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Genome-wide DNA methylation changes in Ulcerative Colitis patients
T.O. Kim1, J.M. Yi2, S.B. Park*3
1University College of Medicine, Haeundae Paik Hospital, Internal Medicine, Busan, South Korea, 2Dongnam Institute of Radiological & Medical Sciences (DIRAMS), Research Center, Busan, South Korea, 3Pusan National University Yangsan Hospital, Internal Medicine, Yangsan, South Korea
S. Kaymakoglu1, A. Ormeci1, O. Mutluay Soyer1, B. Baran1, S. Gokturk1, S. Evirgen1, F. Akyüz1, C. Karaca1, K. Demir1, F. Besisik1, N. Gürel polat2, 1Istanbul university, Gastroenterology, Istanbul, Turkey, 2Istanbul university, Microbiology, Istanbul, Turkey
RNA sequencing shows transcriptomic changes in affected and unaffected mucosa of Crohn's disease patients compared to normal colonic mucosa of healthy controls.
S.N. Hong*1, J.S. Koo2, S.J. Park3, J.P. Im4, Y.S. Kim5, J.W. Kim4, Y.-H. Kim1
1Samsung Medical Center, Sungkyunkwan University School of Medicine, Medicine, Seoul, South Korea, 2Korea University College of Medicine, Internal Medicine, Ansan, Korea, Republic of, 3Yonsei University, Yonsei university school of medicine, Seoul, Korea, Republic of, 4Seoul National University College of Medicine, Internal Medicine, Seoul, Korea, Republic of, 5Inje University College of Medicine, Internal Medicine, Seoul, Korea, Republic of
N.A. Kennedy1, A.W. Walker2, UK IBD Microbiota Consortium3, UK IBD Genetics Consortium3, S.H. Berry4, S.H. Duncan5, F. Farquarson5, P. Louis5, J. Satsangi1, H.J. Flint5, C.W. Lees1, G.L. Hold4, 1Western General Hospital, Gastointestinal Unit, Molecular Medicine Centre, Edinburgh, United Kingdom, 2Wellcome Trust Sanger Institute, Pathogen genomics, United Kingdom, 3, United Kingdom, 4Aberdeen University, Gastrointestinal Research Group, Division of Applied Medicine, Aberdeen, United Kingdom, 5Aberdeen University, Rowett Institute of Nutrition and Health, Aberdeen, United Kingdom
Identification of 10 regions associated with IBD in a non- Caucasian Moroccan Population
L. Amininejad*1, M. Elansary2, I. Hama3, I. Ratbi3, V. Muls4, M. Talib5, P. Closset6, M. Van Gossum4, I. Errabih7, E. Théâtre2, B. Charloteaux2, Y. Momozawa2, E. Quertinmont1, V. Wambacq1, L. Karim2, N. Cambisano2, N. Ahariz2, H. Ouazzani7, E. Louis8, M. Abramowicz9, J. Devière1, A. Van Gossum1, A. Sefiani3, W. Coppieters2, M. Georges2, D. Franchimont1
1Erasme Hospital, Université Libre de Bruxelles, Department of Gastroenterology, Hepatopancreatology and Digestive Oncology and Laboratory of Experimental Gastroenterology, Brussels, Belgium, 2Groupe Interdisciplinaire de génoprotéomique Appliquée (GIGA-R) and Faculty of veterinary medicine, University of Liège (B34), Unit of Animal Genomic, Liège, Belgium, 3Faculté de médecine et de pharmacie, Université de Mohammed V, Centre de Génomique humaine, Rabat, Morocco, 4Saint Pierre Hospital, Department of Gastroenterology, Brussels, Belgium, 5Brugmann Hospital, Department of Gastroenterology, Brussels, Belgium, 6Ixelles Hospital, Department of Gastroenterology, Brussels, Belgium, 7Avicenne Hospital, Department of Medecine B, Rabat, Morocco, 8Sart Tilman Hospital, University of Liège (B34), Department of Gastroenterology, Liège, Belgium, 9Erasme Hospital, Université Libre de Bruxelles, Department of Human Genetics, Brussels, Belgium
Metallothioneins are downregulated in ileal mucosa of familial diarrhea syndrome patients susceptible to Crohn's disease.
R.R. Tronstad*1, 2, H.-R. Brattbakk1, C. Stansberg1, K. Hanevik1, K.D.-C. Pham3, E. Ellinghaus4, K. Ersland1, H.L. von Volkmann5, S.F. Jørgensen6, 7, O.H. Gilja8, 9, N. Hovdenak3, T. Hausken3, 5, M.H. Vatn10, 11, A. Franke4, P.M. Knappskog1, 12, T.H. Karlsen7, 13, 14, S. Le Hellard15, 16, 17, T. Fiskerstrand1, 18
1University of Bergen, Department of Clinical Science, Bergen, Norway, 2Haukeland University Hospital, Department of Pediatrics, Bergen, Norway, 3Haukeland University Hospital, Department of Medicine, Bergen, Norway, 4Christian Albrechts University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany, 5University of Bergen, Department of Clinical Medicine, Bergen, Norway, 6Oslo University Hospital Rikshospitalet, Research Institute of Internal Medicine Department of Transplantation Medicine,, Division of Cancer medicine,Surgery and Transplantation, Oslo, Norway, 7University of Oslo, K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, Oslo, Norway, 8University of Bergen, Deartment of Clinical Medicine, Bergen, Norway, 9Haukeland University Hospital, National Centre for Ultrasound in Gastroenterology,Department of Medicine, Bergen, Norway, 10University of Oslo, Department of Clinical Molecular Biology and Laboratory Sciences (EpiGen), Division of Medicine, Akershus University Hospital, Oslo, Norway, 11Oslo University Hospital, Rikshospitalet, Medical Clinic, Oslo, Norway, 12Haukeland University Hospital, Centre for Medical Genetics and Molecular Medicine, Bergen, Norway, 13Oslo University Hospital Rikshospitalet, Research Institute of Internal Medicine Department of Transplantation Medicine,, Division of Cancer medicine,Surgery and Transplantation, Oslo, Norway, 14Oslo University Hospital, Rikshospitalet, Norwegian PSC Research Center, Department of Transplantation Medicine,, Division of Cancer medicine,Surgery and Transplantation, Oslo, Norway, 15University of Bergen, K. G. Jebsen Centre for Psychosis Research,Department of Clinical Science, Bergen, Norway, 16Haukeland University Hospital, Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine , Bergen, Norway, 17University of Bergen, NORMENT,Department of Clinical Science , Bergen, Norway, 18Haukeland University Hospital, Centre for Medical Genetics and Molecular Medicine, Bergen , Norway
Gene expression of AKAP12 in the colonic mucosa is a marker associated with disease extension in patients with Ulcerative Colitis
J. Yamamoto-Furusho*, G. Fonseca-Camarillo
IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico
What causes recurrence of Crohn's Disease after intestinal resection? A prospective evaluation of microbiota, smoking and anti-TNF therapy. Results from the POCER study
E. Wright*1, M. Kamm1, 2, J. Wagner3, S.M. Teo4, P. De Cruz1, A. Hamilton1, K. Ritchie1, M. Inouye4, C. Kirkwood3
1St Vincent's Hospital & University of Melbourne, Gastroenterology, Melbourne, Australia, 2Imperial College London, Medicine, London, United Kingdom, 3Murdoch Children's Research Institute, Enteric Virus Group, Melbourne, Australia, 4The University of Melbourne, Pathology, Melbourne, Australia
Association between genotypes of Bacteroidetes in fecal samples from patients with Crohn’s disease and its assessment using an experimental mouse model
R. Sueiro1, A.P. De Felipe1, L. Urisarri2, R. Ferreiro2, A. Lorenzo2, J.E. Dominguez-Munoz2, J.M. Leiro1, M. Barreiro-de Acosta*2
1University of Santiago de Compostela, Department of Microbiology and Parasitology, Institute of Food Research and Analysis, Santiago, Spain, 2University Hospital Santiago de Compostela, Gastroenterology, Santiago, Spain
Microbiota dynamics in paediatric Crohn's disease from active disease upon achieving clinical remission
T. de Meij*1, E. de Groot2, M. Benninga3, D. Budding4, N. de Boer2, A. van Bodegraven2, P. Savelkoul5
1VU university medical center, paediatric gastroenterology, amsterdam, Netherlands, 2VU University Medical Centre, Gastroenterology and Hepatology, Amsterdam, Netherlands, 3Academic medical centre , paediatric gastroenterology, amsterdam, Netherlands, 4VU university medical center, Medical Microbiology and infection control, Amsterdam, Netherlands, 5VU University Medical Centre, Medical Microbiology and Infection control, Amsterdam, Netherlands
Metabolic dysbiosis concept and its biomarkers in ulcerative colitis and celiac disease
S. Sitkin*1, 2, T. Vakhitov1, E. Tkachenko2, L. Oreshko2, T. Zhigalova2
1State Research Institute of Highly Pure Biopreparations, Dept. of Applied Microbiology, St. Petersburg, Russian Federation, 2North-Western State Medical University named after I.I. Mechnikov, Dept. of Propaedeutics of Internal Diseases, St. Petersburg, Russian Federation
Rapid identification of Bacteroidetes in biopsies of inflammatory bowel disease (IBD) patients.
R. Sueiro1, A.P. De Felipe1, L. Urisarri2, R. Ferreiro2, A. Lorenzo2, J.E. Dominguez-Munoz2, J.M. Leiro1, M. Barreiro-de Acosta*2
1University of Santiago de Compostela, Department of Microbiology and Parasitology, Institute of Food Research and Analysis, Santiago, Spain, 2University Hospital Santiago de Compostela, Gastroenterology, Santiago, Spain
Clinical remission induced by exclusive enteral nutrition (EEN) in pediatric Crohn's disease is associated with microbiome metabolic changes toward altered xenobiotic biodegradation and metabolism
J. Connors1, K.A. Dunn2, J.P. Bielawski2, A. Stadnyk3, N. Thomas4, A.R. Otley1, J. Van Limbergen*1, 4
1IWK Health Centre - Dalhousie University, Pediatric Gastroenterology & Nutrition, Halifax, Canada, 2Dalhousie University, Biology, Halifax, Canada, 3Dalhousie, Microbiology & Immunology, Halifax, Canada, 4Dalhousie University, Microbiology & Immunology, Halifax, Canada
Intestinal microbial signature predicts postoperative Crohn's disease recurrence following ileocaecal resection with ileocolonic anastomosis
K. Machiels*1, W. Vanhove1, J. Sabino1, M. Joossens2, 3, 4, I. Arijs1, I. Terrasson5, V. Ballet1, G. Van Assche1, J. Verhaegen6, A. Wolthuis5, A. de Buck van Overstraeten5, A. D'Hoore5, M. Ferrante1, P. Rutgeerts1, S. Vermeire1
1University Hospitals Leuven, KU Leuven, Translational Research Center for Gastrointestinal Disorders (TARGID), Leuven, Belgium, 2VUB, Department of Microbiology, Brussels, Belgium, 3KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, 4VIB, Center for the Biology of Disease, Leuven, Belgium, 5University Hospitals Leuven, Department of Abdominal Surgery, Leuven, Belgium, 6KU Leuven, Department of Clinical Microbiology, Leuven, Belgium
Assessment of community structure and predictive functional profiling of the mucosa-associated microbiome implicates alterations in benzoate metabolism in 'de novo' IBD after pouch-surgery and in treatment-naïve pediatric IBD
J. Connors1, R. Hansen2, K.A. Dunn3, M.G. Langille4, R.K. Russell2, A.R. Otley1, B. MacIntyre1, E. El-Omar5, J.P. Bielawski3, G.L. Hold5, J. Van Limbergen*1, 6
1IWK Health Centre - Dalhousie University, Pediatric Gastroenterology & Nutrition, Halifax, Canada, 2Yorkhill Hospital, Pediatric Gastroenterology & Nutrition, Glasgow, United Kingdom, 3Dalhousie University, Biology, Halifax, Canada, 4Dalhousie University, Pharmacology, Halifax, Canada, 5University of Aberdeen, Gastrointestinal Research Group, Division of Applied Medicine, Aberdeen, United Kingdom, 6Dalhousie University, Microbiology & Immunology, Halifax, Canada
Enterohepatic helicobacter species as a potentially causative factor of Inflammatory Bowel Disease: A meta-analysis
Q. Yu*, S. Zhang, L. Li, L. Xiong, K. Chao, B. Zhong, M. Chen
The First Affiliated Hospital of Sun Yat-Sen University, Gastroenterology, Guangzhou, China
C.difficile colonisation and infection rates are now low in IBD - a matched cohort study
N. Joshi*1, R. Crowson1, D. Ball2, D. Rampton1
1Queen Mary, University of London, Blizard Institute, Centre for Digestive Diseases, London, United Kingdom, 2Barts Health NHS Trust, Medical Microbiology, London, United Kingdom
Diagnostic yield of colonoscopic images and biopsy Results by tuberculosis culture (solid and liquid) in patients with intestinal ulceration
M. Basaranoglu*1, 2, O. Coskun3, M. Yuksel3, M. Kaplan2, A. Aksoy2, N. Ucarman4, N. Turhan5, A. Arslantürk4
1Bezmialem University, Gastroenterology, Istanbul, Turkey, 2Türkiye Yuksek Ihtisas Hospital, Gastroenterology, Ankara, Turkey, 3Türkiye Yüksek Ihtisas, Gastroenterology, Ankara, Turkey, 4Türkiye Halk Sagligi, Hifzisihha Instute, Microbiology, Ankara, Turkey, 5Türkiye Yuksek Ihtisas Hospital, Pathology, Ankara, Turkey
Metronidazol verus rifaximin in the treatment of Clostridium difficile infection in inflammatory bowel disease children: a randomized study.
A. Gawronska1, D. Lachowicz2, P. Obuch-Woszczatynski2, I. Lazowska-Przeorek1, K. Karolewska-Bochenek1, M. Kotowska1, H. Pituch2, P. Albrecht*1, A. Banaszkiewicz1
1Medical University of Warsaw, Dept. of Pediatric Gastroenterology and Nutrition, Warsaw, Poland, 2Medical University of Warsaw, Department of Medical Microbiology, Warsaw, Poland
Anti-TNF-a induction regimen modulates gut microbiota molecular composition while inducing clinical response in Crohn's Disease patients: Toward a personalised medicine
F. Scaldaferri*1, V. Gerardi1, S. Pecere1, V. Petito1, L. Lopetuso1, D. Zambrano1, E. Schiavoni1, D. D'Ambrosio1, A. D'Agostino1, L. Laterza1, F. Paroni Sterbini2, F. Franceschi1, E. Gaetani1, G. Cammarota1, M. Sanguinetti2, L. Masucci2, A. Gasbarrini1
1Catholic University of Sacred Heart, Internal Medicine Department, Gastroenterology division, Rome, Italy, 2Catholic University of Sacred Heart, Microbiology, Rome, Italy