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P551

Comparison of 4 assay kits for measuring infliximab trough levels and antibodies to infliximab in patients with inflammatory bowel disease

Authors:

I. Perez1, L. Fernandez2, S. Sanchez-Ramón2, C. Alba3, D. Olivares1, J. L. Mendoza3, E. Rey4, C. Taxonera*1

1Hospital Clínico San Carlos, IBD Unit, Madrid, Spain, 2Hospital Clínico San Carlos, Clinical Immunology, IdiSSC, Madrid, Spain, 3Hospital Clinico San Carlos, IBD Unit, Madrid, Spain, 4Hospital Clinico San Carlos, Gastroenterology, IdiSSC, Madrid, Spain

P552

Development and validation of a tandem liquid chromatographic mass spectrometric assay for the measurement of vedolizumab levels in patient serum

Authors:

C. Christ*1, A. Dignass2, 3, F. Hartmann2, 3, J. Stein3, 4

1Immundiagnostik AG, Bensheim, Germany, 2Agaplesion Markus Krankenhaus, Frankfurt/Main, Germany, 3Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, 4DGD Clinics Sachsenhausen, Frankfurt/Main, Germany

P553

Clinical and surgical recurrences in Crohn’s disease: a 15-year follow-up cohort study from a tertiary centre in Northern Italy

Authors:

L. Campanati*1, G.-E. Nita1, A. Indriolo2, F. Rubertà, E. Poiasina1, P. Ravelli2, L. Ansaloni1

1Papa Giovanni XXIII Hospital, I General Surgery Unit, Bergamo, Italy, 2Papa Giovanni XXIII Hospital, Gastroenterology and Digestive Endoscopy Unit, Bergamo, Italy

P554

A negative screening does not eliminate tuberculosis risk under anti-TNF treatment in inflammatory bowel disease: a descriptive study

Authors:

Y. Abitbol*1, D. Laharie2, J. Cosnes3, M. Allez4, S. Nancey5, A. Amiot6, A. Aubourg7, M. Fumery8, R. Altwegg9, P. Michetti10, E. Chanteloup11, P. Seksik3, V. Abitbol12, C. Baudry4, M. Flamant13, G. Bouguen14, C. Stefanescu15, A. Bourrier3, G. Bommelaer16, N. Dib17, M.A. Bigard18, S. Viennot19, X. Hébuterne20, J.M. Gornet4, P. Marteau21, Y. Bouhnik15, S. Nahon1

1Groupe hospitalier de Montfermeil, Montfermeil, France, 2Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France, 3Hôpital Saint-Antoine, Paris, France, 4Hôpital Saint-Louis, Paris, France, 5Centre Hospitalier Universitaire de Lyon, Lyon, France, 6Centre Hospitalier Universitaire Mondor, Créteil, France, 7Centre Hospitalier Universitaire de Tours, Tours, France, 8Hôpital Nord d’Amiens, Amiens, France, 9Hôpital Saint-Eloi, Montpellier, France, 10La source-Beaulieu, Lausanne, Switzerland, 11Hôpital Saint-Joseph, Paris, France, 12Hopital Cochin, Paris, France, 13Centre Hospitalier Universitaire de Nantes, Nantes, France, 14Centre Hospitalier Universitaire et Régionales Pontchaillou, Rennes, France, 15Hôpital Beaujon, Clichy, France, 16Hôpital Hôtel Dieu, Clermont Ferrand, France, 17Centre Hospitalier Universitaire de Angers, Angers, France, 18Hôpital de Brabois, Nancy, France, 19Hôpital Côte de Nacre, Caen, France, 20Hôpital de l’Archet, Nice, France, 21Hôpital Lariboisière, Paris, France

P555

Failure of infliximab treatment in Crohn’s disease is associated with the presence of fibrosis

Authors:

J. de Bruyn*1, J. Steenkamer2, M. Wildenberg1, S. Meijer3, W. Bemelman4, G. van den Brink1, G. D’Haens1

1Academic Medical Centre, Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Academic Medical Centre, Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 3Academic Medical Centre, Pathology, Amsterdam, Netherlands, 4Academic Medical Centre, Surgery, Amsterdam, Netherlands

P556

Endogenous conversion of ω-6 to ω-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/β-catenin signalling or activating IL-18

Authors:

K. B. Hahm*1, Y. J. Kim2, J.M. Park1

1CHA University, Gastroenterology, Seongnam, South Korea, 2Gachon University, Gastroenterology, Incheon, South Korea

P557

The value of mercaptopurine therapy after failing azathioprine in inflammatory bowel disease patients

Authors:

B. Meijer*1, M. Seinen1, N. Leijte1, C. Mulder1, A. van Bodegraven1, 2, N. de Boer1

1VU University Medical Centre, Gastroenterology and Hepatology, Amsterdam, Netherlands, 2Zuyderland Medical Centre, Internal Medicine, Geriatrics and Gastroenterology, Sittard-Geleen, Netherlands

P558

Long-term scheduled therapy with infliximab in inflammatory bowel disease: a single-centre observational study

Authors:

C. Felice*1, 2, P. M. Ferraro3, M. Marzo1, D. Pugliese1, A. Papa1, G. L. Rapaccini1, L. Guidi1, A. Armuzzi1

1Catholic University of the Sacred Heart, Internal Medicine and Gastroenterology Unit, Complesso Integrato Columbus, Rome, Italy, 2Queen Mary University of London, Centre for Genomics and Child Health, Blizard Institute, London, United Kingdom, 3Catholic University of the Sacred Heart, Nephrology, Complesso Integrato Columbus, Rome, Italy

P559

Awareness of human papilloma virus infection amongst women with inflammatory bowel diseases: results from patients’ survey

Authors:

V. Suchá*1, B. Kadleckova2, B. Repakova2, K. Otottova2, L. Jurgos3, S. Kinova4, Z. Zelinkova2

1Outpatient Department of Gastroenterology, Jurgos s.r.o., Bratislava, Slovakia, 2IBD Centre, Assiduo, Bratislava, Slovakia, 3Outpatient Department of Gastroenterology, Jurgos s.r.o,, Bratislava, Slovakia, 4Faculty of Medicine, Comenius University, First Department of Internal Medicine, Bratislava, Slovakia

P560

Concomitant granulocyte and monocyte adsorption apheresis accelerates clinical efficacy and mucosal healing of colonic lesions in patients with active Crohn’s disease

Authors:

S. Yasukawa*, F. Hirai, Y. Takada, Y. Yano

Fukuoka University Chikushi Hospital, Department of Gastroenterology, Chikushino, Japan

P561

A first-in-human randomised double-blind placebo-controlled clinical trial of a novel narrow spectrum kinase inhibitor

Authors:

A. Rowley1, A. Duggal1, M. Taylor*1, M. Foster1, Y. Solanke1, S. Sirohi1, C. Walshe1, S. Webber1, P. Irving2, S. Travis3

1Topivert Pharma Ltd, London, United Kingdom, 2Guy’s and St Thomas’ NHS Foundation Trust, Department of Gastroenterology, London, United Kingdom, 3Oxford University Hospitals Trust, Translational Gastroenterology Unit, Oxford, United Kingdom

P562

Effectiveness and safety of golimumab in inducing remission in outpatient ulcerative colitis patients: a first ‘real-life’ experience in primary gastroenterology centres in Italy

Authors:

A. Tursi1, L. Allegretta2, N. Della Valle3, Y. Hadad4, A. Penna*5, G. Pranzo6, C. Ricciardelli7, P. Paiano7, M. Picchio8

1Azienda Sanitaria Locale BAT, Servizio di Gastroenterologia Territoriale, Andria, Italy, 2’Santa Caterina Novella’ Hospital, Division of Gastroenterology, Galatina (LE), Italy, 3A.O. ‘Ospedali Riuniti’, Division of Gastroenterology, Foggia, Italy, 4’Card. Panico’ Hospital, Division of Internal Medicine, Tricase (LE), Italy, 5’S. Paolo’ Hospital, Division of Gastroenterology, Bari, Italy, 6’Valle D’Itria’ Hospital, Ambulatory of IBD, Martina Franca (TA), Italy, 7’Veris Delli Ponti’ Hospital, Division of Gastroenterology, Scorrano (LE), Italy, 8’P. Colombo’ Hospital, ASL RMH, Division of Surgery, Velletri (Rome), Italy

P563

Subtotal colectomy for ulcerative colitis: distinct short-term and long-term advantages of the laparoscopic approach

Authors:

N. Buchs*1, A. Bloemendaal2, C. Wood2, N. Mortensen3, R. Guy3, B. George3

1Oxford University Hospitals, Department of Colorectal Surgery, Oxford, United Kingdom, 2OUH, Oxford, United Kingdom, 3Oxford University Hospitals, Oxford, United Kingdom

P564

Ipilimumab-induced colitis: clinical, endoscopic, and histological characteristics

Authors:

S. I. Siakavellas*1, G. Bamias1, I. Delladetsima2, M. Perdiki2, M. Gizis1, G. L. Daikos3, H. Gogas3

1Laikon Hospital, Academic Department of Gastroenterology, Athens, Greece, 2Medical School, First Department of Pathology, Athens, Greece, 3Laikon General Hospital, First Department of Internal Medicine, Athens, Greece

P565

Maintenance of clinical remission in inflammatory bowel disease patients after discontinuation of anti-TNF agents, an Italian experience

Authors:

R. Monterubbianesi*1, F. Furfaro2, G. Costantino3, C. Bezzio2, D. Giannarelli4, W. Fries3, G. Maconi2, A. Kohn1

1AO San Camillo Forlianini, Gastroenterology Operative Unit, Rome, Italy, 2Luigi Sacco University Hospital, Department of Gastroenterology and IBD Unit, Milan, Italy, 3University of Messina, Department of Gastroenterology, Messina, Italy, 4Nuovo Regina Elena Hospital, Biostatistic Unit, Rome, Italy

P566

Are relatives aware of inflammatory bowel disease patients’ worries?

Authors:

L. Fernández-Salazar*, E. Berroa, B. Antolín, J. M. González

Hospital Clínico Universitario, Gastroenterology, Valladolid, Spain

P567

Functional outcomes and factors influencing quality of life in patients with ulcerative colitis after total proctocolectomy with ileal pouch anal anastomosis

Authors:

K. Watanabe*, M. Nagao, T. Abe, H. Karasawa, S. Ohnuma, H. Musha, T. Naitoh, M. Unno

Tohoku University Graduate School of Medicine, Department of Surgery, Sendai, Japan

P568

Health-related quality of life, work productivity, and satisfaction with treatment amongst inflammatory bowel disease patients receiving adalimumab mono- versus adalimumab combo-therapy

Authors:

S. Wang*1, R. Jakubanis2, J. Piercy2, M. Skup1

1AbbVie Inc., North Chicago, Illinois, United States, 2Adelphi Real World, Manchester, United Kingdom

P569

Nutritional status in a cohort of paediatric patients with inflammatory bowel disease at diagnosis

Authors:

N. Egea Castillo*1, G. Pujol2, K. Rosales3, A. Gutierrez4, D. Garcia-Arenas2, V. Vila5, S. Pinillos6, J. Martin de Carpi7

1Hospital Sant Joan de Déu, Gastroenterology, Barcelona, Spain, 2Hospital Sant Joan de Déu, Barcelona, Spain, 3Hospital Sant Joan de Déu, Barcelona, Spain, 4Hospital Sant Joan de Déu, Barcelona, Spain, 5Hospital Sant Joan de Déu, Barcelona, Spain, 6Hospital Sant Joan de Deu, Barcelona, Suriname, 7Hospital Sant Joan de Deu, Barcelona, Spain

P570

More than 10 years of experience of use methotrexate in Crohn’s disease at Macarena Hospital, Sevilla, Spain

Authors:

M. F. Guerra Veloz*1, M. B. Maldonado Pérez1, A. Caunedo Álvarez1, L. Castro Laria1, J. L. Cotrina Lino2, F. Argüelles Arias1, A. Flores Cucho2, M. Romero Gómez2

1Unidad de Gestión Clínica de Aparato Digestivo Hospital Universitario Virgen Macarena, Seville, Spain, 2Hospital Universitario Virgen Macarena, Gastroenterology, Sevilla, Spain