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Induction of IL-10 positive cells in the colon mucosa of ulcerative colitis patients by the TLR-9 agonist DIMS0150
U. Billmeier1, C. Admyre2, T. Knittel2, A. Zargari2, M. Neurath1, R. Atreya1, 1University of Erlangen-Nuremberg, Medical clinic 1, Erlangen, Germany, 2InDex Pharmaceuticals AB, R&D Department, Stockholm, Sweden
Early transabdominal ultrasonography to assess intestinal wall thickness and vascularity appears to predict long-term outcome in Crohn's disease patients undergoing infliximab therapy: A prospective study
H. Yasuhara*1, R. Kunisaki1, S. Tsunoda1, N. Kawashima1, S. Yamamoto1, S. Tsuda1, T. Ogashiwa1, R. Koh1, K. Goto1, H. Kimura1, K. Numata1, S. Maeda2
1Yokohama City University Medical Centre, Inflammatory Bowel Disease Centre, Yokohama, Japan, 2Yokohama City University Graduate School of Medicine, Gastroenterology, Yokohama, Japan
C-Jun N-terminal kinase 2 in non-hematopoietic cells protects against stress-induced apoptosis and improves gastrointestinal barrier functions
A.D. Mandic, E. Bennek, C. Liedtke, F.J. Cubero, C. Trautwein, G. Sellge, University Hospital Aachen, Department of Medicine III, Aachen, Germany
Large bowel mucosal dysplasia in the original specimen influences on severity of pouchitis and higher risk of J-pouch dysplasia
A. Bobkiewicz*, L. Krokowicz, M. Borejsza-Wysocki, T. Banasiewicz, M. Drews
Poznan Poznan University of Medical Sciences, Department of General, Endocrinological and Gastroenterological Oncological Surgery, Poznan, Poland
IFI16 is dysregulated in inflammatory bowel diseases and its epithelial expression induced by pro-inflammatory cytokines
L. Pastorelli1,2, L.F. Pisani1, V. Caneparo3, M. Bawadekar3, N. Munizio2, B. Bruni4, G.E. Tontini2,5, C. Clemente4, S. Landolfo6, M. Gariglio3, M. Vecchi1,2, 1University of Milan, Department of Biomedical Sciences for Health, Milan, Italy, 2IRCCS Policlinico San Donato, Gastroenterology and Digestive Endoscopy Unit, San Donato Milanese, Italy, 3University of Piemonte Orientale, Department of Translational Medicine, Novara, Italy, 4IRCCS Policlinico San Donato, Pathology and Cytodiagnostic Unit, San Donato Milanese, Italy, 5University of Erlangen-Nuremberg, Medicine I, Erlangen, Germany, 6University of Turin, Department of Public Health and Microbiology, Turin, Italy
Histological normalisation is associated with superior clinical relapse free survival compared to histological activity and histological quiescence in ulcerative colitis
B. Christensen*1, O. Kassim1, J. Erlich1, S.B. Hanauer2, D.T. Rubin1
1University of Chicago Inflammatory Bowel Disease Center, Gastroenterology, Chicago, IL, United States, 2Northwestern University Feinberg School of Medicine, Digestive Health Center, Chicago, United States
Intestinal epithelial-specific deletion of Sphingosine kinase 1 protects against colitis-associated cancer in mice models
B.J. Lee, M.K. Joo, J.-J. Park, J.S. Kim, Y.-T. Bak, Y.T. Jeen, Korea University Medical center, Gastroenterology, Seoul, South Korea
Mucosal healing in ulcerative colitis: when zero is better
P. Boal Carvalho*1, F. Dias de Castro1, B. Rosa1, M.J. Moreira1, J. Cotter1, 2, 3
1Centro Hospitalar do Alto Ave, Gastroenterology, Guimaraes, Portugal, 2Universidade do Minho, Life and Health Sciences Research Institute, Braga/Guimarães, Portugal, 3ICVS/3B’s , PT Associate Laboratory, Braga/Guimarães, Portugal
The absence of the Triggering Receptor Expressed on Myeloid Cells type-2 (TREM-2) induces a transmissible and protective intestinal microbiota for colitis and colitis associated cancer
M. Genua1,2, C. Monico3, S. D'Alessio1, C. Correale1, J. Cibella1, A. Gandelli1, V. Arena4, A. Spinelli5, S. Guglielmetti6, S. Vetrano1, S. Danese1, 1Humanitas Research Hospital, IBD Center, Rozzano, Milan, Italy, 2Humanitas Research Hospital, Medical Biotechnologies and Translational Medicine, Milano, Italy, 3University of Milan, School of Medicine and Surgery, Milan, Italy, 4Catholic University of Sacred Heart, Internal Medicine and Gastroenterology, Rome, Italy, 5Humanitas Research Hospital, IBD Surgery Unit, Milano, Italy, 6University of Milan, DeFENS, Milan, Italy
Plexitis as a predictive factor for early post-operative endoscopic recurrence in patients with Crohn's disease undergoing a right hemicolectomy with ileocolonic anastomosis: Results from a prospective, single center trial.
B. Lemmens*1, G. Van Assche2, A. de Buck van Overstraeten3, S. Vermeire2, A. Tertychnyy4, S. Fieuws5, K. Geboes6, A. D'Hoore3, G. De Hertogh6, M. Ferrante2
1KU Leuven, Imaging and Pathology, Leuven, Belgium, 2University Hospital Leuven, Gastroenterology, Leuven, Belgium, 3University Hospital Leuven, Department of Abdominal Surgery, Leuven, Belgium, 4First Moscow State Medical University, Pathology, Moscow, Russian Federation, 5KU Leuven, Biostatistics and Statistical Bioinformatics, Leuven, Belgium, 6UZ Leuven, Imaging and Pathology, Leuven, Belgium
Ulcerative colitis: The αEβ7 integrin is associated with a high frequency of Th17, Th1 and Th17/Th1 CD4 lymphocytes
C.A. Lamb1,2, J.C. Mansfield2,3, G.W. Tew4, D.L. Gibbons5, A.K. Long6, P.M. Irving5,7, L. Diehl4, J. Eastham-Anderson4, G. O'Boyle8, D.E.J. Jones1, A.C. Hayday5, M.E. Keir4, J.G. Egen4, J.A. Kirby1, 1Newcastle University, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, 2Newcastle Upon Tyne Hospitals NHS Foundation Trust, Gastroenterology, Newcastle Upon Tyne, United Kingdom, 3Newcastle University, Institute of Genetic Medicine, Newcastle upon Tyne, United Kingdom, 4Genentech, Research and Early Development, South San Francisco, United States, 5King's College London, Peter Gorer Department of Immunobiology, London, United Kingdom, 6Newcastle upon Tyne Hospitals NHS Foundation Trust, Pathology, Newcastle upon Tyne, United Kingdom, 7Guy's & St Thomas' NHS Foundation Trust, Gastroenterology, London, United Kingdom, 8University of Sunderland, Department of Pharmacy Health and Well-being, Sunderland, United Kingdom
Development of a Simplified histological Geboes Score for ulcerative colitis
A. Jauregui-Amezaga*1, G. De Hertogh2, T. Bessissow3, B. Lemmens2, T. Lobatón4, M. Ferrante1, R. Bisschops1, G. Van Assche1, S. Vermeire1, K. Geboes2
1University Hospitals Leuven, Gastroenterology - Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2University Hospitals Leuven, Pathology, Leuven, Belgium, 3Mc Gill University Health Center, Gastroenterology, Montreal, Canada, 4Hospital Universitari Germans Trias i Pujol, Gastroenterology, Badalona, Spain
Epigenome-wide analysis in childhood-onset Crohn's disease implicates MIR21 in pathogenesis and identifies multiple methylation-based diagnostic biomarkers
N.A. Kennedy1,2, A.T. Adams1, R. Hansen3, N.T. Ventham1, K.R. O'Leary1, H. Drummond1, C.L. Noble1,2, E. El-Omar3, R.K. Russell4, D.C. Wilson5, E.R. Nimmo1, G.L. Hold3, J. Satsangi1,2, 1University of Edinburgh, Gastrointestinal Unit, Centre for Genomic and Experimental Medicine, Edinburgh, United Kingdom, 2Western General Hospital, Gastrointestinal Unit, Edinburgh, United Kingdom, 3University of Aberdeen, Gastrointestinal Research Group, Division of Applied Medicine, Aberdeen, United Kingdom, 4Royal Hospital for Sick Children, Paediatric Gastroenterology, Glasgow, United Kingdom, 5University of Edinburgh, Paediatric Gastroenterology and Nutrition, Child Life and Health, Edinburgh, United Kingdom
Incidence of inflammatory bowel diseases in the Faroe Islands from 1960-2014: a 54-year overview from a population-based cohort
T. Hammer*1, K. Rubek Nielsen2, J. Burisch3, P. Munkholm4, E. Lynge5
1University of Copenhagen , Department of Public Health, Copenhagen , Denmark, 2National Hospital of the Faroe Islands, Medical Department , Genetic Biobank, Tóshavn , Faroe Islands, 3Hvidovre University Hospital , Gastrounit, Medical section , Hvidovre , Denmark, 4North Zealand Hospital, Capital Region, University of Copenhagen , DEEP – Danish Center for eHealth and Epidemiology, Copenhagen , Denmark, 5University of Copenhagen , Department of Public Health , Copenhagen , Denmark
A genome wide association study identifying association of the MHC region with 5-aminosalicylate (5-ASA) induced nephrotoxicity in inflammatory bowel disease
G. Heap1, C. Bewshea1, A. Singh1, M. Weedon2, J. Goldstein3, N. Ebney4, C. Mulgrew4, R. D'Souza4, R. Oram4, T. Orchard5, T. Shirazi6, E. Wesley7, K. So8, E. Wesley7, P. Irving9, A. Cole10, S. Sebastian11, D. Gaya12, C. Lees13, I. Lawrence8, C. Hawkey14, J. Mansfield15, M. Parkes16, G. Radford-Smith17, E. Tsianos18, V. Annese19, G.C. Sturniolo20, R. Weersma21, M. D'Amato22, M. Silverberg23, A. Hart24, A. Holden25, UK IBDGC26, The International Serious Adverse Events Consortium27, T. Ahmad1, 1Royal Devon and Exeter NHS Foundation Trust, IBD Pharmacogenetics, Exeter, United Kingdom, 2University of Exeter, Biomedical Informatics Hub, Exeter, United Kingdom, 3The Broad Institute, Analytical and Translational Genetics Unit, Boston, United States, 4Royal Devon and Exeter NHS Foundation Trust, Renal Medicine, Exeter, United Kingdom, 5Imperial College, St Mary's Campus, London, United Kingdom, 6Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom, 7Taunton and Somerset NHS Trust, Musgrove Park Hospital, Gastroenterology, Taunton, United Kingdom, 8Fremantle Hospital, Centre for Inflammatory Bowel Disease, Fremantle, Australia, 9Guy's & St Thomas' NHS Foundation Trust, Gastroenterology, London, United Kingdom, 10Royal Derby Hospital, Gastroenterology, Derby, United Kingdom, 11Hull and East Yorkshire Hospitals NHS Trust, Gastroenterology, Hull, United Kingdom, 12Glasgow Royal Infirmary, Gastroenterology, Glasgow, United Kingdom, 13Western General Hospital, Gastrointestinal Unit, Edinburgh, United Kingdom, 14Nottingham University Hospital NHS Trust, Nottingham Digestive Diseases Centre, Nottingham, United Kingdom, 15Newcastle Upon Tyne Hospitals NHS Foundation Trust, Gastroenterology, Newcastle Upon Tyne, United Kingdom, 16Cambridge University Hospitals, Biomedical Campus, Cambridge, United Kingdom, 17Royal Brisbane and Women's Hospital, Gastroenterology and Hepatalogy Department, Brisbane, Australia, 18University of Ioannina School of Medicine, Department of Internal Medicine, Ioannina, Greece, 19AOU Careggi, Largo Brambilla, Gastroenterologia, Firenze, Italy, 20Univerita di Padova, Gastroenterologia, Padova, Italy, 21University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, 22Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden, 23Mount Sinai Hospital, Division of Gastroenterology, Toronto Ontario, Canada, 24St Mark's Hospital, Gastroenterology, London, United Kingdom, 25International Serious Adverse Event Consortium (iSAEC), Bryn Mawr Avenue, Chicago, United States, 26The UK IBD Genetic Consortium, United Kingdom, 27SAEC Consortium, Ltd, Bryn Mawr Avenue, Chicago, United States
The ongoing rapid and significant rise of incident paediatric-onset inflammatory bowel disease in Scotland
P. Henderson*1, F.L. Cameron1, F. Jagger2, P. Rogers3, R. Hansen4, S. Loganathan2, P. McGrogan4, R.K. Russell4, D.C. Wilson1
1University of Edinburgh, Child Life and Health, Edinburgh, United Kingdom, 2Royal Aberdeen Children's Hospital, Department of Paediatric Gastroenterology, Aberdeen, United Kingdom, 3Royal Hospital for Sick Children, Paediatric Gastroenterology, Edinburgh, United Kingdom, 4Royal Hospital for Sick Children, Paediatric Gastroenterology, Glasgow, United Kingdom
Overexpression of Suppressor of Cytokine Signaling-3 reduces the role of IL22 in mucosal healing and defense
A.T. Xu, Y. Li, Z.H. Ran, J. Shen, X.T. Xu, M.M. Zhu, Y.Q. Qiao, Z.H. Dai, T.R. Wang, Q. Zheng, D. Zhao, School of Medicine, Shanghai Jiao-Tong University, Department of Gastroenterology, Renji hospital, Shanghai, China
Incidence and risk factors of cutaneous manifestations in pediatric-onset Crohn'sdisease: A population-based study
C. Templier1, H. Sarter2, D. Turck3, M. Fumery*4, G. Savoye5, B. Catteau1, C. Spyckerelle6, E. Laberenne7, O. Mouterde8, D. Djeddi9, S. Buche1, L. Peyrin-Biroulet10, E. Delaporte1, C. Gower-Rousseau2
1Lille University Hospital , Dermatology, Lille, France, 2Lille University Hospital, Epidemiology, Lille, France, 3Lille University Hospital, Pediatrics, Lille, France, 4Amiens University Hospital, Gastroenterology, Amiens, France, 5Rouen University Hospital, Gastroenterology, Rouen, France, 6Lille Catholic University Hospital, Pediatrics, Lille, France, 7Seclin Hospital, Gastroenterology, Seclin, France, 8Rouen University Hospital, Pediatrics, Rouen, France, 9Amiens University Hospital, Pediatrics, Amiens, France, 10Nancy University Hospital , Gastroenterology , Nancy, France
Pre-treatment differential microRNA expression profile in ulcerative colitis patients according to their response to corticosteroids
J.E. Naves1, J. Mañe1, V. Loren1, M. Mañosa1, I. Moret2, A. García-Jaraquemada1, G. Bastida2, E. Cabré1, B. Beltrán2, E. Domènech1, 1Hospital Universitari Germans Trias i Pujol, Gastroenterology, Badalona, Spain, 2Hospital Universitari I Politècnic La Fe, Valencia, Gastroenterology, Valencia, Spain
Increase of Inflammatory Bowel Disease incidence in teenagers in a prospective population-based-study over a 21-year period (1988-2008)
S. Ghione*1, H. Sarter2, L. Armengol-Debeir3, M. Fumery4, G. Savoye3, L. Dauchet5, D. Ley1, C. Spyckerelle6, O. Mouterde7, D. Djeddi8, B. Pariente9, L. Peyrin-Biroulet10, D. Turck1, C. Gower-Rousseau11
1Lille University Hospital, Pediatrics, Lille, France, 2Lille University Hospital, Epidemiology, Lille, France, 3Rouen University Hospital, Gastroenterology, Rouen, France, 4Amiens University Hospital, Gastroenterology, Amiens, France, 5Lille University Hospital , Public Health, Lille, France, 6Lille Catholic University Hospital, Pediatrics, Lille, France, 7Rouen University Hospital, Pediatrics, Rouen, France, 8Amiens University Hospital, Pediatrics, Amiens, France, 9Lille University Hospital, Gastroenterology, Lille, France, 10Nancy University Hospital , Gastroenterology , Nancy, France, 11Lille University Hospital , Biostatistics, Lille, France