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P674

Differences in Mucosal Distribution and Clinical Characteristics of Ulcerative Colitis in South Asians and Caucasians in the North of England

Authors:

M. Khan*

University of Manchester/Manchester Royal Infirmary, Department of Genetic Medicine/Department of Colorectal Surgery, Manchester, United Kingdom

P675.

Alterations in composition and diversity of the intestinal microbiota in Korean Crohn's disease patients

Authors:

C.S. Eun1, D.S. Han1, A.R. Lee1, D.I. Park2, S.-K. Yang3, 1Hanyang University Guri Hospital, Gastroenterology, Guri, Korea, Republic of, 2Sungkyunkwan University, Gastroenterology, Seoul, Korea, Republic of, 3Ulsan University, Gastroenterology, Seoul, Korea, Republic of

P675. A locus on chromosome 8q24 near MYC and anti-OmpC are associated with perianal Crohn's disease
Authors:

T.B. Murdoch1, A.V. Weizman2, W. Xu3, A.M. Griffiths4, T.D. Walters4, A.H. Steinhart2, R. Milgrom2, J.M. Stempak2, M.S. Silverberg2, 1University of Calgary, Division of Gastroenterology, Calgary, Canada, 2Mount Sinai Hospital, Zane Cohen Centre for Digestive Diseases, Toronto, Canada, 3University of Toronto, Dalla Lana School of Public Health, Toronto, Canada, 4Hospital for Sick Children, Division of Gastroenterology, Toronto, Canada

P675

Natural history of paediatric IBD around transition to adult services: a regional cohort study

Authors:

V. Merrick*1, P. Henderson1, N. Kennedy2, P. Rogers3, I. Arnott4, J. Satsangi2, D. Wilson1

1University of Edinburgh, Child Life and Health, Edinburgh, United Kingdom, 2University of Edinburgh, Gastrointestinal Unit, Centre for Genomic and Experimental Medicine, Edinburgh, United Kingdom, 3Royal Hospital for Sick Children, Paediatric Gastroenterology, Edinburgh, United Kingdom, 4Western General Hospital, Gastrointestinal Unit, Edinburgh, United Kingdom

P676.

Listeria monocytogenes infection in inflammatory bowel disease patients: case series

Authors:

J. Miranda-Bautista1, C. Padilla Suárez1, E. Bouza2, P. Muñoz2, M. Rodriguez-Creixems2, L. Menchen1, I. Marin-Jimenez1, 1Hospital General Universitario “Gregorio Marañón”, Gastroenterology Unit, Madrid, Spain, 2Hospital General Universitario “Gregorio Marañón”, Microbiology Unit, Madrid, Spain

P676. Primary response to infliximab in Crohn's disease is associated with the TNFRSF1A rs1800693 gene polymorphism
Authors:

T. Billiet1, I. Cleynen2, V. Ballet2, M. Ferrante2, P. Rutgeerts2, S. Vermeire2, 1KU Leuven, IBD Group, Leuven, Belgium, 2KU Leuven, IBD Group, Belgium

P676

Influence of alexithymia on the clinical course of Inflammatory Bowel Disease (IBD)

Authors:

R. Ferreiro*, M. Barreiro-de Acosta, A. Lorenzo, J.E. Dominguez-Munoz

University Hospital Santiago de Compostela, Gastroenterology, Santiago, Spain

P677. Gasdermin B (GSDMB) is implicated as a contributor to IBD susceptibility
Authors:

J. Söderman1, L. Berglind1, S. Almer2, 1Ryhov County Hospital, Division of Medical Diagnostics, Jönköping, Sweden, 2Linköping University, Department of Clinical and Experimental Medicine, Linköping, Sweden

P677

Hormonal contraceptive use is not associated with increased disease activity in IBD women - Results from an online survey

Authors:

A. de Lima*1, L. de Groot2, C.J. van der Woude1

1Erasmus Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands, 2ErasmusMC University Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands

P678. Relation between a single nucleotide polymorphism in MORC4, NOD2 variants and outcome after allogeneic stem cell transplantation for haematological malignancies
Authors:

E. Norén1, D. Verma2, J. Söderman3, K. Lotfi4, S. Almer1, 1Linköping University, Department of Clinical and Experimental Medicine, Linköping, Sweden, 2University of California, Department of Paediatrics, San Diego, United States, 3Ryhov County Hospital, Division of Medical Diagnostics, Jönköping, Sweden, 4Linköping University Hospital, Department of Hematology, Linköping, Sweden

P678

Childlessness in IBD patients - Analysis of data from the prospective multicentre Swiss IBD Cohort Study

Authors:

M. Sulz*1, N. Fournier2, L. Biedermann3, G. Rogler3

1Cantonal Hospital St. Gallen, Division of Gastroenterology and Hepatology, St. Gallen, Switzerland, 2Institute of Social and Preventive Medicine, Healthcare Evaluation Unit, Lausanne, Switzerland, 3University Hospital Zurich, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Zurich, Switzerland

P679. X-linked inhibitor of apoptosis protein in early-onset inflammatory bowel disease
Authors:

Y. Zeissig1, B. Petersen2, E. Bosse3, S. Milutinovic4, S. Billmann2, M. Kohl1, P. Rosenstiel2, J. Reed4, S. Schreiber3, A. Franke2, S. Zeissig3, 1University Medical Center Schleswig-Holstein Kiel, Department of Pediatrics, Kiel, Germany, 2Institute of Clinical Molecular Biology, Kiel, Germany, 3University Medical Center Schleswig-Holstein Kiel, Department of Internal Medicine I, Kiel, Germany, 4Sanford-Burnham Medical Research Institute, United States

P679

Can we trust on patient's infectious history? A prospective study on the agreement between medical history, vaccination record and serology.

Authors:

B. Moreira Gonçalves*, M. Rodrigues, F. Dália, S. Costa, R. Costa, J.B. Soares, P. Bastos, R. Gonçalves

Hospital Braga, Gastroenterology Department, Braga, Portugal

P680. The Notch signaling pathway could be involved in the early post-surgical recurrence of Crohn's disease
Authors:

Y. Zabana1, E. Pedrosa2, J. Mañé3, E. Domènech4, V. Lorén3, M. Mañosa4, M. Piñol5, J. Troya5, J. Boix6, J. Lozano7, E. Cabré4, 1Hospital-Institut Germans Trias i Pujol, Centro de Investigación Biomédica en Red sobre enfermedades hepáticas y digestivas (CIBERehd), Gastroenterology Department and Experimental Digestive Pathology Unit, Badalona, Spain, 2Germans Trias i Pujol Institute, Centro de Investigación Biomédica en Red sobre enfermedades hepáticas y digestivas (CIBERehd), Functional Genetics Unit, Badalona, Spain, 3Germans Trias i Pujol Institute, Centro de Investigación Biomédica en Red sobre enfermedades hepáticas y digestivas (CIBERehd), Experimental Digestive Pathology Unit, Badalona, Spain, 4Hospital Universitari Germans Trias i Pujol, Centro de Investigación Biomédica en Red sobre enfermedades hepáticas y digestivas (CIBERehd), Gastroenterology Department, Badalona, Spain, 5Hospital Universitari Germans Trias i Pujol, General Surgery Department, Badalona, Spain, 6Hospital Universitari Germans Trias i Pujol, Endoscopy Department, Badalona, Spain, 7CIBERehd, Bioinformatic Platform, Barcelona, Spain

P680

Post-operative clinical recurrence of Crohn's Disease in clinical practice in Spain. Practicrohn, a retrospective study

Authors:

E. Domènech*1, V. García2, M. Barreiro3, A. Gutiérrez4, M.D. Martín Arranz5, B. Juliá6, L. Cea-Calvo6

1Hospital Universitari Germans Trias i Pujol and CIBERehd, Gastroenterology Unit, Badalona, Spain, 2Hospital Universitario Reina Sofia, Unidad Clinica de Aparato Digestivo, Cordoba, Spain, 3Complejo Hospitalario Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, 4Hospital General Universitario Alicante, Gastroenterology unit, Alicante, Spain, 5Hospital Universitario La Paz, Gastroenterology Unit, Madrid, Spain, 6MSD Spain, Medical Department, Madrid, Spain

P681. Serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease
Authors:

M. Iborra1, F. Bernuzzi2, B. Beltrán1, M. Locati3, P. Nos4, P. Invernizzi5, S. Danese6, 1Hospital La Fe, Gastroenterology. CIBEREHD, Valencia, Spain, 2IRCCS Istituto Clinico Humanitas, Division of Internal Medicine and Hepatobiliary Immunopathology, Milano, Italy, 3IRCCS Istituto Clinico Humanitas, Laboratorio di Biologia dei Leucociti, Milano, Italy, 4Hospital La Fe, Gastroenterology. CIBERehd, Valencia, Spain, 5IRCCS Istituto Clinico Humanitas, Division of Rheumatology, Allergy and Clinical, Milano, Italy, 6IRCCS Istituto Clinico Humanitas, Division of Gastroenterology, Milano, Italy

P681

Incidence of endoscopically and histologically confirmed ileal ulceration in a sequential cohort of patients undergoing screening colonoscopy as part of the UK Bowel Cancer Screening Programme

Authors:

M. McDonnell*, A. Al Badri, S. Burningham, J. Gordon

Royal Hampshire County Hospital, Hampshire Hospitals NHS Foundation Trust, Winchester, Hampshire, SO22 5DG, United Kingdom

P682. Identification of catalase and Mn-SOD gene polymorphisms and their implication in Crohn's disease pathology
Authors:

M. Iborra1, M. Inés2, J. Panés3, J.P. Gisbert4, E. Cabré5, M. Esteve6, A. Cañas-Ventura7, E. García-Planella8, M. Peñalva9, E. Busó10, B. Beltrán1, 1Hospital La Fe, Gastroenterology. CIBEREHD, Valencia, Spain, 2Fundación Investigación Sanitaria Hospital La Fe. CIBEREHD, Valencia, Spain, 3Hospital Clínic i Provincial de Barcelona. CIBEREHD, Gastroenterology, Barcelona, Spain, 4Hospital de la Princesa, Aparato Digestivo, Madrid, Spain, 5Hospital Universitari Germans Trias i Pujol, Gastroenterology, Badalona-Barcelona, Spain, 6Hospital Universitari Mútua de Terrassa, Fundació per la Recerca Mútua de Terrassa. CIBEREHD, Gastroenterology, Terrasa-Barcelona, Spain, 7Hospital del Mar, Gastroenterology, Barcelona, Spain, 8Hospital de la Santa Creu i Sant Pau, Gastroenterology, Barcelona, Spain, 9Hospital Universitari de Bellvitge, Gastroenterology, Hospitalet de Llobregat-Barcelona, Spain, 10Universitat de Valencia, Unidad Central de Investigación. Facultad de Medicina, Valencia, Spain

P682

Elderly onset inflammatory bowel disease is a risk factor for gastric cancer development

Authors:

L.H. Nissen*1, E.L. Assendorp1, C.S. van der Post2, L.A.A.P. Derikx1, D.J. de Jong1, W. Kievit1, M. Pierik3, T. van den Heuvel3, R. Verhoeven4, L. Overbeek5, F. Hoentjen1, I.D. Nagtegaal2

1Radboud University Medical Center, Department of Gastroenterology and Hepatology, Nijmegen, Netherlands, 2Radboud University Medical Center, Department of Histopathology, Nijmegen, Netherlands, 3Maastricht University Medical Center, Department of Gastroenterology and Hepatology, Maastricht, Netherlands, 4Dutch Cancer Registry, Epidemiology, Eindhoven, Netherlands, 5PALGA, the Nationwide Network and Registry of Histo- and Cytopathology, Biomedical Research, Utrecht, Netherlands

P683. Gene expression profiles of ileal inflammatory bowel disease provide insights on disease immunopathology
Authors:

S. Ben-Shachar1, H. Yanai2, L. Baram2, H. Elad2, E. Mehirovihtz2, A. Ofer2, H. Tulchinsky3, M. Psamnik-Shor4, I. Dotan2, 1Tel Aviv Medical Center, Genetic Institute, Tel Aviv, Israel, 2Tel Aviv Medical Center, 2. IBD center, Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel, 3Tel Aviv Medical Center, 3. Department of Surgery, Tel Aviv, Israel, 4Tel Aviv University, 3. Bioinformatics unit, G.S.W. Faculty of Life Sciences, Tel Aviv, Israel