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P683

C.difficile colonisation or infection does not appear to increase the risk of a diagnosis of IBD in the subsequent 2 years

Authors:

N. Joshi*1, R. Crowson1, D. Ball2, D. Rampton1

1Queen Mary, University of London, Blizard Institute, Centre for Digestive Diseases, London, United Kingdom, 2Barts Health NHS Trust, Medical Microbiology, London, United Kingdom

P684. Endoplasmic reticulum aminopeptidase 1 is a promising candidate gene for inflammatory bowel disease
Authors:

D. Laukens1, H. Peeters1, P. Hindryckx1, M. De Vos1, 1Ghent University, Department of Gastroenterology, Gent, Belgium

P684

Patient clinical characteristics at diagnosis of Ulcerative Colitis

Authors:

I. Marin-Jimenez*1, C. Saro2, V. Díaz3, A. Gutierrez4, N. Borruel5, M. Gómez-García6, M. Barreiro-de Acosta7

1Hospital General Universitario Gregorio Marañón, Digestive Medicine- Gastroenterology section, Madrid, Spain, 2Hospital de Cabueñes, Digestive Department, Gijon, Spain, 3AbbVie Farmacéutica S.L.U., Inmunology, Madrid, Spain, 4Hospital General Universitario, Digestive Medicine Department, Alicante, Spain, 5Hospital Universitario Vall d´Hebrón, Gastroenterology, Barcelona, Spain, 6Hospital Universitario Virgen de las Nieves, Digestive Department, Granada, Spain, 7Hospital Clínico Universitario, Gastroenterology- Inflammatory Bowel Disease Unit, Santiago de Compostela, Spain

P685. Ulcerative colitis risk loci in Lithuanian-Latvian case control sample – a replication study
Authors:

J. Skieceviciene1, L. Kupcinskas1, L. Jonaitis1, A. Zvirbliene1, G. Denapiene2, J. Valantinas2, M. Leja3, A. Derovs4, G. Kiudelis1, S. Schreiber5, A. Franke5, 1Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania, 2Vilnius University, Center of Hepatology, Gastroenterology and Dietetics, Vilnius, Lithuania, 3University of Latvia, Institute of Oncology, Riga, Latvia, 4Riga Stradins University, 5Internal Disease Department, Riga, Latvia, 5Christian-Albrechts-University, Institute of Clinical Molecular Biology, Kiel, Germany

P685

Characteristics of non-responders to self-reported questionnaires in a large Inflammatory Bowel Disease cohort study

Authors:

E. Multone1, J.-P. Vader1, C. Mottet2, A. Schoepfer3, N. Fournier1, B. Burnand1, P. Michetti4, V. Pittet*1

1Institute of Social and Preventive Medicine, Healthcare Evaluation Unit, Lausanne, Switzerland, 2Hôpital Neuchâtelois, Service of Gastroenterology, Neuchâtel, Switzerland, 3Lausanne University Hospital, Department of Gastroenterology & Hepatology, Lausanne, Switzerland, 4Clinique La Source-Beaulieu, Crohn and Colitis Center, Lausanne, Switzerland

P686. Thiopurine methyltransferase polymorphism in Lithuanian inflammatory bowel disease patients
Authors:

J. Kupcinskas1, R. Steponaitiene1, G. Kiudelis1, G. Denapiene2, J. Valantinas2, L. Jonaitis1, L. Kupcinskas1, J. Skieceviciene1, 1Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania, 2Vilnius University, Center of Hepatology, Gastroenterology and Dietetics, Vilnius, Lithuania

P686

Clostridium difficile infection in inflammatory bowel disease and non-inflammatory bowel disease patients

Authors:

O. Stoica1, C. Stanciu2, C. Cojocariu1, A.-M. Singeap1, I. Girleanu1, R. Maxim1, A. Trifan*1

1University of Medicine and Pharmacy "Gr. T Popa ", Iasi, Institute of Gastroenterology and Hepatology, Iasi, Romania, 2Institute of Gastroenterology and Hepatology, Bd. Independentei, no. 1, Gastroenterology and Hepatology, Iasi, Romania

P687. Genetic associations with high-grade dysplasia and colorectal cancer in patients with colonic inflammatory bowel disease: preliminary results from ImmunoChip using a targeted analytic approach
Authors:

M. Waterman1, J. Knight2, J. Stempak3, K. Krishnaprasad4, I. Cleynen5, S. Vermeire6, P. Schumm7, D. McGovern8, S. Brant9, G. Radford-Smith10, M. Silverberg11, 1Rambam Health Care Campus, Department of Gastroenterology, Haifa, Israel, 2Neuroscience Research, Toronto, Canada, 3Mount Sinai Hospital, Toronto, Canada, 4Australia and New Zealand Inflammatory Bowel Disease Consortium, Australia, 5Katholieke Universiteit Leuven, Department of Clinical and Experimental Medicine, Leuven, Belgium, 6Department of Gastroenterology, University hospitals Leuven, Belgium, 7University of Chicago, United States, 8Cedars Sinai Hospital, University of California, Los Angeles, United States, 9The Johns Hopkins Hospital Division of Gastroenterology, the Meyerhoff Inflammatory Bowel Disease Center, Baltimore, United States, 10Inflammatory Bowel Diseases Research Group, Queensland Institute of Medical Research, Brisbane, Australia, 11Mount Sinai Hospital, University of Toronto, Toronto, Canada

P687

Work disability in IBD: prevalence, severity and predictive factors.

Authors:

R.-R. Huascar A.*1, C. Xavier2, S. Beatriz3, V. Mercedes4, F. Ariadna5, G. Fernando6

1Universitary Hospital of Burgos, Gastroenterology and hepatology, Burgos, Spain, 2Corporació sanitaria universitaria Parc Taulí, Servei aparell digestiu, Sabadel, Spain, 3Hospital Universitary of Burgos, Gastroenterology and Hepatology, Burgos, Spain, 4InstituTO de Salud Carlos III, Gastroenterology, Madrid, Spain, 5Fundación Universitaria de Bages, Gastroenterology, Barcelona, Spain, 6Hospital clínico universitario de Zaragoza, Gastroenterologia, Zaragoza, Spain

P688. Associations between host transcription and the intestinal microbiome
Authors:

B. Kabakchiev1, A. Tyler1, J. Stempak1, M. Silverberg2, 1Mount Sinai Hospital, SLRI, Toronto, Canada, 2Mount Sinai Hospital, Gastroenterology, Toronto, Canada

P688

The SOLE Survey: Disease related concerns of a large cohort of Italian patients with active Crohn's Disease

Authors:

A. Armuzzi*1, G. Riegler2, F. Furfaro3, M. Baldoni4, F. Costa5, M. Fortuna6, M. Vecchi7, G. Iaquinto8, P. Paese9, C. Papi10, F. Bossa11, V. Tornatore12, F. Rizzello13

1Complesso Integrato Columbus, Università Cattolica del Sacro Cuore, IBD Unit, Roma, Italy, 2Seconda Università di Napoli, Gastroenterology, Napoli, Italy, 3Ospedale Universitario L. Sacco, Gastroenterology, Milano, Italy, 4Università di Perugia, Gastroenterology, Perugia, Italy, 5Azienda Ospedaliero-Universitaria Pisana, Gastroenterology, Pisa, Italy, 6Ospedale Sacro Cuore Don Calabria, Gastroenterology, Negrar-Verona, Italy, 7Irccs Policlinico San Donato, Gastroenterology, Milano, Italy, 8Azienda Ospedaliera San Giuseppe Moscati, Gastroenterology, Avellino, Italy, 9Azienda Ospedaliera di Cosenza, Gastroenterology, Cosenza, Italy, 10Azienda Ospedaliera San Filippo Neri, Gastroenterology, Roma, Italy, 11Ospedale Casa Sollievo della Sofferenza, Gastroenterology, San Giovanni Rotondo, Italy, 12AbbVie srl, Medical Affairs, Campoverde, Italy, 13Policlinico S. Orsola-Malpighi, Gastroenterology, Bologna, Italy

P689. Iron supplemented diet protects against chronic immune mediated colitis in mice
Authors:

N. Maharshak1, M. Ellermann1, R. Gharaibeh2, W. Sha2, E. Perez-Chanona3, K. Whitehead1, C. Jobin1, A. Fodor2, S.E. Plevy1, R.B. Sartor1, 1University of North Carolina, Department of Immunology and Microbiology, Chapel Hill, United States, 2University of North Carolina, Department of Bioinformatics and Genomics, Charlotte, United States, 3University of North Carolina, Department of Pharmacology, Chapel Hill, United States

P689

Inflammatory Bowel Disease and psychological status: Determinants and social consequences

Authors:

P. Bertomoro*, M. G. Vettorato, F. Simonetti, L. Dall’angelo, G. Brogiato, A. Rigo, R. D’Incà, G. C. Sturniolo

Policlinico Universitario di Padova, Gastroenterologia, Padova, Italy

P690. Determination of the discriminant score of intestinal microbiota as a biomarker of disease activity in patients with ulcerative colitis
Authors:

K. Fukuda1, Y. Fujita1, 1St. Luke's international hospital, Gastroenterology, Tokyo, Japan

P690

Current views and concerns of European UC patients based on an online survey

Authors:

R. Hofmann*1, X. Guillaume2

1Tillotts Pharma, Medical Affairs, Rheinfelden, Switzerland, 2Kantar Health , Research, Montrouge, France

P691. New test for profiling of the gut microbiota in non-IBD and IBD patients
Authors:

H. Vebø1, C. Casen1, D. Vangen1, F.T. Hegge1, G. Perminov2, P. Ricanec3, M.H. Vatn4, 1Genetic Analysis AS, Oslo, Norway, 2Oslo University Hospital, Department of pediatrics, Oslo, Norway, 3Oslo University Hospital, Department of Gastroenterology, Oslo, Norway, 4Oslo University Hospital, Department of Medicine, Oslo, Norway

P691

Budget impact analysis of introducing biosimilar infliximab for the treatment of gastro intestinal disorders in five European countries

Authors:

A. Jha*1, W. Dunlop1, A. Upton2

1Mundipharma International Ltd., Market Access, Cambridge, United Kingdom, 2Abacus International, Health Economics and Outcomes Research, Bicester, United Kingdom

P692. Quorum sensing driven by N-acyl-homoserine lactone in inflammatory bowel diseases associated dysbiosis
Authors:

C. Landman1, A. Besse1, M.-A. Maubert1, L. Brot1, L. Humbert1, J. Cosnes2, L. Beaugerie2, G. Trugnan1, H. Sokol1, D. Rainteau1, Q. Elodie1, P. Seksik1, 1St Antoine Hospital, Inserm Erl U 1057, UMR 7203, Paris, France, 2St Antoine Hospital, Gastroenterology, Paris, France

P692

Therapeutic management of Ulcerative Colitis at gastroenterology units in Spain

Authors:

I. Marin-Jimenez*1, C. Saro2, V. Díaz3, A. Gutierrez4, N. Borruel5, M. Gómez-García6, M. Barreiro-de Acosta7

1Hospital General Universitario Gregorio Marañón, Digestive Medicine- Gastroenterology section, Madrid, Spain, 2Hospital de Cabueñes, Digestive Department, Gijon, Spain, 3AbbVie Farmacéutica S.L.U., Inmunology, Madrid, Spain, 4Hospital General Universitario, Digestive Medicine Department, Alicante, Spain, 5Hospital Universitario Vall d´Hebrón, Gastroenterology, Barcelona, Spain, 6Hospital Universitario Virgen de las Nieves, Digestive Department, Granada, Spain, 7Hospital Clínico Universitario, Gastroenterology- Inflammatory Bowel Disease Unit, Santiago de Compostela, Spain

P693. Prevalence of Clostridium perfringens infection in pediatric patients with inflammatory bowel disease: a pilot study
Authors:

A. Banaszkiewicz1, A. Gawronska1, J. Kadzielska2, I. Lazowska-Przeorek1, K. Karolewska-Bochenek1, P. Obuch-Woszczatynski2, D. Wultanska2, H. Pituch2, A. Radzikowski1, 1Medical University of Warsaw, Dept of Paediatric Gastroenterology and Nutrition, Warsaw, Poland, 2Medical University of Warsaw, Dept of Medical Microbiology, Warsaw, Poland