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P091

Sonic hedgehog inhibitor prevented colitis-associated cancer via stem inhibition

Authors:

K. B. Hahm*1, Y. J. Kim2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Gachon University, Gastroenterology, Incheon, South Korea

P092

Characterisation of the lymphoid stress surveillance response performed by human colon resident γδ T-cells

Authors:

R. J. Dart*1, 2, 3, R. Woolf2, P. M. Irving3, A. C. Hayday1, 2

1Francis Crick Institute, Immunosurveillance Lab, London, United Kingdom, 2King’s College London, Immunobiology, DIIID, London, United Kingdom, 3Guy’s and St Thomas’ NHS Foundation Trust, IBD Centre, London, United Kingdom

P093

15-d-PGJ2 – a possible regulator of iron homeostasis

Authors:

J. Martin*1, 2, S. Ulrich-Rueckert2, J. Stein1, 3

1Interdisciplinary Crohn Colitis Centre Rhein-Main, Frankfurt/Main, Germany, 2Goethe University Frankfurt, Insitute of Pharmaceutical Chemistry, Frankfurt/Main, Germany, 3DGD Clinics Sachsenhausen, Frankfurt/Main, Germany

P094

Human neutrophil elastase shows increased elastinolytic activity in ulcerative colitis and contributes to loss of function of anti-TNF-alpha agents in ulcerative colitis

Authors:

P. Giuffrida*1, K. Kok2, A. Di Sabatino1, P. Biancheri2, A. Vanoli3, G. Mazza4, R. Curciarello2, A. Pasini1, N. Aronico1, M. Pinzani4, G. R. Corazza1, T. T. MacDonald2

1Fondazione IRCCS Policlinico San Matteo, University of Pavia, First Department of Medicine, Pavia, Italy, 2Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, London, United Kingdom, 3Fondazione IRCCS Policlinico San Matteo, University of Pavia, Department of Molecular Medicine, Pavia, Italy, 4Institute for Liver and Digestive Health, University College London, London, United Kingdom

P095

Immune compromised mice develop colitis upon denervation of the superior mesenteric nerve.

Authors:

R. Willemze*1, L. Nijhuis1, O. Welting1, J. Folgering2, H. Darwinkel2, D. Chew3, A. Sridhar3, J. Witherington3, J. Seppen1, S. Heinsbroek1, W. de Jonge1

1Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 2Brains On-line B.V., Groningen, Netherlands, 3Glaxo Smith Kline, Bioelectronics, Middlesex, United Kingdom

P096

Low-dose naltrexone reduces in-vitro endoplasmic reticulum stress and stimulates wound healing in intestinal epithelial cells

Authors:

G. Fuhler*, M. Lie, P. Dimitrijevic, C. J. van der Woude, M. Peppelenbosch

Erasmus MC University Medical Centre Rotterdam, Gastroenterology and Hepatology, Rotterdam, Netherlands

P097

MicroRNA23a is overexpressed in the colonic epithelium in Crohn’s disease

Authors:

R. Felwick*1, G. Dingley1, T. Sanchez-Elsner1, J. Collins1, F. Cummings2

1University of Southampton, Clinical and Experimental Sciences, Southampton, United Kingdom, 2University Hospital Southampton, Gastroenterology, Southampton, United Kingdom

P098

Anti-fibrotic effects of a novel small compound that promotes the nuclear translocation of YB-1 in a mouse model of colorectal fibrosis

Authors:

J. Imai*1, K. Hozumi2, Y. Inagaki3, T. Mine1

1Tokai university School of Medicine, Gastroenterology, Isehara, Japan, 2Tokai university School of Medicine, Immunology, Isehara, Japan, 3Tokai university School of Medicine, Regenerative Medicine, Isehara, Japan

P099

Inhibitory effect of 6-aminopyridin-3-ol analogues on TNF-α-induced monocyte-colon epithelial cell adhesion and TNBS-induced rat colitis

Authors:

B.-S. Jeong*1, S. Banskota1, P. Grung1, T.-g. Nam2, J.-A. Kim1

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea, 2Hanyang University, College of Pharmacy, Ansan, South Korea

P100

Effects of a narrow spectrum kinase inhibitor and selective kinase inhibitors on the intestinal pro-inflammatory immune response in ulcerative colitis

Authors:

M. R. Foster*1, P. Biancheri2, Y. Solanke1, S. Sirohi1, M. C. Fyfe1, A. Rowley1, T. T. MacDonald2, E. Wood3, S. Webber1, C. A. Walshe1

1Topivert Pharma Ltd, London, United Kingdom, 2Barts and the London, School of medicine and dentistry, London, United Kingdom, 3Homerton University Hospital, Academic Department of Medical and Surgical Gastroenterology, London, United Kingdom

P101

Functional translation of IBD-associated genetic variation in patient-derived intestinal epithelial cells

Authors:

W. Vanhove*1, K. Nys1, I. Arijs1, I. Cleynen2, G. Van Assche1, M. Ferrante1, S. Vermeire1

1KU Leuven, Translational Research Centre for Gastrointestinal Disorders (TARGID), Department of Clinical and Experimental Medicine, Leuven, Belgium, 2KU Leuven, Department of Human Genetics, Leuven, Belgium

P102

α-Defensins(αDef) 1-3 are specific plasmatic markers for Crohn’s disease (CD) at diagnosis and tissue α-Def 5 methylation is a pathogenic mechanism for αDef-5 down regulation in CD.

Authors:

E. Cerrillo1, I. Moret-Tatay2,3, M. Iborra1,2, E. Sáez-González1, E. Busó4, D. Ramos5, L. Tortosa1, P. Nos1,3, B. Beltrán*1,3

1Hospital Universitari La Fe, Gastroenterology, Valencia, Spain, 2Ciberehd, Gastroenterology, Valencia, Spain, 3IIS Hospital La Fe, Gastroenterology, Valencia, Spain, 4School of Medicine. Valencia University, Central Unit of Medical Research, Valencia, Spain, 5Hospital Universitari La Fe, Pathology, Valencia, Spain

P103

Selective M1 macrophage polarisation in Crohn’s disease in comparison to intestinal tuberculosis: a novel observation

Authors:

P. Das1, S. Pilli2, T. Kumar1, R. Rampal2, I. A. Khan2, A.K. Singh2, D. Kumar3, V. Ahuja*2

1All India Institute of Medical Sciences, Pathology, New Delhi, India, 2All India Institute of Medical Sciences, Gastroenterology, New Delhi, India, 3International Centre for Genetic Engineering and Biotechnology, Mammalian Biology, New Delhi, India

P104

Risk factors associated with the negativisation of anti-HBs antibodies in inflammatory bowel disease patients

Authors:

A. C. Marín*1, M. Chaparro1, M. Ramas1, R. R. Ribot1, P. M. Linares1, J. R. Villagrasa2, D. Bernardo1, J. P. Gisbert1

1Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, 2Hospital Universitario de La Princesa and IIS-IP , Preventive medicine unit, Madrid, Spain

P105

Inhibition of cytokine release from HT-29 cells and ulcerative colitis biopsies is potentiated by combination of selective kinase inhibitors, and such effects are mimicked by TOP1210, a narrow spectrum kinase inhibitor

Authors:

M. R. Foster*1, P. Biancheri2, S. Sirohi1, Y. Solanke1, M. C. Fyfe1, A. Rowley1, T. T. MacDonald2, E. Wood3, S. Webber1, C. A. Walshe1

1Topivert Pharma Ltd, London, United Kingdom, 2Barts and the London, School of Medicine and Dentistry, London, United Kingdom, 3Homerton University Hospital, Academic Department of Medical and Surgical Gastroenterology, London, United Kingdom

P106

Maintenance treatment with granulocyte/monocyte adsorption in patients with inflammatory bowel disease and an initial response to treatment: a Swedish long-term prospective registry study

Authors:

A. Lindberg1, 2, S. Lindgren3, M. Lördal4, S. Nilsson5, H. Svensson6, P. Karlen*1

1Department of Clinical Science, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden, Stockholm, Sweden, 2Karolinska Institutet, Danderyds hospital, Department of Clinical Science, Stockholm, Sweden, 3Department of Gastroenterology, University Hospital Skane, Sweden, Malmö, Sweden, 4Department of Medicine, Division of Gastroenterology and Hepathology at Karolinska Institutet, Huddinge, Sweden, Stockholm, Sweden, 5Department of Medicine, Kristianstad Hospital, Kristianstad, Sweden,, Kristianstad, Sweden, 6Departments of Internal Medicine, Vrinnevi Hospital, Norrköping, Sweden, Norrköping, Sweden

P107

IL-34 and IL-36 family expressing cytotoxic T-cells and plasmacytoid dendritic cells are increased 
in patients with active inflammatory bowel disease

Authors:

G. Fonseca Camarillo*1, E. Iturriaga Goyon2, J. Furuzawa Carballeda3, J. Yamamoto Furusho2

1Instituto Nacional de Ciencias Médicas y Nutrición, Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Mexico, Mexico, 2Instituto Nacional de Ciencias Médicas y Nutrición, Inflammatory Bowel Disease Clinic. Department of Gastroenterology, Mexico, Mexico, 3Instituto Nacional de Ciencias Médicas y Nutrición, Department of Immunology and Rheumatology, Mexico, Mexico

P108

Cytokine levels differ during pregnancy amongst women with ulcerative colitis and Crohn’s disease

Authors:

V. W. Huang*1, N. Hotte2, L. Ambrosio1, K. Smith2, J. Bal1, R. Foshaug1, K. I. Kroeker1, B. Halloran1, L. Dieleman1, R. N. Fedorak1, K. Madsen2

1University of Alberta, Gastroenterology, Edmonton, Canada, 2University of Alberta, Edmonton, Canada

P109

Effect of dysbiosis on the growth and colitis susceptibility in DSS colitis model

Authors:

C. S. Eun*, D. S. Han, A. R. Lee, Y. R. Lee

Hanyang University Guri Hospital, Gastroenterology, Guri, South Korea

P110

Cigarette smoke modulates the effect of dextran sulfate sodium–induced colitis on a subpopulation of T-cells in blood and colon in mice

Authors:

J. Daniluk*1, U. Daniluk2, M. Rusak3, J. Reszec4, M. Dabrowska3, A. Dabrowski1

1Medical University of Bialystok, Department of Gastroenterology and Internal Medicine, Bialystok, Poland, 2Medical University of Bialystok, Department of Paediatrics, Gastroenterology and Allergology, Bialystok, Poland, 3Medical University of Bialystok, Department of Haematological Diagnostics, Bialystok, Poland, 4Medical University of Bialystok, Department of Medical Pathomorphology, Bialystok, Poland