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P521.

Cytomegalovirus infection and response to influenza vaccination in inflammatory bowel disease patients on anti-TNF therapy

Authors:

L. Guidi1, G. Andrisani1, D. Frasca2, P. Cattani3, M. Marzo1, C. Felice1, D. Pugliese1, A. Papa1, G.L. Rapaccini1, B.B. Blomberg2, A. Armuzzi1, 1Catholic University, IBD Unit, Complesso Integrato Columbus, Rome, Italy, 2Miller School of Medicine, Department of Microbiology and Immunology, Miami, United States, 3Catholic University, Clinical Laboratory Unit, Complesso integrato Columbus, Rome, Italy

P521. Efficacy and safety of adalimumab in children with Crohn's disease previously treated with infliximab
Authors:

A. Jacob1, M. Fumery2, J. Salleron3, L. Michaud1, C. Spyckerelle4, J.-F. Colombel5, C. Gower-Rousseau6, D. Turck1, 1University Hospital, Pediatric Unit, Lille, France, 2Amiens University and Hospital, Gastroenterology, Amiens, France, 3University Hospital EA 2694, Biostatistics, Lille, France, 4St Vincent Hospital, Paediatric Unit, Lille, France, 5University Hospital, Gastroenterology, Lille, France, 6University Hospital, Epidemiology EA 2694, Lille, France

P521

Correcting iron deficiency anaemia in IBD with oral ferric maltol: Use of proton pump inhibitors does not affect efficacy

Authors:

C. Büning*1, T. Ahmad2, B. Bokemeyer3, F. Cummings4

1Krankenhaus Waldfriede, Internal Medicine, Berlin, Germany, 2Royal Devon and Exeter NHS Foundation Trust, Gastroenterology, Exeter, United Kingdom, 3Gastroenterology Practice Minden, Gastroenterology , Minden, Germany, 4University Hospital Southampton, Gastroenterology, Southampton, United Kingdom

P522.

Cytapheresis as remission induction therapy in 154 ulcerative colitis patients: A five year experience

Authors:

O. Nomura, T. Shibuya, T. Osada, D. Ishikaw, N. Sakamoto, T. Ogihara, S. Watanabe, Juntendo University, Gastroenterology, Tokyo, Japan

P522. Efficacy and safety of adalimumab 80 mg weekly in Crohn's disease
Authors:

G. Bouguen1, D. Laharie2, S. Nancey3, X. Hébuterne4, B. Flourié3, J. Filippi4, X. Roblin5, C. Trang6, A. Boureille6, A. Babouri7, J.-F. Bretagne1, L. Siproudhis1, L. Peyrin-Biroulet7, 1CHU Pontchaillou, Service des Maladies de l'Appareil Digestif, Rennes, France, 2University Hospital of Bordeaux, Hôpital Haut-Lévêque, Gastroenterology, Bordeaux, France, 3University Hospital of Lyon, Gastroenterology, Lyon, France, 4University Hospital of Nice, Gastroenterology, Nice, France, 5University Hospital of Saint-Etienne, Gastroenterology, Saint-Etienne, France, 6University Hospital of Nancy, Gastroenterology, Nantes, France, 7University Hospital of Nancy, Gastroenterology, Nancy, France

P522

Factors reducing bone mineral density in patients with inflammatory bowel disease

Authors:

D. Abdulganieva*1, E. Bodryagina1, A. Odintsova2

1Kazan State Medical University, Department of Hospital Therapy, Kazan, Russian Federation, 2Republican Clinical Hospital, Department of Gastroenterology, Kazan, Russian Federation

P523.

Cyclosporin rescue therapy is as effective as infliximab at preventing colectomy

Authors:

S. O'Connor1,2, M. Lalji1, G. Holtmann1,2, P. Pillans2,3, N. Martin1, D. Burger1, 1Princess Alexandra Hospital, Gastroenterology, Brisbane, Australia, 2University of Queensland, Gastroenterology, Brisbane, Australia, 3Princess Alexandra Hospital, Clincal Pharmacology, Brisbane, Australia

P523. Efficacy and safety of adalimumab (ADA) therapy in pediatric Crohn's disease (CD) patients who failed infliximab (IFX): a multicenter experience of the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (SIGENP)
Authors:

P. Alvisi1, A. Barabino2, S. Cucchiara3, E. Miele4, C. Romano5, A. Ravelli6, D. Knafelz7, P. Lionetti8, G. Guariso9, M. Aloi3, S. Arrigo2, L. Balzani10, S. Martellossi11, 1Maggiore hospital, Pediatric unit, Bologna, Italy, 2Gaslini hospital, Gastroenterology and Endoscopy unit, Genua, Italy, 3Sapienza University of Rome, Pediatric Gastroenterology and Liver unit, Rome, Italy, 4University of Naples Federico II, Pediatric unit, Naples, Italy, 5University of Messina, Pediatric Gastroenterology and Liver unit, Messina, Italy, 6Children's hospital, Gastroenterology and GI Endoscopy unit, Brescia, Italy, 7Bambino Gesù Hospital, Hepatology and Gastroenterology unit, Rome, Italy, 8Meyer Pediatric Hospital, Gastroenterology and Nutrition unit, Florence, Italy, 9University of Padua, Pediatric Gastroenterology unit, Padua, Italy, 10Bologna Hospitals, Directional Staff, Bologna, Italy, 11Institute of Child Health, IRCSS Burlo Garofolo, Department Of Pediatrics, Trieste, Italy

P523

Efficacy of cyclosporine therapy in intestinal Behçet's disease

Authors:

T. Kawaguchi*, R. Tanaka, M. Sako, N. Yoshimura, M. Takazoe

Tokyo Yamate Medical Center, Department of IBD, Tokyo, Japan

P524.

Crohn's disease localization does not contribute to response for induction therapy with infliximab in children

Authors:

M. Dadalski, A. Wegner, J. Kierkus, Children's Memorial Health Institute, Gastroenterology, Hepatology and Feeding Disorders, Warsaw, Poland

P524. Efficacy of infliximab treatment in acute severe ulcerative colitis
Authors:

S. Gokturk1, O. Mutluay Soyer1, A. Ciftcibasi Ormeci1, B. Baran1, S. Evirgen1, F. Akyüz1, Ç. Karaca1, K. Demir1, F. Besisik1, S. Kaymakoglu1, 1Istanbul School of Medicine, Gastroenterohepatology, Istanbul, Turkey

P524

Could histological lesions predict reactivation in ulcerative colitis patients with mucosal healing?

Authors:

L. Laterza*1, S. Bibbò2, A.C. Piscaglia3, V. Arena4, M. Brisigotti5, G. Fabbretti5, A. Amato6, M.L. Stefanelli3, E. Gaetani1, V. Cesario1, 3, G. Cammarota1, A. Gasbarrini1, F. Scaldaferri1

1Catholic University of Rome, Inernal Medicine and Gastroenterology, Rome, Italy, 2Catholic University of Rome, Internal Medicine and Gastroenterology, Rome, Italy, 3State Hospital, Gastroenterology and Endoscopy Unit, Borgo Maggiore, San Marino, 4Catholic University, Institute of Pathology, Rome, Italy, 5"Infermi" Hospital, Instiute of Pathology, Rimini, Italy, 6Catholic University of Rome, Institute of Anesthesiology and Resuscitation, Rome, Italy

P525.

Crohn's disease outcome in patients under azathioprine: a tertiary referral center experience

Authors:

J. Santos-Antunes1, F. Magro1, F. Vilas-Boas1, E. Rodrigues-Pinto1, R. Coelho1, O. Ribeiro2, S. Lopes1, G. Macedo1, 1Centro Hospitalar São João, Gastroenterology, Porto, Portugal, 2Centro Hospitalar S. João, Centre for Research in Health Informatics Systems and Technologies (CINTESIS), Porto, Portugal

P525. Efficacy infliximab with immunomodulator and infliximab alone of maintenance therapy in children with Crohn's disease – multicenter randomized study
Authors:

J. Kierkus1, B. Iwanczyk2, A. Wegner1, M. Dadalski1, U. Grzybowska-Chlebowczyk3, I. Lazowska4, J. Maslana5, E. Toporowska-Kowalska6, G. Czaja-Bulsa7, G. Mierzwa8, B. Korczowski9, E. Czkwianianc10, A. Zabka11, E. Szymanska1, E. Krzesiek2, S. Wiecek12, M. Sladek13, 1The Childrens Memorial Health Institute, Gastroenterology, Hepatology and Immunology, Warsaw, Poland, 2Medical University of Wroclaw, Department of Pediatrics, Gastroenterology and Nutrition, Wroclaw, Poland, 3Medical University of Silesia, Gastroenterology Unit, Upper-Silesian Child Health Care Centre in Katowice, Department of Paediatrics, Katowice, Poland, 4Medical University of Warsaw, Department of Pediatric Gastroneterology and Nutrition, Warsaw, Poland, 5Wl. Buszkowski Kielce Province Children's Hospital, Kielce, Poland, Kielce, Poland, 6Medical University of Lodz Poland, Department of Paediatric Allergology, Gastroenterology and Nutrition, Lodz, Poland, 7Pomeranian Medical University, Division of Paediatrics, Gastroenterology and Rheumatology of Zdroje Hospital in Szczecin, Paediatric Nursery Unit, Szczecin, Poland, 8Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Poland, Chair and Department of Pediatrics, Allergology and Gastroenetrology, Bydgoszcz, Poland, 9State Hospital. Medical College. University of Rzeszów. Poland, Department of Pediatrics, Rzeszow, Poland, 10Polish Mother's Memorial Hospital. Research Institute Lodz, Gastroenterology and Pediatric Depts, Lodz, Poland, 11Medical University of Silesia, Zabrze, Department of Pediatrics, Zabrze, Poland, 12Medical University of Silesia, Gastroenterology Unit, Upper-Silesian Child Health Care Centre in Katowice, The Department of Paediatrics, Katowice, Poland, 13Jagiellonian University School of Medicine, Krakow, Department of Pediatrics, Gastroenterology and Nutrition, Krakow, Poland

P525

Evolution of IBD-related costs over two years of follow up: increase of anti-TNF α therapy related costs with a decline of hospitalization costs

Authors:

M. Van der Valk*1, M.-J. Mangen2, M. van der Have1, M. Severs3, G. Dijkstra4, A. van Bodegraven5, H. Fidder3, D. de Jong6, M. Pierik7, J. van der Woude8, M. Romberg-Camps9, C. Clemens10, J. Jansen11, P. van de Meeberg12, N. Mahmmod13, A. van der Meulen- de Jong14, C. Ponsioen15, C. Bolwerk16, R. Vermeijden17, P. Siersema3, M. Leenders3, B. Oldenburg3

1University Medical Center Utrecht, Gastroenterology and hepatology, Utrecht, Netherlands, 2University Medical Centre Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, Netherlands, 3University Medical Centre Utrecht, Gastroenterology and hepatology, Utrecht, Netherlands, 4University Medical Centre Groningen, Gastroenterology and hepatology, Groningen, Netherlands, 5VU University Medical Centre, Gastroenterology and hepatology, Amsterdam, Netherlands, 6Radboud University Medical Centre, Gastroenterology and hepatology, Nijmegen, Netherlands, 7Maastricht University Medical Centre, Gastroenterology and hepatology, Maastricht, Netherlands, 8Erasmus University Medical Centre, Gastroenterology and hepatology, Rotterdam, Netherlands, 9Orbis Medical Centre, Gastroenterology and hepatology, Sittard, Netherlands, 10Diaconessenhuis, Gastroenterology and hepatology, Leiden, Netherlands, 11Onze Lieve Vrouwe Gasthuis, Gastroenterology and hepatology, Amsterdam, Netherlands, 12Slingeland Hospital, Gastroenterology and hepatology, Doetinchem, Netherlands, 13Antonius Hospital, Gastroenterology and hepatology, Nieuwegein, Netherlands, 14Leiden Univesity Medical Centre, Gastroenterology and hepatology, Leiden, Netherlands, 15Academic Medical Centre Amsterdam, Gastroenterology and hepatology, Amsterdam, Netherlands, 16Reinier de Graaf Group, Gastroenterology and hepatology, Delft, Netherlands, 17Meander Medical Centre, Gastroenterology and hepatology, Amersfoort, Netherlands

P526.

Correlation of 6-TGN levels with clinical remission in patients with ulcerative colitis treated with azathioprine

Authors:

C. Primas, W. Eigner, A. Eser, C. Gratzer, S. Reinisch, H. Vogelsang, G. Novacek, W. Reinisch, L. Kazemi-Shirazi, Medical University of Vienna, Dept. for Gastroenterology and Hepatology, Vienna, Austria

P526. Efficacy, safety, and predictors of response to infliximab therapy for ulcerative colitis: a Korean multicentre study
Authors:

K.-M. Lee1, Y.T. Jeen2, J.Y. Cho3, C.K. Lee4, D.I. Park3, J.-P. Im5, S.-A. Jung6, H. Choi7, S.J. Park8, Y.S. Kim9, 1The Catholic University of Korea, Suwon, South Korea, 2Korea University, South Korea, 3Sungkyunkwan University, South Korea, 4Kyung Hee University, South Korea, 5Seoul National University, South Korea, 6Ewha Womans University, South Korea, 7The Catholic University of Korea, South Korea, 8Yonsei University, South Korea, 9Inje University, South Korea

P526

Impact of postinduction infliximab trough level and disease activity on primary response in Crohn's Disease

Authors:

A. Echarri*1, R. Ferreiro2, R. Fraga1, J. Cid3, M. Barreiro2, D. Carpio4, S. Pereira5, L. De Castro5, S. Soto6, A. Fernandez-Villaverde7, B. Gonzalez8, E. Santos9

1Complejo Hospitalario Ferrol, Gastroenterology, Ferrol, Spain, 2Complejo Hospitalario Universitario Santiago, Gastroenterology, Santiago, Spain, 3Complejo Hospitalario Coruña, Immunology, Coruña, Spain, 4Complejo Hospitalario Pontevedra, Gastroenterology, Pontevedra, Spain, 5Complejo Hospitalario Vigo, Gastroenterology, Vigo, Spain, 6Complejo Hospitalario Orense, Gastroenterology, Orense, Spain, 7Povisa, Gastroenterology, Vigo, Spain, 8Complejo Hospitalario Coruña, Gastroenterology, Coruña, Spain, 9Complejo Hospitalario Lugo, Gastroenterology, Lugo, Spain

P527.

Correlation between the Crohn's Disease Activity Index and a web-based self-reporting symptoms diary of Crohn's disease

Authors:

E.S. Kim1, K.B. Cho1, K.S. Park1, B.I. Jang2, K.O. Kim2, E.Y. Kim3, S.W. Jeon4, M.K. Jung4, C.H. Yang5, 1Keimyung University School of Medicine, Internal Medicine, Daegu, Korea, Republic of, 2Yeungnam University College of Medicine, Internal Medicine, Daegu, Korea, Republic of, 3Catholic University of Daegu School of Medicine, Internal Medicine, Daegu, Korea, Republic of, 4Kyungpook National University School of Medicine, Internal Medicine, Daegu, Korea, Republic of, 5Dongguk University College of Medicine, Division of gastroenterology and Hepatology, department of Internal Medicine, Kyungju, Korea, Republic of

P527. Effects of diet and physical activity interventions on fatigue in patients with quiescent ulcerative colitis
Authors:

M. Sanges1, O. Donatore1, D. Trio1, M. Miniero1, A. Piacente1, M.G. Ceriello1, L. Florio1, D. Mattera1, R. Sollazzo1, A. D'Arienzo1, 1Federico II University of Naples, Gastroenterology Unit, Department of Clinical and Experimental Medicine, Naples, Italy