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P011

Distinct inflammatory signatures in primary sclerosing cholangitis associated with inflammatory bowel disease

Authors:

A. Gwela1, P. Siddhanathi1, R. W. Chapman1, C. Arancibia1, S. P .L. Travis1, F. Powrie2, A. Geremia*1

1John Radcliffe Hospital, Department of Translational Gastroenterology, Oxford, United Kingdom, 2University of Oxford, Kennedy Institute for Rheumatology, Oxford, United Kingdom

P012

MAIT cell activation reflects mucosal inflammation in ulcerative colitis

Authors:

K. Haga*1, A. Chiba2, T. Shibuya1, T. Osada1, D. Ishikawa1, T. Kodani1, O. Nomura1, S. Watanabe1, S. Miyake2

1Juntendo University, Department of Gastroenterology, Tokyo, Japan, 2Juntendo University, Department of Immunology, Tokyo, Japan

P013

Automated image analysis in the diagnosis of microscopic colitis: validation and implications for diagnosis and research

Authors:

P. J. H. Engel*1, 2, L. K. Munck2, 3, U. H. Engel4, S. Holck4, A.-M. Kanstrup-Fiehn1, M. Kristensson5

1Roskilde Hospital, Department of Pathology, Roskilde, Denmark, 2University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark, 3Koege Sygehus, Department of Gastroenterology, Koege, Denmark, 4Copenhagen University Hospital, Department of Pathology, Hvidovre, Denmark, 5Visiopharm, Hoersholm, Denmark

P014

Tofacitinib and a selective Janus kinase 1 inhibitor are equally potent in suppressing human macrophage function and T-cell proliferation

Authors:

L. De Vries*1, 2, M. Wildenberg2, V. Ludbrook3, G. D’Haens1, 
W. De Jonge2

1Academic Medical Centre (AMC), Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 3GlaxoSmithKline, ImmunoInflammation Therapy Area, Stevenage, United Kingdom

P015

Interaction between enteric glia and myeloid cells as critical players in intestinal immune homeostasis.

Authors:

G. Goverse*, M. Stakenborg, M. van Winge, E. Labeeuw, G. Farro, M. Hao, P. J. Gomez Pinilla, G. Boeckxstaens, G. Matteoli

KU Leuven, P.O. Box 701, Department of Clinical and Experimental Medicine, Leuven, Belgium

P016

Guggulsterone ameliorates colitis by suppressing TREM-1 hyperactivation and modulating macrophage phenotypes

Authors:

X. Che*1, 2, K. C. Park3, S. J. Park1, 4, Y. H. Kang1, H. A. Jin1, 2, D. H. Seo1, 2, S. W. Kim1, 2, 4, T. I. Kim1, W. H. Kim1, J. H. Cheon1, 2, 4

1Yonsei University, Internal Medicine and Institute of Gastroenterology, Seoul, South Korea, 2Yonsei University, Brain Korea 21 PLUS Project for Medical Science, Seoul, South Korea, 3Yonsei University, Seoul, South Korea, 4Severance Biomedical Science Institute, Seoul, South Korea

P017

Periostin aggravates the development of colitis-associated colon cancer in mice

Authors:

S.-J. Koh*1, J. W. Kim1, B. G. Kim1, K. L. Lee1, J. S. Kim2

1Seoul National University Boramae Hospital, Seoul National University College of Medicine, Internal Medicine, Seoul, South Korea, 2Seoul National University College of Medicine, Internal Medicine and Liver Research Institute, Seoul, South Korea

P018

Biologic functions between non-affected and affected margins of ileum samples from Crohn’s disease patients who will develop post-surgical recurrence.

Authors:

V. Loren*1, 2, A. Garcia-Jaraquemada1, A. Aterido3, F. Kamberovic1, A. Julià3, Y. Zabana4, A. Alonso3, M. Mañosa2, 5, S. Marsal3, E. Domènech2, 5, E. Cabré2, 5, J. Manyé2, 6

1Health Sciences Research Institute of the ‘Germans Trias i Pujol’ Foundation (IGTP), Inflammatory Bowel Disease Unit, Badalona, Spain, 2Centro de Investigación Biomédica en Red (CIBER), Madrid, Spain, 3Institute for research in Biomedicine, Rheumatology Research Group, Barcelona, Spain, 4Mútua de Terrassa Hospital, Terrassa, Spain, 5Germans Trias i Pujol Hospital, Inflammatory Bowel Disease Unit, Badalona, Spain, 6Health Sciences Research Institute of the ‘Germans Trias i Pujol’ Foundation (IGTP), Inflammatory Bowel Disease Unit, Badalona, Spain

P019

Informing ulcerative colitis pathophysiology and outcomes through metabolic pofiling

Authors:

S. Fong*1, C. Le Roy2, J. Sanderson1, S. Claus2

1Guy’s and St Thomas’ NHS Foundation Trust, IBD Centre, London, United Kingdom, 2University of Reading, Department of Food and Nutritional Sciences, Reading, United Kingdom

P020

The efficacy of tofacitinib and a selective Janus kinase 1 inhibitor in dextran sulphate sodium colitis models

Authors:

L. De Vries*1, 2, F. van Leeuwen-Hilbers2, P. van Hamersveld2, V. Ludbrook3, G. D’Haens1, W. De Jonge2

1Academic Medical Centre (AMC), Gastroenterology & Hepatology, Amsterdam, Netherlands, 2Academic Medical Centre (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands, 3GlaxoSmithKline, Immuno-Inflammation Therapy Area, Stevenage, United Kingdom

P021

Inflammatory monocytes are key regulators of colonic inflammation in murine and human IBD

Authors:

G.-R. Jones*1, P. Cook2, A. MacDonald2, T. Fenton2, A. Kelly2, M. Travis2, S. Campbell3

1University of Edinburgh, Gastroenterology, Edinburgh, United Kingdom, 2University of Manchester, Department of Immunology, Manchester, United Kingdom, 3University of Manchester / Manchester Royal Infirmary, Department of Gastroenterology, Jean Mcfarlane Building; School for Nursing, Manchester, United Kingdom

P022

Parthenolide enhances the efficacy of anti-tumour effect of balsalazide in human colon cancer cells and colitis-associated colorectal cancer by blockade of NF-kB activation

Authors:

G. S. Seo1, S.-L. Kim2, S. W. Kim*2

1Wonkwang university college of medicine, Internal medicine, Iksan, South Korea, 2Chonbuk national university hospital, Internal medicine, Jeonju, South Korea

P023

Development of methods to investigate effects of narrow spectrum kinase inhibitors on cellular phosphorylation of kinase substrates

Authors:

S. Sirohi*, M. Foster, M. Fyfe, Y. Solanke, S. Webber, C. Walshe

Topivert Pharma, London, United Kingdom

P024

Therapeutic potential of the human amniotic fluid mesenchymal stem cells/stroma cells secreted molecules in a mice model of colitis

Authors:

M. Gazouli*1, E. Legaki1, M. Roubelakis1, A. Lazaris2, G. Karamanolis3, E. Marinos1, G. Theodoropoulos4

1School of Medicine, University of Athens, Biology, Athens, Greece, 2School of Medicine, University of Athens, Pathology, Athens, Greece, 3School of Medicine, University of Athens, Gastroenterology, Athens, Greece, 4School of Medicine, University of Athens, Surgery, Athens, Greece

P025

Tonsil-derived mesenchymal stem cell ameliorate intestinal fibrosis in chronic murine colitis model

Authors:

E. M. Song*1, S.-A. Jung1, S.-E. Kim1, K. E. Lee1, J. Y. Chang1, H. M. Son1, M. S. Ryu1, Y. H. Joo1, C. H. Tae1, C. M. Moon1, H.-K. Jung1, K.-N. Shim1, I. H. Jo2, Y. S. Yu2

1Ewha Woman’s University School of Medicine, Department of Internal Medicine, Ewha Medical Research Institute, Seoul, South Korea, 2Ewha Woman’ University School of Medicine, Department of Molecular Medicine, Ewha Medical Research Institute, Seoul, South Korea

P026

Characterisation of mucosal CD4+ T-cells in peripheral blood of healthy controls and paediatric inflammatory bowel disease patients

Authors:

M. Joosse*1, C. Menckeberg1, L. de Ruiter1, H. Raatgeep1, L. van Berkel1, F. Muskens2, R. Hendriks2, R. Hoogenboezem3, T. Cupedo3, L. de Ridder4, H. Escher4, S. Veenbergen1, J. Samsom1

1Erasmus MC, Laboratory of Paediatrics, division Gastroenterology and Nutrition, Rotterdam, Netherlands, 2Erasmus MC, Department of Pulmonary Medicine, Rotterdam, Netherlands, 3Erasmus MC, Department of Haematology, Rotterdam, Netherlands, 4Erasmus MC, Department of Paediatric Gastroenterology, Rotterdam, Netherlands

P027

Characterisation of human intestinal dendritic cells and macrophages through the lower gastrointestinal tract.

Authors:

D. Bernardo*, A. C. Marín, P. M. Linares, M. Jiménez, M. Chaparro, J. P. Gisbert

Hospital Universitario de La Princesa, IIS-IP and CIBERehd, Gastroenterology Unit, Madrid, Spain

P028

Inflammatory bowel disease is associated with cytoskeleton rearrangement in the epithelial cells

Authors:

A. Portyanko1, P. Perevoschikov1, K. Ruksha1, J. Gorgun*2

1Belarusian State Medical University, Department of Pathology, Minsk, Belarus, 2Belarusian Medical Academy of Postgraduate Education, Department of Gastroenterology and Nutrition, Minsk, Belarus

P029

Intestinal mesenchymal-specific IKK2 promotes initiation of colitis and colitis-associated cancer

Authors:

V. Koliaraki*1, M. Pasparakis2, G. Kollias1, 3

1BSRC "Alexander Fleming", Vari, Greece, 2University of Cologne, Institute of Genetics, Cologne, Germany, 3University of Athens, Department of Physiology, Athens, Greece

P030

Development of small bowel tissue phantom for microultrasound 
investigation

Authors:

T. Anbarasan*1, C. E. M. Démoré1, H. Lay2, M. R. S. Sunoqrot1, R. Poltarjonoks1, S. Cochran2, B. F. Cox1

1University of Dundee, Dundee, United Kingdom, 2University of Glasgow, Glasgow, United Kingdom