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P541.

Can we predict myelotoxicity development during thiopurine therapy for inflammatory bowel disease?

Authors:

A. Kharitonov1, O. Shchukina1, S. Lapin2, T. Bulgakova2, A. Baranovsky1, 1North-Western state medical university named after I.I.Mechnikov, Chair of gastroenterology and dietology, Saint-Petersburg, Russian Federation, 2First Saint-Petersburg state medical university named after I.P. Pavlov, Laboratory of autoimmune diseases, Saint-Petersburg, Russian Federation

P541. Does smoking increase the need for the use of immunomodulator treatment in Crohn's disease patients?
Authors:

P. Ellul1, C. Saliba2, N. Azzopardi3, D. Grech Margeurat3, G. Laferla2, G. Grech2, 1Mater Dei Hospital, Msida, Malta, 2University of Malta, Malta, 3Mater Dei Hospital, Malta

P541

Long-term colectomy rates in patients with Ulcerative Colitis treated with Infliximab: A single Canadian tertiary care centre's experience

Authors:

M. Cooray*1, A. Meadley2, S. Halder3

1McMaster University, Gastroenterology, Burlington, Canada, 2McMaster University, Department of Internal Medicine, Hamilton, Canada, 3McMaster University, Gastroenterology, Hamilton, Canada

P542.

Crohn's Disease (CD) in the elderly – an IG-IBD study

Authors:

A. Viola1, L. Cantoro2, R. Monterubbianesi2, F. Castiglione3, M. Principi4, I. Frankovic5, D. Pugliese6, F. Callela7, S. Saibeni8, A. Aratri9, S. Orlando10, M. Cappello11, G. Costantino12, N. Mannetti13, G. Mocci14, L. Samperi15, G. Inserra15, A.C. Privitera16, F. Caprioli17, V. Annese18, C. Papi19, A. Armuzzi20, R. D'Incà21, A. Kohn2, F. Manguso22, W. Fries1, 1University of Messina, Dept. of Clinical and Experimental Medicine, Messina, Italy, 2San Camillo-Forlanini, UOC Gasteroenterologia, Roma, Italy, 3Università “Federico II” di Napoli, Gastroenterologia, Napoli, Italy, 4University of Bari, Gastroenterology Section (D.E.T.O.), Bari, Italy, 5Gastroenterologia, Departimento di Medicina, Padova, Italy, 6Complesso Integrato Columbus, Catholic University, IBD UNIT, Roma, Italy, 7Ospedale San Giuseppe, UOC Gastroenterologia, Empoli (FI), Italy, 8AO Fatebenefratelli e Oftalmico, UOC di Medicina Interna ed Epatologia, Milano, Italy, 9ACO San Filippo Neri, UOC Gastroenterologia ed Epatologia, Roma, Italy, 10Fondazione IRCCS Cá Grande Ospedale Policlinico di Milano, UO Gastroenterologia, Milano, Italy, 11A.O.U. Policlinico, UOC Gastroenterologia ed Epatologia, Palermo, Italy, 12Università di Messina, Dept. of Clinical and Experimental Medicine, Messina, Italy, 13Careggi, University Hospital, Gastroenterology Unit, Florence, Italy, 14Ospedale Brodzu, UOC di Gastroenterologia, Cagliari, Italy, 15University of Catania, Dip. di Scienze Mediche e Pediatriche, UO Medicina Interna, Catania, Italy, 16A.O. per l'Emergenza Cannizzaro, IBD UNIT, Catania, Italy, 17Fondazione IRCCS Cá Grande Ospedale Policlinico di Milano, Dipartimento di Fisiopatologia medico-chirurgica e dei trapianti, Milano, Italy, 18Careggi, University Hospital, Gastroenterology Unit, Firenze, Italy, 19AOU Policlinico Federico II of Naples, Gastroenterology, Naples, Italy, 20Catholic University, Rome, Complesso Integrato Columbus, IBD UNIT, Roma, Italy, 21Dip. di Medicina, OC Padova, Gastroenterologia, Padova, Italy, 22AORN A. Cardarelli, Napoli, UOC of Gastroenterology, Napoli, Italy

P542. Correlates of IBD fatigue: a meta-analysis and systematic review
Authors:

I. Nathan1, K.C. Fragkos1, A. Forbes1, 1University College London, Centre for Gastroenterology and Nutrition, London, United Kingdom

P542

Care of women with gastrointestinal conditions during family planning and pregnancy

Authors:

M. Clowse*1, M. Druzin2, M. Khamashta3, D. Pushparajah4, S. Horst5

1Duke University Medical Center, Duke University, Durham, United States, 2School of Medicine, Stanford University, Stanford, California, United States, 3Lupus Research Unit, The Rayne Institute, St Thomas Hospital, London, United Kingdom, 4UCB Pharma, Patient Affairs, Brussels, Belgium, 5Vanderbilt University, Medical Center, Nashville, United States

P543.

Combined immunosuppression, corticoids and menopause have significant influence on bone mineral density of IBD patients. A prospective study

Authors:

A. Krajcovicova, T. Hlavaty, Z. Killinger, E. Miznerova, J. Toth, D. Cierny, T. Koller, J. Letkovsky, Z. Zelinkova, M. Huorka, J. Payer, University Hospital Bratislava, 5th Department of Internal Medicine, Bratislava, Slovakia

P543. Better response rates to anti-TNFα than cyclosporin in steroid refractory acute severe colitis: data from the UK IBD audit
Authors:

R. Lynch1, A. Protheroe2, M. Roughton2, I. Arnott1, UK IBD Audit Steering Group2, 1NHS Lothian, Gastroenterology, Edinburgh, United Kingdom, 2RCP, CEEU, London, United Kingdom

P543

Assessment of Lactose Intolerance in Ulcerative Colitis Patients on Remission

Authors:

E. AHISHALI*1, E.E. AKKUS2, C. DOLAPCIOGLU1, M. SAYINER2, T. ARSLAN2, R. YILMAZ3, A. KURAL1, R. DABAK2

1Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Gastroenterology, ISTANBUL, Turkey, 2Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Family Medicine, ISTANBUL, Turkey, 3Dr. Lutfi Kirdar Kartal Education and Research Hospital, Department of Endocrinology, ISTANBUL, Turkey

P544.

Bone mineral density measurement using dual energy X-ray in inflammatory bowel disease patients – Are we screening our patients for osteoporosis?

Authors:

F.A. Rana1, D. Tate2, M.M. Shaikh3, J. Bowles1, 1Great Western Hospital NHS Foundation Trust, Gastroenterology, Swindon, United Kingdom, 2Royal United Hospital NHS Trust, Gastroenterology, Bath, United Kingdom, 3James Cook University Hospital, Rheumatology, Middlesbrough, United Kingdom

P544. Does measuring IFX and human anti-chimeric antibody concentrations in patients with inflammatory bowel disease impact clinical management? A Canadian experience
Authors:

U. Chauhan1, U. Dutta2, D. Armstrong2, J. Marshall2, F. Tse2, E. Greenwald2, T. Xenodemetropoulos2, S. Halder2, 1McMaster University Medical Centre, Digestive Disease Speciality Adult Service, Hamilton ON, Canada, 2McMaster University, Division of Gastroenterology, Hamilton ON, Canada

P544

Factors associated with drug non-adherence in an Indian IBD patient cohort: It's not always the cost

Authors:

R. Banerjee1, U. Basavaraju*2, B. Adigopula1, V. Nagalaxmi1, N. Reddy1

1Asian Institute of Gastroenterology, Inflammatory Bowel Disease, Hyderabad, India, 2Aberdeen Royal Infirmary, Nhs Grampian, Digestive Disorders, Aberdeen, United Kingdom

P545.

Bolus administration of steroid therapy is more favourable than the conventional use in preventing decrease of bone density and the increase of body fat percentage in patients with inflammatory bowel disease

Authors:

K. Farkas1, A. Bálint1, Z. Valkusz1, Z. Szepes1, F. Nagy1, M. Szücs2, R. Bor1, T. Wittmann1, T. Molnár1, 1University of Szeged, First Department of Medicine, Szeged, Hungary, 2University of Szeged, Department of Medical Physics and Informatics, Szeged, Hungary

P545. Disease duration does not influence the rates of loss of efficacy to anti-TNF therapy in Brazilian Crohn's disease patients
Authors:

P.G. Kotze1, J. Ludvig2, F.V. Teixeira3, H. Kleinubing Jr.4, E.F. Malluta5, E.F. Miranda1, M. Hardt1, M. Olandoski6, L.M.S. Kotze7, 1Catholic University of Parana, Colorectal Surgery Unit, Curitiba – PR, Brazil, 2Esadi, Gastroenterology unit, Blumenau – SC, Brazil, 3Gastrosaude, Colorectal Surgery Unit, Marilia – SP, Brazil, 4Univille, Colorectal Surgery unit, Joinville – SC, Brazil, 5Univali, Gastroenterology unit, Itajai – SC, Brazil, 6Catholic University of Parana, Statistics, Curitiba – PR, Brazil, 7Catholic University of Parana, Gastroenterology unit, Curitiba – PR, Brazil

P545

An Open-label Prospective Randomized Multicentre Study of Daily Granulocyte and Monocyte Adsorptive Apheresis as Compared with Intensive Treatment in Patients with Active Ulcerative Colitis

Authors:

K. Mizukami*, A. Sonoda, T. Okimoto, M. Kodama, K. Murakami

Oita university, Gastroenterology, Oita, Japan

P546.

Biological therapy in children and adolescents: infliximab and adalimumab, a comparison of their side effects

Authors:

F. Calzolari, F. Vincenzi, F. Fornaroli, B. Bizzarri, A. Ghiselli, C. Calzolari, A. Salerno, G. Nervi, G.L. de' Angelis, University Hospital of Parma, Gastroenterology and Digestive Endoscopy Unit, Parma, Italy

P546. Diagnostic value of laboratory tests in the assessment of malnutrition in patients with ulcerative colitis
Authors:

M. Sanges1, M. Miniero1, M.G. Ceriello1, A. Piacente1, L. Florio1, D. Trio1, O. Donatore1, D. Mattera1, R. Sollazzo1, A. D'Arienzo1, 1Federico II University of Naples, Gastroenterology Unit, Department of Clinical and Experimental Medicine, Naples, Italy

P546

Impact of mucosal healing on the clinical course in a cohort of paediatric patients affected by Crohn's Disease

Authors:

F. Nuti, F. Viola, M. Aloi, F. Civitelli, S. Oliva, S. Cucchiara*

Sapienza, Rome, Pediatric Gastroenterology and Liver Unit, Rome, Italy

P547.

Biological agents for moderately-to-severely active ulcerative colitis in adults: a network meta-analysis of randomized controlled trials

Authors:

S. Danese1, G. Fiorino1, L. Peyrin-Biroulet2, E. Lucenteforte3, G. Virgili4, L. Moja5,6, S. Bonovas7, 1Humanitas Research Hospital, IBD Center, Rozzano, Milan, Italy, 2Nancy University Hospital, Université de Lorraine, Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France, 3University of Florence, Department of Neurosciences, Psychology, Drug Research and Child Health, Florence, Italy, 4University of Florence, Department of Specialised Surgical Sciences, Florence, Italy, 5IRCCS Galeazzi Orthopedic Institute, Unit of Clinical Epidemiology, Milan, Italy, 6University of Milan, Department of Biomedical Sciences for Health, Milan, Italy, 7IRCCS Mario Negri Institute for Pharmacological Research, Laboratory of Drug Regulatory Policies, Milan, Italy

P547. Diagnostic radiation exposure in patients with Crohn's disease treated with infliximab
Authors:

H.-L. Ching1, F. Chariah1, G. Lipman1, M. Train2, S. Mann1, 1Barnet and Chase Farm Hospitals NHS Trust, Gastroenterology, London, United Kingdom, 2Barnet and Chase Farm Hospitals NHS Trust, Radiology, London, United Kingdom