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P005.

Transcriptome of intestinal epithelial barrier genes in the colonic mucosa from patients with ulcerative colitis

Authors:

G. Fonseca-Camarillo, J. Yamamoto-Furusho, IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico

P005. Autophagy induces immune tolerance by regulating interactions between dendritic cells–epithelial cell in the gut
P005. Restoration of Foxp3 regulatory T cells in blood correlates with clinical response to anti‑TNF therapy for IBD
P005. T cell KV1.3 channel expression level in biopsies from patients with active ulcerative colitis is higher in patients treated with immunosuppressants and 5-ASA versus 5-ASA alone
Authors:

L.K. Hansen1, J. Kjeldsen2, T. Knudsen3, D. Larsen1, R. Köhler1, 1University of Southern Denmark, Institute of Molecular Medicine, Odense, 2Odense University Hospital, Department of Gastroenterology and Hepatology, Odense, 3Hospital of South Denmark, Esbjerg, Department of Gastroenterology and Hepatology, Esbjerg, Denmark

P005

Characterization of human colonic and ileal dendritic cells in health and Crohn's disease

Authors:

I. Moret-Tatay*1, 2, 3, Y.H. Siaw1, 4, R. Man5, H.O. Al-Hassi1, R. Vora1, 4, D. Reddi1, A.L. Hart4, B. Beltrán3, 6, P. Nos3, 6, S.C. Knight**1, D. Bernardo1

1Imperial College London, Northwick Park and St. Mark's Campus, Antigen Presentation Research Group, Harrow, HA1 3UJ, United Kingdom, 2IIS Hospital La Fe, Gastroenterology, Valencia, Spain, 3Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, CIBERehd, , Spain, 4St. Mark's Hospital, North West London Hospitals NHS Trust, Digestive Medicine, Harrow, HA1 3UJ, United Kingdom, 5St. Mark's Hospital, North West London Hospitals NHS Trust, Wolfson Unit for Endoscopy, Harrow, HA1 3UJ, United Kingdom, 6Hospital Universitari i Politècnic La Fe, Digestive Medicine, Valencia, Spain

P006.

The therapeutic potential of the pharmacological inhibition of PBEF/NAMPT/Visfatin in inflammatory bowel disease

Authors:

R. Gerner, V. Wieser, A. Bichler, A. Moschen, H. Tilg, Medical University of Innsbruck, Department of Internal Medicine 1, Innsbruck, Austria

P006. Demonstration of functional matrix metalloproteinase activity in Crohn's disease fistulas: Effect of ramiprilate
P006. Regulation of inflammatory bowel diseases by myeloid-derived suppressor cells
P006. Tauro-ursodeoxycholic acid ameliorates experimental colitis in mice
Authors:

Y.H. Kim1, S.-J. Koh1, W.J. Choi1, S.H. Kim1, J.W. Kim1, B.G. Kim1, K.L. Lee1, 1Seoul National University Boramae Hospital, Internal Medicine, Seoul, South Korea

P006

Intestinal alkaline phosphatase ameliorates experimental colitis via TLR4-dependent pathway

Authors:

S.W. Hwang*, J.W. Lee, J. Chun, H. Yoon, C. Lee, J.P. Im, J.S. Kim

Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea, Republic of

P007.

The ratio of circulating estrogen receptors beta and alpha (ERβ/ERα) indicates endoscopic activity in patients with Crohn's disease

Authors:

P.M. Linares1, A. Algaba2, M. Chaparro1, A. Urzainqui3, M. Guijarro-Rojas4, J.P. Gisbert1, F. Bermejo2, M.E. Fernández-Contreras1, 1Hospital Universitario de La Princesa, IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, 2Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Fuenlabrada, Spain, 3Hospital Universitario de La Princesa and IP, Immunology Unit, Madrid, Spain, 4Hospital Universitario de La Princesa and IP, Pathology Unit, Madrid, Spain

P007. Differential cleavage of anti-tumor necrosis factor-alpha agents by matrix metalloproteinase (MMP)-10 and MMP-12 in inflammatory bowel disease
P007. Rates of lactose malabsorption amongst Irish Caucasian inflammatory bowel disease patients
P007. The aetiology, immune activation and homing profile of dendritic cells in fistulating perianal Crohn's disease
Authors:

N.A. Yassin1, H. Al-Hassi2, G.H. Lee2, G. Malietzis2, P. Tozer3, D. Bernardo-Ordiz2, E. Mann2, R.K.S. Phillips1, S. Knight2, A.L. Hart4, 1St Mark's Hospital and Academic Institute, Harrow, The Department of Colorectal Surgery, London, 2Antigen Presentation Research Group, St Mark's and Northwick Park Hospitals, 3St Mark's Hospital and Academic Institute, Harrow, London, 4IBD Unit, St Mark's Hospital and Academic Institute, Harrow, London, United Kingdom

P007

Disruption of phosphatidylcholine paracellular movement to intestinal mucus predisposes to Ulcerative Colitis

Authors:

W. Stremmel*1, S. Staffer1, M. Schneider2, H. Gan-Schreier1, A. Wannhoff1, H. Wolburg3, M. Bach4, T. Efferth2

1University Hospital of Heidelberg, Internal Medicine IV, Div. of Gastroenterology, Heidelberg, Germany, 2Johannes Gutenberg University, Institute of Pharmacy & Biochemistry, Mainz, Germany, 3University Hospital of Tübingen, Medicine, Tübingen, Germany, 4Kirchhoff Institute of Physics, Physics, Heidelberg, Germany

P008.

The pro-apoptotic galectin-1 is functionally inhibited in inflamed intestinal areas of IBD patients

Authors:

R. Papa Goby1, A. Rocca2, A. Sambuelli3, G. Ravinovich4, M. Toscano4, A. Gil5, S. Negreira6, S. Huernos5, S. Goncalves5, M. Bellicoso5, S. Goncalves5, P. Tirado5, R. Curciarello7, A. Irigoyen6, C. Muglia8, M. Yantorno9, G. Docena7, 1Fac. de Ciencias Exactas Universidad Nacional del Comahue (Laboratorio de Investigacione, LISINs del Sistema Inmune), La Plata, Argentina, 2Bonorino Udaondo Gastroenterology Hopital, Endoscopy Service, Buenos Aires, Argentina, 3Institute, Medicine, IBD Section, Gastroenterology, Buenos Aires, Argentina, 4IBYME, Laboratorio de Inmunopatologia, Buenos Aires, Argentina, 5Bonorino Udaondo Gastroenterology Hopital, IBD Section, Buenos Aires, Argentina, 6Bonorino Udaondo Gastroenterology Hopital, Buenos Aires, Buenos Aires, Argentina, 7LISIN (Laboratorio de Investigaciones del Sistema Inmune), Laboratorio de Investigaciones del Sistema Inmune, La Plata, Argentina, 8UNLP, Servicio de Gastroenterologia, La Plata, Argentina, 9Hospital Interzonal de Agudos, Gastroenterologia, La Plata, Argentina

P008. Enhanced induction of regulatory macrophages upon azathioprine/infliximab combination treatment in vitro
P008. Pharmacokinetics and pharmacodynamics in cynomolgus monkeys of AMG 181, a fully human anti α4 β7 antibody for treating inflammatory bowel disease
P008. The amount of keratins in colonic epithelial cells matter for stress protection
Authors:

M.N. Asghar1, J.S.G. Silvander1, L.E. Fortelius1, J.O. Misiorek1, I. Lähdeniemi1, T. Helenius1, D.M. Toivola1, 1Åbo Akademi University, Department of Biology, Turku, Finland

P008

IL-34 antibody ameliorates experimental Colitis by alternating IL-12p40 expression in macrophages

Authors:

T. Yoshino*, M. Matsuura, H. Nakase

Graduate School of Medicine, Kyoto University, Gastroenterology and Hepatology, Kyoto, Japan