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P531

Inflammatory bowel disease and fatigue: the effect of physical activity and/or omega-3 supplementation

Authors:

A. McNelly1, I. Nathan1, M. Monti2, G. Grimble3, C. Norton*4, F. Bredin5, W. Czuber-Dochan4, S. Berliner6, M. Gay6, M. Darvell6, H. Terry6, A. Forbes7

1UCL, Centre for Gastroenterology and Nutrition, London, United Kingdom, 2UCL Hospitals Foundation Trust, GI Services Division, London, United Kingdom, 3UCL, Institute of Liver and Digestive Health, London, United Kingdom, 4Kings College London, Florence Nightingale Faculty of Nursing & Midwifery, London, United Kingdom, 5Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Gastroenterology, Cambridge, United Kingdom, 6Crohn’s & Colitis UK, St Albans, United Kingdom, 7Norwich Medical School/UEA, Gastroenterology, Norwich, United Kingdom

P532

Effectiveness of balloon dilation using single balloon enteroscopy in multiple small bowel stricture

Authors:

J.-S. Kim*1, Y.-S. Cho2

1Catholic University of Korea, Department of Internal Medicine, Seoul, South Korea, 2Catholic University of Korea, Department of Internal Medicine, Seoul, South Korea

P533

Assessment of 6-thioguanine nucleotide metabolite level in inflammatory bowel disease patients treated with azathioprine

Authors:

K. Pavlovska*1, M. Slaninka Miceska1, P. Mishevska2, J. Tonic Ribarska3, E. Atanasovska1, I. Kikerkov1, L. Efremovska4, M. Petrushevska1

1Medical faculty, Department of preclinical and clinical pharmacology and toxicology, Skopje, Macedonia, the former Yugoslav Republic of, 2Medical faculty, Gastroenterohepatology clinic, Skopje, Macedonia, the former Yugoslav Republic of, 3Faculty of pharmacy, Skopje, Macedonia, the former Yugoslav Republic of, 4Medical faculty, Institute of physiology, Skopje, Macedonia, the former Yugoslav Republic of

P534

Risk factors for infusion reactions of infliximab in patients with Crohn’s disease

Authors:

Y. Inaba*1, M. Taruishi1, M. Fujiya2, Y. Saitoh1

1Asahikawa City Hospital, Gastroenterology, Asahikawa, Japan, 2Asahikawa Medical University, Internal Medicine, Asahikawa, Japan

P535

Major nutritional diagnoses amongst outpatient inflammatory bowel disease patients

Authors:

A. Ferguson*1, C. Rogge2, E. Gruber1, R. Jennings1, M. Carrie1, J. Roberts2, T. Lee2

1Illawarra Shoalhaven Local Health District, Nutrition and Dietetics, Wollongong, Australia, 2Wollongong Hospital, Gastroenterology, Wollongong, Australia

P536

Does Lémann Index reflect the quality of life in Crohn’s disease patients on treatment with biological therapy?

Authors:

G. Pellegatta*1, G. Bodini1, E. Giannini1, C. De Maria1, I. Baldissarro2, V. Savarino2, E. Savarino3

1University of Genoa, Department of Gastroenterology and Internal Medicine, Genoa, Italy, 2University of Genoa, Internal Medicine Department, Genoa, Italy, 3University of Padua, Gastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, Padua, Italy

P537

Weight and body composition compartments do not predict thiopurine metabolite levels

Authors:

D. Holt*1, B. Strauss2, G. Moore1, 2

1Monash Health, Department of Gastroenterology & Hepatology, Clayton, Australia, 2Monash University, School of Clinical Sciences, Melbourne, Australia

P538

Hypophosphataemia after different intravenous iron infusion drugs

Authors:

P. Bager*1, J. Frederik Dahlerup2

1Aarhus University Hospital, Department of Hepatology and Gastroenterology, Aarhus, Denmark, 2Aarhus University Hospital, Department of Hepatology and Gastroenterology, Aarhus, Denmark

P539

Clinical experience with vedolizumab in anti-TNF refractory inflammatory bowel patients

Authors:

B. Christopher*1, O. Aoko2, A. O’Toole3, S. Patchett3, C. Smyth1, S. Sengupta2, R. Farrell1

1Connolly Hospital Blanchardstown, Department of Gastroenterology, Dublin, Ireland, 2Our Lady of Lourdes Hospital, Department of Gastroenterology, Drogheda, Ireland, 3Beaumont Hospital, Department of Gastroenterology, Dublin, Ireland

P540

Efficacy and safety of adalimumab in the treatment of inflammatory bowel disease in children

Authors:

G. De Caro*, C. Madia, F. Gaiani, A. Fugazza, B. Bizzarri, A. Ghiselli, F. Fornaroli, F. Vincenzi, G.L. de’ Angelis

Azienda Ospedaliero Universitaria di Parma, Gastroenterologia ed Endoscopia Digestiva, Parma, Italy

P541

Cyclosporine therapy is effective in acute severe steroid-refractory ulcerative colitis

Authors:

R. Iliaz1, S. Evirgen1, F. Akyuz1, B. Cavus1, B. Pinarbasi2, C. Karaca1, K. Demir1, F. Besisik1, S. Kaymakoglu*1

1Istanbul University, Department of Gastroenterology, Istanbul, Turkey, 2Liv Hospital, Department of Gastroenterology, Istanbul, Turkey

P542

Per oral antiviral treatment with valganciclovir for patients with cytomegalovirus-positive ulcerative colitis in the outpatient setting: report of 5 cases

Authors:

H. Tamaki*, T. Noda, S. Arasawa, M. Izuta, A. Kubo, C. Ogawa, T. Matsunaka, M. Shibatoge

Takamatsu Red Cross Hospital, Gastroenterology, Takamatsu, Japan

P543

Cannabis use patterns in patients with IBD

Authors:

T. Naftali*1, 2, L. Bar Lev Schlieder3, J. Hirsch4, I. Lish5, F. Benjaminov6, F. Konikoff6

1Meir Medical Centre, Gastroenterology, Kfar Saba, Israel, 2Tel Aviv University Sackler School of Medicine, Internal Medicine, Tel Aviv, Israel, 3Bar Ilan University, Behavioural Sciences, Tel Aviv, Israel, 4Meir Medical Centre, Department of Gastroenterology & Hepatology, Kfar Saba, Israel, 5Tel Aviv University Sackler School of Medicine, Internal Medicine, Tel Aviv, Israel, 6Tel Aviv University Sackler School of Medicine, Internal Medicine, Tel Aviv, Israel

P544

Prospective observational study on inflammatory bowel disease patients treated with infliximab biosimilars: preliminary results of the PROSIT-BIO cohort of the IG-IBD

Authors:

G. Fiorino1, N. Manetti*2, A. Variola3, F. Bossa4, G. Rizzuto5, L. Guidi6, G. Maconi7, S. Ghione8, L. Cantoro9, G. Lorenzon10, W. Fries11, M. L. Annunziata12, F. Costa13, M. M. Terpin14, B. Principi15, C. Cortelezzi16, L. Biancone17, A. Amato18, P. Occhipinti19, S. Mazzuoli20, S. Ardizzone21, M. Di Girolamo22, P. Alvisi23, G. Meucci24, L. Caserta25, S. Saibeni26, C. Petruzzellis27, A. Ronchetti28, M. Cappello29, F. Castiglione30, S. Danese1, A. Massella3, D. Varvara4, A. Orlando5, A. Armuzzi6, A. Massari7, P. Lionetti8, A. Kohn9, R. D’Incà10, M. Vecchi12, L. Bertani13, V. Annese on behalf of IG-IBD2, 31

1Humanitas Research Hospital and University, Gastroenterology and IBD Centre, Rozzano, Italy, 2AOU Careggi, DEA, Gastroenterology, Florence, Italy, 3Sacro Cuore Don Calabria Hospital, Gastroenterology and Hepatology, Negrar, Italy, 4IRCCS-CSS Hospital, Gastroenterology, San Giovanni Rotondo, Italy, 5Riuniti Villa Sofia - Cervello Hospital, Internal Medicine 2, Palermo, Italy, 6Complesso Integrato Columbus - Catholic University, Internal Medicine and Gastroenterology, Rome, Italy, 7Luigi Sacco University Hospital, Gastroenterology and IBD Unit, Milan, Italy, 8Meyer Children’s Hospital, Gastroenterology and Nutrition, Florence, Italy, 9S. Camillo-Forlanini Hospital, Gastroenterology, Rome, Italy, 10University of Padova, Gastroenterology, Padova, Italy, 11University of Messina, Gastroenterology, Messina, Italy, 12IRCCS Policlinico, Gastroenterology, San Donato Milanese - MI, Italy, 13AOUP, Gastroenterology, Pisa, Italy, 14AO Hospital, Gastroenterology and Endoscopy, Legnano, Italy, 15University Bari, Gastroenterology, Bari, Italy, 16AOU di Circolo Fondazione Macchi, Gastroenterology, Varese, Italy, 17Tor Vergata, Gastroenterology, Roma, Italy, 18Ospedale Valduce, Gastroenterology, Como, Italy, 19AOU Maggiore, Gastroenterology, Novara, Italy, 20S. Pellegrino Hospital, Gastroenterology, Trani, Italy, 21Fatebenefratelli - Oftalmico Hospital, Gastroenterology, Milano, Italy, 22University Hospital, Gastroenterology, Modena, Italy, 23Maggiore Hospital, Paediatric Department, Bologna, Italy, 24S. Giuseppe Hospital, Gastroenterology, Milano, Italy, 25IRCCS AOU S. Martino-ISTl, Gastroenterology, Genova, Italy, 26AO Hospital, Gastroenterology, Rho, Italy, 27Poliambulanza Hospital, Gastroenterology and Digestive Endoscopy, Brescia, Italy, 28AO Hospital, Internal Medicine, Lecco, Italy, 29University Hospital, Gastroenterology, Palermo, Italy, 30Federico II University, Gastroenterology, Naples, Italy, 31Italian Group for the Study of IBD, IG-IBD, Italy

P545

The effect of total and free anti-drug antibodies on infliximab pharmacokinetics between 2 drug administrations

Authors:

L. Roque Ramos1, R. Barosa1, A. Nunes2, A. Regalado3, A. Vieira1, J. Freitas1, J. Demengeot3, S. Garcês*4

1Hospital Garcia de Orta, Gastroenterology, Almada, Portugal, 2Hospital Garcia de Orta, Department of Gastroenterology, Almada, Portugal, 3Instituto Gulbenkian Ciência, Oeiras, Portugal, 4Hospital Garcia de Orta, Rheumatology, Almada, Portugal

P546

Psychiatric disorder, iron deficiency, active disease and female gender are independent risk factors for fatigue in patients with ulcerative colitis

Authors:

B. Jonefjäll1, 2, M. Simrén1, 3, A. Lasson4, L. Öhman1, 5, H. Strid*1, 4

1Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Department of Internal Medicine and Clinical Nutrition, Gothenburg, Sweden, 2Department of Internal Medicine, Kungälv Hospital, Kungälv, Sweden, 3University of Gothenburg Centre for Person-Centreed Care (GPCC), Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden, 4Department of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden, 5Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Department of Microbiology and Immunology, Gothenburg, Sweden

P547

Effectiveness of patient education in inflammatory bowel disease

Authors:

A. Berding*1, 2, C. Witte1, B. Kaltz1, R. Weiland2, A. Reusch2, H. Faller2

1German Crohn’s and Colitis Association (DCCV e.V.), Berlin, Germany, 2University of Würzburg, Department of Medical Psychology, Medical Sociology and Rehabilitation Sciences, Würzburg, Germany

P548

Anti-TNF monotherapy for Crohn’s disease: a 13-year multicentre experience

Authors:

L. Peyrin-Biroulet1, J. Salleron2, J. Filippi*3, C. Reenaers4, O. Antunes3, V. Filipe1, E. Louis4, X. Hébuterne3, X. Roblin5

1Nancy University Hospital, Université de Lorraine, Nancy 1, Inserm U954 and Department of Gastroenterology, Vandoeuvre-lès-Nancy, France, 2Institut de Cancérologie de Lorraine, Department of biostatistics, Vandoeuvre les Nancy, France, 3Archet 2 Hospital, University of Nice, Gastroenterology and Nutrition Department, Nice, France, 4University of Liège, Gastroenterology Department, Liège, Belgium, 5University hospital of Saint-Etienne, Inserm, CIC1408, Gastroenterology Department, Saint-Etienne, France

P549

Adalimumab improves growth velocity in children with Crohn’s disease naïve to anti-TNF treatment

Authors:

J. Martín-de-Carpi*1, E. Llerena1, M. Navalón-Rubio2, G. Pujol Muncunill1, D. Gil-Ortega2, V. Varea1, C. Sierra-Salinas3, V.M. Navas-López3, 4

1Unit for the Comprehensive Care of Paediatric Inflammatory Bowel Disease, Department of Paediatric Gastroenterology, Hepatology and Nutrition, Barcelona, Spain, 2Pediatric Gastroenterology Unit. Hospital Virgen de la Arrixaca, Murcia, Spain, 3Pediatric Gastroenterology and Nutrition Unit. Hospital Materno Infantil, Málaga, Spain, 4IBIMA, Biomedical Institute of Málaga, Málaga, Spain

P550

Patients’ perceptions about thiopurines are associated with early discontinuation in patients with inflammatory bowel diseases

Authors:

M. Broekman*1, M. Coenen2, O. Klungel3, C. van Marrewijk2, G. Wanten1, L. Derijks4, S. Vermeulen2, 5, D. Wong6, A. Verbeek5, P. Hooymans6, H. Scheffer2, H.-J. Guchelaar7, M. Bouvy3, 8, D. de Jong1

1Radboud University Medical Centre, Department of Gastroenterology, Nijmegen, Netherlands, 2Radboud University Medical Centre, Department of Human Genetics, Nijmegen, Netherlands, 3Utrecht University, Departement of Pharmacoepidemiology and Clinical Pharmacotherapy, Utrecht, Netherlands, 4Maxima Medical Centre Loc. Veldhoven, Department of Gastroenterology and Hepatology, Veldhoven, Netherlands, 5Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, Netherlands, 6Zuyderland Medical Centre, Department of Clinical Pharmacy, Pharmacology and Toxicology, Sittard, Netherlands, 7Leiden University Medical Centre, Department of Clinical Pharmacy and Toxicology, Leiden, Netherlands, 8SIR institute for Pharmacy Practice and Policy, Leiden, Netherlands