G. D'Haens¹, S. Vermeire², F. Cataldi³, H. Vogelsang⁴, M. Allez⁵, P. Desreumaux⁶, A. Van Gossum⁷, D. Baumgart⁸, W.J. Sandborn⁹, K.J. Gorelick³, R. Ransohoff¹⁰, O. Stuve¹¹, J. Cheng³, S. Rivers³, G.M. Comer³, B. Jin³, B. Jin³, V. Pradhan³, M. Hassan-Zahraee³, A. Kaminski³, W. Reinisch⁴, ¹University of Amsterdam, Academic Medical Center, Amsterdam, Netherlands, ²University Hospital Leuven, Gastroenterology, Leuven, Belgium, ³Pfizer Inc., Gastroenterology, Cambridge, United States, ⁴Medical University of Vienna, Internal Medicine/Gastroenterology, Vienna, Austria, ⁵Hopital Saint-Louis – APHP, Gastroenterologie, Paris, France, ⁶CHU de Lille, Gastroenterologie, Lille, France, ⁷Erasme Hospital, Free University of Brussels, Gastroenterology, Brussels, Belgium, ⁸Humboldt-University of Berlin, Charite Medical School, Berlin, Germany, ⁹University of California San Diego, Division of Gastroenterolgy, San Diego, United States, ¹⁰Cleveland Clinic, Neurology, Cleveland, OH, United States, ¹¹University of Texas, Neurology, Dallas, TX, United States

M. Bortlik*¹, D. Duricová¹, N. Machkova¹, V. Hruba¹, M. Lukas¹, K. Mitrova¹, I. Romanko¹, V. Bina², M. Lukas¹

¹ISCARE and Charles University, IBD Clinical and Research Centre, Prague, Czech Republic, ²Faculty of Management in Jindrichuv Hradec, University of Economics in Prague, Department of Exact Methods, Jindrichuv Hradec, Czech Republic

J. Burisch¹, I. Kaimakliotis², D. Duricova³, N. Thorsgaard⁴, V. Andersen^5,6,7, K.R. Nielsen⁸, E.V. Tsianos⁹, K. Ladefoged¹⁰, Y. Bailey¹¹, R. D'Incà^12,13, L. Kupcinskas¹⁴, S. Turcan¹⁵, F. Magro^16,17,18, A. Goldis¹⁹, E. Belousova²⁰, V. Hernandez²¹, S. Almer^22,23, J. Halfvarson^24,25, S. Sebastian²⁶, E. Langholz²⁷, S. Odes²⁸, P. Munkholm¹, ¹Herlev University Hospital, Department of Gastroenterology, Herlev, Denmark, ²Nicosia private practice, Private practice, Nicosia, Cyprus, ³Charles University, IBD Center ISCARE, Prague, Czech Republic, ⁴Herning Central Hospital, Department of medicine, Herning, Denmark, ⁵Viborg Regional Hospital, Medical Department, Viborg, Denmark, ⁶University of Southern Denmark, Institute of Regional Health Research, Odense, Denmark, ⁷Hospital of Southern Jutland, Medical Department, Aabenraa, Denmark, ⁸The National Hospital of the Faroe Islands, Medical Department, Thorshavn, Faroe Islands, ⁹University Hospital, Ioannina, 1st Division of Internal Medicine and Hepato-Gastroenterology Unit, Ioannina, Greece, ¹⁰Dronning Ingrids Hospital, Medical Department, Nuuk, Greenland, ¹¹Adelaide and Meath Hospital, TCD, Department of Gastroenterology, Dublin, Ireland, ¹²Azienda Ospedaliera, Università di Padova, UO Gastroenterologia, Padova, Italy, ¹³On behalf of the EpiCom Northern Italy centre based in Crema & Cremona, Firenze, Forlì, Padova and Reggio Emilia, Northern Italy, Italy, ¹⁴Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania, ¹⁵State University of Medicine and Pharmacy of the Republic of Moldova, Department of Gastroenterology, Chisinau, Moldova, Republic of, ¹⁶Oporto Medical School, Institute of Pharmacology and Therapeutics, Porto, Portugal, ¹⁷Hospital de São João, Department of Gastroenterology, Porto, Portugal, ¹⁸University of Porto, Institute for molecular and cell biology, Porto, Portugal, ¹⁹University of Medicine ‘Victor Babes’, Clinic of Gastroenterology, Timisoara, Romania, ²⁰Moscow Regional Research Clinical Institute, Department of Gastroenterology, Moscow, Russian Federation, ²¹Complejo Hospitalario Universitario de Vigo, Gastroenterology, Vigo, Spain, ²²County council of Östergötland, Department of Gastroenterology/UHL, Linköping, Sweden, ²³Karolinska Institutet, Division of Gastroenterology and Hepatology, Stockholm, Sweden, ²⁴Örebro University, School of Health and Medical Sciences, Örebro, Sweden, ²⁵Örebro University Hospital, 24. Department of Medicine, Division of Gastroenterology, Örebro, Sweden, M, ²⁶Hull Royal Infirmary, Hull and East Yorkshire NHS Trust & Hull and York Medical School, Hull, United Kingdom, ²⁷Gentofte Hospital, Department of Medical Gastroenterology, Copenhagen, Denmark, ²⁸Soroka Medical Center and Ben Gurion University of the Negev, Department of Gastroenterology and Hepatology, Beer Sheva, Israel

O. Niewiadomski*¹, C. Studd¹, C. Hair², J. Wilson¹, J. Ding¹, N. Heerasing², A. Ting², K. Ross², J. Santamaria³, E. Prewett², P. Dabkowski², S. Alexander², D. Dowling², B. Allen², B. Popp⁴, G. Alex⁵, T. Catto-Smith⁵, J. McNeill⁶, W. Connell¹, P. Desmond¹, S. Bell¹

¹St Vincent's Hospital, Gastroenterology, Fitzroy, Australia, ²Barwon Health, Gastroenterology, Geelong, Australia, ³St Vincent's Hospital, Intensive Care Unit, Fitzroy, Australia, ⁴St John of God Pathology, Pathology, Geelong, Australia, ⁵Royal Children's Hospital, Gastroenterology, Parkville, Australia, ⁶Monash University, Preventative Medicine and Public Health, Melbourne, Australia

W. Reinisch^1,2, P. Gibson³, W.J. Sandborn⁴, B.G. Feagan⁵, C. Marano⁶, R. Strauss⁶, J. Johanns⁶, H. Zhang⁶, L. Padgett⁶, J.-F. Colombel⁷, J. Collins⁸, P. Rutgeerts⁹, ¹Universitäts­klinik für Innere Medizin III, Vienna, Austria, ²McMaster University, Hamilton, ON, Canada, ³Alfred Hospital, Melbourne, VIC, Australia, ⁴University of California San Diego, La Jolla, CA, United States, ⁵Robarts Research Institute, University of Western Ontario, London, ON, Canada, ⁶Janssen Research & Development, LLC, Spring House, PA, United States, ⁷Hôpital Claude Huriez, Lille Cedex, France, ⁸Oregon Health Sciences University, Portland, OR, United States, ⁹University Hospital, Gasthuisberg, Leuven, Belgium

J. Burisch*¹, I. Kaimakliotis², D. Duricova³, L. Kievit⁴, J.F. Dahlerup⁵, R. Salupere⁶, K.R. Nielsen⁷, P. Manninen⁸, E.V. Tsianos⁹, Z. Vegh¹⁰, S. Odes¹¹, R. D'Inca¹², L. Kupcinskas¹³, S. Turcan¹⁴, F. Magro^{15, 16, 17}, A. Goldis¹⁸, V. Hernandez¹⁹, J. Halfvarson²⁰, N. Arebi²¹, E. Langholz²², P.L. Lakatos¹⁰, P. Munkholm²³

¹Hvidovre University Hospital, Gastrounit, Medical section, Hvidovre, Denmark, ²Nicosia Private practice, Nicosia Private practice, Nicosia, Cyprus, ³Charles University, IBD Center ISCARE, Prague, Czech Republic, ⁴Herning Central Hospital, Department of medicine, Herning, Denmark, ⁵Aarhus University Hospital, Department of Hepatology and Gastroenterology, Aarhus, Denmark, ⁶Tartu University Hospital, Division of Endocrinology and Gastroenterology, Tartu, Estonia, ⁷The National Hospital of the Faroe Islands, Medical Department, Thorshavn, Faroe Islands, ⁸Tampere University Hospital, Department of Gastroenterology and Alimentary Tract Surgery, Tampere, Finland, ⁹University Hospital, Ioannina, 1st Division of Internal Medicine and Hepato-Gastroenterology Unit, Ioannina, Greece, ¹⁰Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ¹¹Soroka Medical Center and Ben Gurion University of the Negev, Department of Gastroenterology and Hepatology, Beer Sheva, Israel, ¹²On behalf of the EpiCom Northern Italy, Florence, Forlì, and Padova, Northern Italy, Italy, ¹³Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania, ¹⁴State University of Medicine and Pharmacy of the Republic of Moldova, Department of Gastroenterology, Chisinau, Moldova, Republic of, ¹⁵University of Porto, Institute for molecular and cell biology, Porto, Portugal, ¹⁶Hospital de São João, Department of Gastroenterology, Porto, Portugal, ¹⁷Oporto Medical School, Institute of Pharmacology and Therapeutics, Porto, Portugal, ¹⁸University of Medicine ←Victor Babes→, Clinic of Gastroenterology, Timisoara, Romania, ¹⁹Complexo Hospitalario Universitario de Vigo, Gastroenterology Department, Vigo, Spain, ²⁰Faculty of Medicine and Health, Örebro University, Department of Gastronterology, Örebro, Sweden, ²¹St Mark's Hospital, Gastroenterology, London, United Kingdom, ²²Gentofte Hospital, Department of Medical Gastroenterology, Copenhagen, Denmark, ²³Herlev University Hospital, Department of gastroenterology, Herlev, Denmark

M. Keir¹, G.W. Tew¹, D. Luca¹, J. Eastham-Anderson¹, L. Diehl¹, J.G. Egen¹, S. Vermeire², J.C. Mansfield³, C.A. Lamb³, J. Panes⁴, D.C. Baumgart⁵, S. Schreiber⁶, I. Dotan⁷, W.J. Sandborn⁸, G. De Hertogh², J.A. Kirby³, G. Van Assche², P. Rutgeerts², S. O'Byrne¹, ¹Genentech, Research and Early Development, South San Francisco, United States, ²KU Leuven, Division of Gastroenterology, Leuven, Belgium, ³Royal Victoria Infirmary, Gastroenterology, Newcastle upon Tyne, United Kingdom, ⁴Hospital Clínic Barcelona, Gastroenterology, Barcelona, Spain, ⁵Humboldt-University of Berlin, Charite Medical School, Berlin, Germany, ⁶Christian Albrechts University, Institute of Clinical Molecular Biology, Kiel, Germany, ⁷Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, ⁸University of California, San Diego, Gastroenterology, San Diego, United States

B.P.M. Verhaegh*^{1, 2}, F. de Vries^{3, 4}, A.A. Masclee^{1, 2}, A. Keshavarzian³, A. de Boer³, P. Souverein³, D.M. Jonkers^{1, 2}, M.J. Pierik¹

¹Maastricht University Medical Center+, Internal Medicine - Division of Gastroenterology-Hepatology, Maastricht, Netherlands, ²Maastricht University Medical Center+, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands, ³Utrecht Institute of Pharmaceutical Sciences, Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht, Netherlands, ⁴Maastricht University Medical Center+, Clinical Pharmacology & Toxicology, Maastricht, Netherlands

S. Danese¹, J. Rudzinski², W. Brandt³, J.L. Dupas⁴, L. Peyrin-Biroulet⁵, Y. Bouhnik⁶, D. Kleczkowski⁷, P. Uebel⁸, M. Lukas⁹, M. Knutsson¹⁰, F. Erlandsson¹⁰, M. Berner Hansen¹⁰, S. Keshav¹¹, ¹Istituto Clinico Humanitas, IBD Center, Milan, Italy, ²10 Wojskowy Szpital Kliniczny z Poliklinik?, Kliniczny Oddzia? Gastroenterologii, Warsaw, Poland, ³Facharzt für Innere Medizin, Internal Medicine, Potsdam, Germany, ⁴CHU d'Amiens Hôpital Nord, Hepato-Gastroenterology, Amiens, France, ⁵CHU Nancy Brabois, Gastrology, Vandoeuvre les Nancy, France, ⁶Hopital Beaujon – APHP, Gastroenterologie, Clichy, France, ⁷Endoskopia Sp.z o.o., Gastroenterology, Sopot, Poland, ⁸Haus der Gesundheit, Internal Medicine, Ludwigshafen, Germany, ⁹Iscare, Gastroenterology, Prague, Czech Republic, ¹⁰AstraZeneca, Innovative Medicines, Mölndal, Sweden, ¹¹John Radcliffe Hospital, Translational Gastroenterology Unit, Oxford, United Kingdom

D.T. Rubin*¹, R.D. Cohen¹, W.J. Sandborn², G.R. Lichtenstein³, J. Axler⁴, R. Riddell⁵, C. Zhu⁶, A.C. Barrett⁶, E. Bortey⁶, W.P. Forbes⁷

¹The University of Chicago, Medicine, Chicago, United States, ²University of California San Diego, UC San Diego Health System, San Diego, United States, ³University of Pennsylvania, Perelman School of Medicine, Philadelphia, United States, ⁴Toronto Digestive Disease Associates Inc., Toronto, Canada, ⁵Mt. Sinai Hospital, Pathology and Molecular Medicine, Toronto, Canada, ⁶Salix Pharmaceuticals, Inc., Raleigh, United States, ⁷Salix Pharmaceuticals Inc., Raleigh, United States

G.-R. Jones¹, P. Cook², A. MacDonald², ¹University of Edinburgh, Institute of Immunology and infection research, Edinburgh, United Kingdom, ²Manchester Collaborative Centre for Inflammation Research, Faculty Life Sciences, Manchester, United Kingdom

V. Pittet*¹, C. Vaucher¹, M.H. Maillard², M. Girardin³, P. de Saussure³, G. Rogler⁴, P. Michetti⁵

¹Institute of Social and Preventive Medicine, Healthcare Evaluation Unit, Lausanne, Switzerland, ²Lausanne University Hospital, Department of Gastroenterology & Hepatology, Lausanne, Switzerland, ³Geneva University Hospital, Division of Gastroenterology & Hepatology, Geneva, Switzerland, ⁴University of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland, ⁵Clinique La Source-Beaulieu, Crohn and Colitis Center, Lausanne, Switzerland

K. Nys¹, W. Vanhove¹, I. Cleynen¹, M. Ferrante¹, G. Van Assche¹, P. Rutgeerts¹, P. Agostinis², S. Vermeire¹, ¹Department of Clinical and Experimental Medicine, KU Leuven, Translational Research in GastroIntestinal Disorders, Leuven, Belgium, ²KU Leuven, Cellular & Molecular Medicine, Leuven, Belgium

A. Stallmach*¹, U. Dennler², U. Marschall³, C. Schmidt⁴

¹University Hospital Jena, Clinic for Internal Medicine IV, Jena, Germany, ²Friedrich Schiller University Jena, Geschäftsbereich Medizincontrolling, Jena, Germany, ³BARMER GEK Hauptverwaltung 1100, Kompetenzzentrum Medizin und Versorgungsforschung, Berlin, Germany, ⁴Clinic for Internal Medicine IV, Jena University Hospital, Jena, Germany

D. Turner¹, C. Griffiths², J.C. Gana³, R. Shaoul⁴, R. Shamir⁵, E. Shteyer⁶, T. Bdolah-Abram⁶, A. Schechter¹, ¹Shaare Zedek Medical Centre, Pediatric Gastroenterology and Nutrition, Jerusalem, Israel, ²The Hospital for Sick Children, Department of Paediatrics, Toronto, ON, Canada, ³Pontificia Universidad Católica de Chile, Department of Pediatrics, Chile, Chile, ⁴Rambam Medical Cenetr, Pediatric GI, Haifa, Israel, ⁵Schneider Children's Medical Center of Israel, Institute of Gastroenterology, Petach Tikva, Israel, ⁶Hadassah Medical Center, Pediatric GI, Jerusalem, Israel

M.D. Larsen*¹, J. Kjeldsen², N. Qvist³, B. Nørgård¹, J. Nielsen¹

¹Odense University Hospital, Clinical Epidemiology, Odense, Denmark, ²Odense Hospital, Dept. of Medical Gastroenterology S, Odense, Denmark, ³Odense University Hospital, Surgical Department , Odense, Denmark

N.A. Yassin¹, A. Askari¹, Y.H. Siaw¹, E. Mann², D. Bernardo², R.K.S. Phillips¹, S. Knight², H. Al-Hassi², A.L. Hart¹, ¹St Mark's Hospital, and Academic Institute, London, United Kingdom, ²Imperial College London, Antigen Presentation Research Group, London, United Kingdom

R. Atreya*¹, S. Bloom², F. Scaldaferri³, V. Gerardi³, A. Karlsson⁴, T. Knittel⁴, J. Kowalski⁴, M. Lukas⁵, R. Lofberg⁶, R. Petryka⁷, G. Rydzewska⁸, R. Schnabel⁹, U. Seidler¹⁰, S. Nancey¹¹, M. Neurath¹², C. Hawkey¹³

¹University of Erlangen-Nuremberg, Department of Medicine 1, Erlangen, Germany, ²University College London Hospital, Gastroenterology, London, United Kingdom, ³Catholic University of Rome, Internal Medicine/Gastroenterology Division, Rome, Italy, ⁴InDex Pharmaceuticals, Clinical Research, Stockholm, Sweden, ⁵Clinical Centre Isacre Lighthouse, IBD Clinical & Research Centre, Prague, Czech Republic, ⁶Karolinska Institute and Sophiahemmet, Gastro Center, Stockholm, Sweden, ⁷NZOZ Vivamed, Gastroenterology, Warsaw, Poland, ⁸Central Clinical Hospital Ministry of Interior in Warsaw, Department of Gastroenterology, Warsaw, Poland, ⁹Pannonia Maganorvosi Centrum, Gastroenterology, Budapest, Hungary, ¹⁰MHH, Dept. of Gastroenterology, Hepatology and Endocrinology, Hanover, Germany, ¹¹Lyon-Sud Hospital, Gastroenterology, Pierre-Benite, France, ¹²University of Erlangen-Nuremberg, Gastroenterology, Erlangen, Germany, ¹³University of Nottingham, Nottingham Digestive Diseases Centre, Nottingham, United Kingdom

R.K. Weersma¹, International IBD Genetics Consortium², ¹University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, Netherlands, ², Netherlands