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P391

Gender differences in adalimumab continuation rates: Results of a Crohn’s disease cohort

Authors:

M. Lie*, J. Kreijne, J. van der Woude

Erasmus MC, Gastroenterology and Hepatology, Rotterdam, Netherlands

P392

Comparing the accuracy and ease of use of self-administered ‘Malnutrition Universal Screening Tool’ (MUST) to screening by a health care professional using MUST to explore malnutrition rates in an outpatient inflammatory bowel disease clinic

Authors:

S. Zacharopoulou-Otapasidou*1, K. Keetarut1, S. Bloom2, S. McCartney2

1University College London Hospital, Nutrition and Dietetics Department, London, United Kingdom, 2University College London Hospital, Department of Gastroenterology, London, United Kingdom

P393

Investigation of Crohn’s disease patients receiving anti-TNF α therapy after surgery for intestinal stenosis

Authors:

T. Kuriyama*, B. Iizuka, H. Kashiwagi, T. Hara, A. Ito, T. Omori, M. Yonezawa, K. Tokushige

Tokyo Women’s Medical University, Gastroenterology, Tokyo, Japan

P394

Psychosexual dysfunction in a cohort of Greek inflammatory bowel disease patients in clinical remission: preliminary results

Authors:

D. Xanthis*, K. Soufleris, E. Gavalas, P. Anyfanti, G. Chatzinakos, N. Grammatikos, A. Tsimperidis, O. Giouleme

Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Thessaloniki, Greece

P395

Real-life prospective experience with adalimumab in ulcerative colitis in Italy: preliminary results of a pilot study

Authors:

M. Daperno*1, A. Armuzzi2, D. Pugliese2, A. Lavagna1, P. Gionchetti3, F. Rizzello3

1AO Ordine Mauriziano, Gastroenterology Unit, Torino, Italy, 2Complesso Integrato Columbus, Internal Medicine, Roma, Italy, 3AO S. Orsola-Malpighi & University, Internal Medicine, Bologna, Italy

P396

Cyclosporin A efficacy in a paediatric ulcerative colitis: a retrospective single-centre study

Authors:

M. Osiecki*, M. Dadalski, J. Kierkus

The Children’s Memorial Health Institute, Gastroenterology, Hepatology, Feeding Disorders and Paediatrics, Warsaw, Poland

P397

Efficacy and safety of sequential rescue therapy with infliximab and tacrolimus in patients with corticosteroid-refractory ulcerative colitis

Authors:

K. Matsuoka*, E. Saito, T. Fujii, K. Takenaka, F. Iwamoto, M. Kimura, M. Nagahori, K. Ohtsuka, M. Watanabe

Tokyo Medical and Dental University, Department of Gastroenterology and Hepatology, Tokyo, Japan

P398

The costs of care for patients with ulcerative colitis: effect of adalimumab on health care resources utilisation in clinical practice from INSPIRADA

Authors:

S. Travis*1, B. Feagan2, L. Peyrin-Biroulet3, R. Panaccione4, S. Danese5, A. Lazar6, A. Robinson7, J. Petersson7, M. Bereswill6, M. Skup7, N. Chen7, S. Wang7, R. Thakkar7, J. Chao7

1Oxford University Hospitals, Oxford, United Kingdom, 2Robarts Research Institute, Ontario, Canada, 3University Hospital of Nancy, Les Nancy, France, 4University of Calgary, Calgary, Canada, 5Istituto Clinico Humanitas, Milan, Italy, 6AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, 7AbbVie Inc., North Chicago, United States

P399

Testing patients initiating anti-TNFα agents for mycobacterial infection using interferon-gamma release assays (IGRA): The combined experience of a large dermatology and Inflammatory Bowel Disease service

Authors:

S. Rajagopal*1, K. Greveson2, S. McBride3, A. Waite3, M. Lipman4, C. Murray2

1University College London, Medicine, London, United Kingdom, 2Royal Free Hospital, Centre for Gastroenterology, London, United Kingdom, 3Royal Free Hospital, Centre for Dermatology, London, United Kingdom, 4Royal Free Hospital, Respiratory Medicine, London, United Kingdom

P400

Anti-TNF treatment for extraintestinal manifestations of inflammatory bowel disease in the Swiss IBD Cohort Study

Authors:

T. Greuter*1, L. Biedermann1, G. Rogler1, E. Safroneeva2, A. Schoepfer3, S. Vavricka1, 4

1University Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland, 2University of Bern, Institute of Social and Preventive Medicine, Bern, Switzerland, 3University Hospital Lausanne - CHUV, Division of Gastroenterology and Hepatology, Lausanne, Switzerland, 4Triemli Hospital Zurich, Division of Gastroenterology and Hepatology, Zurich, Switzerland

P401

Confocal laser endomicroscopy predicts response in patients with acute inflammatory bowel disease undergoing anti-integrin therapy with vedolizumab

Authors:

M. Ellrichmann*1, J. Bethge1, G. Aust1, A. Arlt1, B. Brandt1, S. Zeissig1, 2, S. Nikolaus1, K. Aden1, S. Schreiber1

1University Hospital Schleswig-Holstein, Campus Kiel, Medical Department I, Kiel, Germany, 2University Hospital Dresden, Department of Gastroenterology, Dresden, Germany

P402

A novel high-dose mesalazine tablet is as effective as conventional low-dose mesalazine tablets in inducing remission in patients with mildly to moderately active ulcerative colitis (UC): A double-blind, double-dummy, multicentre, randomised trial

Authors:

A. Dignaß*1, R. Schnabel2, J. Romatowski3, V. Pavlenko4, A. Dorofeyev5, J. Derova6, L. Jonaitis7, T. Nacak8, R. Greinwald8

1Agaplesion Markus Krankenhaus, Dept. of Medicine I, Frankfurt a.M., Germany, 2Pannónia Magánorvosi Centrum Kft, Budapest, Hungary, 3Gastromed sc, Bialystok, Poland, 4Stavropol State Medical University, Stavropol, Russian Federation, 5Regional Bowel Diseases Centre of Donetsk State Medical University, Donetsk, Ukraine, 6Latvian Maritime Medical Centre, Riga, Latvia, 7Lithuanian University of Health Sciences, Dept. of Gastroenterology, Kaunas, Lithuania, 8Dr. Falk Pharma GmbH, Clinical Research, Freiburg, Germany

P403

Combined therapy with anti-TNF and immunomodulator is superior to monotherapy for postoperative prophylaxis in Crohn’s disease after intestinal resection: a retrospective analysis from a tertiary centre

Authors:

A. O’Connor*1, J. Taylor1, N. Scott2, C. Selinger1, J. Hamlin1, A. Ford1, 3

1Leeds Gastroenterology Institute, Leeds, United Kingdom, 2St James’s University Hospital, Histopathology, Leeds, United Kingdom, 3University of Leeds, Leeds Institute of Biochemical and Clinical Sciences, Leeds, United Kingdom

P404

Real-life experience with golimumab in ulcerative colitis patients according to prior anti-TNF use

Authors:

C. Taxonera*1, F. Bertoletti2, C. Rodriguez3, I. Marin4, J. Arribas5, P. Martinez-Montiel6, M. Sierra7, L. Arias8, M. Rivero9, A. Juan10, E. Iglesias11, N. Manceñido12, J.L. Perez-Calle13, A. Algaba14, M. Barreiro-de Acosta15, A. Gutierrez16, F. Argüelles17, D. Busquets18, M. Chaparro19, C. Alba1, D. Olivares1, M. Calvo20, J.P. Gisbert19

1Hospital Clinico San Carlos, IBD Unit, Madrid, Spain, 2Hospital Santa Creu i Sant Pau, Barcelona, Spain, 3Hospital de Navarra A, Department of Gastroenterology, Pamplona, Spain, 4Hospital Gregorio Marañón, Madrid, Spain, 5Hospital Ramón y Cajal, Department of Gastroenterology, Madrid, Spain, 6University Hospital 12 De Octubre, Department of Gastroenterology, Madrid, Spain, 7Hospital de León, Gastroenterology, León, Spain, 8Hospital de Burgos, Burgos, Spain, 9University Hospital Marques de Valdecilla - HUMV, Department of Gastroenterology, Santander, Spain, 10Hospital Germans Trias i Pujol, Barcelona, Spain, 11Hospital Reina Sofía, Gastroenterology, Córdoba, Spain, 12Hospital Infanta Sofía, Gastroenterology, Madrid, Spain, 13Hospital Universitario Fundación Alcorcón, Gastroenterology, Madrid, Spain, 14Hospital de Fuenlabrada, Gastroenterology, Madrid, Spain, 15Hospital Clínico de Santiago, Gastroenterology, Santiago de Compostela, Spain, 16Hospital Universitario de Alicante, Alicante, Spain, 17Hospital Universitario Virgen Macarena, Sevilla, Spain, 18Hospital Universitari Dr Trueta, Girona, Spain, 19Hospital La Princesa, IP and CIBERehd, Gastroenterology, Madrid, Spain, 20Hospital Puerta de Hierro, Gastroenterology, Madrid, Spain

P405

Infliximab trough level measured during treatment induction may be predictive of the loss of response to Infliximab during treatment maintenance in inflammatory bowel disease patients: a longitudinal observational retrospective study

Authors:

C. Liefferinckx*1, C. Minsart2, A. Cremer1, L. Amininejad1, J.-F. Toubeau3, E. Quertinmont2, J. Deviere1, A. Van Gossum1, D. Franchimont1

1Erasme Hospital, Gastro-enterology, Brussels, Belgium, 2Université libre de Bruxelles, Laboratory of Experimental Gastroenterology, Brussels, Belgium, 3Université de Mons, Department of Electrical Engineering, Mons, Belgium

P406

AlphaE+ cells have increased expression of inflammatory markers and are correlated in the ileum and colon

Authors:

R. Ichikawa1, J. Eastham-Anderson1, A. Scherl1, J. Hackney1, L. Orozco1, W. Faubian2, J. Mansfield3, 4, J. Kirby3, C. Lamb3, 5, M. Keir*1

1Genentech, Inc, a member of the Roche Group, South San Francisco, California, United States, 2Mayo Clinic, Division of Gastroenterology & Hepatology, Rochester, Minnesota, United States, 3Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, 4Institute of Genetic Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom, 5Department of Gastroenterology, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, United Kingdom

P407

Clinical manifestations of thiopurine S-methyltransferase variants in Korean paediatric patients with inflammatory bowel disease

Authors:

M. Kim*

Inje University College of Medicine, Ilsan Paik Hospital, Paediatrics, Goyang-si, Gyeonggi-do, South Korea

P408

Are pharmacokinetics more unfavourable in inflammatory bowel disease patients aged over 60 years?

Authors:

L. Rinaldi1, N. Williet*2, E. Del tedesco2, c. Jarlot3, J. M. Phelip2, s. Paul4, X. Roblin3

1Gastroenterology, Saint Etienne, France, 2CHU Saint Etienne, Saint Etienne, France, 3University Hospital, Gastroenterology, Saint Etienne, France, 4University of Saint Etienne, Immunology, Saint Etienne, France

P409

Impact of biological therapy in postoperative morbidity in elective surgical resections in Crohn’s disease

Authors:

P. G. Kotze*1, M. P. Saab1, B. Saab1, L. M. S. Kotze1, M. Olandoski2, L. V. Pinheiro3, C. A. R. Martinez3, M. L. S. Ayrizono3, D. O. Magro3, C. S. R. Coy3

1Catholic University of Paraná, Colorectal Surgery Unit - Cajuru University Hospital, Curitiba, Brazil, 2Catholic University of Parana, Department of Statistics, Curitiba, Brazil, 3Campinas State University (UNICAMP), Colorectal Surgery department, Campinas, Brazil

P410

Segmental endoscopic scoring improves outcome prediction in acute severe colitis

Authors:

S. Raimundo Fernandes*, P. Santos, C. Moura, P. Marques da Costa, J. Rita Carvalho, C. Baldaia, A. Valente, A. Rita Gonçalves, P. Moura Santos, L. Correia, J. Velosa

Centro Hospitalar Lisboa Norte, Gastrenterology, Lisbon, Portugal