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P001.

miR-301a and miR-301b are highly expressed in inflamed mucosa of inflammatory bowel disease and promotes Th1/Th17 immune responses

Authors:

R. Wu, W. Wu, Z. Liu, Shanghai Tenth People's Hospital, Tongji University, Department of Gastroenterology, Shanghai, China

P001. Activation of toll-like (TLR) and nod-like (NLR) receptors of human intestinal mucosal endothelial cells induces CEACAM1-mediated angiogenesis
P001. Interleukin-21 exerts pathogenic and host-protective effects in experimental models of colitis
Authors:

M. Shale1, F. Powrie1, 1University of Oxford, Translational Gastroenterology, Oxford, United Kingdom

P001. Ulcerative colitis-associated carcinogenesis depends on alternatively activated “M2 macrophages” – from mice to men
P001

Chronic exposure to LPS but not MDP induces goblet cell development in human colonic enteroids

Authors:

E. Rodrigues1, 2, L. Slobbe1, S. Gadeock1, A.G. Butt1, M. Schultz*2

1University of Otago, Department of Physiology, Otago School of Medical Sciences, Dunedin, New Zealand, 2University of Otago, Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand

P002.

miR-10a suppresses dendrite cell activation and Th1/Th17 cell responses in inflammatory bowel disease

Authors:

W. Wu, C. Liu, Z. Liu, Shanghai Tenth People's Hospital, Tongji University, Department of Gastroenterology, Shanghai, China

P002. Intestinal homeostasis is critically regulated by the transcription factor T-bet
Authors:

N. Powell1, E. Stolarczyk1, J. Lo1, J. Canavan1, E. Marks1, T. MacDonald2, G. Lord1, 1King's College London, Experimental Immunobiology, London, 2Queen Mary University, Immunity and Infectious Diseases, London, United Kingdom

P002. The gastrointestinal-selective biologic vedolizumab does not impair immune surveillance of the central nervous system in non-human primates
P002. The potential role of IL‑33 in inflammatory-associated gut fibrosis: Induction of pro-fibrogenic gene expression and myofibroblast hypertrophy
P002

Genetic deletion of tissue inhibitor of metalloproteinase-1/TIMP-1 attenuates DSS-induced inflammation and fibrosis in a mouse model of colitis.

Authors:

M. de Bruyn*1, 2, C. Breynaert3, I. Arijs2, 4, J. Cremer3, L. Van Lommel4, K. Geboes5, G. De Hertogh5, M. Ferrante2, S. Vermeire2, G. Van Assche2, J. Ceuppens3, G. Opdenakker1

1Rega Institute for Medical Research - KU Leuven, Microbiology and Immunology, Leuven, Belgium, 2University Hospitals Leuven - KU Leuven, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 3KU Leuven - Laboratory of Clinical Immunology, Department of Microbiology and Immunology, Leuven, Belgium, 4KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium, 5KU Leuven - Translational Cell and Tissue Research, Department of Imaging and Pathology, Leuven, Belgium

P003.

Vitamin D deficiency enhances adherent invasive Escherichia coli induced barrier dysfunction and experimental colonic injury

Authors:

A. Assa1, L. Pinnell2, J. Rautava2, L. Vong2, K. Johnson-Henry2, P. Sherman2, 1Tel Aviv University, Gastroenterology, Petach Tikvah, Israel, 2University of Toronto, Cell Biology, Toronto, Canada

P003. Dendritic cell homing and immune cell function in Crohn's anal fistulae
P003. Selective inhibition of eIF2alpha dephosphorylation prevents colitis and shows therapeutic potential in a new model of ulcerative colitis
Authors:

X. Treton1, E. Pedruzzi1, C. Guichard2, M. Vallee1, S. Sedghi1, Y. Ladeiro1, N. Montcuquet3, J.N. Freund4, I. Van Seuningen5, F. Barreau1, J.P. Hugot1, D. Cazals-Hatem6, F. Daniel1, E. OgierDenis1, Y. Bouhnik7, 1Paris 7 University, Inserm U773, Paris, 2Univ. Paris-Diderot Sorbonne Paris-Cité, INSERM U674, 3Univ. Paris-Diderot Sorbonne Paris-Cité, INSERM U989, 4Inserm U 682, Strasbourg, 5INSERM UMR837, Lille, 6Hôpital Beaujon, APHP, Pathology, Clichy, 7Hôpital Beaujon, APHP, Gastroenterology, Clichy, France

P003. Tumour microenvironment differs between murine sporadic and inflammation-associated colorectal tumourigenesis
P003

Anti-fibrotic Effects of Pirfenidone in Gut-derived Fibroblasts from Patients with Active Crohn's Disease

Authors:

S.-I. Kadir*1, T.W. Kragstrup2, A. Dige1, S. Jensen2, J.F. Dahlerup1, J. Kelsen3

1Aarhus University Hospital, Department of Hepatology and Gastroenterology, Aarhus, Denmark, 2Aarhus University, Institute of Biomedicine, Department of Immunology, Aarhus, Denmark, 3Regional Hospital Randers, Medical Department, Randers, Denmark

P004.

Transcriptome of unfolded protein response (UPR) genes in the colonic mucosa of patients with ulcerative colitis

Authors:

G. Fonseca-Camarillo, A. Peredo-Escarcega, J. Yamamoto-Furusho, IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico

P004. Involvement of the endocannabinoid system in Crohn's disease fibrogenesis
P004. Smooth muscle cells participate in Crohn's disease intestinal fibrosis
Authors:

A. Scirocco1, S. Rosati1, R. Sferra2, A. Vetusti2, N. Pallotta1, G. Tellan1, A. Pronio3, E. Corazziari1, C. Severi1, 1La Sapienza, Medicina Interna e Specialità Mediche, Rome, 2Università degli Studi dell'Aquila, 3Università Sapienza, Italy

P004. SPARC enhances intestinal inflammation in dextran sodium sulphate-induced murine colitis
P004

Activation of the GCN2/eIF2alpha/ATF4 signaling pathway triggers autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli

Authors:

A. Bretin1, J. Carrière1, G. Dalmasso1, N. Barnich1, A. Bergougnoux1, A.-C. Maurin1, A. Bruhat2, H. Nguyen*3

1UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation et Susceptibility of the host, Clermont-Ferrand, France, 2INRA, Human Nutrition Unit (UNH), Theix, France, 3University of Auvergne, UMR 1071/Inserm, Clermont-Ferrand, France