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P751
Low enteric microbial diversity in patients with ulcerative colitis after pouch surgery having a mature normal ileal pouch may be predictive of pouchitis
N. Maharshak*1, N.A. Cohen1, L. Reshef2, H. Tulchinsky3, U. Gophna2, I. Dotan4
1Tel Aviv Medical Centre, IBD Centre, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel, 2Tel Aviv University, Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv, Israel, 3Tel Aviv Sourasky Medical Centre, affiliated to Sackler Faculty of Medicine, Tel Aviv University, Proctology Unit, Department of Surgery, Tel Aviv, Israel, 4Tel Aviv Medical Centre, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel
P752
A reduction of the butyrate-producing microbiota in Asian patients with ulcerative colitis
Y. T. Jeen, E. S. Kim*, B. Keum, J. S. Koo
Korea University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul, South Korea
P753
Immunosuppression for inflammatory bowel disease does not affect Epstein–Barr viral load in the short-term: preliminary results
I. Rodríguez - Lago*1, 2, O. Merino2, 3, M. J. López de Goicoechea4, M. Aranzamendi5, L. Zubiaurre2, 6, J. Ortiz de Zárate2, 7, A. Muñagorri2, 8, C. G. Cilla9, J. L. Cabriada1, 2
1Galdakao Hospital, Gastroenterology, Galdakao, Spain, 2IBD Study Group of the Basque – Navarre Society of Gastrointestinal Diseases, Pais Vasco - Navarra, Spain, 3Cruces University Hospital, Gastroenterology, Bilbao, Spain, 4Galdakao Hospital, Microbiology, Galdakao, Spain, 5Cruces University Hospital, Microbiology, Bilbao, Spain, 6Mendaro Hospital, Gastroenterology, Mendaro, Spain, 7Basurto University Hospital, Gastroenterology, Bilbao, Spain, 8Donostia Hospital, Gastroenterology, Donostia, Spain, 9Donostia Hospital, Microbiology, Donostia, Spain
P754
IBD phenotypes differ in gut mycobiota composition
P. Drastich1, L. Bajer*1, K. Klimesova2, M. Kostovcik2, M. Kverka2, J. Brezina1, J. Spicak1
1Institute for Clinical and Experimental Medicine, Hepatogastroenterology, Prague, Czech Republic, 2Institute for Microbiology of the CAS, Prague, Czech Republic
P755
Effect of carboxylic acids of gut microbial origin on host cell proliferation in organotypic tissue cultures
T. Vakhitov1, N. Chalisova2, S. Sitkin*1, 3
1State Research Institute of Highly Pure Biopreparations, Dept. of Microbiology, St. Petersburg, Russian Federation, 2Pavlov Institute of Physiology of the Russian Academy of Sciences, St. Petersburg, Russian Federation, 3North-Western State Medical University named after I.I. Mechnikov, Dept. of Internal Diseases, St. Petersburg, Russian Federation
Epithelial polarity is disrupted by interleukin-22
L. Lebenheim1, C. May1, M. Munoz2, M.M. Heimesaat2, B. Siegmund1, J.-D. Schulzke1, M. Schumann1, 1Charité University Medicine, Gastroenterology Infectious Diseases and Rheumatology, Berlin, Germany, 2Charité University Medicine, Dept. for Microbiology, Berlin, Germany
Comparison of rectosigmoidoscopy and colonoscopy for assessment of endoscopic activity in ulcerative colitis
J.-F. Colombel1, I. Ordas2, T. Ullman1, P. Rutgeerts3, A. Chai4, S. O'Byrne4, T. Lu4, J. Panés*2
1Icahn School of Medicine at Mount Sinai, Department of Gastroenterology, New York, United States, 2Hospital Clinic de Barcelona, IDIBAPS and CIBERehd, Gastroenterology Unit, Barcelona, Spain, 3KU Leuven, Division of Gastroenterology, Leuven, Belgium, 4Genentech, Research and Early Development, South San Francisco, United States
Conditional deletion of Prep1 in the intestinal epithelium alters epithelial homeostasis, intestinal development, and controls colitis susceptibility
S. D'Alessio1, C. Tacconi1, A. Gandelli1, C. Correale1, M. Genua1, S. Vetrano1, F. Blasi2, S. Danese1, 1Humanitas Clinical and Research Center, IBD Center, Rozzano, Italy, 2IFOM-IEO Campus, Transcriptional mechanisms in development and tumor formation, Milan, Italy
The impact of magnetic resonance enterography and capsule endoscopy on the classification of disease in patients with known Crohn's disease: A PROSPECTIVE ISRAELI IBD RESEARCH NETWORK (IIRN) STUDY
T. Greener1, U. Kopylov*1, D. Yablecovitch1, A. Lahat1, M.M. Amitai2, E. Klang2, S. Neuman1, N. Levhar1, S. Ben-Horin1, R. Eliakim1
1Chaim Sheba Medical Center, Gastroenterology, Tel Hashomer, Israel, 2Chaim Sheba Medical Center, Radiology , Tel Hashomer, Israel
FcR-mediated effector function contributes to the therapeutic response of anti-TNF monoclonal antibodies in a mouse model of IBD
A. Levin1, M. Wildenberg1, G. D'Haens2, G. van den Brink2, 1Academic Medical Center, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 2Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands
Diffusion-weighted magnetic resonance entero-colonography is highly effective to detect endoscopic ulcerations in ileocolonic Crohn's disease
A. Buisson*1, 2, C. Hordonneau3, M. Goutte1, 2, L. Boyer3, B. Pereira4, G. Bommelaer1, 2
1University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, 2UMR 1071 Inserm/Université d'Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France, 3University Hospital Estaing, Radiology Department, Clermont-Ferrand, France, 4GM-Clermont-Ferrand University and Medical Center, , Biostatistics Unit , Clermont-Ferrand, France