Medicine, Pavia, Italy, 3Luigi Sacco University Hospital, Surgery Division, Department of Clinical Sciences, Milan, Italy, 4Luigi Sacco University Hospital, Chair of Pathology, Milan, Italy

P014.

The effect of the anti-TNFα adalimumab on the levels of angiogenic factors in mucosal cultures from patients with inflammatory bowel disease (IBD)

Authors:

P.M. Linares1, M.E. Fernández-Contreras1, A. Algaba2, M. Chaparro1, F. Bermejo2, J.P. Gisbert1, 1Hospital Universitario de La Princesa, IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, 2Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Fuenlabrada, Spain

P014. Pharmacological evaluation of the SCID T cell transfer model of colitis
P014. Pretreatment with interferon-gamma enhances the therapeutic activity of mesenchymal stromal cells in dextran sodium sulfate (DSS) induced colitis
P014. The inflammasome induces macrophage-mediated disruption of the epithelial barrier
Authors:

D. Lissner1, M. Schumann1, L.-I. Kredel1, A. Batra1, T. Stroh1, A. Kühl1, B. Siegmund1, 1Charité – Universitätsmedizin Berlin, Gastroenterologie/Infektiologie/Rheumatologie, Berlin, Germany

P014

Selective Janus Kinase 1 inhibitor targets monocytes and tissue macrophages during DSS colitis

Authors:

L. De Vries*1, 2, J. Duarte2, F. Hilbers2, M. De Winther3, P. Moerland4, M. Woodrow5, M. Sims5, V. Ludbrook5, G. D'Haens1, W. De Jonge2

1Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 3Academic Medical Center, Medical Biochemistry, Amsterdam, Netherlands, 4Academic Medical Center, Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam, Netherlands, 5GlaxoSmithKline, Kinase DPU, Stevenage, United Kingdom

P015.

The VEGFC/VEGFR3 pathway controls colitis associated cancer formation and progression through lymphangio­genesis and lymphatic endothelial VE-cadherin

Authors:

C. Tacconi, S. D'Alessio, C. Correale, A. Gandelli, S. Vetrano, S. Danese, Humanitas Research Hospital, IBD Center, Rozzano, Milan, Italy

P015. Enteroendocrine cells and appetite dysregulation in Crohn's disease
P015. The influence of COX-1/COX-2 inhibitors on the Na/Li-countertransport and Na,K,2Cl-cotransport in erythrocytes of rats with experimental colitis
Authors:

N. Grynchyshyn1, 1Danylo Halytsky Lviv National Medical University, Ukraine

P015. The PA system controls inflammatory response during experimental colitis
P015

Exploring the barrier; RNA sequencing of laser microdissected epithelium from IBD patients

Authors:

A. van Beelen Granlund*1, 2, 3, S. Thorsvik1, 2, 3, A.E. Østvik1, 2, 3, V. Beisvåg1, A. Flatberg1, I. Bakke1, 3, A.K. Sandvik1, 2, 3

1Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Trondheim, Norway, 2Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, Trondheim, Norway, 3St. Olav's University Hospital, Department of Gastroenterology and Hepatology, Trondheim, Norway

P016. ABCG2 down regulation in active inflammatory bowel disease is due to incorrect protein folding
P016. Stimulation of lymphatic function via VEGFR‑3 as a novel therapy for chronic experimental intestinal inflammation
P016. The lack of tumour necrosis factor alpha downregulation on basic fibroblast growth factor/syndecan 1 link may be a relevant molecular pathway in Crohn's disease fibrotic stenosis
Authors:

E. Ierardi1, F. Giorgio1, D. Piscitelli2, M. Fiore1, R. Rossi1, S. Cantatore1, M. Principi2, A. Di Leo2, C. Panella1, 1University of Foggia, 2University of Bari, Bari, Italy

P016

Adipokines link childhood Crohn's disease and the gut immune system.

Authors:

H. Al-Hassi*1, R. Vora2, R. Durga2, M. Inés2, A. Hart3, D. Bernardo2, F. John4, S. Knight2

1Imperial College London, Immunology, London, United Kingdom, 2Imperial College London, Antigen Presentation Research Group(APRG), London, United Kingdom, 3St Mark's Hospital, Colorectal Surgery & IBD Unit, London, United Kingdom, 4Chelsea and Westminster Hospital, Paediatric Gastroenterology, London, United Kingdom

P017.

The effect of intestinal alkaline phosphatase on intestinal epithelial cells, macrophages and chronic colitis in interleukin-10-deficient mice

Authors:

C. Lee1, J. Chun2, S.W. Hwang2, S.J. Kang1, J.P. Im2, J.S. Kim2, 1Healthcare sytem, Gangnamcenter, Seoul national university hospital, Internal medicine, Seoul, Korea, Republic of, 2Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of