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P071

Improvement of experimental mouse models in inflammatory bowel diseases using flexible video endoscopic colon evaluation

Authors:

C. Gay*1, O. Martin Rodriguez2, A. Daoui2, S. Koch1, P. Saas2, S. Valmary Degano3, S. Perruche2, L. Vuitton1

1CHU Jean Minjoz, Gastro-entérologie, besançon, France, 2UMR 1098 INSERM, Besançon, France, 3CHU Jean Minjoz, Anatomopathologie, besançon, France

P072

TREM-1 stimulation ameliorates colitis in mice

Authors:

H. W. Ma*1, 2, X. Che1, 2, D. H. Seo1, 2, J. H. Kim1, 2, D. H. Kim1, 
T. I. Kim1, W. H. Kim1, S. W. Kim1, 2, 3, J. H. Cheon1, 2, 3

1Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, 2Yonsei University College of Medicine, Brain Korea 21 PLUS Project for Medical Science, Seoul, South Korea, 3Yonsei University College of Medicine, Severance Biomedical Science Institute, Seoul, South Korea

P073

TNF-alpha activity in plasma from patients with inflammatory bowel disease under adalimumab and infliximab treatment evaluated in a cell-based assay

Authors:

P. M. Linares*1, H. De la Fuente2, M. Chaparro1, I. Guerra3, P. L. Majano4, M. Iborra5, J. L. Cabriada6, L. Bujanda7, M. Barreiro-de Acosta8, V. García-Sánchez9, I. Marín-Jiménez10, D. Bernardo1, 
J. P. Gisbert1

1Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain, 2Hospital Universitario de La Princesa, IIS-IP, Immunology Unit, Madrid, Spain, 3Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain, 4Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Molecular Biology Unit, Madrid, Spain, 5Hospital Universitario La Fe and CIBERehd, Gastroenterology Unit, Valencia, Spain, 6Hospital Galdakao, Gastroenterology Unit, Vizcaya, Spain, 7Hospital de Donostia, Instituto Biodonostia, UPV/EHU and CIBEREHD, Gastroenterology Unit, Guipuzcoa, Spain, 8Hospital Clínico Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain, 9Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain, 10Hospital Gregorio Marañón and IiSGM, Gastroenterology Unit, Madrid, Spain

P074

Association of colonic mucosal infiltration of IgG4 plasma cells with ulcerative colitis activity and presence of primary sclerosing cholangitis

Authors:

F. Alborzi*1, Z. Azizi2, N. Ebrahimi Daryani3, F. Azmude Ardalan3, N. Aletaha3, R. Taslimi3, N. Roshan3

1Tehran University of Medical Science, Gastrenterology, Tehran, Iran, Islamic Republic of, 2Iran University of Medical Science, Tehran, Iran, Islamic Republic of, 3Tehran University of Medical Science, Tehran, Iran, Islamic Republic of

P075

Innate immunity in inflammatory bowel disease and colon cancer

Authors:

E. Lo Presti*1, R. Di Mitri2, F. Dieli1, F. Mocciaro2, G. Pecoraro2, G. Russo2, S. Meraviglia1

1University of Palermo, Central Laboratory of Advanced Diagnosis & Biomedical Research (CLADIBIOR), Department of Biopathology, Palermo, Italy, 2ARNAS Civico-Di Cristina-Benfratelli Hospital, Department of Gastroenterology and Endoscopy, Palermo, Italy

P076

The role for T-cells in the pathogenesis of Crohn’s disease–associated fistulae

Authors:

R. Bruckner*, M. Spalinger, G. Rogler, M. Scharl

University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland

P077

The efficacy of tyrosine kinase inhibitor dasatinib on colonic mucosal damage in murine model of colitis

Authors:

G. Can*1, S. Ayvaz2, H. Can3, I. Karaboğa4, S. Demirtaş4, H. Akşit5, B. Yilmaz6, U. Korkmaz7, M. Kurt7, T. Karaca4

1Abant Izzet Baysal University, Faculty of Medicine, Department of Gastroenterology, Bolu, Turkey, 2Trakya University, Faculty of Medicine, Department of Paediatric Surgery, Edirne, Turkey, 3Abant Izzet Baysal University, Faculty of Medicine, Department of Internal Medicine, Bolu, Turkey, 4Trakya University, Faculty of Medicine, Department of Histology and Embryology, Edirne, Turkey, 5Balikesir University, Faculty of Veterinary, Balikesir, Turkey, 6Selcuk University, Faculty of Medicine, Department of Gastroenterology, Konya, Turkey, 7Abant Izzet Baysal University, Medical Faculty, Department of Gastroenterology, Bolu, Turkey

P078

Walnut extract ameliorates acute and chronic colitis in murine models of colitis

Authors:

S.-J. Koh*, K. L. Lee, J.W. Kim, B. G. Kim, Y. J. Jung

Seoul National University Boramae Hospital, Seoul National University College of Medicine, Internal Medicine, Seoul, South Korea

P079

Trehalose ameliorates colitis by increasing mucosal autophagy and M2 polarisation

Authors:

J. Cosin-Roger*1, D. Ortiz-Masia1, D. C. Macias-Ceja2, P. Salvador1, L. Gisbert-Ferrandiz1, C. Hernandez2, S. Calatayud1, M. D. Barrachina1

1University of Valencia, Valencia, Spain, 2Fisabio Hospital Peset, Valencia, Spain

P080

Modulation of T-cell glycosylation and the control of intestinal inflammation

Authors:

A. M. Dias*1, 2, A. Correia3, M. Pereira1, C. R. Almeida4, M. Lima5, 6, R. Marcos-Pinto2, 7, 8, M. Vilanova2, 3, C. A. Reis1, 2, 9, P. Lago8, 
S. S. Pinho1, 2

1Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) & i3S – Instituto de Investigação e Inovação em Saúde, Glycobiology in Cancer, Porto, Portugal, 2Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Porto, Portugal, 3Instituto de Investigação e Inovação em Saude (I3S)/Institute for Molecular and Cell Biology (IBMC), Immunobiology Group, Porto, Portugal, 4Instituto de Investigação e Inovação em Saude (I3S)/ Institute of Biomedical Engineering (INEB), NEWTherapies Group, University of Porto, Porto, Portugal, 5Centro Hospitalar do Porto , Multidisciplinary Unit for Biomedical Research (UMIB), Porto, Portugal, 6Centro Hospitalar do Porto, Haematology Department, Porto, Portugal, 7Medical Faculty, Centre for Research in HealthTechnologies and Information Systems (CINTESIS), Porto, Portugal, 8Centro Hospitalar do Porto, Department of Gastroenterology, Porto, Portugal, 9University of Porto, Medical Faculty, Porto, Portugal

P081

Evaluation of intestinal permeability with a triple sugar test in inflammatory bowel disease

Authors:

D. Mukhametova1, D. Abdulganieva*1, S. Koshkin2, S. Abdulhakov1, A. Odintsova3

1Kazan State Medical University, Kazan, Russian Federation, 2Kazan (Volga region) Federal University, Kazan, Russian Federation, 3Republican Clinical Hospital, Kazan, Russian Federation

P082

Anti-TNF-alpha therapy and apoptosis

Authors:

R. Zaharie1, F. Zaharie2, A. Tantau*3, B. Petrushev4, M. Tantau4

1University of Medicine and Pharmacy, Third Medical Clinic, Cluj-Napoca, Romania, 2University of Medicine and Pharmacy, Third Surgery Clinic, Cluj-Napoca, Romania, 3University of Medicine and Pharmacy, Fourth Medical Clinic, Cluj-Napoca, Romania, 4University of Medicine and Pharmacy, Third Medical Clinic, Cluj-Napoca, Romania

P083

Intestinal fatty acid binding protein as a biomarker of intestinal damage in children with coeliac and Crohn’s disease

Authors:

C. M. Clark*1, A. Kountouri1, M. MacKinder1, R. Hansen2, R. K. Russell2, K. Gerasimidis1

1University of Glasgow, Human Nutrition, School of Medicine, Glasgow, United Kingdom, 2Royal Hospital for Children, Department of Paediatric Gastroenterology, Glasgow, United Kingdom

P084

Intestinal organoids derived from patients with inflammatory bowel disease show unaltered transcriptional profiles when compared with healthy controls

Authors:

M. Noben*1, 2, N. Hendriks1, 2, G. Van Assche1, S. Vermeire1, C. Verfaillie2, M. Ferrante1

1KU Leuven, Translational Research Centre for Gastrointestinal Disorders (Targid), Leuven, Belgium, 2KU Leuven, Stem Cell Institute Leuven, Leuven, Belgium

P085

Altered proportions of myeloid and plasmacytoid dendritic cells in children with inflammatory bowel disease

Authors:

M. F. Elshal1, 2, 3, 4, A. M. Aldahlawi2, 3, 5, O. I. Saadah*6, 7, J. P. McCoy8

1Facuty of Sciences, King Abdulaziz Uinversity, Biochemistry Department, Jeddah, Saudi Arabia, 2Inflammatory Bowel Disease Research Group, King Abdulaziz University, Jeddah, Saudi Arabia, 3Immunology Unit, King Fahd Medical Research Centre, Jeddah, Saudi Arabia, 4Sadat City University, Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute, Cairo, Egypt, 5Faculty of Sciences, KIng Abdulaziz University, Biological Sciences Department, Jeddah, Saudi Arabia, 6Faculty of Medicine, King Abdulaziz University, Paediatric Department, Jeddah, Saudi Arabia, 7Inflammatory Bowel Disease Research Group, King Abdulaziz Uinversity, Jeddah, Saudi Arabia, 8National Heart, Lung, and Blood Institute, National Institutes of Health, Flow Cytometry Core, Bethesda, MD, United States

P086

Glycosylation of T-cells as a new molecular biomarker in inflammatory bowel disease: an opportunity for new therapeutic strategies

Authors:

A. M. Dias1, M. Pereira1, R. Marcos-Pinto2, A. Correia3, M. Vilanova3, C. Reis1, P. Lago2, S. S. Pinho*1

1IPATIMUP/i3S, University of Porto, Glycobiology in Cancer, Porto, Portugal, 2Porto Centre Hospital, Hospital Santo António, Gastrenterology department, Porto, Portugal, 3Institute of Biomedical Sciences of Abel Salazar (ICBAS), University of Porto, Immunology department, Porto, Portugal

P087

Contributions of monocytes to gut inflammation in acute and chronic colitis models

Authors:

F. Becker*1, F. N. Gavins2, T. Vowinkel1, I. Tsunoda3, E. Rijcken1, D. V. Ostanin4, J. S. Alexander2

1University Hospital Muenster, Department of General and Visceral Surgery, Muenster, Germany, 2Louisiana State University Health Sciences Centre-Shreveport, Department of Molecular & Cellular Physiology, Shreveport, Louisiana, United States, 3Louisiana State University Health Sciences Centre-Shreveport, Department of Microbiology and Immunology, Shreveport, Louisiana, United States, 4Louisiana State University Health Sciences Centre-Shreveport, Centre of Excellence for Arthritis and Rheumatology, Shreveport, Louisiana, United States

P088

Loss of intestinal Desmoglein 2 promotes chemically and pathogenic induced colitis

Authors:

A. Gross*1, L. Pack1, S. Kant2, C. Krusche2, G. Sellge1, C. Trautwein1, R. Leube2, P. Strnad1

1University Hospital Aachen, Medicine III, Aachen, Germany, 2University Hospital Aachen, Institute of Molecular and Cellular Anatomy, Aachen, Germany

P089

Stimulation of the ω-3 docosahexaenoic acid metabolism via MFSD2A as a novel therapy for inflammatory bowel disease.

Authors:

F. Ungaro*1, 2, C. Correale1, P. Corsetto3, L. Massimino4, P. Fonteyne1, C. Tacconi1, K. R. Maddipati5, A. Rizzo3, S. D’Alessio1, 2, S. Danese1

1Humanitas Research Institute, Laboratory of Immunology in Gastroenterology, Milan, Italy, 2University of Milan, Department of Biotechnology and Translational Medicine, Milan, Italy, 3University of Milan, Department of Pharmacology and Biomolecular Science, Milan, Italy, 4San Raffaele Research Institute, Division of Neuroscience, Milan, Italy, 5Wayne State University, Department of Pathology, Detroit, Michigan, United States

P090

Differences in expression of G protein–coupled receptor 55 (GPR55) in patients with Crohn’s disease and ulcerative colitis

Authors:

M. Wlodarczyk*1, A. Sobolewska-Włodarczyk1, A. Cygankiewicz2, D. Jacenik2, W. Krajewska3, K. Stec-Michalska1, A. Piechota-Polanczyk4, J. Fichna4, M. Wisniewska-Jarosinska1

1Medical University of Lodz, Department of Gastroenterology, Lodz, Poland, 2University of Lodz, Department of Cytobiochemistry, Lodz, Poland, 3University of Lodz, Cytobiochemistry, Lodz, Poland, 4Medical University of Lodz, Department of Biochemistry, Lodz, Poland