Welcome to the e-CCO Library Archive!
D. Keegan1, K. Byrne1, E. McDermott1, N. Rafter1, G. Cullen1, G. Doherty1, H. Mulcahy1, 1St Vincent's University Hospital, Centre for Colorectal Disease, Dublin, Ireland
Y. Houston1, M. Rawle2, D. Patterson2, L. Rook2, 1Yorkshire & Humber IBD Network, Hull Royal Infirmary, Dept of Gastroenterology, Hull, United Kingdom, 2Yorkshire & Humber IBD Network, United Kingdom
Innate lymphoid cells accumulate in IBD
A. Geremia, C. Arancibia, A. Gwela, R.W. Chapman, S.P.L. Travis, F. Powrie, University of Oxford, Translational Gastroenterology Unit, Oxford, United Kingdom
Transmissive Crohn's disease-like ileitis is caused by functional dysbiosis in the intestinal microbiota independent of inflammation-driven Paneth cell failure
M. Schaubeck*1, T. Clavel2, I. Lagkouvardos1, J. Calasan1, S.B. Haange3, N. Jehmlich3, M. von Bergen4, M. Basic5, A. Bleich6, D. Haller2
Table 1.
Proportion of patients with mucosal healing (MH — Mayo 0 or 1) by treatment group, visit, and extent of evaluation. n= No. of patients with mucosal healing; N= total no. of patients with evaluable videos. P values: vs placebo.
1Technische Universität München, Chair of Nutrition and Immunology, Weihenstephan, Germany, 2Technische Universität München, Chair of Nutrition and Immunology, Freising-Weihenstephan, Germany, 3Helmholtz-Centre for Environmental Research, UFZ, Department of Proteomics, Leipzig, Germany, 4University of Aalborg, Department of Biotechnology, Aalborg, Denmark, 5Hannover Medical School, Institute for Laboratory AnimHannover Medical School, Hannover, Germany, 6Hannover Medical School, Institute for Laboratory AnimHannover Medical School, Hannover, Germany
The GCN2/eIF2α/ATF4 signaling pathway is necessary for autophagy response to infection with Crohn's disease-associated adherent-invasive Escherichia coli
H. Nguyen1, J. Carriere1, G. Dalmasso1, A.-C. Maurin2, A. Bruhat2, A. Darfeuille-Michaud1, 1University of Auvergne, UMR 1071/Inserm, Clermont-Ferrand, France, 2INRA, Human nutrition unit (UNH), Theix, France
UK IBD twin and multiplex registry: Concordance and environmental risk factors of twins with IBD
H. Gordon*1, T. Orchard2, A. Steel1, M. Harbord1
1Chelsea and Westminster Hospital, Gastroenterology, London, United Kingdom, 2St Mary's Hospital, Gastroenterology, London, United Kingdom
Circadian clock function maintains mucosal architecture and protects against intestinal inflammation in mice
R. Pagel, F. Bär, T. Schröder, J. Büning, K. Fellermann, C. Sina, University Hospital Schleswig-Holstein, Campus Lübeck, Medical Department I, Gastroenterology, Lübeck, Germany
Faecal microbiota transplantation in Ulcerative Colitis: A randomised controlled trial
N. Rossen*1, S. Fuentes2, M. van der Spek1, J. Tijssen3, J. Hartman2, A. Duflou1, L. Mathus-Vliegen1, W. de Vos2, E. Zoetendal2, G. D'haens1, C. Ponsioen1
1Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Wageningen University, Laboratory of Microbiology, Wageningen, Netherlands, 3academic medical center, cardiology, Amsterdam, Netherlands
Early combined immunosuppression for the management of Crohn's disease: A community-based cluster randomized trial
R. Khanna1, B.G. Levesque1,2, B. Bressler3, G. Zou1,4, L. Stitt1, G.R. Greenberg5, R. Panaccione6, A. Bitton7, P. Pare8, S. Vermeire9, G. D'Haens1,10, D. MacIntosh11, W.J. Sandborn1,2, M.K. Vandervoort1, J.C. Morris1, B.G. Feagan1,12, 1Robarts Clinical Trials Inc., Robarts Research Institute, Western University, London, Ontario, Canada, 2University of California, San Diego, Division of Gastroenterology, La Jolla, United States, 3St. Paul's Hospital, Department of Gastroenterology, Vancouver, British Columbia, Canada, 4Western University, Department of Epidemiology and Biostatistics, London Ontario, Canada, 5Mount Sinai Hospital, Division of Gastroenterology, Toronto Ontario, Canada, 6University of Calgary, Division of Gastroenterology & Hepatology, Calgary Alberta, Canada, 7McGill University, Division of Gastroenterology, Montreal Quebec, Canada, 8Laval University, Hopital du St-Sacrement, Quebec City, Quebec, Canada, 9Department of Clinical and Experimental Medicine, KU Leuven, Translational Research in GastroIntestinal Disorders, Leuven, Belgium, 10University of Amsterdam, Academic Medical Center, Amsterdam, Netherlands, 11Dalhousie University, Division of Gastroenterology, Halifax, Canada, 12Western University, Department of Epidemiology and Biostatistics, Department of Medicine, London Ontario, Canada
Adalimumab and infliximab levels in neonates (ERA study)
M. Julsgaard*1, 2, L.A. Christensen1, P.R. Gibson3, R. Gearry4, J. Fallingborg5, J. Kjeldsen6, S. Wildt7, L. Svenningsen8, W. Connell2, C.L. Hvas1, M.P. Sparrow3, A. Walsh9, S.J. Connor10, G. Radford-Smith11, I. Lawrence12, J.M. Andrews13, K. Ellard14, O. Rosella3, A. Grosen1, J. Santamaria15, S.J. Bell2
1Aarhus University Hospital, Department of Hepatology and Gastroenterology, Aarhus, Denmark, 2St Vincent's Hospital & University of Melbourne, Department of Gastroenterology, Melbourne, Australia, 3Alfred Hospital and Monash University, Department of Gastroenterology, Melbourne, Australia, 4University of Otago, Christchurch Hospital, Department of Medicine and Gastroenterology, Christchurch, New Zealand, 5Aalborg Hospital, Department of Gastroenterology, Aalborg, Denmark, 6Odense University Hospital, Department of Gastroenterology and Hepatology, Odense, Denmark, 7Koege Hospital, Department of Gastroenterology, Koege, Denmark, 8Herning Hospital, Department of Medicine and Gastroenterology, Herning, Denmark, 9St. Vincent's hospital , Department of Gastroenterology, Sydney, Australia, 10Liverpool Hospital & University of NSW, Dept. of Gastroenterology, Sydney, Australia, 11Royal Brisbane & Women's Hospital, Department of Gastroenterology, Brisbane, Australia, 12Fremantle Hospital, Centre for Inflammatory Bowel Disease, Fremantle, Australia, 13Royal Adelaide Hospital, University of Adelaide , IBD Service, Dept of Gastroenterology & Hepatology & School of Medicine, Adelaide, Australia, 14Royal North Shore Hospital, Department of Gastroenterology, Sydney, Australia, 15St Vincent's Hospital & University of Melbourne, Department of Intensive Care, Melbourne, Australia
Is elderly-onset ulcerative colitis a different entity? – Natural disease course and treatment response compared to adult-onset disease in the population-based IBD-SL cohort
S. Jeuring1,2, T. Van den Heuvel1,2, M. Zeegers3,4, W. Hameeteman1, M. Romberg-Camps5, L. Oostenbrug6, A. Masclee1,2, D. Jonkers1,2, M. Pierik1,2, 1Maastricht University Medical Center+, Internal Medicine – Division Gastroenterology-Hepatology, Maastricht, Netherlands, 2Maastricht University Medical Center+, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands, 3University of Birmingham, Epidemiology and Public Health, Birmingham, United Kingdom, 4Maastricht University Medical Center+, Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht, Netherlands, 5ORBIS Medical Centre, Gastroenterology and Hepatology, Sittard, Netherlands, 6Atrium Medical Center, Internal Medicine and Gastroenterology, Heerlen, Netherlands
Infliximab trough level thresholds vary depending on the efficacy criterion chosen in IBD patients
X. Roblin*1, M. Rinaudo2, C. Jarlot1, E. Del Tedesco1, J.M. Phelip1, L. Clavel1, L. Peyrin Biroulet3, S. Paul2
1University Hospital, Gastroenterology, Saint Etienne, France, 2University of Saint Etienne, Immunology, Saint Etienne, France, 3CHU de Nancy, Department of Gastroenterology, Vandoeuvre-les-Nancy, France
Personalized thiopurine dosing based on TPMT genotyping reduces leucopenia occurrence and results in cost-savings in IBD patients. Results from a randomized trial in the Netherlands
M. Coenen1, C. van Marrewijk1, L. Derijks2, S. Vermeulen1,3, D. Wong4, O. Klungel5, A. Verbeek3, P. Hooymans4, H. Scheffer1, H.-J. Guchelaar6, B. Franke1,7, D. de Jong8, 1Radboud university medical center, Human Genetics, Nijmegen, Netherlands, 2Máxima Medical Centre, Clinical Pharmacy, Veldhoven, Netherlands, 3Radboud university medical center, Health Evidence, Nijmegen, Netherlands, 4Orbis Medical Centre, Clinical Pharmacy and Toxicology, Nijmegen, Netherlands, 5Utrecht Institute of Pharmaceutical Sciences, Pharmacoepidemiology and Pharmacotherapy, Utrecht, Netherlands, 6University Medical Center, Clinical Pharmacy and Toxicology, Leiden, Netherlands, 7Radboud university medical center, Psychiatry, Nijmegen, Netherlands, 8Radboud university medical center, Gastroenterology, Nijmegen, Netherlands
Disease burden outweighs the impact of drug concentrations and antibodies to infliximab in primary non-response to infliximab in Crohn's disease patients
T. Billiet*1, I. Cleynen1, V. Ballet2, K. Claes1, F. Princen3, S. Singh3, M. Ferrante2, G. Van Assche2, S. Vermeire2
1Department of Clinical and Experimental Medicine, KU Leuven, Translational Research in GastroIntestinal Disorders, Leuven, Belgium, 2University Hospitals Leuven, Gastroenterology - Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 3Prometheus Laboratories, Department of Research and Development, San Diego, United States