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P668.

Interspace microbiome profiling (IS-pro) enables to differentiate IBD subclasses and disease activity by specific loss of bacterial diversity

Authors:

M. Grasman1, R. van der Borden1, A. Budding2, A. Eck Hauer2, P. Savelkoul2, A. van Bodegraven3, 1VU University Medical Centre, Gastroenterology and Hepatology, Amsterdam, Netherlands, 2VU University Medical Centre, Medical Microbiology and Infection control, Amsterdam, Netherlands, 3ORBIS Medical Centre, Gastroenterology and Hepatology, Sittard, Netherlands

P668. ATG16L1 genotype is associated with response to anti-TNF in vitro
Authors:

M. Wildenberg1, A. Levin2, C. Vos2, J. Brandse1, J. de Bruyn1, G. D'Haens1, G. van den Brink1, 1Academic Medical Center, Gastroenterology, Amsterdam, Netherlands, 2Academic Medical Center, Tytgat Institute for Intestinal and Liver Research, Netherlands

P668

Fertility in IBD women is comparable to fertility in non-IBD controls

Authors:

A. de Lima*1, M. van Amelsfort1, E. Steegers2, C.J. van der Woude1

1Erasmus Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands, 2Erasmus Medical Center, Obstetrics and Gynecology, Rotterdam, Netherlands

P669.

Inflammatory bowel disease and Epstein–Barr virus: analysis of our experience

Authors:

Á. Araujo Míguez, C. Trigo Salado, J.L. Márquez Galán, M.D. De la Cruz Ramírez, J.M. Herrera Justiniano, E. Leo Carnerero, Hospital Universitario Virgen del Rocío, Gastroenterology, Seville, Spain

P669. Familial occurrence of inflammatory bowel disease in children
Authors:

U. Grzybowska-Chlebowczyk1, A.L. Sieron2, H. Koryciak-Komarska2, S. Wiecek3, M. Kniazewska3, L. Sieron2, H. Wos3, 1Medical University of Silesia, Department of Paediatrics, Katowice, Poland, 2Medical University of Silesia, Department of General and Molecular Biology and Genetics, Poland, 3Medical University of Silesia, Department of Pediatrics, Katowice, Poland

P669

Inflammatory Bowel Disease is prevalent in Australia but rare in Indigenous Australians

Authors:

G. Iyngkaran*1, J. Hunt2, T. Thambimuthu2, M. Bottolfsen2, E. Tse3, S. Sivanesan1, D. Liew4

1Royal Melbourne Hospital, Colorectal Medicine and Genetics, Parkville, Australia, 2Royal Darwin Hospital, Medicine, Darwin, Australia, 3Royal Adelaide Hospital, Medicine, Adelaide, Australia, 4Royal Melbourne Hospital, Medicine, Parkville, Australia

P670.

Efficacy of vaccination against hepatitis A and B in inflammatory bowel disease patients

Authors:

K. Karmiris1, E. Voudoukis1, M. Choustoulaki2, A. Sfiridaki2, G.A. Paspatis1, 1Venizeleio General Hospital, Gastroenterology, Heraklion, Crete, Greece, 2Venizeleio General Hospital, Blood Bank Center, Heraklion, Crete, Greece

P670. Identification of new genetic variants related to thiopurine-induced myelotoxicity in inflammatory bowel disease (IBD) patients with normal thiopurine s-methyltransferase (TPMT): a genome-wide association study
Authors:

M. Chaparro1, A. González-Neira2, M. Román3, G. Pita2, T. Cabaleiro4, D. Herrero2, B. Herraez2, R. Alonso2, C. Taxonera5, P. López-Serrano6, P. Martínez Montiel7, I. Vera8, F. Bermejo9, A. López-San Román10, F. Abad-Santos4, J.P. Gisbert1, 1Hospital Universitario de la Princesa-IP, Gastroenterology and CIBEREHD, Madrid, Spain, 2Spanish National Cancer Research Centre, Madrid, Spain, 3Hospital Universitario de la Princesa-IP, Clinical Pharmacology and CIBEREHD, Madrid, Spain, 4Hospital Universitario de La Princesa, Clinical Pharmacology Service, Madrid, Spain, 5Hospital Universitario Clínico San Carlos, Gastroenterology, Madrid, Spain, 6Hospital de Alcorcón, Gastroenterology, Madrid, Spain, 7Hospital Universitario Doce de Octubre, Gastroenterology, Madrid, Spain, 8Hospital Universitario Puerta de Hierro, Gastroenterology, Madrid, Spain, 9Hospital Universitario de Fuenlabrada, Gastroenterology, Madrid, Spain, 10Hospital Universitario Ramón y Cajal, Gastroenterology, Madrid, Spain

P670

Perception about disease activity and treatment attributes in patients with Ulcerative Colitis from Spain - UC-life survey

Authors:

A. López-Sanromán*1, D. Carpio2, X. Calvet3, L. Cea-Calvo4, C. Romero4, F. Argüelles5

1Hospital Ramón y Cajal, Gastroenterology Unit, Madrid, Spain, 2Complexo Hospitalario Universitario , Gastroenterology, Pontevedra, Spain, 3Corporació Sanitària Universitària Parc Taulí, Digestive Disease Department. Departament de Medicina. Universitat Autònoma de Barcelona. CIBEREHD – Instituto de Salud Carlos III, Sabadell, Spain, 4Merck Sharp & Dohme, Medical Affairs, Madrid, Spain, 5Hospital Universitario Virgen Macarena, Gastroenterology Unit, Sevilla, Spain

P671.

Effects of isotretinoin treatment on murine gut microbiota composition

Authors:

E. Becker1, C. Stanzel1, S. Schmidt2, K. Atrott1, L. Biedermann1, A. Rehman3, D. Jonas3, C. von Mering2, G. Rogler1, I. Frey-Wagner1, 1University Hospital Zurich, Gastroenterology & Hepatology, Zurich, Switzerland, 2University of Zurich, Molecular Life Sciences, Zurich, Switzerland, 3University Medical Center, Environmental Health Sciences, Freiburg, Germany

P671. An IL23R risk variant is associated with changes in CD4+ T-cell subsets in peripheral blood of Crohn's disease patients
Authors:

T.B. Murdoch1, A. Ueno1, G. Kaplan1, R. Panaccione1, H. Jijon1, M. Silverberg2, C. Hirota1, S. Ghosh1, 1University of Calgary, Division of Gastroenterology, Calgary, Canada, 2University of Toronto, Toronto, Canada

P671

The 5 year incidence of post-operative clinical recurrence following ileocolonic resection for terminal ileal Crohn's disease

Authors:

P. Morar*, O. Faiz, A. Hart, J. Warusavitarne

St Mark's Hospital, Colorectal Surgery & IBD Unit, London, United Kingdom

P672.

Does the ileocecal valve functionally separate ileal and right-sided colon microbiota compositions?

Authors:

N. Rossen1, S. Fuentes2, G. D'Haens1, H. Heilig2, K. Boonstra1, E. Zoetendal2, W. de Vos2, C. Ponsioen1, 1Academic Medical Center, Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Wageningen University, Laboratory of Microbiology, Wageningen, Netherlands

P672. T300A variant of autophagy ATG16L1 gene is associated with decreased antigen sampling and processing by dendritic cells in pediatric IBD
Authors:

C. Strisciuglio1, E. Miele1, M.E. Wildenberg2, F.P. Giugliano1, M. Andreozzi1, A. Vitale1, F. Capasso1, M.V. Barone1, A. Staiano1, R. Troncone1, C. Gianfrani1, 1Federico II, Pediatrics, Naples, Italy, 2Intestinal and Liver Research, Academic Medical Center, Gastroenterology and Hepatology and Tytgat, Amsterdam, Netherlands

P672

The impact of ethnicity on the prevalence and length of hospital stay in patients with Crohn's Disease

Authors:

J. Khan*1, S. Shan1, F. Ziaei1, R. Bhayani1, S. Shakir1, H. Uppal2, S. Chandran3, R. Potluri2

1Pennine Acute Hospitals NHS Trust, Medicine, Manchester, United Kingdom, 2Aston University, ACALM Study Unit in collaboration with Aston Medical School, Birmingham, United Kingdom, 3North Western Deanery, Department of Acute Medicine, Manchester, United Kingdom

P673.

Determination of the discriminant score of intestinal microbiota as a biomarker of disease activity in patients with ulcerative colitis

Authors:

K. Fukuda, Y. Fujita, St Luke's International Hospital, Department of Gastroenterology, Tokyo, Japan

P673. ATG16L1 and IRGM1 polymorphisms in pediatric Crohn's disease: correlation with phenotype
Authors:

C. Strisciuglio1, M. Martinelli1, F.P. Giugliano1, M. Andreozzi1, C. Greco1, C. Gianfrani1, A. Staiano1, R. Troncone1, E. Miele1, 1Federico II, Pediatrics, Naples, Italy

P673

Annual Incidence of IBD in Otago, New Zealand: An 18-year Epidemiological Analysis

Authors:

C. Galts1, F. Huinzing1, A. Gray2, J. Norton1, K. Copell1, M. Schultz*1

1University of Otago, Department of Medicine, Dunedin School of Medicine, Dunedin, New Zealand, 2University of Otago, Department of Preventive and Social Medicine, Dunedin School of Medicine, Dunedin, New Zealand

P674.

DNA of Helicobacter species is present in patients with inflammatory bowel diseases

Authors:

M. Biernat1, R. Kempinski2, K. Neubauer2, A. Binkowska1, J. Grabinska1, G. Gosciniak1, E. Poniewierka2, 1Wroclaw Medical University, Microbiology, Wroclaw, Poland, 2Wroclaw Medical University, Gastroenterology and Hepatology, Wroclaw, Poland

P674. Pancreatitis associated to inflammatory bowel disease (IBD): clinical and genetic patterns in children
Authors:

S. Cardile1, I. Loddo2, R. Mallamace1, F. Sancetta1, T. Alterio1, R. Centorrino1, C. Romano1, 1AOU G. Martino, Pediatric Department, Messina, Italy, 2AOU G. Martino, Genetic and Pediatric Immunology, Messina, Italy