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P031

STAT6 deficiency alters macrophage polarisation and promotes fibrosis in a murine model of chronic inflammation

Authors:

P. Salvador*1, D. Ortiz-Masiá1, D. C. Macias-Ceja1, 2, J. Cosín-Roger1, L. Gisbert-Ferrándiz1, C. Hernández2, S. Calatayud1, M. D. Barrachina-Sancho1

1University of Valencia, Valencia, Spain, 2Fisabio Hospital Peset, Valencia, Spain

P032

IFN-γ controls the immunomodulatory properties of bone marrow mesenchymal stem cells via a microRNA29a/STAT-3 dependent mechanism

Authors:

A. Oikonomopoulos*1, P. Lacey1, T. Tomakili1, D. Iliopoulos2, 
D. W. Hommes1

1UCLA Centre for Inflammatory Bowel Diseases, Division of Digestive Diseases, Los Angeles, California, United States, 2UCLA Centre for Systems Biomedicine, Division of Digestive Diseases, Los Angeles, California, United States

P033

Anti-TNF-α therapy normalises aberrant cytokine production and homing profile of circulating dendritic cells in Crohn’s disease

Authors:

P. Hendy*1, 2, D. Reddi2, D. Bernardo3, L. Durant2, A. Noble2, N. English2, S. Knight2, A. Hart1

1St Mark’s Hospital, Gastroenterology, LONDON, United Kingdom, 2Imperial College, Antigen Presentation Research Group, London, United Kingdom, 3Hospital Universitario de La Princesa, Department of Immunology, Madrid, Spain

P034

Immunoregulatory properties of human adipose–derived stem cells in inflammatory diseases: differences between Crohn´s disease and obesity

Authors:

C. Serena*1, 2, N. Keiran2, M. Millan2, M. Ejarque1, 2, R. Fradera3, E. Espin4, K. Roche1, 2, J. Vendrell1, 2, S. Fernandez-Veledo1, 2

1Health Institute Pere Virgili, Research Unit, Tarragona, Spain, 2Hospital Joan XXIII, Tarragona, Spain, 3Hospital St. Pau i Sta Tecla, Tarragona, Spain, 4Hospital Vall d’Hebron, Barcelona, Spain

P035

Lamina propria CD4+LAP+ Foxp3- regulatory cells are involved in limiting the disease extension in Ulcerative Colitis

Authors:

A. Butera1, A. Amendola1, M. Sanchez2, S. Piroli3, A. Pronio3, D. De Nitto4, R. Pica4, M. Boirivant*1

1Istituto Superiore di Sanità, Dept Infectious, Parasitic and Immune-mediated Diseases, Roma, Italy, 2Istituto Superiore di Sanità, Dept Cell Biology and Neurosciences, Rome, Italy, 3University ‘Sapienza’, Dept General Surgery, ‘P. Stefanini’, Roma, Italy, 4Sandro Pertini Hospital, IBD, GE Unit, Roma, Italy

P036

Colon targeted delivery of tofacitinib inhibits oxazolone-induced colitis in mice, despite low systemic exposure

Authors:

F. Shen*, P. Brassil, S. Hegde, D. Beattie

Theravance Biopharma, South San Francisco, California, United States

P037

Remodelling events preceding clinical onset of intestinal inflammation reveal the predictive power of the extracellular matrix

Authors:

E. Shimshoni*1, R. Afik1, L. Puricelli2, A. Shenoy3, T. Geiger3, A. Podestà2, I. Sagi1

1Weizmann Institute of Science, Biological Regulation, Rehovot, Israel, 2University of Milan, Physics, Milan, Italy, 3Tel Aviv University, Human Genetics, Tel Aviv, Israel

P038

Revised roles of matrix metalloproteinase/MMP-9 in inflammatory bowel diseases: from target to biomarker

Authors:

M. de Bruyn*1, 2, C. Breynaert3, I. Arijs2, G. De Hertogh4, K. Geboes4, G. Thijs1, J. Hu5, J. Van Damme1, B. Arnold6, M. Ferrante7, S. Vermeire7, G. Van Assche7, J. Ceuppens3, G. Opdenakker1

1Rega Institute for Medical Research, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, 2Translational Research Centre for Gastrointestinal Disorders (TARGID), KU Leuven, Department of Clinical and Experimental Medicine, Leuven, Belgium, 3Laboratory of Clinical Immunology, KU Leuven, Department of Microbiology and Immunology, Leuven, Belgium, 4Translational Cell and Tissue Research, KU Leuven, Department of Imaging and Pathology, Leuven, Belgium, 5Key Laboratory of Modern Chinese Medicines, China Pharmaceutical University, Ministry of Education, Nanjing, China, 6German Cancer Research Centre (DKFZ), Department of Molecular Immunology, Heidelberg, Germany, 7University Hospitals Leuven, KU Leuven, Department of Gastroenterology, Leuven, Belgium

P039

Expression of the liver homing receptor CXCR3+ on colonic CD8+ T lymphocytes in patients with primary sclerosing cholangitis provides a possible link between colonic and biliary duct inflammation.

Authors:

M. Lampinen*1, A. Fredricsson1, J. Vessby1, A. Wanders2, F. Rorsman1, M. Carlson1

1Uppsala University, Medical Sciences, Uppsala, Sweden, 2Umeå University, Medical Biosciences, Umeå, Sweden

P040

Sonic hedgehog inhibitor prevented colitis-associated cancer via concerted mechanisms of IL-6/gp130 inhibition, 15-prostaglandin dehydrogenase induction, Bcl-2 abrogation, and tumour sphere inhibition

Authors:

K. B. Hahm*1, N. Kangwan1, Y. J. Kim2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Gachon University, Gastroenterology, Incheon, South Korea

P041

Automated image analysis as a diagnostic tool in discriminating between subgroups of microscopic colitis

Authors:

A.-M. Kanstrup-Fiehn1, M. Kristensson2, U. H. Engel3, L. K. Munck4, 5, 
S. Holck3, P. J. H. Engel*1, 5

1Roskilde Hospital, Department of Pathology, Roskilde, Denmark, 2Visiopharm, Hoersholm, Denmark, 3Copenhagen University Hospital, Department of Pathology, Hvidovre, Denmark, 4Koege Sygehus, Department of Gastroenterology, Koege, Denmark, 5University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark

P042

Circulating IL9 in inflammatory bowel disease: possible marker of mucosal non-healing

Authors:

K. Neubauer*1, M. Krzystek-Korpacka2, M. Matusiewicz2, M. Zawadzki3, I. Bednarz-Misa2, S. Górska4, W. Witkiewicz5, A. Gamian6, 7

1Wroclaw Medical University, Gastroenterology and Hepatology, Wroclaw, Poland, 2Wroclaw Medical University, Medical Biochemistry, Wroclaw, Poland, 3Regional Specialist Hospital, Vascular Surgery, Wroclaw, Poland, 4LudwikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Medical Microbiology, Wroclaw, Poland, 5Research and Development Centre at Regional Specialist Hospital, Wroclaw, Poland, 6Medical Wroclaw University, Medical Biochemistry, Wroclaw, Poland, 7LudwikHirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

P043

Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis

Authors:

N. Duijvis*1, C. Kunne1, M. Slaman1, F. van Dooren1, E. Vogels1, S. Meijer2, K. Fluiter3, P. Moerland3, A. te Velde1

1Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 2Academic Medical Centre (AMC), Department of Pathology, Amsterdam, Netherlands, 3Academic Medical Centre (AMC), Department of Clinical Epidemiology, Amsterdam, Netherlands

P044

Roles of IL-33 on murine colitis and M2 macrophage differentiation in inflammatory bowel diseases

Authors:

D. H. Seo*1, 2, M. S. Kawk1, X. Che1, 2, H. W. Ma1, 2, J. H. Kim1, 2, D. H. Kim1, T. I. Kim1, W. H. Kim1, S. W. Kim1, 2, 3, J. H. Cheon1, 2, 3

1Yonsei University, Department of Internal Medicine and Institute of Gastroenterology, College of Medicine, Seoul, South Korea, 2Yonsei University, Brain Korea 21 PLUS Project for Medical Science, College of Medicine, Seoul, South Korea, 3Yonsei University, Severance Biomedical Science Institute, College of Medicine, Seoul, South Korea

P045

The relationship between thiol/disulphide and inflammatory bowel disease

Authors:

H. Akinci*1, Y. Coskun1, O. Erel2, M. Hamamci1, F. Karaahmet1, S. Kilincalp1, M. Alisik2, I. Yuksel1, 3

1Diskapi Yildirim Beyazit Education and Research Hospital, Gastroenterology, Ankara, Turkey, 2Yildirim Beyazit University School of Medicine, Biochemistry, Ankara, Turkey, 3Yildirim Beyazit University School of Medicine, Gastroenterology, Ankara, Turkey

P046

Therapeutic effects of mouse bone marrow–derived single clonal mesenchymal stem cells in a mouse model of inflammatory bowel disease

Authors:

K. B. Hahm*1, S. U. Song2, S. H. Park3

1CHA University, Gastroenterology, Seongnam, South Korea, 2Inha University, Gastroenterology, Incheon, South Korea, 3Sungkyunkwan University, Ciological Science, Suwon, South Korea

P047

Enterocytes and dendritic cells both contribute to the intestinal inflammation in paediatric inflammatory bowel diseases

Authors:

C. Strisciuglio*1, S. Vitale2, L. Pisapia3, E. Miele4, P. Barba3, A. Vitale1, S. Cenni4, G. Del Pozzo3, R. Troncone4, A. Staiano4, C. Gianfrani2

1Second University of Naples, Department of Woman, Child and General and Specialised Surgery, Naples, Italy, 2Institute of Protein Biochemistry, CNR, Naples, Italy, 3Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy, 4University Federico II, Department of Translational Medical Science, Section of Paediatrics, Naples, Italy

P048

Cigarette smoke impairs intestinal epithelial cell polarity development and morphogenesis

Authors:

L. J. Klunder*1, T. Blokzijl2, R. Ferreira1, K.-N. Faber2, G. Dijkstra2, S. C. D. van IJzendoorn1

1University Medical Centre Groningen, Department of Cell Biology, Groningen, Netherlands, 2University Medical Centre Groningen, Department of Gastroenterology and Hepatology, Groningen, Netherlands

P049

Prevalence and factors associated with vitamin D deficiency in patients with inflammatory bowel disease on biologic therapies

Authors:

K. Sugrue, D. Fitzgerald, M. Buckley, J. McCarthy, D. Farrell*

Mercy University Hospital, Department of Gastroenterology, Cork, Ireland

P050

Proinflammatory action of 5-HT in colon epithelial cell response to gut bacteria through NOX2 induction

Authors:

J.-A. Kim*, S. Banskota, S. Regmi, P. Grung, B.-S. Jeong, H. W. Chang

Yeungnam University, College of Pharmacy, Gyeongsan, South Korea