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P711

Clinical characteristics of patients with Crohn’s disease or ulcerative colitis treated with vedolizumab: a real-world data analysis

Authors:

H. Liang1, S. Manne1, J. Shick1, S. Yu1, G. Fusco1, P. Dolin*2

1Takeda Development Centre Americas, Inc, Deerfield, Illinois, United States, 2Takeda Development Centre Europe Ltd, London, United Kingdom

P712

Examination of the relationship between disease activity, psychological distress and patient-reported outcome measures in an inflammatory bowel disease cohort

Authors:

B. Jackson*1, D. Con1, A. Gorelik2, D. Liew2, P. De Cruz1

1Austin Health, Gastroenterology, Melbourne, Australia, 2Melbourne Health, Melbourne, Australia

P713

Exploring the epidemiological aspects of inflammatory bowel disease: preliminary data from ‘epimici’ study in San Marino

Authors:

L. R. Lopetuso*1, A. Piscaglia2, L. Laterza1, V. Gerardi1, S. Boccia3, E. Leoncini2, E. Sacchini2, A. Armuzzi1, A. Gasbarrini1, M. L. Stefanelli2

1Catholic University of Sacred Heart, Internal Medicine Department, Gastroenterology Division, Rome, Italy, 2State Hospital, Endoscopy and Gastroenterology Unit, San Marino, San Marino, 3Catholic University of Sacred Heart, Rome, Italy

P714

Risk factors for vitamin D, zinc, and selenium deficiency in the patients with inflammatory bowel disease

Authors:

Y. M. Han1, H. Yoon*2, S. Lim3, M.-k. Sung4, C. M. Shin3, Y. S. Park3, N. Kim1, 3, D. H. Lee1, 3, J. S. Kim1

1Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, South Korea, 2Seoul National University Bundang Hospital, Departments of Internal Medicine, Seongnam, South Korea, 3Seoul National University Bundang Hospital, Departments of Internal medicine, Seongnam, South Korea, 4Sookmyung Women’s University, Department of Food and Nutrition, Seoul, South Korea

P715

Hepatobiliary and pancreatic manifestations in patients with inflammatory bowel disease: retrospective study from north-western Greece

Authors:

F. Fousekis*, K. Katsanos, D. Christodoulou, E. Tsianos

Medical school, university of Ioannina, Internal medicine and hepatology & gastroenterology, Ioannina, Greece

P716

A well-maintained inflammatory bowel disease (IBD) registry can help assess and optimise treatment for the local population: a 10-year experience in an Indian IBD registry cohort

Authors:

R. Banerjee*1, U. Basavaraju2, B. Adigopula1, N. Reddy1

1Asian Institute of Gastroenterology, Inflammatory Bowel Disease, Hyderabad, India, 2Aberdeen Royal Infirmary, NHS Grampian, Digestive Disorders, Aberdeen, United Kingdom

P717

Predictive factors for unfavourable disease course in inflammatory bowel diseases (IBD): data analysis of almost 1 000 patients from a Hungarian tertiary IBD centre

Authors:

K. Farkas1, T. Nyári2, A. Bálint1, R. Bor1, A. Milassin1, M. Rutka*1, Z. Szepes1, F. Nagy1, T. Molnár1

1University of Szeged, First Department of Medicine, Szeged, Hungary, 2University of Szeged, Department of Medical Physics and Informatics, Szeged, Hungary

P718

Faecal calprotectin combined with faecal lactoferrin in predicting the endoscopic outcomes of patients with moderate-to-severe Crohn’s disease receiving infliximab: a pilot study

Authors:

J. Wu*1, W. Huang2

1Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Gastroenterology, Shanghai, China, 2Janssen, Medical Affairs, Shanghai, China

P719

Identification of a genetic risk variant in the WWOX gene associated with recurrent fibrostenotic Crohn’s disease

Authors:

M. C. Visschedijk*1, 2, L. M. Spekhorst1, 2, G. Dijkstra1, E. S. van Loo3, D. J. de Jong4, A. E. van der Meulen-de Jong5, H. W. Verspaget5, C. Y. Ponsioen6, V. B. Nieuwenhuijs7, B. Oldenburg8, M. Pierik9, N. K. H. de Boer10, C. J. van der Woude11, F. Imhann1, 2, R. Alberts1, S. van Sommeren1, 2, K. N. Faber1, C. M. Aldaz12, R. K. Weersma1, E.A. M. Festen1, 2

1University of Groningen and University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands, 2University of Groningen and University Medical Centre Groningen, Department of Genetics, Groningen, Netherlands, 3University of Groningen and University Medical Centre Groningen, Department of Surgery, Groningen, Netherlands, 4University Medical Centre St. Radboud, Department of Gastroenterology and Hepatology, Nijmegen, Netherlands, 5Leiden University Medical Centre, Department of Gastroenterology and Hepatology, Leiden, Netherlands, 6Amsterdam Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, Netherlands, 7Isala Clinics, Department of Surgery, Zwolle, Netherlands, 8University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, Netherlands, 9University Medical Centre Maastricht, Division of Gastroenterology and Hepatology, Maastricht, Netherlands, 10VU University Medical Centre, Department of Gastroenterology and Hepatology, Amsterdam, Netherlands, 11Erasmus Medical Centre, Department of Gastroenterology and Hepatology, Rotterdam, Netherlands, 12The University of Texas M.D. Anderson Cancer Centre, Department of Molecular Carcinogenesis, Science Park, Smithville, United States

P720

Increased mitochondrial DNA copy number and higher expression of energy metabolic genes predict ulcerative colitis carcinogenesis

Authors:

T. Tanaka*1, T. Kobunai2, T. Watanabe1

1University of Tokyo, Division of Surgical Oncology, Department of Surgery, Tokyo, Japan, 2Translational Research Laboratory, Taiho Pharmaceutical Co, Ltd, Tokyo, Japan

P721

The biological and clinical relevance of anti-metalloproteinase-9 antibody (GS-5745) in treatment of ulcerative colitis patients

Authors:

B. R. Bhandari1, S. Lee2, X. Zhao*3, E. Huntzicker3, X. Guo3, Z. Jiang3, D. Ge3, D. French3, M. Subramanian3, J.G. McHutchison3, B. Kanwar3, B. Levesque4, W. Sandborn4, 5

1Delta Research Partners, LLC, Monroe, Louisiana, United States, 2University of Washington, Seattle, Washington, United States, 3Gilead Sciences, Inc., Foster City, California, United States, 4University of Western Ontario, Robarts Clinical Trials, London, Ontario, Canada, 5University of California, San Diego, California, United States

P722

Clinical and genetic characterisation of patients with graft-vs-host disease after allogeneic hematopoietic cell transplantation suggests a role for JAK2, IL2RA, and HLA-DRB1

Authors:

S. van Sommeren*1, H. M. de Jonge1, J. Kuball2, L. te Boome2, E. Vellenga3, G. Huls3, R. Weersma1

1University Medical Centre Groningen, Department of Gastroenterology and Hepatology MDL BB41, Groningen, Netherlands, 2University Medical Centre Utrecht, Haematology, Utrecht, Netherlands, 3University Medical Centre Groningen, Haematology, Groningen, Netherlands

P723

NUDT15 R139C genotype is a determinant of thiopurines-induced leukopenia in Chinese patients with Crohn’s disease

Authors:

X. Zhu1, K. Chao*2, X. Wang1, P. Hu2, M. Huang1, X. Gao2

1Sun Yat-Sen University, School of Pharmaceutical Sciences, Guangzhou, China, 2The Sixth Affiliated Hospital, Sun Yat-sen University, Gastroenterology and Hepatology, Guangzhou, China

P724

Common genetic predisposition between fatigue-related syndromes and inflammatory bowel disease: a systematic review

Authors:

J. Kreijne*, G. Fuhler, C. J. van der Woude, M. Peppelenbosch

Erasmus MC, Gastroenterology and Hepatology, Rotterdam, Netherlands

P725

The common homozygous glutathione S-transferase Mu null genotype leads to higher 6-MMP levels in patients treated with azathioprine but not in those treated with 6-mercaptopurine

Authors:

M. Broekman*1, M. Coenen2, C. van Marrewijk2, G. Wanten1, H. Roelofs1, L. Derijks3, S. Vermeulen2, 4, O. Klungel5, A. Verbeek4, P. Hooymans6, H. Scheffer2, H.-J. Guchelaar7, D. Wong6, D. de Jong1

1Radboud University Medical Centre, Department of Gastroenterology, Nijmegen, Netherlands, 2Radboud University Medical Centre, Department of Human Genetics, Nijmegen, Netherlands, 3Maxima Medical Centre Loc. Veldhoven, Department of Gastroenterology and Hepatology, Veldhoven, Netherlands, 4Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands, 5Utrecht University, Department of Pharmacoepidemiology and Clinical Pharmacotherapy, Utrecht, Netherlands, 6Zuyderland Medical Centre, Department of Clinical Pharmacy, Pharmacology and Toxicology, Sittard, Netherlands, 7Leiden University Medical Centre, Department of Clinical Pharmacy and Toxicology, Leiden, Netherlands

P726

TNFAIP6 is a disease activity marker in inflammatory bowel disease

Authors:

Q. Yu1, S. Zhang1, H. Wang1, S. Ben-Horin1, 2, R. Mao1, Y. Zhang1, T. Feng1, L. Li1, B. Chen1, Y. HE1, M. Chen*1

1The First Affiliated Hospital, Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China, 2Sheba Medical Centre Tel Hashomer & Sackler School of Medicine, Tel-Aviv University, Gastroenterology, Tel-Aviv, Israel

P727

Genome-wide methylation profiling of Crohn’s disease in women

Authors:

N. Duijvis*1, A. Li Yim2, 3, J. Zhao1, W. de Jonge1, A. Mul2, G. D’Haens4, A. te Velde1, P. Henneman2

1Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 2Academic Medical Centre, Department of Clinical Genetics, Amsterdam, Netherlands, 3GlaxoSmithKline, Epinova Epigenetics DPU, Stevenage, United Kingdom, 4Academic Medical Centre (AMC), Department of Gastroenterology, Amsterdam, Netherlands

P728

Inflammation-associated DNA methylation patterns in epithelium of ulcerative colitis

Authors:

A. Barnicle*1, C. Seoighe2, A. Golden3, J. Greally3, L. Egan1

1NUI Galway, Clinical Pharmacology, Galway, Ireland, 2NUI Galway, School of Mathematics, Statistics and Applied Mathematics, Galway, Ireland, 3Albert Einstein College of Medicine, Centre of Epigenomics and Department of Genetics, New York, United States

P729

The clinical relevance of the CD-associated SNP within the gene locus encoding protein tyrosine phosphatase non-receptor type 22 in patients of the Swiss IBD Cohort

Authors:

J. Zeitz*1, M. Spalinger1, L. Biedermann1, J.-B. Rossel2, M. C. Sulz1, 3, S. R. Vavricka1, 4, M. Fried1, 4, G. Rogler1, 4, M. Scharl1, 4

1University Hospital Zurich, Division of Gastroenterology and Hepatology, Zürich, Switzerland, 2Université de Lausanne, Institute of Social and Preventive Medicine, Lausanne, Switzerland, 3Kantonsspital St. Gallen, Division of Gastroenterology and Hepatology, St. Gallen, Switzerland, 4University of Zurich, Zurich Centre for Integrative Human Physiology, Zürich, Switzerland

P730

Circulating microRNA223 is a new biomarker for inflammatory bowel disease

Authors:

H. Wang, S. Zhang, Q. Yu, M. Li, Z. Zeng, Y. He, B. Chen, M. Chen*

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China