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P222. Incidence and risk factors for free bowel perforation in patients with Crohn's disease
Authors:

J.W. Kim1, B.D. Ye1, S.-K. Yang1, S.-K. Park1, S.H. Park1, D.-H. Yang1, K.W. Jung1, K.-J. Kim1, J.-S. Byeon1, S.-J. Myung1, J.-H. Kim1, 1Asan Medical Center, Gastroenterology, Seoul, South Korea

P222. Methotrexate use in inflammatory bowel disease: A referral centre's 30 years of experience
P222

Delay in Meeting Diagnostic Criteria in Crohn's Disease.

Authors:

G. Radford-Smith*1, E. Ferguson2, K. Hanigan3, L. Simms3, J. Irwin3

1Royal Brisbane and Women's Hospital, Gastroenterology, Brisbane, Australia, 2Royal Brisbane & Women's Hospital, Department of Gastroenterology, Brisbane, Australia, 3QIMR Berghofer Medical Research Institute, Complex Diseases, Brisbane, Australia

P223.

Faecal calprotectin testing in primary and secondary care – Are the current manufacturer's cut-off values clinically useful?

Authors:

S. Lee1, H. Borthwick2, A. Dhar1, 1County Durham & Darlington NHS Foundation Trust, Gastroenterology, Co. Durham, United Kingdom, 2County Durham & Darlington NHS Foundation Trust, Clinical Biochemistry, Co. Durham, United Kingdom

P223. Dermatological surveillance of inflammatory bowel disease patients treated with biological therapy
P223. Improved work productivity in caregivers of pediatric patients with Crohn's disease treated with adalimumab
Authors:

F.M. Ruemmele1, W. Crandall2, J.C. Escher3, G. Veereman-Wauters4, A. Lazar5, M. Skup5, M. Yang5, P.M. Mulani5, J. Chao5, R. Thakkar5, J. Hyams6, 1Hôpital Necker-Enfants Malades, Paris, France, 2Nationwide Children's Hospital, Columbus, OH, United States, 3Erasmus MC-Sophia Children's Hospital, Rotterdam, Netherlands, 4UZ Brussels, Brussels, Belgium, 5Abbott Laboratories, Abbott Park, IL, United States, 6Connecticut Children's Medical Center, Hartford, CT, United States

P223. Skin lesions in patients with inflammatory bowel disease treated with immunomodulators and/or anti-tumor necrosis factor
P223

Idelalisib-induced acute proctocolitis: Clinical and histological findings

Authors:

P. Hendy*1, C. Rosty2, J. Bashford3, A. Clouston2, D. Burger4

1University of Queensland, School of Medicine, Brisbane, Australia, 2Envoi Pathology, Histopathology, Brisbane, Australia, 3Wesley Hospital , Haematology and Oncology, Brisbane, Australia, 4Wesley Hospital, Wesley Gastroenterology and Liver Diseases, Brisbane, Australia

P224.

Exhaled pentane may identify disease activity in patients with inflammatory bowel diseases

Authors:

M. Bortlik1, K. Dryahina2, D. Duricova1, N. Machkova1, P. Spanel2, M. Lukas1, 1ISCARE and Charles University, IBD Clinical and Research Centre, Prague, Czech Republic, 2J. Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

P224. Anti TNF-alpha therapy and steroids increase the risk of opportunistic infection in patients with inflammatory bowel disease
P224. Impact of transition on clinical and developmental outcomes of young IBD patients following transfer from paediatric to adult IBD services
Authors:

R.A. Cole1, N. Rao2, D. Ashok2, S. Besarovich2, A. Azaz2, S. Sebastian3, 1Hull & York Medical School, United Kingdom, 2Hull & East Yorkshire NHS Trust, United Kingdom, 3Hull & East Yorkshire NHS Trust, Hull & York Medical School, United Kingdom

P224. Use of adalimumab in anti-TNF naive Crohn's disease patients: Clinical experience in a multicenter cohort
P224

The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) is useful to evaluate endoscopic improvement and to predict medium-term prognosis in ulcerative colitis patients treated with tacrolimus.

Authors:

K. Matsuoka*, E. Saito, T. Fujii, K. Takenaka, M. Nagahori, K. Ohtsuka, M. Watanabe

Tokyo Medical and Dental University, Gastroenterology and Hepatology, Tokyo, Japan

P225.

Evaluation of the relationship between serum ghrelin, C-reactive protein and interleukin-6 levels and disease activity in inflammatory bowel diseases

Authors:

C. Çekiç, S. Ipek, F. Aslan, E. Alper, B. Unsal, Katip Çelebi University, Atatürk Training and Research Hospital, Gastroenterology, Izmir, Turkey

P225. Effects of TNF-α antagonists on lipid profile in patients with IBD
P225. Impact of subcutaneously administered golimumab on disease specific and generic health-related quality of life in patients with moderately to severely active ulcerative colitis: Results from PURSUIT-SC induction
Authors:

B. Feagan1, P. Gibson2, C. Marano3, R. Strauss3, C. Han4, J. Johanns3, H. Zhang3, C. Guzzo3, J.-F. Colombel5, W. Reinisch6, J. Collins7, G. Jarnerot8, P. Rutgeerts9, W. Sandborn10, 1Robarts Research Institute, Canada, 2Alfred Hospital, Melbourne, Australia, 3Janssen Research & Development, LLC, United States, 4Janssen Global Services LLC, United States, 5Hôpital Claude Huriez, France, 6Universitätsklinik für Innere Medizin IV, Austria, 7Oregon Health Sciences University, United States, 8Orebro University Hospital, Sweden, 9University Hospital, Gasthuisberg, Belgium, 10University of California San Diego, United States

P225. Pharmacokinetics/pharmacodynamics and safety of AMG 181, a fully human anti-α 4 β 7 antibody for treating inflammatory bowel diseases (IBD)
P225

Anticipate to defer: predicting surgical outcome at the moment of diagnosis of Crohn's disease

Authors:

T. Cúrdia Gonçalves*1, M. Costa2, M.J. Moreira1, J. Cotter1, 3, 4

1Centro Hospitalar do Alto Ave, Gastroenterology, Guimarães, Portugal, 2University of Minho, School of Health Sciences, Braga/Guimarães, Portugal, 3University of Minho, Life and Health Sciences Research Institute, Braga/Guimarães, Portugal, 4University of Minho, ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal

P226.

Evaluation of intestinal permeability on the basis of zonulin levels, in children with inflammatory bowel disease

Authors:

U. Chlebowczyk1, D. Pabijasz2, S. Wiecek1, H. Wos1, 1Medical University of Silesia, Department of Pediatrics, Gastroenterology Unit, Katowice, Poland, 2Upper-Silesian Child Health Care Centre Katowice, Poland, Department of Pediatrics, Katowice, Poland

P226. Long-term impact of both deliveries and Crohn's disease on anoperineal lesions
Authors:

A. Grouin1, L. Siproudhis2, J. Leveque1, J.-F. Bretagne2, P. Poulain1, G. Bouguen2, 1CHU Pontchaillou, Service de Gynécologie-Obstétrique, Rennes, France, 2CHU Pontchaillou, Service des Maladies de l'Appareil Digestif, Rennes, France