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P647

EBV and CMV status in children with IBD at diagnosis: a case control study

Authors:

S. Gatti*, R. Annibali, P. Coccia, P. Pierani, C. Catassi

Università Politecnica delle Marche, Department of Pediatrics, Ancona, Italy

P648.

What is the risk of malignancy at normal appearing mucosa in left-side ulcerative colitis patients?

Authors:

E. Altintas1, S. Yaras1, F. Ates1, B. Saritas1, M.K. Aydin1, O. Sezgin1, G. Orekici Temel2, E. Üçbilek1, T. Kara3, R. Arpaci3, 1Mersin University Faculty Of Medicine, Gastroenterology Departments, Mersin, Turkey, 2Mersin University Faculty of Medicine, Biostatistic Department, Mersin, Turkey, 3Mersin University Faculty of Medicine, Pathology Department, Mersin, Turkey

P648. Environmental factors prior to IBD diagnosis in Europe – an ECCO–EpiCom study
Authors:

J. Burisch1, R. Seerup1, S. Cukovic-Cavka2, I. Kaimakliotis3, D. Duricova4, O. Shonova5, I. Vind6, N. Pedersen1, E. Langholz7, N. Thorsgaard8, V. Andersen9, J.F. Dahlerup10, R. Salupere11, K.R. Nielsen12, P. Manninen13, E. Tsianos14, K. Ladefoged15, E. Björnsson16, Y. Bailey17, S. Odes18, M. Martinato19, L. Kupcinskas20, S. Turcan21, F. Magro22, A. Goldis23, E. Belousova24, V. Hernandez25, S. Almer26, J. Halfvarson27, N. Arebi28, S. Sebastian29, P. Lakatos30, P. Munkholm1, 1Herlev University Hospital, Department of Gastroenterology, Copenhagen, Denmark, 2University Hospital Rebro, Division of Gastroenterology and Hepatology, Zagreb, Croatia, 3Nicosia private practice, Nicosia, Cyprus, 4Charles University, IBD Center ISCARE, Prague, Czech Republic, 5Hospital Ceske Budejovice, Gastroenterology Department, Ceske Budejovice, Czech Republic, 6Amager Hospital, Department of Medicine, Amager, Denmark, 7Gentofte Hospital, Department of Medical Gastroenterology, Gentofte, Denmark, 8Herning Central Hospital, Department of Medicine, Herning, Denmark, 9Viborg Regional Hospital, Medical department, Viborg, Denmark, 10Arhus University Hospital, Department of Medicine V (Hepatology and Gastroenterology), Aarhus, Denmark, 11Tartu University Hospital, Division of Endocrinology and Gastroenterology, Tartu, Estonia, 12The National Hospital of the Faroe Islands, Medical department, Torshavn, Faroe Islands, 13Tampere University Hospital, Department of Gastroenterology and Alimentary Tract Surgery, Tampere, Finland, 14University Hospital, 1st Division of Internal Medicine and Hepato-Gastroenterology Unit, Ioannina, Greece, 15Dronning Ingrids Hospital, Medical department, Nuuk, Greenland, 16The National University Hospital, Department of Internal Medicine, Section of Gastroenterology and Hepatology, Reykjavik, Iceland, 17Adelaide and Meath Hospital, TCD, Department of Gastroenterology, Dublin, Ireland, 18Soroka Medical Center and Ben Gurion University of the Negev, Department of Gastroenterology and Hepatology, Beer Sheva, Israel, 19On behalf of the EpiCom Northern Italy center based in Crema, Cremona, Firenze, Forlì, Padova and Reggio Emilia, Italy, 20Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania, 21State University of Medicine and Pharmacy, Laboratory of Gastroenterology, Medical Clinic IY, Chisinau, Moldova, Republic of, 22Hospital de São João, Department of Gastroenterology, Porto, Portugal, 23University of Medicine ‘Victor Babes’, Clinic of Gastroenterology, Timisoara, Romania, 24Moscow Regional Research Clinical Institute, Department of Gastroenterology, Moscow, Russian Federation, 25Complexo Hospitalario Universitario de Vigo, Gastroenterology Department, Vigo, Spain, 26Department of Clinical and Experimental Medicine, Linköping University, Division of Gastroenterology and Hepatology, Linköping, Sweden, 27Örebro University Hospital and School of Health and Medical Sciences, Örebro University, Department of Medicine, Division of Gastroenterology, Örebro, Sweden, 28St. Mark's Hospital, Imperial College London, London, United Kingdom, 29Hull and East Yorkshire NHS Trust & Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom, 30Semmelweis University, 1st Department of Medicine, Budapest, Hungary

P648

The epidemiology of microscopic colitis from 1997-2014 - a single centre study

Authors:

A.V. Patai*1, C. Csóka1, Á.A. Csontos1, T. Micsik2, M. Juhász1, K. Müllner1, E. Mihály1, L. Herszényi1, Z. Tulassay1, P. Miheller1

1Semmelweis University, 2nd Department of Medicine, Budapest, Hungary, 2Semmelweis University, 1st Department of Pathology and Experimental Cancer Research, Budapest, Hungary

P649.

Relationship between clinical characteristics and vitamin D receptor polymorphisms in Crohn's disease

Authors:

O. Terjek1, A.A. Csontos1, K. Lorinczy1, A. Bors2, A. Torday2, P.L. Lakatos3, P. Miheller1, 1Semmelweis University, 2nd Department of Medicine, Budapest, Hungary, 2Hungarian National Blood Transfusion Service, Department of Molecular Diagnostics, Budapest, Hungary, 3Semmelweis University, 1st Department of Medicine, Budapest, Hungary

P649. Inflammatory bowel disease-associated with colorectal cancers in Korea: a single-center experience
Authors:

J.Y. Lee1, B.D. Ye1, S.-K. Yang1, J.W. Kim1, S.H. Park1, S.-K. Park1, D.-H. Yang1, K.W. Jung1, K.-J. Kim1, J.-S. Byeon1, S.-J. Myung1, J.-H. Kim1, 1University of Ulsan College of Medicine, Asan Medical Center, Department of Gastroenterology and Inflammatory Bowel Disease Center, Seoul, South Korea

P649

The incidence of glomerulonephritis in a population-based inception cohort of patients with Inflammatory Bowel Diseases

Authors:

Z. Vegh*1, B. Lovasz1, P.A. Golovics1, K. Gecse1, E. Macsai2, I. Szita2, M. Balogh3, L. Lakatos2, P. Lakatos1

1Semmelweis University, 1st Department of Medicine, Budapest, Hungary, 2Csolnoky F. Province Hospital, Department of Medicine, Veszprem, Hungary, 3Grof Eszterhazy Hospital, Department of Medicine, Papa, Hungary

P650. Entero-urinary fistulas in Crohn's disease: prevalence and clinical manifestations
Authors:

C. Taxonera1, I. Fernández-Blanco2, M. Barreiro-de Acosta3, G. Bastida4, A. López-San Román5, O. Merino6, V. García-Sánchez7, J.P. Gisbert8, I. Marín-Jiménez9, P. López-Serrano10, E. Iglesias7, J. Martínez-González5, M. Chaparro8, F. Bermejo11, C. Saro12, L. Pérez-Carazo9, R. Plaza13, D. Olivares1, M. Cañas1, J.L. Mendoza1, 1H Clinico San Carlos, IBD Unit, IdiSSC, Madrid, Spain, 2Hospital Moncloa, Madrid, Spain, 3H Clínico de Santiago, Santiago de Compostela, Spain, 4H La Fe, Valencia, Spain, 5H Ramón y Cajal, Madrid, Spain, 6H Cruces, Barakaldo, Spain, 7H Reina Sofía, Córdoba, Spain, 8H La Princesa, CIBERehd, Madrid, Spain, 9H Gregorio Marañón, Madrid, Spain, 10H Alcorcón, Madrid, Spain, 11H Fuenlabrada, Madrid, Spain, 12H de Cabueñes, Gijón, Spain, 13H Infanta Leonor, Madrid, Spain

P650

Age of onset is associated with disease seasonality in inflammatory bowel disease: A multi-center observational study by the Osaka Gut Forum

Authors:

M. Araki*1, S. Shinzaki1, H. Iijima1, S. Hiyama1, T. Yamada2, S. Arimitsu3, M. Komori4, M. Ito5, A. Mukai6, S. Nakajima7, F. Terabe8, K. Kinoshita9, S. Kitamura10, Y. Murayama11, H. Ogawa12, Y. Yasunaga13, M. Oshita14, E. Masuda15, M. Tsujii1, T. Takehara1

1Osaka University Graduate School of Medicine, Department of Gastroenterology and Hepatology, 2-2 Yamadaoka, Suita, Japan, 2Osaka Medical Center, National Hospital Organization, Department of Gastroenterology, 2-1-14, Hoenzaka, Chuo-ku, Osaka, Japan, 3Kinshukai , Infusion Clinic, Osaka, Japan, 4Osaka Rosai Hospital, Department of Gastroenterology, 1179-3, Nagasone-cho, Kita-ku, Sakai, Osaka, Japan, 5NTT-west Hospital, Department of Gastroenterology, 2-6-40, Karasugatsuji, Tennoji-ku, Osaka, Japan, 6Sumitomo Hospital, Department of Gastroenterology, 5-3-20, Nakanoshima, Kita-ku, Osaka, Japan, 7Toyonaka Municipal Hospital, Department of Gastroenterology, 4-14-1, Shibahara-cho, Toyonaka, Osaka, Japan, 8Yao Municipal Hospital, Department of Gastroenterology, 1-3-1, Ryukacho, Yao, Osaka, Japan, 9Otemae Hospital, Department of Gastroenterology, 1-5-34, Otemae, Chuo-ku, Osaka, Japan, 10Sakai City Hospital, Department of Gastroenterology, 1-1-1, Minamiyasui-cho, Sakai-ku, Sakai, Osaka, Japan, 11Itami City Hospital, Department of Gastroenterology, 1-100, Koyaike, Itami, Hyogo, Japan, 12Nishinomiya Municipal Central Hospital, Department of Gastroenterology, 8-24, Hayashida-cho, Nishinomiya, Hyogo, Japan, 13Hyogo Prefectural Nishinomiya Hospital, Department of Gastroenterology, 13-9, Rokutanji-cho, Nishinomiya, Hyogo, Japan, 14Osaka Police Hospital, Department of Gastroenterology, 10-31, Kitayama-cho, Tennoji-ku, Osaka, Japan, 15Osaka Minami Medical Center, National Hospital Organization, Department of Gastroenterology, 2-1, Kidohigashimachi, Kawachinagano, Osaka, Japan

P651.

Identification of new genetic variants related to thiopurine-induced myelotoxicity in inflammatory bowel disease (IBD) patients with normal thiopurines-methyltransferase (TPMT): a genome-wide association study

Authors:

M. Chaparro1, A. González-Neira2, M. Román3, G. Pita2, T. Cabaleiro4, D. Herrero2, B. Herráez2, R. Alonso2, C. Taxonera5, P. López-Serrano6, P. Martínez-Montiel7, I. Vera8, F. Bermejo9, A. López-San Román10, F. Abad-Santos4, J.P. Gisbert1, 1Hospital Universitario de La Princesa, IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, 2Spanish Narional Cancer Research Institute, Madrid, Spain, 3Hospital Universitario de La Princesa and IP, Farmacy Unit, Madrid, Spain, 4Hospital Universitario de La Princesa and IP, Clinical Pharmacology Unit, Madrid, Spain, 5Hospital Clínico San Carlos, Gastroenterology Unit, Madrid, Spain, 6Hospital de Alcorcón, Gastroenterology Unit, Madrid, Spain, 7Hospital Doce de Octubre, Gastroenterology Unit, Madrid, Spain, 8Hospital Puerta de Hierro, Gastroenterology Unit, Madrid, Spain, 9Hospital de Fuenlabrada, Gastroenterology Unit, Madrid, Spain, 10Hospital Ramón y Cajal, Gastroenterology Unit, Madrid, Spain

P651. Association between Crohn's disease and small bowel cancers: a Danish nationwide population based study
Authors:

R.D. Bojesen1, L.B. Riis2, O.H. Nielsen3, T. Jess1, 1Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark, 2Herlev Hospital, University of Copenhagen, Department of Pathology, Herlev, Denmark, 3Herlev Hospital, University of Copenhagen, Department of Gastroenterology, Medical Section, Herlev, Denmark

P651

Complementary and alternative medicine (CAM) use in patients with inflammatory bowel disease - preliminary Results of a multicenter study of the Austrian IBD study group

Authors:

H.P. Gröchenig*1, C. Dejaco2, L. Dzirlo3, G. Eckhard4, T. Feichtenschlager5, H. Fuchssteiner6, J. Gartner7, T. Haas8, A. Kirchgatterer9, R. Koch10, O. Ludwiczek11, A. Mayer12, W. Miehsler13, P. Papay14, P.-G. Peters15, R. Platzer16, G. Reicht17, P. Steiner18, J. Stimakovits19, T. Waldhör20, H. Wenzl21, G. Novacek2

1Akademisches Lehrkrankenhaus Barmherzige Brüder, Abteilung für Innere Medizin, St. Veit an der Glan, Austria, 2Medizinische Universität Wien, Universitätsklinik für Innere Medizin III, Vienna, Austria, 3Krankenhaus Barmherzige Schwestern, III. Medizinische Abteilung, Wien, Austria, 4Landeskrankenhaus Oberpullendorf, Interne Abteilung, Oberpullendorf, Austria, 5Krankenhaus Rudolfstiftung Wien, IV Medizinische Abteilung, Wien, Austria, 6KH Elisabethinen Linz, Innere Medizin IV, Linz, Austria, 7Hanusch Krankenhaus, Innere Medizin, Wien, Austria, 8Darmpraxis Salzburg, Ordination, Salzburg, Austria, 9Klinikum Wels-Grieskirchen, Abteilung für Innere Medizin V, Grieskirchen, Austria, 10Medizinische Universität Innsbruck, Innere Medizin I, Innsbruck, Austria, 11Landeskrankenhaus Hall in Tirol, Innere Medizin, Hall in Tirol, Austria, 12Universitätsklinikum St. Pölten, 2. Medizinische Abteilung, St. Pölten, Austria, 13Krankenhaus Barmherzige Brüder , Innere Medizin, Salzburg, Austria, 14Hartmannspital Wien, Innere Medizin, Wien, Austria, 15Landeskrankenhaus Feldkirch, Abteilung für Innere Medizin, Feldkirch, Austria, 16Landeskrankenhaus Wiener Neustadt, Abteilung für Innere Medizin I, Wiener Neustadt, Austria, 17Krankenhaus Barmherzige Brüder Graz, Abteilung für Innere Medizin, Graz, Austria, 18Klinikum Wels-Grieskirchen, Abteilung für Innere Medizin I, Wels, Austria, 19Krankenhaus Barmherzige Brüder Eisenstadt, Innere Medizin, Eisenstadt, Austria, 20Medizinische Universität Wien, Abteilung für Epidemiologie, Wien, Austria, 21Medizinische Universität Graz, Abteilung für Gastroenterologie & Hepatologie, Graz, Austria

P652.

Global DNA methylation in inflammatory bowel disease

Authors:

E. McDermott1, C. Rowan1, T. Murphy1, K. Byrne1, G. Doherty1, G. Cullen1, H. Mulcahy1, E. Ryan1, 1St. Vincent's University Hospital, Department of Gastroenterology, Dublin, Ireland

P652. Early treatment with immunomodulators is associated with change in the natural history of inflammatory bowel disease – multicentre longitudinal cohort study – Sydney, Australia
Authors:

V. Kariyawasam1, T. Huang2, P. Lunney2, K. Middleton2, R. Wang2, C. Selinger2, P. Katelaris2, J. Andrews3, R. Leong2, 1Guy's and St Thomas' NHS Foundation Trust, Gastroenterology, Londond, United Kingdom, 2Concord Repatriation General Hospital, Gastroenterology, Concord, Australia, 3Royal Adelaide Hospital, Dept of Gastroenterology & Hepatology, Adelaide, Australia

P652

Treatment, evolution and associated risk factors of extraintestinal manifestations in patients with inflammatory bowel disease

Authors:

M. Syed, A. Algaba*, I. Guerra, M. de Lucas, D. Bonillo, M. Hernández, A. Granja, F. Berrmejo

Hospital Universitario de Fuenlabrada, Gastroenterology, Madrid, Spain

P653.

Genetic predictors of non reversible tissue damage in inflammatory bowel disease

Authors:

J.M. Benitez1, J.M. Mahachie John2, E. Théâtre3, C. Reenaers3, M. De Vos4, O. Dewit5, K. Van Steen2, E. Louis3, 1Reina Sofia University Hospital, IMIBIC, CHU Liège, Gastroenterology, Córdoba, Spain, 2CHU de Liège, Bioinformatics and Modeling, Liège, Belgium, 3CHU de Liège, GIGA, Gastroenterology, Liège, Belgium, 4Ghent University Hospital, Gastroenterology, Ghent, Belgium, 5Saint-Luc Hospital, Gastroenterology, Brussels, Belgium

P653. Disease relapse rates during pregnancy – results from the Erasmus MC Rotterdam prospective cohort
Authors:

A. de Lima1, Z. Zelinkova1, C. van der Ent1, C.J. van der Woude1, 1Erasmus Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands

P653

Increasing prevalence of paediatric Inflammatory Bowel Disease in Japan: Direct comparison with adult disease using national registry data

Authors:

T. Ishige*1, T. Tomomasa1, R. Hatori1, M. Tatsuki1, Y. Igarashi1, K. Arai2, H. Arakawa1

1Gunma University, Department of Pediatrics, Maebashi, Japan, 2National Center for Child Health and Development, Division of Gastroenterology, Tokyo, Japan

P654.

Genetic susceptibility to orofacial granulomatosis

Authors:

R. Goel1, S. Nayee2, M. Escudier2, A. Mentzer3, H. Campbell2, UK IBD consortium4, J. Satsangi5, J. Mansfield6, C. Mathew7, N. Prescott7, J. Sanderson1, 1Guy's & St Thomas' NHS Foundation Trust, Gastroenterology, London, United Kingdom, 2Guy's & St Thomas' Hospitals, Medicine, London, United Kingdom, 3University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, United Kingdom, 4UK IBD consortium, London, United Kingdom, 5Western General Hospital, Gastrointestinal Unit, Edinburgh, United Kingdom, 6Newcastle Upon Tyne Hospitals NHS Foundation Trust, Gastroenterology, Newcastle Upon Tyne, United Kingdom, 7King's College London, Genetics, London, United Kingdom

P654. Disease impact of ulcerative colitis on patients' perception: an Italian survey
Authors:

E. Calabrese1, V. Annese2, G.C. Sturniolo3, G. Venturelli4, L. Neri5, F. Pallone1, 1University of Rome Tor Vergata, GI Unit, Medicine, Rome, Italy, 2AOU Careggi, Italy, 3Università di Padova, Italy, 4Doxafarma, Italy, 5University of Milan, Italy