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9. Clinical and endocopic improvement following hemopoietic stem cell transplantation in the ASTIC trial

C. Hawkey¹, M. Allez², S. Ardizzone³, M. Clark¹, L. Clark⁴, J.-F. Colombel⁵, S. Danese⁶, D. Farge-Bancel⁷, M. Labopin⁸, J. Lindsay⁹, A. Norman¹, F. Onida¹⁰, E. Ricart¹¹, G. Rogler¹², M. Rovira¹¹, N. Russell¹³, J. Satsangi¹⁴, S. Travis¹⁵, A. Tyndall¹⁶, S. Vermeire¹⁷, ¹University of Nottingham, Nottingham Digestive Diseases Centre, Nottingham, United Kingdom, ²Hôpital Saint-Louis, Paris, France, ³L. Sacco University Hospital, Milan, Italy, ⁴European Group for Blood and Marrow Transplantation, United Kingdom, ⁵Hôpital Huriez, Lille, France, ⁶Istituto Clinico Humanitas, Milan, Italy, ⁷Unité de Médecine Interne et Pathologie Vasculaire, France, ⁸European Group for Blood and Marrow Transplantation, France, ⁹Barts & the London School of Medicine, United Kingdom, ¹⁰University of Milan, Italy, ¹¹Hospital Clinic Barcelona, Spain, ¹²University Hospital of Zürich, Switzerland, ¹³University of Nottingham, Clinical Haematology, Nottingham, United Kingdom, ¹⁴University of Edinburgh, United Kingdom, ¹⁵John Radcliffe Hospital, United Kingdom, ¹⁶University Hospital of Basel, Switzerland, ¹⁷University Hospitals Leuven, Belgium

9. Phase I-II safety, immunogenicity and clinical results of TNFα-kinoid immunotherapeutic immunization in Crohn's disease patients

DOP001

Genetic and environmental risk model to predict intestinal inflammation in asymptomatic first-degree relatives of Crohn’s disease patients

Authors:

K. M. Taylor*^{1, 2}, N.S. Taylor³, S. H. Anderson¹, P. M. Irving¹, N. J. Prescott², C. M. Lewis², C. G. Mathew², J. D. Sanderson¹

¹Guy’s & St Thomas’ NHS Foundation Trust, Department of Gastroenterology, London, United Kingdom, ²King’s College London, Department of Medical & Molecular Genetics, London, United Kingdom, ³University Hospital Southampton NHS Foundation Trust, Department of Gastroenterology, Southampton, United Kingdom

DOP002

Molecular response to ustekinumab in moderate-to-severe Crohn’s disease by serum protein analysis: results from the UNITI-1 and UNITI-2 Phase 3 induction studies

Authors:

K. Li*, K. Hayden, E. Wadman, S. Bhagat, S. Emrich, J. R. Friedman, C. Gasink, C. Brodmerkel

Janssen R & D, LLC, Spring House, Pennsylvania, United States

DOP003

Gene expression profiling indicates similar molecular pathways are active in adult and paediatric ulcerative colitis

Authors:

K. Li*¹, J. Ouahed², J. Friedman¹, R. Strauss¹, D. Chan¹, S. Telesco¹, D. Shouval³, J. Canavan⁴, C. Brodmerkel¹, S. Snapper⁵

¹Janssen R & D, LLC, Spring House, Pennsylvania, United States, ²Boston Children’s Hospital/Harvard Medical School, Boston, Massachusetts, United States, ³Boston Children’s Hospital/Harvard Medical School, Boston, Massachusetts, United States, ⁴Harvard Medical School/Brigham & Women’s Hospital, Boston, Massachusetts, United States, ⁵Boston Children’s Hospital/Harvard Medical School/Brigham & Women’s Hospital, Boston, Massachusetts United States

DOP004

Epigenetic control of colonic epithelial antigen processing, barrier function, and the microbiome via methyl-CpG binding domain protein 2

Authors:

G.-R. Jones*¹, A. MacDonald², P. Cook²

¹University of Edinburgh, Gastroenterology, Edinburgh, United Kingdom, ²University of Manchester, Department of Immunology, Manchester, United Kingdom

DOP005

A role for IL1 in mediating intestinal inflammation in IL10 receptor deficiency in mice and humans

Authors:

D. Shouval*^{1, 2}, A. Biswas², Y.-H. Kang², A. Griffith², B. Horwitz², A. Bousvaros², S. Snapper²

¹Safra Children’s Hospital, Paediatric Gastroenterology, Tel Hashomer, Israel, ²Boston Children’s Hospital, Boston, Massachusetts, United States

DOP006

Gut-homing adipose tissue T-cells might influence intestinal barrier function in Crohn’s disease and obesity

Authors:

L. J. Jödicke*¹, L. I. Kredel¹, A. A. Kuehl¹, I. Freise¹, J. Gröne², J. Ordemann³, B. Siegmund¹

¹Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, General, Vascular and Thoracic Surgery, Berlin, Germany, ³Charité, Campus Mitte, Centre for Obesity and Metabolic Surgery, Berlin, Germany

DOP007

Interleukin-10 inhibits human IFNγ and IL-17-producing T helper cells indirectly by controlling antigen-presenting cell function

Authors:

S. Veenbergen*¹, P. Li², H. Raatgeep¹, D. Lindenbergh-Kortleve¹, L. de Ruiter¹, M. van Leeuwen¹, D. Winter³, Y. Simons-Oosterhuis¹, L. van Berkel¹, S. Nugteren¹, J. Arnold¹, Y. Wakabayashi⁴, J. Zhu⁴, L. de Ridder³, G. Driessen⁵, J. Escher³, W. Leonard², J. Samsom¹

¹Erasmus University Medical Centre, Laboratory of Paediatrics, division Gastroenterology and Nutrition, Rotterdam, Netherlands, ²National Heart, Lung and Blood Institute, National Institutes of Health, Laboratory of Molecular Immunology, Bethesda, Maryland, United States, ³Sophia Children’s Hospital-Erasmus Medical Centre, Department of Paediatric Gastroenterology, Rotterdam, Netherlands, ⁴National Heart, Lung and Blood Institute, National Institutes of Health, DNA Sequencing and Genomics Core, Bethesda, Maryland, United States, ⁵Erasmus University Medical Centre, Department of Paediatric Infectious Disease and Immunology, Rotterdam, Netherlands

DOP008

Human intestinal Vδ2+ T-cells acquire antigen-presenting potency upon exposure to microbial phosphoantigen: modulation by mucosal inflammation and vedolizumab therapy

Authors:

C. Tyler¹, N. McCarthy*², B. Moser¹, A. Stagg², M. Eberl¹, J. Lindsay^{2, 3}

¹Cardiff University, Cardiff Institute of Infection & Immunity, School of Medicine, Cardiff, United Kingdom, ²Barts and The London School of Medicine and Dentistry, Queen Mary University of London, The Blizard Institute, Centre for Immunobiology, London, United Kingdom, ³Barts Health NHS Trust, Department of Gastroenterology, Barts and The London Hospitals, London, United Kingdom

DOP009

An autoimmunity-associated variant in PTPN22 protects from disease onset in mouse models of colitis

Authors:

M. Spalinger*¹, S. Kasper¹, C. Gottier¹, S. Lang¹, M. Fried^{1, 2}, G. Rogler^{1, 2}, M. Scharl^{1, 2}

¹University Hospital Zürich, Division of Gastroenterology and Hepatology, Zürich, Switzerland, ²University of Zürich, Zürich Centre for Integrative Human Physiology, Zürich, Switzerland

DOP010

Frequency and characteristics of infusion reactions during biosimilar infliximab treatment in inflammatory bowel diseases: results from a Central European nationwide cohort

Authors:

A. Bálint*¹, K. Farkas¹, M. Rutka¹, Z. Végh², Z. Kürti³, J. Banai⁴, L. Bene⁵, B. Gasztonyi⁶, T. Kristóf⁷, L. Lakatos⁸, P. Miheller⁹, K. Palatka¹⁰, A. Patai¹¹, A. Salamon¹², T. Szamosi⁴, Z. Szepes¹, G.T. Tóth¹³, A. Vincze¹⁴, R. Bor¹, A. Milassin¹, F. Nagy¹, M. Kolar^{15, 16}, M. Bortlik^{15, 17}, D. Duricova^{15, 18}, V. Hruba¹⁵, M. Lukas¹⁵, K. Mitrova^{15, 19}, K. Malickova²⁰, M. Lukas^{15, 20}, P.L. Lakatos², T. Molnár¹

¹University of Szeged, First Department of Medicine, Szeged, Hungary, ²Semmelweis University, First Department of Medicine, Budapest, Hungary, ³Semmelweis University, First Department of Internal Medicine, Budapest, Hungary, ⁴Military Hospital – State Health Centre, Budapest, Hungary, ⁵Peterfy Hospital, First Department of Medicine, Budapest, Hungary, ⁶Zala County Hospital, Second Department of Medicine, Zalaegerszeg, Hungary, ⁷B-A-Z County and University Teaching Hospital, Second Department of Medicine, Miskolc, Hungary, ⁸Csolnoky Ferenc Regional Hospital, Department of Internal Medicine, Veszprem, Hungary, ⁹Semmelweis University, Second Department of Internal Medicine, Budapest, Hungary, ¹⁰University of Debrecen, Second Department of Medicine, Debrecen, Hungary, ¹¹Markusovszky Hospital, Department of Medicine and Gastroenterology, Szombathely, Hungary, ¹²Tolna County Teaching Hospital, Department of Gastroenterology, Szekszard, Hungary, ¹³Janos Hospital, Department of Gastroenterology, Budapest, Hungary, ¹⁴University of Pécs, First Department of Medicine, Pécs, Hungary, ¹⁵IBD Clinical and Research Centre, Iscare a.s, Prague, Czech Republic, ¹⁶Charles University, First Medical Faculty, Prague, Czech Republic, ¹⁷Military Hospital, Charles University, Department of Internal Medicine, Prague, Czech Republic, ¹⁸First Medical Faculty, Charles University, Institute of Pharmacology, Prague, Czech Republic, ¹⁹Faculty Hospital Motol, Second Medical Faculty, Charles University, Department of Paediatrics, Prague, Czech Republic, ²⁰First Medical Faculty and General Teaching Hospital, Charles University, Institute of Medical Biochemistry and Laboratory Diagnostics, Prague, Czech Republic

DOP011

Early immunomodulator exposure and the long-term outcome of Crohn’s disease: target for changing the natural history

Authors:

S. Jeuring*^{1, 2}, D. Wintjens¹, A. Wesselius³, T. Van den Heuvel^{1, 2},  M. Zeegers^{3, 4}, W. Hameeteman¹, M. Romberg-Camps⁵, L. Oostenbrug⁶, A. Masclee^{1, 2}, D. Jonkers^{1, 2}, M. Pierik^{1, 2}

¹Maastricht University Medical Centre, Internal Medicine - Division of Gastroenterology and Hepatology, Maastricht, Netherlands, ²Maastricht University Medical Centre, NUTRIM - School for Nutrition and Translational Research in Metabolism, Maastricht, Netherlands, ³Maastricht University Medical Centre, Complex Genetics - School for Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht, Netherlands, ⁴Maastricht University Medical Centre, CAPHRI - School for Public Health and Primary Care, Maastricht, Netherlands, ⁵Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Sittard-Geleen, Netherlands, ⁶Zuyderland Medical Centre, Internal Medicine and Gastroenterology-Hepatology, Heerlen, Netherlands

DOP012

Do ulcerative colitis patients treated with corticosteroids at diagnosis really have a more aggressive disease course?

Authors:

L. Bertani*¹, N. de Bortoli¹, G. Bodini², G. Mumolo³, L. Ceccarelli⁴, M. C. Plaz Torres², G. Laino¹, M. Bellini³, A. Ricchiuti³, V. Savarino², S. Marchi¹, F. Costa³

¹University of Pisa, Department of Gastroenterology, Pisa, Italy, ²University of Genoa, Department of Gastroenterology, Genoa, Italy, ³Pisa University Hospital, Department of Gastroenterology, Pisa, Italy, ⁴SSD Endoscopy ASL 1, Massa, Italy

DOP013

A 104 week mucosal healing assessment of symptomatic small bowel Crohn’s disease

Authors:

B. Hall*¹, G. Holleran¹, L. Chapman¹, B. Ryan¹, N. Mahmud², D. McNamara¹

¹Adelaide & Meath Hospital, Dublin, Incorporating The National Children’s Hospital, Department of Gastroenterology, Dublin, Ireland, ²Trinity College Dublin, St James Hospital, Department of Gastroenterology, Dublin, Ireland

DOP014

Nutritional optimisation of presurgical Crohn’s disease patients with enteral nutrition significantly decreases length of stay and need for a stoma

Authors:

K. V. Patel*¹, A. M. Sandall², D. V. O’Hanlon³, A. A. Darakhshan⁴, A. B. Williams⁴, S. H. Anderson¹, P. M. Irving¹, M. C. Lomer⁵, J. D. Sanderson¹

¹Guy’s and St Thomas’ NHS Foundation Trust, Gastroenterology, London, United Kingdom, ²King’s College London, Diabetes and Nutritional Sciences Division, London, United Kingdom, ³Guy’s and St Thomas’ NHS Foundation Trust, Dietetics, London, United Kingdom, ⁴Guy’s and St Thomas’ NHS Foundation Trust, Colorectal Surgery, London, United Kingdom, ⁵King’s College London, Diabetes and Nutritional Sciences Division, London, United Kingdom

DOP015

Myenteric plexitis is a risk factor for endoscopic and clinical postoperative recurrence after ileocolonic resection in Crohn’s disease

Authors:

S. Decousus¹, A.-L. Boucher², J. Joubert¹, M. Goutte^{2, 3}, F. Goutorbe², A. Dubois⁴, B. Pereira⁵, P. Dechelotte¹, G. Bommelaer^{2, 3}, A. Buisson*^{2, 3}

¹University Hospital Estaing, Pathology Department, Clermont-Ferrand, France, ²University Hospital Estaing, Gastroenterology Department, Clermont-Ferrand, France, ³UMR 1071 Inserm/Université d’Auvergne; USC-INRA 2018, Microbes, Intestine, Inflammation and Susceptibility of the host, Clermont-Ferrand, France, ⁴CHU Estaing, Department of Digestive surgery, Clermont-Ferrand, France, ⁵GM – Clermont-Ferrand University and Medical Centre, Biostatistics Unit, Clermont-Ferrand, France

DOP016

Postoperative clinical recurrence is not different in Crohn’s disease patients classified as i2 on the Rutgeerts score with lesions confined to the ileocolonic anastomosis than in those with lesions of the neoterminal ileum

Authors:

P. Bayart*¹, N. Duveau¹, M. Nachury¹, P. Zerbib¹, R. Gerard¹, J. Branche¹, V. Maunoury¹, A. Boruchowicz², M. Boualit², J.-E. Laberenne³, O. Manolache³, G. Pineton de Chambrun⁴, B. Pariente¹

¹CHRU de Lille, Lille, France, ²CH Valenciennes, Valenciennes, France, ³CH Seclin, Seclin, France, ⁴CHU Montpellier, Montpellier, France

DOP017

Colectomy-free survival is independent of initial infliximab dosing strategy in hospitalised ulcerative colitis patients

Authors:

S. Shah*, S. Naymagon, B. Sands, B. Cohen, M. Dubinsky

Mount Sinai Hospital, Gastroenterology, New York, New York, United States

DOP018

Long-term follow-up after ileorectal anastomosis in ulcerative colitis (UC) identified factors associated with rectal outcome: a multicentre retrospective cohort of 343 patients from the GETAID/GETAID Surgery

Authors:

M. Uzzan*¹, J. Cosnes², N. Oubaya³, A. Amiot⁴, N. Gault³, J.-M. Gornet⁵, P. Seksik², S. Nancey⁶, E. Cotte⁷, M. Allez⁵, D. Laharie⁸, N. De angelis⁴, M. Nachury⁹, A.-L. Pelletier¹⁰, V. Abitbol¹¹, M. Fumery¹², A. Brouquet¹³, A. Buisson¹⁴, R. Altwegg¹⁵, Y. Panis¹⁶, X. Treton¹

¹APHP Beaujon, Department of Gastroenterology, Clichy, France, ²APHP St. Antoine Hospital, Department of Gastroenterology, Paris, France, ³APHP Beaujon, Epidémiologie et Recherche clinique, Clichy, France, ⁴CHU Henri Mondor, Digestive Surgery, Creteil, France, ⁵Hospital Saint-Louis, Department of Gastroenterology, Paris, France, ⁶Centre Hospitalier Lyon-Sud, Department of Gastroenterology, Pierre-bénite, France, ⁷Lyon-Sud Hospital, Department of Digestive Surgery, Pierre-Bénite, France, ⁸Hospital Haut-Leveque, Department of Gastroenterology and Hepatology, Pessac, France, ⁹CHRU Lille, Department of Gastroenterology, Lille, France, ¹⁰Hospital Bichat Claude Bernard, Department of Gastroenterology, Paris, France, ¹¹Cochin Hospital, Department of Gastroenterology, Paris, France, ¹²Amiens University Hospital, Department of Gastroenterology, Amiens, France, ¹³CHU Bicêtre, Digestive Surgery, Le Kremlin-Bicêtre, France, ¹⁴CHU Estaing, Department of Gastroenterology, Clermont-Ferrand, France, ¹⁵CHU Montpellier Saint Eloi Hospital, Department of Gastroenterology, Montpellier, France, ¹⁶APHP Beaujon, Department of Colorectal Surgery, Clichy, France

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