Z. Vegh*¹, J. Burisch², E.V. Tsianos³, L. Kupcinskas⁴, S. Turcan⁵, F. Magro^{6, 7, 8}, A. Goldis⁹, V. Hernandez¹⁰, S. Bell¹¹, P. Munkholm¹², P. Lakatos¹

¹Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ²Hvidovre University Hospital, Gastrounit, Medical section, Hvidovre, Denmark, ³University of Ioannina, 1st Division of Internal Medicine and Division of Gastroenterology, Faculty of Medicine, Ioannina, Greece, ⁴Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania, ⁵State University of Medicine and Pharmacy, Department of Gastroenterology, Chisinau, Moldova, Republic of, ⁶Hospital de São João, Department of Gastroenterology, Porto, Portugal, ⁷Oporto Medical School, Department of Pharmacology and Therapeutics, Porto, Portugal, ⁸University of Porto, 8 MedInUP - Center for Drug Discovery and Innovative Medicines, Porto, Portugal, ⁹University of Medicine ←Victor Babes→, Clinic of Gastroenterology, Timisoara, Romania, ¹⁰Complexo Hospitalario Universitario de Vigo, Gastroenterology Department, Vigo, Spain, ¹¹St Vincent's Hospital, Department of Gastroenterology, Melbourne, Victoria, Australia, ¹²Herlev University Hospital, Digestive Disease Center, Medical Section, Copenhagen, Denmark

D. Ellinghaus¹, L. Jostins², A. Cortes³, O. Andreassen⁴, Y. Wang⁵, S. Spain⁶, Inflammatory Bowel Disease Genetics Consortium⁷, International Genetics of Ankylosing Spondylitis Consortium⁸, The International PSC Study Group⁹, Collaborative Association Study of Psoriasis¹⁰, Psoriasis Association Genetics Extension¹¹, Genetic Analysis of Psoriasis Consortium¹², Wellcome Trust Case Control Consortium 2¹³, J. Elder¹⁴, R. Trembath⁶, J. Barker⁶, T. Karlsen¹⁵, A. Dale¹⁶, D. McGovern¹⁷, S. Schreiber¹⁸, M. Brown¹⁹, J. Barrett², M. Parkes²⁰, A. Franke¹, ¹Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany, ²Wellcome Trust Genome Campus, Wellcome Trust Sanger Institute, Cambridge, United Kingdom, ³University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia, ⁴University of Oslo, Institute of Clinical Medicine, Oslo, Norway, ⁵Oslo University Hospital, Division of Mental Health and Addiction, Oslo, Norway, ⁶King's College London, Division of Genetics and Molecular Medicine, London, United Kingdom, ⁷on behalf of IIBDGC, Germany, ⁸on behalf of IGAS, Australia, ⁹on behalf of IPSCSG, Norway, ¹⁰on behalf of CASP, United Kingdom, ¹¹on behalf of PAGE, United States, ¹²on behalf of GAPC, United Kingdom, ¹³on behalf of WTCCC2, United Kingdom, ¹⁴University of Michigan, Department of Dermatology, Ann Arbor, United States, ¹⁵Oslo University Hospital, Research Institute of Internal Medicine, Oslo, Norway, ¹⁶University of California, Department of Neurosciences, San Diego La Jolla, United States, ¹⁷Los Angeles, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, United States, ¹⁸University Hospital Schleswig-Holstein, Clinic of Internal Medicine I, Kiel, Germany, ¹⁹Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia, ²⁰University of Cambridge, Inflammatory Bowel Disease Research Group, Cambridge, United Kingdom

D. Laharie*¹, A. Bourreille², J. Branche³, M. Allez⁴, Y. Bouhnik⁵, J. Filippi⁶, F. Zerbib⁷, G. Savoye⁸, L. Vuitton⁹, J. Moreau¹⁰, A. Amiot¹¹, J. Cosnes¹², E. Ricart¹³, O. Dewit¹⁴, A. Lopez-Sanroman¹⁵, J.-L. Dupas¹⁶, F. Carbonnel¹⁷, G. Bommelaer¹⁸, B. Coffin¹⁹, X. Roblin²⁰, G. Van Assche²¹, M. Esteve²², M. Farkkila²³, J.P. Gisbert²⁴, P. Marteau²⁵, S. Nahon²⁶, M. de Vos²⁷, J.-Y. Mary²⁸, E. Louis²⁹

¹Hopital Haut-Leveque, CHU de Bordeaux, Gastroenterologie, Pessac, France, ²CHU de Nantes, Department of Gastroenterology, Nantes, France, ³CHU de Lille, Department of Gastroenterology, Lille, France, ⁴Hopital Saint-Louis, Gastroenterologie, Paris, France, ⁵Hopital Beaujon, Gastroenterologie, Clichy, France, ⁶CHU de Nice, Gastroenterologie, Nice, France, ⁷CHU de Bordeaux, Gastroenterologie, Bordeaux, France, ⁸CHU de Rouen, Gastroenterologie, Rouen, France, ⁹CHU de Besancon, Gastroenterologie, Besancon, France, ¹⁰CHU de Toulouse, Gastroenterologie, Toulouse, France, ¹¹Hopital Henri-Mondor, Gastroenterologie, Creteil, France, ¹²Hopital Saint-Antoine, Gastroenterologie, Paris, France, ¹³Hospital Clinic, Gastroenterology, Barcelona, Spain, ¹⁴UCL Saint-Luc, Gastroenterologie, Bruxelles, Belgium, ¹⁵Hospital ramon y Cajal, Gastroenterology, Madrid, Spain, ¹⁶CHU d'Amiens, Gastroenterologie, Amiens, France, ¹⁷Hopital du Kremlin-Bicetre, Gastroenterologie, Le Kremlin Bicetre, France, ¹⁸CHU de Clermont-Ferrand, Gastroenterologie, Clermont-Ferrand, France, ¹⁹Hopital Louis-Mourier, Gastroenterologie, Colombes, France, ²⁰CHU de Saint-Etienne, Gastroenterologie, Saint-Etienne, France, ²¹University Hospital of Leuven, Gastroenterology, Leuven, Belgium, ²²Hospital Universitari Mútua de Terrassa, Gastroenterology, Barcelona, Spain, ²³Helsinki University Central Hospital, Gastroenterology, Helsinki, Finland, ²⁴Hospital Universitario de La Princesa, Gastroenterology, Madrid, Spain, ²⁵Hopital Lariboisiere, Gastroenterologie, Paris, France, ²⁶Hopital de Montfermeil, Gastroenterologie, Montfermeil, France, ²⁷Ghent University Hospital, Gastroenterology, Gent, Belgium, ²⁸Hopital Saint-Louis, SBIM, Paris, France, ²⁹Hopital Universitaire de Liege, Gastroenterologie, Liege, Belgium

E. Quévrain¹, M.-A. Maubert¹, F. Chain², R. Marquant³, P. Kharrat², L. Carlier³, L. Bermudez², B. Pigneur¹, O. Lequin³, C. Bridonneau², G. Thomas¹, S. Lavielle³, J.-P. Grill¹, G. Chassaing³, J. Masliah¹, G. Trugnan¹, R. Xavier⁴, P. Langella², H. Sokol¹, P. Seksik¹, ¹INSERM, UPMC, ERL U1057/UMR 7203, Paris, France, ²INRA, UMR 1319 Micalis, Jouy-en-Josas, France, ³UPMC, UMR 7203 UPMC, Paris, France, ⁴Harvard University, Center for Computational & Integrative Biology, Boston, United States

C. Hawkey*¹, M. Allez², M. Clark¹, M. Labopin³, J. Lindsay⁴, E. Ricart⁵, G. Rogler⁶, J. Satsangi⁷, D. Farge-Bancel⁸

¹University of Nottingham, Nottingham Digestive Diseases Centre, Nottingham, United Kingdom, ²APHP, Hopital Saint Louis, Department of Gastroenterology, Paris, France, ³European Group for Blood & Marrow Transplantation, Chair-EBMT Statistical Committee, Paris, France, ⁴Blizard Institute, Barts & The London School of Medicine & Dentistry, Queen Mary Univesrity of London, Centre for Digestive Diseases, London, United Kingdom, ⁵Hospital Clinic, CIBER-EHD, Gastroenterology Department, Barcelona, Spain, ⁶University of Zurich, Division of Gastroenterology & Hepatology, Zurich, Switzerland, ⁷Western General Hospital, University of Edinburgh, Gastro-Intestinal Unit, Edinburgh, United Kingdom, ⁸APHP, Hopital Saint Louis, Internal Medicine & Vascular Disease Unit, Paris, France

J. Denizot¹, A. Agus¹, A. Desrichard², N. Uhrhammer², A. Darfeuille-Michaud¹, N. Barnich¹, ¹Université d'Auvergne, M2iSH, UMR INSERM/Université d'Auvergne U1071; Unité Sous Contrat Institut National de la Recherche Agronomique 2018, Clermont-Ferrand, France, ²Université d'Auvergne, Department of Oncogenetics, Department of Breast Oncology, Centre Jean Perrin, Clermont-Ferrand, France

C.H.R. Choi*¹, M. Rutter², S. Thomas-Gibson³, J. Warusavitarne³, M. Moorghen³, B. Saunders³, T. Graham⁴, A. Hart³

¹St Mark's Hospital, Colorectal Surgery & IBD Unit, London, United Kingdom, ²University Hospital of North Tees, Department of Gastroenterology, Stockton-on-Tees, Teesside, United Kingdom, ³St Mark's Hospital, Department of IBD, Colorectal Surgery and Wolfson Unit of Endoscopy, London, United Kingdom, ⁴Queen Mary University of London, Centre for Tumour Biology, Barts Cancer Institute, London, United Kingdom

C. Hedin¹, C. van der Gast², G. Rogers³, S. McCartney⁴, A.J. Stagg⁵, J.O. Lindsay⁶, K. Whelan¹, ¹King's College London, School of Medicine, Diabetes and Nutritional Sciences Division, London, United Kingdom, ²NERC, Centre for Ecology & Hydrology, Wallingford, Oxfordshire, United Kingdom, ³University of Queensland, Translational Research Institute, Immunity, Infection, and Inflammation Program, Mater Research Institute, Woolloongabba, Australia, ⁴University College London, Centre for Gastroenterology and Nutrition, London, United Kingdom, ⁵Blizard Institute, Queen Mary University of London, Centre for Immunology and Infectious Disease, London, United Kingdom, ⁶Barts and the London NHS Trust, Gastroenterology Division, London, United Kingdom

J. Axelrad*¹, O. Bernheim², J.-F. Colombel², S. Malerba³, A. Ananthakrishnan⁴, V. Yajnik⁴, G. Hoffman⁵, M. Agrawal⁶, D. Lukin⁷, A. Desai⁸, E. Mceachern⁹, B. Bosworth⁸, E. Scherl⁸, A. Reyes¹⁰, H. Zaidi¹¹, P. Mudireddy¹², D. DiCaprio¹³, K. Sultan¹¹, B. Korelitz¹², E. Wang¹⁴, R. Williams¹⁴, L. Chen¹⁵, S. Katz¹⁵, S. Itzkowitz²

¹Icahn School of Medicine at Mount Sinai, Medicine, New York, United States, ²Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, New York, United States, ³Icahn School of Medicine at Mount Sinai, Department of Health Evidence and Policy, New York, United States, ⁴Massachusetts General Hospital, Division of Gastroenterology, Boston, United States, ⁵Albert Einstein College of Medicine, Medicine, New York, United States, ⁶Montefiore Medical Center, Medicine, New York, United States, ⁷Montefiore Medical Center, Division of Gastroenterology and Liver Diseases, New York, United States, ⁸New York Presbyterian Weill Cornell Medical Center, Division of Gastroenterology, New York, United States, ⁹Weill Cornell Medical College, Medicine, New York, United States, ¹⁰North Shore- Long Island Jewish University Hospital, Medicine, Manhasset, United States, ¹¹North Shore- Long Island Jewish University Hospital, Division of Gastroenterology, Manhasset, United States, ¹²North Shore- Long Island Jewish Lenox Hill Hospital, Division of Gastroenterology, New York, United States, ¹³North Shore- Long Island Jewish Lenox Hill Hospital, Medicine, New York, United States, ¹⁴NYU Langone Medical Center, Medicine, New York, United States, ¹⁵NYU Langone Medical Center, Division of Gastroenterology, New York, United States

A. Griffiths¹, W. Crandall², R. Colletti³, F. Ruemmele⁴, W.A. Faubion⁵, J. Hyams⁶, A. Lazar⁷, Y. Li⁸, S. Eichner⁸, R.B. Thakkar⁸, ¹The Hospital for Sick Children, Department of Paediatrics, Toronto, ON, Canada, ²Nationwide Children's Hospital, Department of Gastroenterology/Nutrition, Columbus, United States, ³University of Vermont, Department of Pediatrics, Burlington, United States, ⁴Universite Sorbonne Paris-Cite, Hospital Necker-Enfants Malades, APHP, Paris, France, ⁵Mayo Clinic, Gastroenterology, Rochester, United States, ⁶Connecticut Children's Medical Center, Division of Digestive Diseases, Hartford, United States, ⁷AbbVie Deutschland GmbH & Co, KG, GPRD, Ludwigshafen, Germany, ⁸AbbVie Inc, GPRD, North Chicago, United States

S. Vermeire*¹, W. Sandborn², S. Danese³, X. Hebuterne⁴, B. Salzberg⁵, M. Klopocka⁶, D. Tarabar⁷, T. Vanasek⁸, M. Gregus⁹, P. Hellstern¹⁰, J.-S. Kim¹¹, M. Sparrow¹², K.J. Gorelick¹³, A. Ahmad¹⁴, M. Hassan-Zahraee¹⁴, V. Pradhan¹⁴, F. Cataldi¹⁴, W. Reinisch¹⁵

¹Leuven University Hospital, Leuven, Belgium, ²University of California San Diego, CA, United States, ³IBD-Division Gastroenterologia, Istituto Clinico Humanitas, Rozzano, Italy, ⁴Hospitall→Archet, Nice Cedex, France, ⁵Atlanta Gastroenterology Specialist, Suwanee, United States, ⁶University Hospital, Nicolaus Copernicus University, Torun Bydgoszcz, Poland, ⁷Military Medical Academy, Belgrade, Serbia, ⁸Hepato-gastroenterologie, Hradec Kralove, Czech Republic, ⁹Gastroenterologicke a hepatologicke, Nitra, Slovakia, ¹⁰Nature Coast Clinical Research, Inverness, Florida, United States, ¹¹Seoul National University Hospital, Seoul, South Korea, ¹²Alfred Hospital of Melbourne, Melbourne, Australia, ¹³Pfizer Inc., Collegeville, United States, ¹⁴Pfizer Inc., Cambridge, United Kingdom, ¹⁵McMaster University Health Centre, Ontario, Canada

F. Casellas¹, N. Borruel¹, C. Manichanh¹, E. Varela¹, M. Antolín¹, A. Torrejón¹, V. Robles¹, F. Guarner¹, on behalf of MetaHIT Consortium^1,2, ¹Hospital Universitari Vall d'Hebron, Unitat Atenció Crohn-Colitis, Barcelona, Spain, ²MetaHIT Network, Partner Centres, Paris, France

G. D'Haens*¹, S. Lee², D. Tarabar³, E. LOUIS⁴, M. Klopocka⁵, D.I. Park⁶, J. Claus⁷, X. Hébuterne⁸, W. Reinisch⁹, S. Schreiber¹⁰, K.J. Gorelick¹¹, J. Cheng¹¹, M. Hassan-Zahraee¹¹, L. Brown¹², A. Ahmad¹³, A. Banerjee¹³, F. Cataldi¹¹, W. Sandborn¹⁴

¹University of Amsterdam, Academic Medical Center, Amsterdam, Netherlands, ²University of Washington, Gastroenterology, Seattle, WA, United States, ³MMA, Gastroenterology, Belgrade, Serbia, ⁴University Hospital CHU of Liège, Gastroenterology, Liège, Belgium, ⁵Nicolaus Copernicus University in Toruń, Gastroenterology, Bydgoszcz, Poland, ⁶Kangbuk Samsung Hospital-Sungkyunkwan University, Gastroenterology, Seoul, South Korea, ⁷Universitätsklinikum Ulm, Gastroenterology, Ulm, Germany, ⁸CHU de Nice et Université de Nice Sophia-Antipolis, Gastroenterology, Nice, France, ⁹Medical University of Vienna, Internal Medicine/Gastroenterology, Vienna, Austria, ¹⁰University of Kiel, Gastroenterology, Kiel, Germany, ¹¹Pfizer Inc., Gastroenterology, Cambridge, United States, ¹²Pfizer Inc., Gastroenterology, Cambridge, MA, United Kingdom, ¹³Pfizer Inc., Gastroenterology, Cambridge, MA, United States, ¹⁴Univeristy of California San Diego, Division of Gastroenterolgy, San Diego, United States

M.A. Kamm, P.P. De Cruz, E.K. Wright, A.L. Hamilton, K.J. Ritchie, E.O. Krejany, A. Gorelik, D. Liew, L. Prideaux, I.C. Lawrance, J.M. Andrews, P.A. Bampton, S.L. Jakobovits, T.H. Florin, P.R. Gibson, H.S. Debinski, A.S. Day, R.B. Gearry, F.A. Macrae, D. Samuel, R.W. Leong, I.J. Kronborg, G.L. Radford-Smith, W.S. Selby, M.J. Johnson, R.J. Woods, P.R. Elliott, S.J. Bell, S.J. Brown, W.R. Connell, P.V. Desmond, St Vincent's Hospital & University of Melbourne, Gastroenterology, Melbourne, Australia

F. Carbonnel*¹, J.F. Colombel², J. Filippi³, K. Katsanos⁴, L. Peyrin-Biroulet⁵, M. Allez⁶, M. Nachury^{7, 8}, G. Novacek⁹, S. Danese¹⁰, V. Abitbol¹¹, F. Bossa¹², J. Moreau¹³, G. Bommelaer¹⁴, A. Bourreille¹⁵, J.L. Dupas¹⁶, X. Roblin¹⁷, Y. Bouhnik¹⁸, W. Reinisch^{9, 19}, M. Farkkila²⁰, H. Brixi²¹, P. Seksik²², G. Malamut²³, B. Coulibaly²⁴, O. Dewit²⁵, E. Louis²⁶, D. Deplanque²⁷, P. Michetti²⁸, H. Sarter²⁷, D. Laharie²⁹

¹APHP Paris Sud University , Gastroenterology, Le Kremlin Bicêtre, France, ²Icahn Medical School of Medicine at Mount Sinai, , IBD center, New York, United States, ³University Hospital of Nice Archet 2, Gastroenterology, Nice, France, ⁴University of Ioannina School of Medical Sciences, Gastroenterology, Ioannina, Greece, ⁵University Hospital of Nancy, Gastroenterology, Nancy, France, ⁶Saint Louis Hospital APHP, Gastroenterology, Paris, France, ⁷University hospital of Lille, Gastroenterology, Lille, France, ⁸University hopsital of Besançon, Gastroenterology, Besançon, France, ⁹Medizinische Universität Wien, Gastroenterology, Vienna, Austria, ¹⁰Istituto Clinico Humanitas, Gastroenterology, Milano, Italy, ¹¹Cochin University Hospital, Gastroenterology, Paris, France, ¹²Cancer Research and Cure Institute "Casa Sollievo Sofferenza", Gastroenterology, San Giovanni Rotondo, Italy, ¹³Rangueil University Hospital, Gastroenterology, Toulouse, France, ¹⁴University Hospital of Clermont Ferrand, Gastroenterology, Clermont Ferrand, France, ¹⁵Insitut des Maladies de l'Appareil Digestif, , Gastroenterology, Nantes, France, ¹⁶Amiens University Hospital, Gastroenterology, Amiens, France, ¹⁷University hospital of Saint Etienne, Gastroenterology, Saint Etienne, France, ¹⁸University hospital of Beaujon APHP, Gastroenterology, Clichy, France, ¹⁹Mc Master University , Gastroenterology, Hamilton, Canada, ²⁰University Hospital of Helsinki, Gastroenterology, Helsinki, Finland, ²¹University hospital of Reims, Gastroenterology, Reims, France, ²²University Hospital of Saint Antoine, APHP, Gastroenterology, Paris, France, ²³Hôpital Européen Geroges Pompidou, APHP, Gastroenterology, Paris, France, ²⁴General hospital of Avignon, Gastroenterology, Avignon, France, ²⁵UCL Saint Luc, Gastroenterology, Bruxelles, Belgium, ²⁶University hospital of Liège, Gastroenterology, Liège, Belgium, ²⁷University hospital of Lille, Biostatistics and Clinical Research, Lille, France, ²⁸Clinique de la Source, Gastroenterology, Lausanne, Switzerland, ²⁹University hospital of Bordeaux, Gastroenterology, Bordeaux, France

R. Khanna¹, G. Zou^1,2, G. D'Haens^1,3, P. Rutgeerts⁴, J.W. McDonald¹, M. Daperno⁵, B.G. Feagan^1,6, W.J. Sandborn^1,7, E. Dubcenco¹, M.K. Vandervoort¹, A. Luo⁸, B.G. Levesque^1,7, ¹Robarts Clinical Trials Inc., Robarts Research Institute, Western University, London, Ontario, Canada, ²Western University, Department of Epidemiology and Biostatistics, London Ontario, Canada, ³University of Amsterdam, Academic Medical Center, Amsterdam, Netherlands, ⁴University Hospital, Department of Gastroenterology, Leuven, Belgium, ⁵A.O. Ordine Mauriziano, Gastroenterology Division, Torino, Italy, ⁶Western University, Department of Epidemiology and Biostatistics, Department of Medicine, London Ontario, Canada, ⁷University of California, San Diego, Division of Gastroenterology, La Jolla, United States, ⁸Bristol-Myers Squibb, Department, Princeton New Jersey, United States

W. Sandborn*¹, B. Feagan², D. Wolf³, G. D'Haens⁴, S. Vermeire⁵, S. Hanauer⁶, S. Ghosh⁷, H. Smith⁸, M. Cravets⁸, P. Frohna⁸, S. Gujrathi⁸, A. Olson⁸

¹University of California San Diego, Division of Gastroenterology, La Jolla, United States, ²University of Western Ontario, Department of Gastroenterology, London, Canada, ³Atlanta Gastroenterology Associates, Emory Saint Joseph's, Atlanta, United States, ⁴Academic Medical Centre, Inflammatory Bowel Disease Centre, Amsterdam, Netherlands, ⁵University Hospital Leuven, Department of Gastroenterology, Leuven, Belgium, ⁶Northwestern University Feinberg School of Medicine, Digestive Health Center, Chicago, United States, ⁷University of Calgary, Department of Gastroenterology, Alberta, Canada, ⁸Receptos, Inc., Clinical Development, San Diego, United States

B.E. Sands*¹, J. Chen², M. Penney², P. Newbold², R. Faggioni², R. van der Merwe², K. Patra², P. Klekotka³, E. Pulkstenis², J. Drappa², R.A. Gasser, Jr.²

¹Icahn School of Medicine at Mount Sinai, Dr. Henry D. Janowitz Division of Gastroenterology, New York, NY, United States, ²MedImmune, Clinical Development, Gaithersburg, MD, United States, ³Amgen, Clinical Development, Thousand Oaks, CA, United States

J. Kjeldsen*¹, J. Nielsen², M.D. Larsen², N. Qvist³, B. Nørgaard²

¹University of Southern Denmark, Department of Medical Gastroenterology, Odense University Hospital, and Research Unit of Gastroenterology, Odense , Denmark, ²University of Southern Denmark, Center for Clinical Epidemiology, Odense University Hospital, and Research Unit of Clinical Epidemiology, Institute of Clinical Research,, Odense, Denmark, ³University of Southern Denmark, Department of Surgery, Odense University Hospital, and Research Unit of Surgery, Institute of Clinical Research, Odense, Denmark

“Table: Standardized cancer incidence ratios of patients from the population based IBD-SL cohort, and of medication based sub groups