U. Mahadevan¹, S. Vermeire², D.C. Wolf³, F. Forger⁴, J.J. Cush⁵, A. Golembesky⁶, L. Shaughnessy⁶, D. De Cuyper⁷, S. Abbas⁸, M.E.B. Clowse⁹, ¹UCSF Medical Center, San Francisco, United States, ²University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium, ³Atlanta Gastroenterology Associates, Atlanta, United States, ⁴University of Bern, Department of Rheumatology and Clinical Immunology and Allergology, Bern, Switzerland, ⁵Baylor Research Institute and Baylor University Medical Center, Dallas, United States, ⁶UCB Pharma, Raleigh, United States, ⁷UCB Pharma, Brussels, Belgium, ⁸UCB Pharma, Paris, France, ⁹Duke University Medical Center, Rheumatology, Durham, United States

Molendijk I¹, Bonsing BA², Roelofs H³, Peeters KCMJ², Wasser MNJM⁴, Dijkstra G⁵, van der Woude CJ⁶, Veenendaal RA¹, Zwaginga JJ³, Verspaget HW*¹, Fibbe WE³, van der Meulen-de Jong AE¹, Hommes DW^1,5.

¹Dept. Gastroenterology and Hepatology, ²Dept. Surgery, ³Dept. Immunohematology and Blood Transfusion and ⁴Dept. of Radiology, Leiden University Medical Center, Leiden, The Netherlands. ⁵Dept. Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, The Netherlands. ⁶Dep. Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands. ⁷Div. Digestive Diseases, University of California Los Angeles, USA.

F. Trier Moller^1,2, V. Andersen³, T. Jess², ¹Southern University of Denmark, Institute for Regional Health Research, Odense, Denmark, ²Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark, ³Southern University of Denmark, Institute for Regional Health Research – SHS, Odense, Denmark

T. van den Heuvel*^{1, 2}, C. le Clerq², S. Jeuring^{1, 2}, R. Marx², M. Zeegers^{3, 4}, D. Jonkers^{1, 2}, W. Hameeteman², L. Oostenbrug⁵, M. Romberg-Camps⁶, A. Masclee^{1, 2}, S. Sanduleanu², M. Pierik^{1, 2}

¹Maastricht University Medical Centre+, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands, ²Maastricht University Medical Centre+, Internal Medicine - Division Gastroenterology-Hepatology, Maastricht, Netherlands, ³University of Birmingham, Public Health, Epidemiology and Biostatistics, Birmingham, United Kingdom, ⁴Maastricht University Medical Center+, Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht, Netherlands, ⁵Atrium Medical Center, Internal Medicine and Gastroenterology, Heerlen, Netherlands, ⁶Orbis Medical Centre, Gastroenterology and Hepatology, Sittard-Geleen, Netherlands

A. Zand, W.K. Van Deen, C.H. Ha, E. Kane, J.M. Choi, B.E. Roth, A. Centeno, E. Esrailian, D.W. Hommes, UCLA Center for Inflammatory Bowel Diseases, Division of Digestive Diseases, University of California, Los Angeles, Los Angeles, United States

T. van den Heuvel*^{1, 2}, D. Wintjens², S. Jeuring^{1, 2}, W. Hameeteman², L. Oostenbrug³, M. Romberg-Camps⁴, A. Masclee^{1, 2}, M. Zeegers^{5, 6}, D. Jonkers^{1, 2}, M. Pierik^{1, 2}

¹Maastricht University Medical Centre+, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands, ²Maastricht University Medical Centre+, Internal Medicine - Division Gastroenterology-Hepatology, Maastricht, Netherlands, ³Atrium Medical Center, Internal Medicine and Gastroenterology, Heerlen, Netherlands, ⁴Orbis Medical Centre, Gastroenterology and Hepatology, Sittard-Geleen, Netherlands, ⁵University of Birmingham, Public Health, Epidemiology and Biostatistics, Birmingham, United Kingdom, ⁶Maastricht University Medical Center+, Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht, Netherlands

M. Mandel¹, A. Balint², B. Lovasz¹, L. Kiss¹, P.A. Golovics¹, Z. Vegh¹, K. Farkas², T. Molnar², A. Mohas¹, B. Szilagyi¹, P. Lakatos¹, ¹Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ²University of Szeged, 1st Department of Medicine, Szeged, Hungary

A. Askari*¹, S. Nachiappan¹, J. Murphy², S. Mills³, T. Athanasiou⁴, O. Faiz¹

¹St. Mark's Hospital, Imperial College London, Surgical Epidemiology, Trials & Outcomes Centre (SETCO), London, United Kingdom, ²St. Mark's Hospital, Surgery, London, United Kingdom, ³Chelsea & Westminster Hospital, Surgery, London, United Kingdom, ⁴St. Mary's Hospital, Imperial College London, Department of Cardiovascular Medicine, London, United Kingdom

S. Danese¹, G. Fiorino¹, L. Peyrin-Biroulet², P.L. Lakatos³, J.Y. Mary⁴, G. D'Haens⁵, L. Moja^6,7, A. D'Hoore⁸, J. Panes⁹, W. Reinisch¹⁰, W.J. Sandborn¹¹, S. Travis¹², S. Vermeire¹³, J.F. Colombel¹⁴, ¹Humanitas Research Hospital, IBD Center, Rozzano, Milan, Italy, ²Nancy University Hospital, Université de Lorraine, Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France, ³Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ⁴Saint Louis Hospital, INSERM U717, Paris, France, ⁵Academic Medical Center, Department of Gastroenterology, Amsterdam, Netherlands, ⁶IRCCS Galeazzi Orthopedic Institute, Unit of Clinical Epidemiology, Milan, Italy, ⁷University of Milan, Department of Biomedical Sciences for Health, Milan, Italy, ⁸University Hospitals Leuven, Department of Abdominal Surgery, Leuven, Belgium, ⁹Hospital Clinic de Barcelona, IDIBAPS and CIBERehd, Gastroenterology Unit, Barcelona, Spain, ¹⁰AKH, Medizinische Universität, Klinische Abt. Gastroenterologie & Hepatologie, Wien, Italy, ¹¹University of California, San Diego, Inflammatory Bowel Disese Center, Division of Gastroenterology, La Jolla, United States, ¹²John Radcliffe Hospital, Translational Gastroenterology Unit, Oxford, United Kingdom, ¹³Katholieke Universiteit and University Hospital Gasthuisberg, Division of Gastroenterology, Leuven, Belgium, ¹⁴Hemsley Inflammatory Bowel Disease Center, Icahn Medical School of Medicine at Mount Sinai, New-York, United States

B.E. Sands*¹, I. Shafran², F.A. Farraye³, A.S. Cheifetz⁴, B. Abhyankar⁵, S. Sankoh⁶, M. Smyth⁷

¹Icahn School of Medicine at Mount Sinai Hospital, Gastroenterology, New York, United States, ²Shafran Gastroenterology Center, Gastroenterology, Winter Park, FL, United States, ³Boston Medical Center, Gastroenterology, Boston, MA, United States, ⁴Beth Israel Deaconess Medical Center, Medicine, Boston, MA, United States, ⁵Takeda Global Research and Development Centre (Europe) Ltd., Clinical Science, London, United Kingdom, ⁶Takeda Pharmaceuticals International Co., Statistics, Cambridge, Massachusetts, United States, ⁷Takeda Global Research and Development Centre (Europe) Ltd., Medical, London, United Kingdom

A. Rispo¹, P.P. Mainenti², F.P. D'Armiento³, A. Testa¹, M. Rea¹, D. Musto¹, M. Diaferia¹, L. Bucci⁴, G. Pesce⁵, F. Castiglione¹, ¹AOU Policlinico Federico II of Naples, Gastroenterology, Naples, Italy, ²AOU Policlinico Federico II of Naples, Radiology, Naples, Italy, ³AOU Policlinico Federico II of Naples, Pathology, Naples, Italy, ⁴AOU Policlinico Federico II of Naples, Colorectal Surgery, Naples, Italy, ⁵AOU Policlinico Federico II of Naples, General Surgery, Naples, Italy

P. Wils*¹, Y. Bouhnik², B. Flourie³, H. Brixi⁴, J. Cosnes⁵, M. Allez⁶, B. Duclos⁷, P. Michetti⁸, J.-C. Grimaud⁹, G. Bommelaer¹⁰, A. Amiot¹¹, M. Fumery¹², J. Filippi¹³, V. Abitbol¹⁴, B. Coffin¹⁵, M. Simon¹⁶, D. Laharie¹⁷, B. Pariente¹

¹CHU de Lille, Department of Gastroenterology, Lille, France, ²Beaujon Hospital, Gastroenterology Unit, Clichy, France, ³Centre Hospitalier Lyon-Sud, Service d'Hépato-gastro-entérologie, Lyon, France, ⁴CHU de Reims, Gastroenterologie, Reims, France, ⁵University Hospital of Saint Antoine, APHP, Gastroenterology, Paris, France, ⁶APHP, Hopital Saint Louis, Department of Gastroenterology, Paris, France, ⁷Université de Strasbourg, Gastroenterology, Strasbourg, France, ⁸University Hospital Lausanne, Division of Gastroenterology & Hepatology,, Lausanne, Switzerland, ⁹Hôpital Nord, Gastroenterology Unit, Marseille, France, ¹⁰CHU de Clermont-Ferrand, Department of Gastroenterology, Clermont-Ferrand, France, ¹¹Hospital Henri-Mondor, Department of Gastroenterology, Creteil, France, ¹²Amiens University Hospital, Gastroenterology, Amiens, France, ¹³CHU de Nice, Department of Gastroenterology, Nice, France, ¹⁴Cochin University Hospital, Gastroenterology, Paris, France, ¹⁵Hopital Louis-Mourier, Gastroenterologie, Colombes, France, ¹⁶Institut Mutualiste Montsouris , Gastroenterology , Paris, France, ¹⁷CHU de Bordeaux, Gastroenterology, Pessac, France

J. Rimola¹, W.J. Sandborn², P. Higgins³, A. Coimbra⁴, T. Lu⁴, P. Rutgeerts⁵, D. Luca⁴, D. Bruining⁶, S. Vermeire⁵, J. Panes⁷, C. Santillan⁸, M. Al-Hawary⁹, J. Fidler¹⁰, D. Vanbeckevoort¹¹, R. Vanslembrouck¹¹, L. Peyrin-Biroulet¹², V. Laurent¹³, S. O'Byrne⁴, A. de Crespigny⁴, ¹Hospital Clínic de Barcelona, Radiology Department, Barcelona, Spain, ²University of California San Diego, Division of Gastroenterology, La Jolla, United States, ³University of Michigan, Internal Medicine – Gastroenterology, Ann Arbor, MI, United States, ⁴Genentech, Research and Early Development, South San Francisco, United States, ⁵KU Leuven, Division of Gastroenterology, Leuven, Belgium, ⁶Mayo Clinic, Gastroenterology, Rochester, United States, ⁷Hospital Clínic Barcelona, Department of Gastroenterology, Barcelona, Spain, ⁸University of California San Diego, Radiology, San Diego, United States, ⁹University of Michigan, Radiology, Ann Arbor, United States, ¹⁰Mayo Clinic, Radiology, Rochester, United States, ¹¹Biomedical MRI, KU Leuven Department of Imaging and Pathology, Leuven, Belgium, ¹²Nancy University Hospital, Université de Lorraine, Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France, ¹³Brabois Hospital, Gastroenterology, Vandoeuvre les Nancy, France

S. Vermeire*¹, V. Kojecký², V. Knoflícek³, W. Reinisch⁴, T. Van Kaem⁵, F. Namour⁶, J. Beetens⁵, F. Vanhoutte⁵

¹University Hospital Leuven, Gastroenterology, Leuven, Belgium, ²Krajska nemocnice T Bati, Interni klinika IPVZ, Zlin, Czech Republic, ³Nemocnice Znojmo, Internal Medicine, Znojmo, Czech Republic, ⁴McMaster University, Gastroenterology, Hamilton, Canada, ⁵Galapagos NV, Development, Mechelen, Belgium, ⁶Galapagos SASU, Development, Romainville, France

P. Higgins¹, W.J. Sandborn², J. Rimola³, T. Lu⁴, A. Coimbra⁴, P. Rutgeerts⁵, D. Luca⁴, D. Bruining⁶, S. Vermeire⁵, C. Santillan⁷, M. Al-Hawary⁸, J. Fidler⁹, D. Vanbeckevoort¹⁰, R. Vanslembrouck¹⁰, L. Peyrin-Biroulet¹¹, V. Laurent¹², A. de Crespigny⁴, S. O'Byrne⁴, J. Panes¹³, ¹University of Michigan, Internal Medicine – Gastroenterology, Ann Arbor, MI, United States, ²University of California San Diego, Division of Gastroenterology, La Jolla, United States, ³Hospital Clínic de Barcelona, Radiology Department, Barcelona, Spain, ⁴Genentech, Research and Early Development, South San Francisco, United States, ⁵KU Leuven, Division of Gastroenterology, Leuven, Belgium, ⁶Mayo Clinic, Gastroenterology, Rochester, United States, ⁷University of California San Diego, Radiology, San Diego, United States, ⁸University of Michigan, Radiology, Ann Arbor, United States, ⁹Mayo Clinic, Radiology, Rochester, United States, ¹⁰Biomedical MRI, KU Leuven Department of Imaging and Pathology, Leuven, Belgium, ¹¹Nancy University Hospital, Université de Lorraine, Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France, ¹²Brabois Hospital, Gastroenterology, Vandoeuvre les Nancy, France, ¹³Hospital Clínic Barcelona, Department of Gastroenterology, Barcelona, Spain

A. Jauregui-Amezaga*¹, R. Cabezón², A. Ramírez-Morros², C. España², J. Rimola³, C. Bru³, S. Pinó-Donnay², M. Gallego², M.C. Masamunt², I. Ordás², M. Lozano⁴, J. Cid⁴, J. Panés², D. Benítez-Ribas², E. Ricart²

¹University Hospitals Leuven, Gastroenterology - Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, ²Hospital Clínic de Barcelona, Gastroenterology, Barcelona, Spain, ³Hospital Clínic de Barcelona, Radiology, Barcelona, Spain, ⁴Hospital Clínic de Barcelona, Hemotherapy and Hemostasis, Barcelona, Spain

U. Kopylov¹, A. Nemeth², A. Koulaouzidis³, R. Makins⁴, W. Afif⁵, G. Wild¹, A. Bitton¹, G.W. Johansson⁶, T. Bessissow¹, E. Toth⁶, E.G. Seidman¹, ¹McGill University Health Center, Gastroenterology, Montreal, Canada, ²Skåne University Hospital, Lund University, Department of Gastroenterology, Malmo, Sweden, ³Royal Infirmary of Edinburgh, Endoscopy Unit, Centre for Liver and Digestive Disorders, Edinburgh, United Kingdom, ⁴Gloucestershire Hospitals NHS Foundation Trust, Gastroenterology, London, United Kingdom, ⁵McGill University, Division of Gastroenterology, Montreal Quebec, Canada, ⁶University Hospital Skane, Gastroenterology-Hepatology Division, Malmö, Sweden

O. Ryska*¹, Z. Serclova¹, O. Mestak², E. Matouskova³, P. Vesely², I. Mrazova⁴

¹Horovice Hospital, Department of Surgery, Horovice, Czech Republic, ²Bulovka Hospital, Plastic Surgery, Prague, Czech Republic, ³3rd Medical Faculty Charles University, Department of Burns Medicine, Prague, Czech Republic, ⁴Institute for Clinical and Experimental Medicine, Centrum of Experimental Medicine, Prague, Czech Republic

P. Rutgeerts¹, W. Reinisch², W.J. Sandborn³, G. D'Haens⁴, J.-F. Colombel⁵, J. Petersson⁶, Q. Zhou⁶, R.B. Thakkar⁶, ¹KU Leuven, Division of Gastroenterology, Leuven, Belgium, ²McMaster University, Department of Medicine, Hamilton, Canada, ³University of California, San Diego, Division of Gastroenterology, La Jolla, United States, ⁴Academic Medical Center, Department of Gastroenterology, Amsterdam, Netherlands, ⁵Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, New York, United States, ⁶AbbVie Inc, GPRD, North Chicago, United States

R. Combes*¹, R. Altwegg¹, D. Laharie², V. De Ledinghen², S. Radenne³, F. Conti⁴, O. Chazouilleres⁴, C. Duvoux⁵, L. Peyrin-Biroulet⁶, J. Dumortier⁷, V. Leroy⁸, X. Treton⁹, F. Durand⁹, S. Dharancy¹⁰, M. Nachury¹⁰, F. Goutorbe¹¹, G. Lamblin¹¹, G.-P. Pageaux¹

¹University Hospital of St Eloi, Departement of Hepatology and Gastroenterology, Montpellier, France, ²University hospital of Bordeaux, Haut-Leveque Hospital, Hepato-Gastroenterology, Bordeaux, France, ³Hospices Civils de Lyon, Croix-Rousse, Hepato-Gastroenterology, Lyon, France, ⁴University Hospital of Saint Antoine, APHP, Hepato-Gastroenterology, Paris, France, ⁵University Hospital of Henri Mondor, APHP, Hepato-Gastroenterology, Creteil, France, ⁶University Hospital of Nancy, Gastroenterology, Nancy, France, ⁷Hospices Civils de Lyon, Edouard Hériot Hospital, Hepato-Gastroenterology, Lyon, France, ⁸University Hospital of Grenoble, Hepato-Gastroenterology, Grenoble, France, ⁹University hospital of Beaujon, APHP, Gastroenterology, Clichy, France, ¹⁰University hospital of Lille, Hepato-Gastroenterology, Lille, France, ¹¹University Hospital of Clermont-Ferrand, Hepato-Gastroenterology, Clermont-Ferrand, France