T.S. Chew¹, A.M. Smith¹, G.W. Sewell¹, N.R. O'Shea¹, S.L. Bloom², A.W. Segal¹, ¹University College London, Centre for Molecular Medicine, London, United Kingdom, ²University College London Hospital, Department of Gastroenterology, London, United Kingdom

A. Racine*¹, F. Carbonnel¹, S. Chan², A. Hart², B. Bueno de Mesquita³, B. Oldenburg⁴, F. VanSchaik⁴, A. Tjonneland⁵, A. Olsen⁵, C. Dahm⁶, T. Key⁷, R. Luben⁸, K.-T. Kaw⁹, E. Riboli¹⁰, O. Grip¹¹, S. Lindgren¹¹, G. HAllmans¹², P. Karling¹³, F. Clavel-Chapelon¹⁴, M. Bergman¹⁵, H. Boeing¹⁵, B. Buijsse¹⁵, R. Kaaks¹⁶, V. Katzke¹⁷, D. Palli¹⁸, G. Masala¹⁸, P. Jantchou¹⁹, M.C. Boutron Ruault¹⁴

¹University Hospital of Bicêtre, Assistance Publique Hôpitaux de Paris, Université Paris-Sud,, Department of Gastroenterology, Le Kremlin Bicetre, France, ²Norfolk and Norwich University Hospital NHS Trust, Departement of Medicine, Norwich, United Kingdom, ³National Institute for Public Health and the Environment (RIVM, Department. for Determinants of Chronic Diseases (DCD), , Bilthoven, Netherlands, ⁴University Medical Centre, Department . of Gastroenterology and Hepatology, Utrecht, Netherlands, ⁵Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark, ⁶Aarhus University, Section for Epidemiology, Department of Public Health, Aarhus, Denmark, ⁷University of Oxford, , Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, Oxford, United Kingdom, ⁸University of Cambridge, , Strangeways Research Laboratory, Institute of Public Health, Cambridge, United Kingdom, ⁹University of Cambridge, Strangeways Research Laboratory, Institute of Public Health, Cambridge, United Kingdom, ¹⁰Imperial College London,, Division of Epidemiology, London, United Kingdom, ¹¹University Hospital Malmö, , Department of Gastroenterology and Hepatology, Malmö, Sweden, ¹²Umea University, , Department of Public Health and Clinical Medicine, Nutritional Research, , Umea, Sweden, ¹³Umea University, Department of Public Health and Clinical Medicine, GI unit, Umea, Sweden, ¹⁴INSERM, Centre for Research in Epidemiology and Population Health, U1018, Team 9, Institut Gustave Roussy, Université Paris Sud, Villejuif, France, ¹⁵German Institute of Human Nutrition, , Department of Epidemiology, Potsdam, Germany, ¹⁶DKFZ-German Cancer Research Centre Heidelberg, , Division of Clinical Epidemiology, Heidelberg, Germany, ¹⁷DKFZ-German Cancer Research Centre Heidelberg, , Division of Clinicl Epidemiology, Heidelberg, Germany, ¹⁸Cancer Research and Prevention Institute – ISPO, Molecular and Nutritional Epidemiology Unit, Firenze, Italy, ¹⁹Sainte Justine University Hospital, Departement de Gastroenterologie hepatologie Nutrition Pediatrique, Montreal, Canada

M.-L. Tran-Minh¹, E. Quévrain¹, L. Brot¹, G. Thomas¹, J.-P. Grill¹, G. Trugnan¹, P. Seksik^1,2, ¹INSERM, Université Paris 6, ERL U1057/UMR 7203, Paris, France, ²Hopital Saint Antoine, Gastro Enterologie, Paris, France

Y. Shachar¹, M. Avitzour², Y. Chowers³, R. Balicer⁴, N. Lederman⁵, E. Matz⁶, J. Rosenblum⁷, R. Eliakim⁸, S. Ben-Horin⁸, S. Odes⁹, J. Pfeffer¹⁰, Z. Levy¹¹, E. Israeli¹², I. Dotan¹³, D. Turner*²

¹Shaare Zedek Medical Center, The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition, Jerusalem, Israel, ²Shaare Zedek Medical Center, Juliet Keidan Institute of Pediatric Gastroenterology and Nutrition, Jerusalem, Israel, ³Rambam Health Care Campus & Bruce Rappaport School of Medicine, Technion Institute of Technology, Department of Gastroenterology, Haifa, Israel, ⁴Clalit Health Services, Clalit Research Institute, Chief Physician's Office, Tel-Aviv, Israel, ⁵Meuhedet Sick Fund, Medical division, Tel-Aviv, Israel, ⁶Leumit Health Fund, Community Medicine, Tel-Aviv, Israel, ⁷Maccabi Health Services, Medical Informatics, Tel-Aviv, Israel, ⁸Sheba Medical Center, Department of Gastroenterology, Tel Hashomer, Israel, ⁹Soroka Medical Center and Ben-Gurion University of the Negev, Department of Gastroenterology and Hepatology, Beer Sheva, Israel, ¹⁰Tel Aviv Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel, Tel Aviv, Israel, ¹¹Rabin Medical Center, Gastroenterology, Petach Tikva, Israel, ¹²Hadassah Medical Center, Gastroenterology, Jerusalem, Israel, ¹³Sackler Faculty of Medicine, Tel Aviv Israel, IBD Center, Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center , Tel Aviv, Israel

L. Biedermann¹, K. Brülisauer², J. Zeitz¹, P. Frei^1,3, M. Scharl¹, S.R. Vavricka^1,4, M. Fried¹, M.J. Loessner², G. Rogler¹, M. Schuppler², ¹University Hospital Zurich, Gastroenterology & Hepatology, Zurich, Switzerland, ²ETH Zurich, Institute of Food, Nutrition and Health, Zurich, Switzerland, ³Seespital Horgen, Gastroenterology & Hepatology, Horgen, Switzerland, ⁴Hospital Triemli, Gastroenterology & Hepatology, Zurich, Switzerland

B. Lovasz*¹, P.A. Golovics¹, Z. Vegh¹, I. Szita², M. Balogh³, G. Rogler⁴, S. Vavricka⁴, L. Lakatos², P. Lakatos¹

¹Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ²Csolnoky F. Province Hospital, Department of Medicine, Veszprem, Hungary, ³Grof Eszterhazy Hospital, Department of Medicine, Papa, Hungary, ⁴University Hospital Zurich, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Zurich, Switzerland

A. Lavelle^1,2, G. Lennon^1,2, A. Balfe^1,2, N. Docherty², J. Hyland¹, D. O'Donoghue¹, G. Docherty¹, O. O'Sullivan³, P. Cotter³, K. Sheahan¹, H. Mulcahy¹, F. Shanahan³, J.C. Coffey⁴, D. Winter^1,2, P.R. O'Connell^1,2, ¹St. Vincent's University Hospital, Centre for Colorectal Disease, Dublin, Ireland, ²University College Dublin (UCD), School of Medicine and Medical Science, Dublin, Ireland, ³University College Cork, Alimentary Pharmabiotic Centre, Cork, Ireland, ⁴Graduate Entry Medical School, University Hospital Limerick, University of Limerick Ireland, Limerick, Ireland

S. Jeuring*^{1, 2}, T. Van den Heuvel^{1, 2}, M. Zeegers^{3, 4}, W. Hameeteman¹, M. Romberg-Camps⁵, L. Oostenbrug⁶, A. Masclee^{1, 2}, D. Jonkers^{1, 2}, M. Pierik^{1, 2}

¹Maastricht University Medical Center+, Internal Medicine - Division Gastroenterology-Hepatology, Maastricht, Netherlands, ²Maastricht University Medical Center+, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands, ³University of Birmingham, Public Health, Epidemiology and Biostatistics, Birmingham, United Kingdom, ⁴Maastricht University Medical Center+, Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht, Netherlands, ⁵Orbis Medical Center, Gastroenterology and Hepatology, Sittard, Netherlands, ⁶Atrium Medical Center, Internal Medicine and Gastroenterology, Heerlen, Netherlands

N. Borruel¹, H.B. Nielsen², F. Casellas¹, C. Manichanh³, E. Varela³, M. Antolín³, A. Torrejón¹, V. Robles¹, P. Nos⁴, X. Calvet⁵, F. Guarner¹, MetaHIT Consortium⁶, ¹Hospital Vall d'Hebron, Crohn's and Colitis Attention Unit. Digestive System Research Unit, Barcelona, Spain, ²Technical University of Denmark, Center for Biological Sequence Analysis, Department of Systems Biology, Lyngby, Denmark, ³Hospital Vall d'Hebron, Digestive System Research Unit, Barcelona, Spain, ⁴Hospital Universitari i Politècnic La Fe, Servicio de Medicina Digestiva, Valencia, Spain, ⁵Corporació Sanitària Parc Taulí, Servei d'Aparell Digestiu, Sabadell, Spain, ⁶MetaHIT Network, Partner Centres, Paris, France

P. Henderson*¹, P. Rogers², D.C. Wilson¹

¹University of Edinburgh, Child Life and Health, Edinburgh, United Kingdom, ²Royal Hospital for Sick Children, Paediatric Gastroenterology, Edinburgh, United Kingdom

T. van den Heuvel^1,2, D. Jonkers^1,2, S. Jeuring^1,2, W. Hameeteman¹, L. Oostenbrug³, M. Romberg-Camps⁴, A. Masclee^1,2, M. Zeegers^5,6, M. Pierik^1,2, ¹Maastricht University Medical Center+, Internal Medicine – Division Gastroenterology-Hepatology, Maastricht, Netherlands, ²Maastricht University Medical Center+, NUTRIM, School for Nutrition, Toxicology and Metabolism, Maastricht, Netherlands, ³Atrium Medical Center, Internal Medicine and Gastroenterology, Heerlen, Netherlands, ⁴Orbis Medical Centre, Gastroenterology and Hepatology, Sittard-Geleen, Netherlands, ⁵Maastricht University Medical Center+, Complex Genetics, Cluster of Genetics and Cell Biology, Maastricht, Netherlands, ⁶University of Birmingham, Public Health, Epidemiology and Biostatistics, Birmingham, United Kingdom

Y. Zabana*^{1, 2}, L. Rodríguez³, T. Lobatón⁴, M. Martínez⁵, A. Montserrat⁶, R. Mena⁷, M. Dotti¹, O. Benitez¹, J. Guardiola³, E. Domènech^{2, 4}, E. Garcia-Planella⁵, X. Calvet^{2, 6}, M. Piqueras⁷, M. Aceituno^{1, 2}, F. Fernández-Bañares^{1, 2}, M. Esteve^{1, 2}

¹Hospital Universitari Mútua Terrassa, Gastroenterology Department, Terrassa, Spain, ²Centro de Investigación Biomédica en Red sobre enfermedades hepáticas y digestivas, CIBERehd, Madrid, Spain, ³Hospital Universitari Bellvitge, Gastroenterology Department, Barcelona, Spain, ⁴Hospital Universitari Germans Trias i Pujol, Gastroenterology Department, Badalona, Spain, ⁵Hospital de Santa Creu i Sant Pau, Gastroenterology Department, Barcelona, Spain, ⁶Corporació Sanitària Parc Taulí, Gastroenterology Department, Sabadell, Spain, ⁷Consorci Sanitari de Terrassa, Gastroenterology Department, Terrassa, Spain

F.L. Cameron, P. Henderson, D.C. Wilson, University of Edinburgh, Child Life and Health, Edinburgh, United Kingdom

V. Merrick*¹, P. Henderson¹, H. Drummond², J. Van Limbergen³, R. Russell⁴, J. Satsangi², D. Wilson¹

¹University of Edinburgh, Child Life and Health, Edinburgh, United Kingdom, ²University of Edinburgh, Gastrointestinal Unit, Centre for Genomic and Experimental Medicine, Edinburgh, United Kingdom, ³Dalhousie University, Department of Pediatrics, Halifax, Canada, ⁴Royal Hospital for Sick Children, Paediatric Gastroenterology, Glasgow, United Kingdom

F. Trier Moller^1,2, V. Andersen³, T. Jess², ¹Southern University of Denmark, Institute for Regional Health Research, Odense, Denmark, ²Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark, ³Southern University of Denmark, Institute for Regional Health Research – SHS, Odense, Denmark

J. Llaó^*1, A. Bargallo², C. Romero³, M. Mañosa⁴, J. Haya³, L. Yip¹, E. Cabre², E. García-Planella³, E. Domenech²

¹Hospital de la Santa Creu i de Sant Pau, Inflamatory bowel disease, Barcelona, Spain, ²Hospital Germans Trias i Pujol, Gastroenterology, Badalona, Spain, ³Hospital de la Santa Creu i Sant Pau, Gastroenterology, Barcelona, Spain, ⁴Hospital germans Trias i Pujol, Gastroenterology, Barcelona, Spain

A. Morieux¹, C. Mowat², N. Reynolds², J. Todd², A. Meritsi², S. Allstaff³, M. Groome², ¹University of Dundee Medical School, Medical School, Dundee, United Kingdom, ²Ninewells Hospital & Medical School, Gastroenterology, Dundee, United Kingdom, ³Ninewells Hospital & Medical School, Sexual & Reproductive Health, Dundee, United Kingdom

Z. Vegh*¹, P.A. Golovics¹, Z. Kurti¹, B. Lovasz¹, I. Szita², M. Balogh³, T. Pandur², K. Gecse¹, L. Lakatos², P. Lakatos¹

¹Semmelweis University, 1st Department of Medicine, Budapest, Hungary, ²Csolnoky F. Province Hospital, Department of Medicine, Veszprem, Hungary, ³Grof Eszterhazy Hospital, Department of Medicine, Papa, Hungary

A. de Lima¹, Z. Zelinkova^1,2, C. van der Ent¹, C.J. van der Woude¹, ¹Erasmus Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands, ²University Hospital, 5th Department of Internal Medicine, Gastroenterology Unit, Bratislava, Slovakia

B. Griffiths*¹, N. Curry², M. Desborough², S. Henton², R.V. Bryant¹, S.P. Travis¹, V. Jairath¹

¹Oxford University Hospitals NHS Trust, Translational Gastroenterology Unit, Oxford, United Kingdom, ²Oxford University Hospitals NHS Trust, Oxford Haemophillia & Thrombosis Centre, Oxford, United Kingdom