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P731
Impact of the rs1143634 polymorphism in the gene coding for IL1β on pharmacokinetic of infliximab in inflammatory bowel disease patients
J. Guardiola*1, L. Rodriguez-Alonso1, A. Padullés2, P. Ariadna3, H. Colom4, E. Santacana2, C. Arajol1, A. Ruiz-Cerulla1, J. Bas5, F. Morandeira5, F. Rodriguez-Moranta1, N. Padullés2
1Hospital Universitario de Bellvitge, Gastroenterology, L´Hospitalet de Llobregat, Spain, 2Hospital Universitario de Bellvitge, Pharmacy, L´Hospitalet de Llobregat, Spain, 3Hospital Universitario de Bellvitge, Laboratory of Biochemistry, L´Hospitalet de Llobregat, Spain, 4Barcelona University, Pharmacokinetics. School of Pharmacy, Barcelona, Spain, 5Hospital Universitario de Bellvitge, Immunology, L´Hospitalet de Llobregat, Spain
P732
Pooled resequencing of 122 ulcerative colitis genes in a large Dutch population suggests population-specific association of rare variants in MUC2
M.C. Visschedijk*1, 2, R. Alberts1, S. Mucha3, P. Deelen2, D. J. de Jong4, M. Pierik5, A. E. van der Meulen-de Jong6, C. J. van der Woude7, A. A. van Bodegraven8, B. Oldenburg9, M. Lowenberg10, G. Dijkstra1, D. Ellinghaus3, S. Schreiber11, C. Wijmenga2, M. A. Rivas12, A. Franke3, C. C. van Diemen2, R.K. Weersma1
1University of Groningen and University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, 2University of Groningen and University Medical Centre Groningen, Department of Genetics, Groningen, Netherlands, 3Kiel University, Institute of Clinical Molecular Biology, Kiel, Germany, 4University Medical Centre St. Radboud, Department of Gastroenterology and Hepatology, Nijmegen, Netherlands, 5University Medical Centre Maastricht, Division of Gastroenterology and Hepatology, Maastricht, Netherlands, 6Leiden University Medical Centre, Department of Gastroenterology and Hepatology, Leiden, Netherlands, 7Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, Netherlands, 8VU University Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, Netherlands, 9University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, Netherlands, 10Amsterdam Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, Netherlands, 11University Medical Centre Schleswig-Holstein, Department of Internal Medicine, Kiel, Germany, 12The Broad Institute, Centre for the Study of IBD (SCIBD) Genetics, Cambridge, United States
P733
Genetic risk scores for risk and therapy response prediction in Slovenian Crohn’s disease patients
K. Zupančič*1, K. Skok1, K. Repnik1, P. Skok2, U. Potočnik1
1Medical faculty, University of Maribor, Centre for human genetics and pharmacogenomics, Maribor, Slovenia, 2University medical Centre, Department of gastroenterology, Maribor, Slovenia
P734
Gene expression of SELENBP1 is upregulated in the colonic mucosa and is associated with a long-term remission in patients with ulcerative colitis
J. Yamamoto-Furusho*1, L. Salazar-Salas1, G. Fonseca-Camarillo1, R. Barreto2
1IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico, 2Instituto Nacional de Ciencias Medicas y Nutricion, Endoscopy, Mexico, Mexico
P735
Exploring mechanisms of inflammatory bowel disease transmission in utero through the microbiome: the MECONIUM Study Pilot
J. Torres*1, J. Hu2, J. Coté-Daigneault1, H. Panchal2, C. Eisele2, X. Bao2, N. Nangia2, C.-L. Chen3, M. Dubinsky4, J. George1, A. Kornbluth1, P. Legnani1, J. Marion1, E. Maser1, T. Ullman1, B. Jharap1, J. Stone3, J. Clemente2, J.-F. Colombel1, I. Peter2
1Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, Department of Medicine, New York, New York, United States, 2Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, New York, United States, 3Icahn School of Medicine at Mount Sinai, Department of Obstetrics, Gynaecology and Reproductive Science, New York, New York, United States, 4Icahn School of Medicine at Mount Sinai, Division of Pediatric Gastroenterology, Department of Pediatrics, New York, New York, United States
P736
Composition of faecal microbiota in former UC patients after restorative proctocolectomy with and without episodes of pouchitis
P. Bours*1, S. Fuentes2, C. Gerritsen2, 3, A. Masclee1, H. Smidt2, M. Pierik1, D. Jonkers1
1Maastricht University Medical Centre, Gastroenterology and Hepatology, Maastricht, Netherlands, 2Wageningen University, Laboratory of Microbiology, Wageningen, Netherlands, 3Winclove Probiotics B.V., Amsterdam, Netherlands
P737
Host-microbiome interactions in primary sclerosing cholangitis
J. Sabino*1, S. Vieira-Silva2, 3, I. Cleynen4, K. Machiels1, M. Joossens2, 3, 5, G. Falony2, 3, J. Wang2, 3, V. Ballet1, M. Ferrante1, G. Van Assche1, S. Van Der Merwe6, J. Raes2, 3, S. Vermeire1
1KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2REGA institute, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, 3Vlaams Instituut voor Biotechnologie (VIB), Centre for the Biology of Disease, Leuven, Belgium, 4KU Leuven, Human Genetics, Leuven, Belgium, 5VUB, Department of Microbiology, Brussels, Belgium, 6University Hospitals of Leuven, Department of Hepatology, Leuven, Belgium
P738
Disease activity related dysbiosis in inflammatory bowel disease patients
M. E. Grasman*1, R. J. van der Borden1, A. E. Budding2, A. Eck2, N. K. de Boer1, G. Bouma1, P. H. Savelkoul2, A. A. van Bodegraven1
1VU University Medical Centre, Gastroenterology and Hepatology, Amsterdam, Netherlands, 2VU University Medical Centre, Medical Microbiology and Infection control, Amsterdam, Netherlands
P739
Infections with C. difficile in inflammatory bowel disease patients are difficult to treat and frequently recur
E. Gombotz*1, E. Leitner2, I. Zollner-Schwetz3, R. Krause3, C. Kornschober4, H. Wenzl1, P. Kump1, W. Petritsch1, C. Högenauer1
1Medical University of Graz, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Graz, Austria, 2Medical University of Graz, Institute of Hygiene, Microbiology and Environmental Medicine, Graz, Austria, 3Medical University of Graz, Department of Internal Medicine, Section of Infectious Diseases and Tropical Medicine, Graz, Austria, 4Austrian Agency for Health and Food Safety, Graz, Austria
P740
Toxin negative Clostridium difficile colonisation and outcome in acute severe ulcerative colitis: a retrospective single-centre study
K.S. Kok*1, S. Chan1, E. Tsiouli2, N. Elumogo2, M. Tremelling1
1Norfolk and Norwich University Hospital, Department of Gastroenterology, Norwich, United Kingdom, 2Norfolk and Norwich University Hospital, Department of Microbiology, Norwich, United Kingdom
P741
The gut microbiota in primary sclerosing cholangitis and inflammatory bowel disease: correlations with disease and diet
J. Torres*1, C. Palmela2, X. Bao3, A.P. Krieger4, V. Teixeira5, S. Velho5, C. Vieira6, A. Oliveira7, J. Pereira da Silva8, P. Moura Santos9, S. Itzkowitz1, I. Peter3, M. Cravo2, J. Hu3
1Icahn School of Medicine at Mount Sinai, Division of Gastroenterology, Department of Medicine, New York, United States, 2Hospital Beatriz Ângelo, Division of Gastroenterology, Loures, Portugal, 3Icahn School of Medicine at Mount Sinai, Department of Genetics and Genomic Sciences, New York, United States, 4University of Lisbon, Lisbon, Portugal, 5Hospital Beatriz Ângelo, Nutrition, Loures, Portugal, 6Centro Hospitalar Barreiro Montijo, Division of Gastroenterology, Montijo, Portugal, 7Hospital Fernando Fonseca, Division of Gastroenterology, Amadora, Portugal, 8Instituto Português de Oncologia, Division of Gastroenterology, Lisbon, Portugal, 9University of Lisbon, Hospital Santa Maria, Division of Gastroenterology, Lisbon, Portugal
P742
Genetic risk for Crohn’s disease has little effect on intestinal microbiota composition
J. Sabino*1, S. Vieira-Silva2, 3, I. Cleynen4, K. Nys1, K. Machiels1, M. Joossens2, 3, 5, G. Falony2, 3, J. Wang2, 3, V. Ballet1, M. Ferrante1, G. Van Assche1, S. Van Der Merwe6, J. Raes2, 3, S. Vermeire1
1KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2REGA institute, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, 3Vlaams Instituut voor Biotechnologie (VIB), Centre for the Biology of Disease, Leuven, Belgium, 4KU Leuven, Human Genetics, Leuven, Belgium, 5VUB, Department of Microbiology, Brussels, Belgium, 6University Hospitals of Leuven, Department of Hepatology, Leuven, Belgium
P743
Gut microbial gene richness is reduced in smokers with Crohn’s disease
J. Opstelten*1, J. Plassais2, S. van Mil3, B. Oldenburg1, A. Cervino2
1University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, Netherlands, 2Enterome, Paris, France, 3University Medical Centre Utrecht, Centre for Molecular Medicine, Utrecht, Netherlands
P744
Proton pump inhibitors affect the gut microbiome
F. Imhann*1, M. J. Bonder2, A. Vich Vila1, J. Fu2, Z. Mujagic3, L. Vork3, E. F. Tigchelaar2, S. A. Jankipersadsing2, M. C. Cenit2, H. J. M. Harmsen4, G. Dijkstra1, L. Franke2, R. J. Xavier5, D. Jonkers3, C. Wijmenga2, R. K. Weersma1, A. Zhernakova2
1University of Groningen and University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, 2University of Groningen and University Medical Centre Groningen, Department of Genetics, Groningen, Netherlands, 3Maastricht University Medical Centre+, Division Gastroenterology-Hepatology, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands, 4University of Groningen and University Medical Centre Groningen, Department of Medical Microbiology, Groningen, Netherlands, 5The Broad Institute of MIT and Harvard, Cambridge, United States
P745
Clostridium difficile infection in inflammatory bowel disease patients: prevalence and risk factors
M. Su, H. Chen, M. Zhi*, H. He, M. Zhang, J. Tang, J. Hu, Y. Zhang, N. Ding, L. Ma, H. Chen, X. Gao, P. Hu
The Sixth Affiliated Hospital of Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China
P746
Anti-inflammatory properties of Faecalibacterium prausnitzii in the absence and presence of cigarette smoke using a novel epithelium-gut microbe coculture system
J. Z. H. von Martels*1, M. Sadaghian Sadabad2, R. Van der Meer1, A. N. J. Overbeeke2, T. Blokzijl1, H. J. M. Harmsen2, G. Dijkstra1, K. N. Faber1
1University Medical Centre Groningen, Gastroenterology and Hepatology, Groningen, Netherlands, 2University Medical Centre Groningen, Medical Microbiology, Groningen, Netherlands
P747
Microbial communities of Crohn’s disease aphtous ulcers
C. O’Brien*1, 2, D. Gordon3, P. Pavli1, 2
1Canberra Hospital, Gastroenterology and Hepatology Unit, Canberra, Australia, 2Australian National University, Medical school, Canberra, Australia, 3Australian National University, Research School of Biology, Canberra, Australia
P748
Potential role of Fusobacteria in Korean inflammatory bowel disease patients
C. S. Eun*, D. S. Han, A. R. Lee, Y. R. Lee
Hanyang University Guri Hospital, Gastroenterology, Guri, South Korea
P749
Not only butyrate-producing bacteria but possibly also Bacteroides thetaiotaomicron protects against ulcerative colitis
S. Sitkin*1, 2, T. Vakhitov1, E. Tkachenko2, T. Zhigalova2, L. Oreshko2, M. Suvorova3
1State Research Institute of Highly Pure Biopreparations, Department of Microbiology, St Petersburg, Russian Federation, 2North-Western State Medical University named after I.I. Mechnikov, Department of Internal Diseases, St. Petersburg, Russian Federation, 3Institute of Experimental Medicine, St. Petersburg, Russian Federation
P750
Higher frequency of adherent-invasive Escherichia coli within a sub-group of B2 phylogroup strains
C. O’Brien*1, 2, D. Gordon3, P. Pavli1, 2
1Canberra Hospital, Gastroenterology and Hepatology Unit, Canberra, Australia, 2Australian National University, Medical school, Canberra, Australia, 3Australian National University, Research School of Biology, Canberra, Australia