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P051

Chemokines CXCL17, CCL20, and the receptor CXCR5 are overexpressed in the colonic mucosa from patients with active ulcerative colitis: CXCL17 is a potential marker of histological remission

Authors:

J. Yamamoto-Furusho*1, E. Iturriaga-Goyon2, G. Fonseca-Camarillo1

1IBD Clinic, Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico, 2Instituto Nacional de Ciencias Medicas y Nutricion, Gastroenterology, Mexico, Mexico

P052

Intestinal total bacteria concentration and translocation of bacteria in inflammatory bowel disease

Authors:

S. Vrakas1, M. Gazouli*2, K. Mountzouris3, G. Michalopoulos1, G. Karamanolis4, G. Papatheodoridis5, C. Tzathas1

1Tzaneion General Hospital, Gastroenterology Department, Piraeus, Greece, 2Medical School, National & Kapodistrian University, Biology, Athens, Greece, 3Agriculture University, Nutritional Physiology and Feeding, Athens, Greece, 4Medical School, National & Kapodistrian University, Gastroenterology Unit, Second University Surgical Department, Athens, Greece, 5Medical School National & Kapodistrian University, Gastroenterology, Athens, Greece

P053

Histological and immunohistochemical indicators of progression towards malignancy in ulcerative colitis

Authors:

C. Popp*1, G. Micu1, M. Cioplea1, L. Sticlaru1, G. Pop1, B. Mateescu2, F. Staniceanu1, S. Zurac1, L. Nichita1

1Colentina University Hospital, Pathology, Bucuresti, Romania, 2Colentina University Hospital, Gastroenterology, Bucuresti, Romania

P054

Soluble GPVI is raised in patients with inflammatory bowel disease and anaemia

Authors:

S. J. Montague1, A. Chauhan*2, E. E. Gardiner3, R. K. Andrews3, 
S. P. Watson1, T. Iqbal4

1Institute of Biomedical Research, University of Birmingham, Centre for Cardiovascular Sciences, College of Medical and Dental Sciences, Birmingham, United Kingdom, 2Centre for Liver Research, and National Institute of Health Research Birmingham Liver Biomedical Research Unit, Institute of Biomedical Research, College of Medical and Dental Science, Birmingham, United Kingdom, 3Monash University, Australian Centre for Blood Diseases, Melbourne, Australia, 4Queen Elizabeth Hospital, Department of Gastroenterology, Birmingham, United Kingdom

P055

Galectin-3 plays protective roles in intestinal Behçet’s disease

Authors:

J. H. Kim*1, 2, H. J. Lee1, H. W. Ma1, 2, D. H. Seo1, 2, X. Che1, 2, D. H. Kim1, S. W. Kim1, 2, 3, J. H. Cheon1, 2, 3

1Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, 2Yonsei University, Brain Korea 21 Plus Project for Medical Science, Seoul, South Korea, 3Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea

P056

Evaluation of oxidative stress in experimental model of Chron’s disease under hyperbaric oxygen treatment

Authors:

F. S. Nakutis1, I. Nishitokukado1, F. M. d. Santos1, C. Ortiz-Agostinho1, V. S. Nunes2, A. Zonetti1, A. Sipahi*1

1Faculdade de Medicina da USP, Gastroenterologia Lim07, São Paulo, Brazil, 2Universidade de Medicina da USP, Laboratório Lípides, São Paulo, Brazil

P057

HLA B27 transgenic rat: a new animal model of postsurgical ileitis in inflammatory bowel disease

Authors:

A. Chau*1, C. Chater1, S. Speca2, M. Djouina2, C. Dubuquoy2, L. Dubuquoy2, C. Neut3, D. Koriche1, P. Zerbib1, F.R. Pruvot1, P. Desreumaux4, B. Pariente4

1Lille University North of France, INSERM U995, Department of Digestive Surgery and Transplantation, CHRU Lille, Lille, France, 2Lille University North of France, INSERM U995, CHRU Lille, Lille, France, 3Lille University North of France, INSERM U995, Department of Microbiology, Faculty of Pharmacy, Lille, France, 4Hepato-Gastroenterology Department, Claude Huriez Hospital, University of Lille 2, Inserm Unit 995, University of Lille 2, Lille, France

P058

Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis

Authors:

I. Oancea1, 2, I. Das1, D. Aguirre de Cárcer3, R. Movva1, 4, V. Schreiber1, Y. Yang1, 5, M. Proctor1, R. Wang1, Y. Sheng1, M. Lobb1, P. Ó Cuiv6, J. A. Duley1, 4, J. Begun*2, 7, T. H. J. Florin1, 2

1University of Queensland, Mater Research Institute, Brisbane, Australia, 2University of Queensland, School of Medicine, Brisbane, Australia, 3CSIRO, Preventative Health National Research Flagship and Division of Livestock Industries, Brisbane, Australia, 4Griffith University, School of Pharmacy, Gold Coast, Australia, 5University of Queensland, School of Pharmacy, Brisbane, Australia, 6University of Queensland, Diamantina Institute, Brisbane, Australia, 7University of Queensland, Mater Research Institute, South Brisbane, Australia

P059

Two new genetic mouse models for ulcerative colitis based on lateral tight junction disruption.

Authors:

W. Stremmel*1, S. Staffer2, M. Schneider3, H. Gan-Schreier2, A. Wannhoff2, A. Gauss4, H. Wolburg5, M. Bach6, A. Swidsinski7, T. Efferth3

1University Hospital of Heidelberg, Internal Medicine IV, Dept. of Gastroenterology, Heidelberg, Germany, 2University Hospital of Heidelberg, Internal Medicine IV, Div. of Gastroenterology, Heidelberg, Germany, 3Johannes Gutenberg University, Institute of Pharmacy & Biochemistry, Mainz, Germany, 4University Hospital of Heidelberg, Gastroenterology, Heidelberg, Germany, 5University Medical School Tuebingen, Pathology and Neuropathology, Tuebingen, Germany, 6Kirchhoff Institute of Physics, Physics, Heidelberg, Germany, 7Charité - University Hospital Berlin, Berlin, Germany

P060

Alterations of brain structure in Crohn’s disease with extraintestinal manifestations

Authors:

A. Thomann*1, W. Reindl2, P. Thomann3, C. Wolf4, D. Hirjak3, M. Griebe5

1Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany, 2Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany, 3Universitätsklinik Heidelberg, Department of Psychiatry, Heidelberg, Germany, 4Universität des Saarlandes, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Homburg/Saar, Germany, 5Universitätsmedizin Mannheim, Department of Neurology, Mannheim, Germany

P061

Creeping fat contains a unique T-cell compartment with potential impact on intestinal inflammation

Authors:

L. I. Kredel*1, L. J. Jödicke1, A. A. Kuehl1, I. Freise1, J. Gröne2, B. Siegmund1

1Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, General, Vascular and Thoracic Surgery, Berlin, Germany

P062

Critical role of the IL-33/ST2 axis in colitis-associated colorectal cancer

Authors:

L. R. Lopetuso*1, 2, 3, C. De Salvo3, L. Di Martino3, W. Goodman3, F. Scaldaferri2, A. Gasbarrini2, T. T. Pizarro3

1Catholic University of the Sacread Hearth, Internal Medicine, Gastroenterology Division, Rome, Italy, 2Catholic University of Sacred Heart, Internal Medicine Department, Gastroenterology Division, Rome, Italy, 3Case Western Reserve University, Pathology, Cleveland, United States

P063

Dissecting the role of rage in intestinal fibrosis

Authors:

S. Speca*1, M. Body-Malapel1, C. Fradin1, M. Djouina1, E. Boulanger1, A.-M. Schmidt2, P. Desreumaux1, C. Vignal1

1Centre Hospitalier Régional Universitaire de Lille, Lille, France, 2NYU Langone Medical Centre, Departments of Medicine (Endocrinology Div), Biochemistry and Molecular Pharmacology and Pathology (Pathology) , New York, United States

P064

TOP1210 narrow spectrum kinase inhibitor demonstrates superior activity and improved safety profile potential compared with corticosteroid and immunomodulators in preclinical models of colitis

Authors:

C. A. Walshe*, A. Rowley, M. R. Foster, Y. Solanke, S. Sirohi, 
M. C. Fyfe, S. Webber

Topivert Pharma Ltd, London, United Kingdom

P065

Molecular landscape of early Crohn’s disease using an integrated approach of mRNA/miRNA profiling and genomics

Authors:

S. Verstockt*1, J. Van der Goten2, M. Vancamelbeke2, B. Verstockt2, F. Schuit3, P. Rutgeerts2, M. Ferrante2, S. Vermeire2, I. Arijs2, I. Cleynen1

1KU Leuven, Department of Human Genetics, Leuven, Belgium, 2KU Leuven, Department of Clinical and Experimental Medicine, Translational Research Centre for Gastrointestinal Disorders, Leuven, Belgium, 3KU Leuven, Department of Cellular and Molecular Medicine, Gene Expression Unit, Leuven, Belgium

P066

CCR2-monocytes are essential for the resolution of inflammation and tissue repair in colitis.

Authors:

M. Stakenborg, G. Goverse, G. Farro, P. J. Gomez-Pinilla, 
G. E. Boeckxstaens, G. Matteoli*

KU Leuven, P.O. Box 701, Department of Clinical and Experimental Medicine, Leuven, Belgium

P067

Angiogenic characterisation of Crohn’s disease mesenteric adipose tissue

Authors:

M. Eddama*1, R. Cohen1, M. Rodriguez-Justo2, I. Evans3, L. Shen4, L. Clapp4, M. Loizidou5

1University College London Hospital, Colorectal Surgery, London, United Kingdom, 2University College London Hospital, Department of Pathology, London, United Kingdom, 3University College London, Centre for Cardiovascular Biology and Medicine, London, United Kingdom, 4University College London, Institute of Cardiovascular Science, London, United Kingdom, 5University College London, Academic Department of Surgery, London, United Kingdom

P068

Anti-fibrotic therapy for Crohn’s disease: in-vitro proof of concept with a selective ROCK2 inhibitor, LYC-53976, in the treatment of human intestinal myofibroblasts in stiffness and transforming growth factor β models

Authors:

E. Rodansky1, X. Liu2, L. A. Johnson1, K. Demock2, A. J. Celeste2, L. L. Carter2, P. D. R. Higgins*1

1University of Michigan, Internal Medicine - Gastroenterology, Ann Arbor, Michigan, United States, 2Lycera, Inc., Ann Arbor, Michigan, United States

P069

TD-1473, a novel, potent, and orally administered, GI-targeted, pan-Janus kinase (JAK) inhibitor

Authors:

D. Beattie*, P. Tsuruda, F. Shen, P. Brassil, C. Langrish, J. Janc, Z. Ren, R. Hudson, J. Smith, S. Hegde

Theravance Biopharma, South San Francisco, United States

P070

The influence of vitamin D on M1 and M2 macrophages in patients with Crohn’s disease

Authors:

E. Seidman*, S. Dionne

Research Institute of the McGill University Hospital, Gastroenterology, Montreal, Canada