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P527

Characterization of variables determining satisfaction with life in Crohn's Disease patients

Authors:

O. Sarid1, V. Slomin-Nevo1, H. Vardi2, D. Schwartz3, A. Fich3, D. Greenberg4, M. Friger2, S. Odes*4

1Ben-Gurion University of the Negev, Social Work, Beer Sheva, Israel, 2Ben-Gurion University of the Negev, Public Health, Beer Sheva, Israel, 3Soroka University Hospital, Gastroenterology, Beer Sheva, Israel, 4Ben-Gurion University of the Negev, Health Systems Management, Beer Sheva, Israel

P528.

Complications of IBD in the anti-TNF era: reason for optimism?

Authors:

V. Nuij1, G. Fuhler1, A. Edel1, R. Ouwendijk2, M. Rijk3, R. Beukers4, R. Quispel5, A. van Tilburg6, T. Tang7, H. Smalbraak8, K. Bruin9, F. Lindenburg10, L. Peyrin-Biroulet11, C.J. van der Woude1, 1ErasmusMC University Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands, 2Ikazia Hospital, Gastroenterology and Hepatology, Rotterdam, Netherlands, 3Amphia Hospital, Gastroenterology and Hepatology, Breda, Netherlands, 4Albert Schweitzer Hospital, Gastroenterology and Hepatology, Rotterdam, Netherlands, 5Reinier de Graaf Gasthuis, Gastroenterology and Hepatology, Rotterdam, Netherlands, 6Sint Franciscus Gasthuis, Gastroenterology and Hepatology, Rotterdam, Netherlands, 7IJsselland Hospital, Gastroenterology and Hepatology, Capelle aan den IJssel, Netherlands, 8Lievensberg Hospital, Internal Medicine, Bergen op Zoom, Netherlands, 9Tweesteden Hospital, Gastroenterology and Hepatology, Tilburg, Netherlands, 10Franciscus Hospital, Gastroenterology and Hepatology, Roosendaal, Netherlands, 11Nancy University Hospital, Université de Lorraine, Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France

P528. Effect of early induction with immunomodulators on long-term clinical remission in patients with Crohn's disease
Authors:

T. Yoshino1, H. Nakase1, M. Matsuura1, T. Chiba1, 1Kyoto University, Gastroenterology and Hepatology, Kyoto, Japan

P528

Efficacy of vedolizumab with concomitant corticosteroid or immunomodulator use in patients with Crohn's disease in GEMINI 2

Authors:

J.-F. Colombel*1, E.V. Loftus Jr2, C.A. Siegel3, J.D. Lewis4, M. Smyth5, J. Xu6, B. Abhyankar7

1Icahn School of Medicine at Mount Sinai Hospital, Gastroenterology, New York, NY, United States, 2Mayo Clinic, Gastroenterology and Hepatology, Rochester, Minnesota, United States, 3Dartmouth-Hitchcock Medical Center, Gastroenterology and Hepatology, Hanover, New Hampshire, United States, 4University of Pennsylvania Perelman School of Medicine, Gastroenterology, Philadelphia, Pennsylvania, United States, 5Takeda Global Research and Development Centre (Europe) Ltd., Medical, London, United Kingdom, 6Takeda Pharmaceuticals International Co., Biostatistics, Cambridge, Massachusetts, United States, 7Takeda Global Research and Development Centre (Europe) Ltd., Clinical Science, London, United Kingdom

P529.

Compassionate access use of anti-TNF therapy in ulcerative colitis in six Australian IBD centres has been beneficial to patient outcomes

Authors:

S. Costello1, S. Ghaly2, S. O'Connor3, A. Agarwal1, L. Beswick4, B. Headon4, A. Pudipeddi2, A. Sechi5, R. Prosser6, S. Connor5, M. Sparrow4, P. Bampton6, A. Walsh2, J. Andrews1, 1Royal Adelaide Hospital, Gastroenterology and Hepatology, Adelaide, Australia, 2St Vincent's Hospital, Department of Gastroenterology, Sydney, Australia, 3Princess Alexandra Hospital, Gastroenterology, Brisbane, Australia, 4The Alfred Hospital, Department of Gastroenterology, Melbourne, Australia, 5Liverpool Hospital, Department of Gastroenterology, Sydney, Australia, 6Flinders Medical Centre, Department of Gastroenterology, Adelaide, Australia

P529. Effect of the combination therapy of intensive granulocyte and monocyte adsorption apheresis and thiopurines in patients with early-diagnosed Crohn's disease
Authors:

T. Fukuchi1, H. Nakase2, M. Matsuura2, T. Yoshino2, T. Toyonaga2, S. Ubukata1, A. Ueda1, H. Yamashita1, K. Ashida1, 1Osakafu Saiseikai Nakatsu Hospital, Gastroenterology and Hepatology, Osaka, Japan, 2Kyoto university Hospital, Gastroenterology and Hepatology, Kyoto, Japan

P529

Maintenance of clinical remission in Crohn's disease patients after discontinuation of antiTNF agents: Results from a single centre cohort

Authors:

R. Monterubbianesi*1, C. Papi2, A. Kohn1

1AO San Camillo Forlianini, Gastroenterology Operative Unit, Rome, Italy, 2AO S. Filippo Neri, UOC Gastroenterology, Rome, Italy

P530.

Comparison between liposomial iron and ferrous sulfate in patients with iron deficiency anemia and inflammatory bowel disease. A pilot controlled study

Authors:

A. Indriolo, P. Ravelli, Papa Giovanni XXIII Hospital, Gastroenterology and Digestive Endoscopy Unit, Bergamo, Italy

P530. Effectiveness of anti-TNF drugs in Crohn's disease (CD) patients who did not achieve remission with the first anti-TNF
Authors:

M. R-Grau1, M. Chaparro1, F. Mesonero2, M. Barreiro-de Acosta3, L. Castro4, I. Vera5, M. Castro6, E. Domènech7, N. Manceñido8, C. Taxonera9, J.L. Pérez10, J. Barrio11, R. De Francisco12, O. Merino13, L. Oltra14, C. Saro15, F. Bermejo16, V. García17, D. Ginard18, A. Gutiérrez19, X. Calvet20, J.P. Gisbert1, 1Hospital Universitario de la Princesa-IP, Gastroenterology and CIBEREHD, Madrid, Spain, 2Hospital Universitario Ramón y Cajal, Gastroenterology, Madrid, Spain, 3Hospital Universitario Clínico de Santiago, Gastroenterology, Santiago de Compostela, Spain, 4Hospital Virgen Macarena, Gastroenterology, Sevilla, Spain, 5Hospital Universitario Puerta de Hierro, Gastroenterology, Madrid, Spain, 6Hospital Universitario de Valme, Gastroenterology, Sevilla, Spain, 7Hospital Universitario Germans Trias i Pujol, Gastroenterology and CIBEREHD, Badalona, Spain, 8Hospital Universitario Infanta Sofía, Gastroenterology, Madrid, Spain, 9Hospital Universitario Clínico San Carlos, Gastroenterology, Madrid, Spain, 10Hospital Universitario Fundación Alcorcón, Gastroenterology, Madrid, Spain, 11Hospital Universitario Rio Hortega, Gastroenterology, Valladolid, Spain, 12Hospital Universitario Central de Asturias, Gastroenterology, Oviedo, Spain, 13Hospital Universitario Cruces, Gastroenterology, Vizcaya, Spain, 14Hospital de Manises, Gastroenterology, Valencia, Spain, 15Hospital de Cabueñes, Gastroenterology, Gijón, Spain, 16Hospital Universitario de Fuenlabrada, Gastroenterology, Madrid, Spain, 17Hospital Universitario Reina Sofía, Gastroenterology, Córdoba, Spain, 18Hospital Universitario de Son Espases, Gastroenterology, Mallorca, Spain, 19Hospital General Universitario de Alicante, Gastroenterology, Alicante, Spain, 20Corporació Sanitària Parc Taulí, Gastroenterology, Sabadell, Spain

P530

Is microscopic colitis a rare disease in Southern Europe? A prevalence population-based study in Terrassa (Spain)

Authors:

F. Fernández-Bañares*1, A. Salas2, Y. Zabana1, M. Aceituno1, M. Esteve1

1Hospital Universitari Mutua Terrassa, Gastroenterology, Terrassa, Spain, 2Hospital Universitari Mutua Terrassa, Pathology, Terrassa, Spain

P531.

Comparative assessment of the safety of cell and standard anti-inflammatory therapy of ulcerative colitis

Authors:

O. Knyazev1, A. Parfenov1, I. Ruchkina1, A. Konoplyannikov2, P. Shcherbakov1, R. Gudkova3, L. Lazebnik4, 1Central Research Institute of Gastroenterology, Department of Inflammatory Bowel Disease, Moscow, Russian Federation, 2Medical Radiological Scientific Center, Department of Stem Cells Therapy, Obninsk, Russian Federation, 3Central Research Institute of Gastroenterology, Laboratory of Immunology, Moscow, Russian Federation, 4Moscow State Medico-Dentist University, Department of Therapy, Moscow, Russian Federation

P531. Effectiveness of anti-TNF agents in the treatment of entero-urinary fistulas in Crohn's disease
Authors:

C. Taxonera1, I. Fernández-Blanco2, M. Barreiro-de Acosta3, G. Bastida4, A. López-San Román5, O. Merino6, V. García-Sánchez7, J.P. Gisbert8, I. Marín-Jiménez9, P. López-Serrano10, E. Iglesias7, J. Martínez-González5, M. Chaparro8, C. Saro11, F. Bermejo12, L. Pérez-Carazo9, R. Plaza13, D. Olivares1, J.L. Mendoza1, E. Rey14, 1H Clinico San Carlos, IBD Unit, IdiSSC, Madrid, Spain, 2Hospital Moncloa, Madrid, Spain, 3H Clínico de Santiago, Santiago de Compostela, Spain, 4H La Fe, Valencia, Spain, 5H Ramón y Cajal, Madrid, Spain, 6H Cruces, Barakaldo, Spain, 7H Reina Sofía, Córdoba, Spain, 8H La Princesa, CIBERehd, Madrid, Spain, 9H Gregorio Marañón, Madrid, Spain, 10H Alcorcón, Madrid, Spain, 11H de Cabueñes, Gijón, Spain, 12H Fuenlabrada, Madrid, Spain, 13H Infanta Leonor, Madrid, Spain, 14H Clinico San Carlos, IdiSSC, Madrid, Spain

P531

Intravenous corticosteroid dosing in paediatric acute severe Ulcerative Colitis (ASC): A multicenter propensity score study

Authors:

D. Turner*1, H. Finnamore2, M.K. Auth3, E. Shteyer1, D. Mack4, J. Hyams5, N. Leleiko6, A.M. Griffiths7, S. Choshen1

1Shaare Zedek Medical Center , Pediatric Gastroenterolgoy, Jerusalem, Israel, 2AldeHey Children’s NHS Foundation Trust, Liverpool, Pediatric Gastroenterolgoy, Liverpool, United Kingdom, 3Alde Hey Children’s NHS Foundation Trust, Liverpool, Pediatric Gastroenterolgoy, Liverpool, United Kingdom, 4CHEO, Pediatric Gastroenterolgoy, Ottawa, Canada, 5Connecticut Children's Medical Center, Hartford, CT, Pediatric Gastroenterolgoy, Hartford, United States, 6Providence, Pediatric Gastroenterolgoy, Providence, United States, 7SickKids, Pediatric Gastroenterolgoy, Toronto, Canada

P532.

Colon cancer in IBD patients treated or untreated with anti-TNFs: A retrospective matched-pair study in a 13 years follow up

Authors:

M. Ascolani, G. Condino, C. Petruzziello, S. Onali, E. Calabrese, E. Lolli, A. Ruffa, F. Pallone, L. Biancone, Università di Roma Tor Vergata, Medicina dei sistemi, cattedra di Gastroenterologia, Roma, Italy

P532. Economic burden of common comorbidities associated with ulcerative colitis
Authors:

R.D. Cohen1, J. Rizzo2, A. Soliman3, M. Yang2, M. Skup2, P.M. Mulani2, J. Chao2, 1University of Chicago, Chicago, IL, United States, 2Abbott Laboratories, Abbott Park, IL, United States, 3University of Minnesota, Minneapolis, MN, United States

P532

Quality of Care in Family Planning and Pregnancy - an Online Survey among 475 Female Patients with Inflammatory Bowel Disease

Authors:

S. Brunne, J. Walldorf*

Martin Luther University Halle-Wittenberg, Department for Internal Medicine I, Halle, Germany

P533.

Colectomy rate and mortality in hospitalized severe ulcerative colitis patients over the past 40 years

Authors:

V. Clemente1, A. Aratari2, G. Burrelli Scotti1, G. Margagnoni2, C. Papi2, P. Vernia1, 1Sapienza, Dpt of Internal Medicine and Medical Specialties, Rome, Italy, 2San Filippo Neri Hospital, Gastroenterology & Hepatology Unit, Rome, Italy

P533. Excellent long-term outcome in infliximab treated patients with chronic active ulcerative colitis
Authors:

L. Angelison1, S. Almer2, U. Hindorf3, E. Hertervig3, 1Helsingborg Hospital, Dep. of Medicine, Helsingborg, Sweden, 2Linköping University, Dep of Gastroenterology, Linköping, Sweden, 3Skåne University Hospital, Dep of Gastroenterology, Lund, Sweden

P533

Assessment of disease-related therapeutic protein drug-drug interaction (TP-DDI) for etrolizumab in patients with moderately to severely active ulcerative colitis (UC)

Authors:

X.T. Wei*, J. Kenny, L. Dickmann, R. Maciuca, C. Looney, C. Khojasteh-Bakht, M.T. Tang

Genentech, Clinical Pharmacology, South San Francisco, United States

P534.

Co-prescription of allopurinol can overcome adverse events of thiopurine therapy and lead to remission in inflammatory bowel disease patients

Authors:

L. Beswick1, J.P. Dwyer2, A.B. Friedman1, S.L. Jakobovits1, E. Paul3, B. Headon1, A. McFarlane2, P.R. Gibson1, D.R. Van Langenberg2, M.P. Sparrow1, 1Alfred Health, Department of Gastroenterology, Melbourne, Australia, 2Eastern Health, Department of Gastroenterology, Melbourne, Australia, 3Monash University, Department of Epidemiology and Preventive Medicine, Melbourne, Australia